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Protein

Zinc finger and BTB domain-containing protein 2

Gene

ZBTB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 276C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 410C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST21
Zinc fingeri448 – 468C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 2
Gene namesi
Name:ZBTB2
Synonyms:KIAA1483, ZNF437
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000181472.4
HGNCiHGNC:20868 ZBTB2
MIMi616595 gene
neXtProtiNX_Q8N680

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57621
OpenTargetsiENSG00000181472
PharmGKBiPA134949885

Polymorphism and mutation databases

BioMutaiZBTB2
DMDMi30316315

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477091 – 514Zinc finger and BTB domain-containing protein 2Add BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei341PhosphoserineCombined sources1
Cross-linki362Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki465Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki505Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki506Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8N680
MaxQBiQ8N680
PaxDbiQ8N680
PeptideAtlasiQ8N680
PRIDEiQ8N680

PTM databases

iPTMnetiQ8N680
PhosphoSitePlusiQ8N680
SwissPalmiQ8N680

Expressioni

Gene expression databases

BgeeiENSG00000181472
CleanExiHS_ZBTB2
GenevisibleiQ8N680 HS

Organism-specific databases

HPAiHPA023136
HPA023137
HPA023458
HPA023487

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi12166725 interactors.
DIPiDIP-53681N
IntActiQ8N680 33 interactors.
MINTiQ8N680
STRINGi9606.ENSP00000323183

Structurei

3D structure databases

ProteinModelPortaliQ8N680
SMRiQ8N680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 89BTBPROSITE-ProRule annotationAdd BLAST66

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 276C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 410C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST21
Zinc fingeri448 – 468C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00850000132316
HOGENOMiHOG000013138
HOVERGENiHBG058134
InParanoidiQ8N680
KOiK10489
OMAiRQSMELC
OrthoDBiEOG091G05Z0
PhylomeDBiQ8N680
TreeFamiTF332229

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q8N680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLANHGLIL LQQLNAQREF GFLCDCTVAI GDVYFKAHKS VLASFSNYFK
60 70 80 90 100
MLFVHQTSEC VRLKPTDIQP DIFSYLLHLM YTGKMAPQLI DPVRLEQGIK
110 120 130 140 150
FLHAYPLIQE ASLASQGAFS HPDQVFPLAS SLYGIQIADH QLRQATKIAS
160 170 180 190 200
APEKLGRDPR PQTSRISQEQ VPEASQLSQL TSNLAQVNRT NMTPSDPLQT
210 220 230 240 250
SLSPELVSTP VPPPPPGEET NLEASSSDEQ PASLTIAHVK PSIMKRNGSF
260 270 280 290 300
PKYYACHLCG RRFTLRSSLR EHLQIHTGVP FTSSQQGESR VPLTLCSNAA
310 320 330 340 350
DLGKDAMEVP EAGMISDSEL QHISDSPIID GQQQSETPPP SDIADIDNLE
360 370 380 390 400
QADQEREVKR RKYECTICGR KFIQKSHWRE HMYIHTGKPF KCSTCDKSFC
410 420 430 440 450
RANQAARHVC LNQSIDTYTM VDKQTLELCT FEEGSQMDNM LVQTNKPYKC
460 470 480 490 500
NLCDKTFSTP NEVVKHSCQN QNSDVFALDE GRSILLGSGD SEVTEPDHPV
510
LASIKKEQET VLLD
Length:514
Mass (Da):57,337
Last modified:October 1, 2002 - v1
Checksum:i2087A104CCA3DD85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti466H → L in BAA96007 (PubMed:10819331).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291942 mRNA Translation: BAF84631.1
AL590413 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47751.1
BC020172 mRNA Translation: AAH20172.1
AB040916 mRNA Translation: BAA96007.1
CCDSiCCDS5231.1
RefSeqiNP_065912.1, NM_020861.2
XP_005267133.1, XM_005267076.2
XP_011534306.1, XM_011536004.2
UniGeneiHs.520073

Genome annotation databases

EnsembliENST00000325144; ENSP00000323183; ENSG00000181472
GeneIDi57621
KEGGihsa:57621
UCSCiuc003qoh.4 human

Similar proteinsi

Entry informationi

Entry nameiZBTB2_HUMAN
AccessioniPrimary (citable) accession number: Q8N680
Secondary accession number(s): A8K7C7, Q5SZ81, Q9P245
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome