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Q8N682 (DRAM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA damage-regulated autophagy modulator protein 1
Alternative name(s):
Damage-regulated autophagy modulator
Gene names
Name:DRAM1
Synonyms:DRAM
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy. Ref.3 Ref.4

Subcellular location

Lysosome membrane; Multi-pass membrane protein Ref.3.

Induction

By p53/TP53 and TP73/p73. Directly activated by p53/TP53. Significantly down-regulated in tumor cell lines by methylation-dependent transcriptional silencing. Ref.3 Ref.4

Sequence similarities

Belongs to the DRAM/TMEM150 family.

Sequence caution

The sequence BAA92091.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processApoptosis
Autophagy
   Cellular componentLysosome
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

autophagy

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

lysosomal membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 238238DNA damage-regulated autophagy modulator protein 1
PRO_0000287436

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane53 – 7321Helical; Potential
Transmembrane91 – 11121Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane200 – 22021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8N682 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 511875677737F6C0

FASTA23826,253
        10         20         30         40         50         60 
MLCFLRGMAF VPFLLVTWSS AAFIISYVVA VLSGHVNPFL PYISDTGTTP PESGIFGFMI 

        70         80         90        100        110        120 
NFSAFLGAAT MYTRYKIVQK QNQTCYFSTP VFNLVSLVLG LVGCFGMGIV ANFQELAVPV 

       130        140        150        160        170        180 
VHDGGALLAF VCGVVYTLLQ SIISYKSCPQ WNSLSTCHIR MVISAVSCAA VIPMIVCASL 

       190        200        210        220        230 
ISITKLEWNP REKDYVYHVV SAICEWTVAF GFIFYFLTFI QDFQSVTLRI STEINGDI 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver and Skin.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-238.
Tissue: Placenta.
[3]"DRAM, a p53-induced modulator of autophagy, is critical for apoptosis."
Crighton D., Wilkinson S., O'Prey J., Syed N., Smith P., Harrison P.R., Gasco M., Garrone O., Crook T., Ryan K.M.
Cell 126:121-134(2006) [PubMed: 16839881] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
[4]"p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death."
Crighton D., O'prey J., Bell H.S., Ryan K.M.
Cell Death Differ. 14:1071-1079(2007) [PubMed: 17304243] [Abstract]
Cited for: FUNCTION, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC013773 mRNA. Translation: AAH13773.4.
BC018435 mRNA. Translation: AAH18435.1.
AK002121 mRNA. Translation: BAA92091.1. Different initiation.
IPIIPI00300813.
RefSeqNP_060840.2. NM_018370.2.
UniGeneHs.525634.

3D structure databases

ProteinModelPortalQ8N682.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8N682.

Polymorphism databases

DMDM74729109.

Proteomic databases

PRIDEQ8N682.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258534; ENSP00000258534; ENSG00000136048.
GeneID55332.
KEGGhsa:55332.
UCSCuc001tix.1. human.

Organism-specific databases

CTD55332.
GeneCardsGC12P102271.
H-InvDBHIX0010926.
HGNCHGNC:25645. DRAM1.
MIM610776. gene.
neXtProtNX_Q8N682.
PharmGKBPA165512564.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG11973.
GeneTreeENSGT00530000062905.
InParanoidQ8N682.
OMAFLTFIHD.
OrthoDBEOG4KSPKJ.
PhylomeDBQ8N682.

Gene expression databases

ArrayExpressQ8N682.
BgeeQ8N682.
GenevestigatorQ8N682.

Family and domain databases

InterProIPR019402. Frag1/DRAM/Sfk1.
[Graphical view]
PfamPF10277. Frag1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio59626.
SOURCESearch...

Entry information

Entry nameDRAM1_HUMAN
AccessionPrimary (citable) accession number: Q8N682
Secondary accession number(s): Q7L3E3, Q9NUN1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families