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Protein

Zinc finger and BTB domain-containing protein 2

Gene

ZBTB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri254 – 27623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41021C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 46821C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 2
Gene namesi
Name:ZBTB2
Synonyms:KIAA1483, ZNF437
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20868. ZBTB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949885.

Polymorphism and mutation databases

BioMutaiZBTB2.
DMDMi30316315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Zinc finger and BTB domain-containing protein 2PRO_0000047709Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei341 – 3411Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N680.
PaxDbiQ8N680.
PRIDEiQ8N680.

PTM databases

PhosphoSiteiQ8N680.

Expressioni

Gene expression databases

BgeeiQ8N680.
CleanExiHS_ZBTB2.
GenevisibleiQ8N680. HS.

Organism-specific databases

HPAiHPA023136.
HPA023137.
HPA023458.
HPA023487.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SP1P080474EBI-2515601,EBI-298336

Protein-protein interaction databases

BioGridi121667. 19 interactions.
IntActiQ8N680. 3 interactions.
MINTiMINT-4658354.
STRINGi9606.ENSP00000323183.

Structurei

3D structure databases

ProteinModelPortaliQ8N680.
SMRiQ8N680. Positions 3-85, 245-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 8966BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri254 – 27623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41021C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 46821C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG255202.
GeneTreeiENSGT00690000102095.
HOGENOMiHOG000013138.
HOVERGENiHBG058134.
InParanoidiQ8N680.
KOiK10489.
OMAiQGTFSHP.
OrthoDBiEOG747PHK.
PhylomeDBiQ8N680.
TreeFamiTF332229.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLANHGLIL LQQLNAQREF GFLCDCTVAI GDVYFKAHKS VLASFSNYFK
60 70 80 90 100
MLFVHQTSEC VRLKPTDIQP DIFSYLLHLM YTGKMAPQLI DPVRLEQGIK
110 120 130 140 150
FLHAYPLIQE ASLASQGAFS HPDQVFPLAS SLYGIQIADH QLRQATKIAS
160 170 180 190 200
APEKLGRDPR PQTSRISQEQ VPEASQLSQL TSNLAQVNRT NMTPSDPLQT
210 220 230 240 250
SLSPELVSTP VPPPPPGEET NLEASSSDEQ PASLTIAHVK PSIMKRNGSF
260 270 280 290 300
PKYYACHLCG RRFTLRSSLR EHLQIHTGVP FTSSQQGESR VPLTLCSNAA
310 320 330 340 350
DLGKDAMEVP EAGMISDSEL QHISDSPIID GQQQSETPPP SDIADIDNLE
360 370 380 390 400
QADQEREVKR RKYECTICGR KFIQKSHWRE HMYIHTGKPF KCSTCDKSFC
410 420 430 440 450
RANQAARHVC LNQSIDTYTM VDKQTLELCT FEEGSQMDNM LVQTNKPYKC
460 470 480 490 500
NLCDKTFSTP NEVVKHSCQN QNSDVFALDE GRSILLGSGD SEVTEPDHPV
510
LASIKKEQET VLLD
Length:514
Mass (Da):57,337
Last modified:October 1, 2002 - v1
Checksum:i2087A104CCA3DD85
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti466 – 4661H → L in BAA96007 (PubMed:10819331).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291942 mRNA. Translation: BAF84631.1.
AL590413 Genomic DNA. Translation: CAI13589.1.
CH471051 Genomic DNA. Translation: EAW47751.1.
BC020172 mRNA. Translation: AAH20172.1.
AB040916 mRNA. Translation: BAA96007.1.
CCDSiCCDS5231.1.
RefSeqiNP_065912.1. NM_020861.2.
XP_005267133.1. XM_005267076.1.
UniGeneiHs.520073.

Genome annotation databases

EnsembliENST00000325144; ENSP00000323183; ENSG00000181472.
GeneIDi57621.
KEGGihsa:57621.
UCSCiuc003qoh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291942 mRNA. Translation: BAF84631.1.
AL590413 Genomic DNA. Translation: CAI13589.1.
CH471051 Genomic DNA. Translation: EAW47751.1.
BC020172 mRNA. Translation: AAH20172.1.
AB040916 mRNA. Translation: BAA96007.1.
CCDSiCCDS5231.1.
RefSeqiNP_065912.1. NM_020861.2.
XP_005267133.1. XM_005267076.1.
UniGeneiHs.520073.

3D structure databases

ProteinModelPortaliQ8N680.
SMRiQ8N680. Positions 3-85, 245-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121667. 19 interactions.
IntActiQ8N680. 3 interactions.
MINTiMINT-4658354.
STRINGi9606.ENSP00000323183.

PTM databases

PhosphoSiteiQ8N680.

Polymorphism and mutation databases

BioMutaiZBTB2.
DMDMi30316315.

Proteomic databases

MaxQBiQ8N680.
PaxDbiQ8N680.
PRIDEiQ8N680.

Protocols and materials databases

DNASUi57621.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325144; ENSP00000323183; ENSG00000181472.
GeneIDi57621.
KEGGihsa:57621.
UCSCiuc003qoh.3. human.

Organism-specific databases

CTDi57621.
GeneCardsiGC06M151685.
HGNCiHGNC:20868. ZBTB2.
HPAiHPA023136.
HPA023137.
HPA023458.
HPA023487.
neXtProtiNX_Q8N680.
PharmGKBiPA134949885.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG255202.
GeneTreeiENSGT00690000102095.
HOGENOMiHOG000013138.
HOVERGENiHBG058134.
InParanoidiQ8N680.
KOiK10489.
OMAiQGTFSHP.
OrthoDBiEOG747PHK.
PhylomeDBiQ8N680.
TreeFamiTF332229.

Miscellaneous databases

ChiTaRSiZBTB2. human.
GenomeRNAii57621.
NextBioi64298.
PROiQ8N680.

Gene expression databases

BgeeiQ8N680.
CleanExiHS_ZBTB2.
GenevisibleiQ8N680. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Melanoma.
  5. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-514.
    Tissue: Brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiZBTB2_HUMAN
AccessioniPrimary (citable) accession number: Q8N680
Secondary accession number(s): A8K7C7, Q5SZ81, Q9P245
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.