Q8N682 (DRAM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA damage-regulated autophagy modulator protein 1

Alternative name(s):
Damage-regulated autophagy modulator

Gene names

Name:	DRAM1
Synonyms:	DRAM

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy. Ref.3 Ref.4
Subcellular location	Lysosome membrane; Multi-pass membrane protein Ref.3.
Induction	By p53/TP53 and TP73/p73. Directly activated by p53/TP53. Significantly down-regulated in tumor cell lines by methylation-dependent transcriptional silencing. Ref.3 Ref.4
Sequence similarities	Belongs to the DRAM/TMEM150 family.
Sequence caution	The sequence BAA92091.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis Autophagy
Cellular component	Lysosome Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW autophagy Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW lysosomal membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	DNA damage-regulated autophagy modulator protein 1		PRO_0000287436
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	53 – 73	21	Helical; Potential
	Transmembrane	91 – 111	21	Helical; Potential
	Transmembrane	116 – 136	21	Helical; Potential
	Transmembrane	161 – 181	21	Helical; Potential
	Transmembrane	200 – 220	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8N682 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 511875677737F6C0	FASTA	238	26,253
	10 20 30 40 50 60 MLCFLRGMAF VPFLLVTWSS AAFIISYVVA VLSGHVNPFL PYISDTGTTP PESGIFGFMI 70 80 90 100 110 120 NFSAFLGAAT MYTRYKIVQK QNQTCYFSTP VFNLVSLVLG LVGCFGMGIV ANFQELAVPV 130 140 150 160 170 180 VHDGGALLAF VCGVVYTLLQ SIISYKSCPQ WNSLSTCHIR MVISAVSCAA VIPMIVCASL 190 200 210 220 230 ISITKLEWNP REKDYVYHVV SAICEWTVAF GFIFYFLTFI QDFQSVTLRI STEINGDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver and Skin.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-238. Tissue: Placenta.
[3]	"DRAM, a p53-induced modulator of autophagy, is critical for apoptosis." Crighton D., Wilkinson S., O'Prey J., Syed N., Smith P., Harrison P.R., Gasco M., Garrone O., Crook T., Ryan K.M. Cell 126:121-134(2006) [PubMed: 16839881] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
[4]	"p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death." Crighton D., O'prey J., Bell H.S., Ryan K.M. Cell Death Differ. 14:1071-1079(2007) [PubMed: 17304243] [Abstract] Cited for: FUNCTION, INDUCTION.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC013773 mRNA. Translation: AAH13773.4. BC018435 mRNA. Translation: AAH18435.1. AK002121 mRNA. Translation: BAA92091.1. Different initiation.
IPI	IPI00300813.
RefSeq	NP_060840.2. NM_018370.2.
UniGene	Hs.525634.
3D structure databases
ProteinModelPortal	Q8N682.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8N682.
Polymorphism databases
DMDM	74729109.
Proteomic databases
PRIDE	Q8N682.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258534; ENSP00000258534; ENSG00000136048.
GeneID	55332.
KEGG	hsa:55332.
UCSC	uc001tix.1. human.
Organism-specific databases
CTD	55332.
GeneCards	GC12P102271.
H-InvDB	HIX0010926.
HGNC	HGNC:25645. DRAM1.
MIM	610776. gene.
neXtProt	NX_Q8N682.
PharmGKB	PA165512564.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11973.
GeneTree	ENSGT00530000062905.
InParanoid	Q8N682.
OMA	FLTFIHD.
OrthoDB	EOG4KSPKJ.
PhylomeDB	Q8N682.
Gene expression databases
ArrayExpress	Q8N682.
Bgee	Q8N682.
Genevestigator	Q8N682.
Family and domain databases
InterPro	IPR019402. Frag1/DRAM/Sfk1. [Graphical view]
Pfam	PF10277. Frag1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	59626.
SOURCE	Search...

Entry information

Entry name

DRAM1_HUMAN

Accession

Primary (citable) accession number: Q8N682
Secondary accession number(s): Q7L3E3, Q9NUN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.