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Q8N680

- ZBTB2_HUMAN

UniProt

Q8N680 - ZBTB2_HUMAN

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Protein

Zinc finger and BTB domain-containing protein 2

Gene

ZBTB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri254 – 27623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41021C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 46821C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 2
Gene namesi
Name:ZBTB2
Synonyms:KIAA1483, ZNF437
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:20868. ZBTB2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949885.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Zinc finger and BTB domain-containing protein 2PRO_0000047709Add
BLAST

Proteomic databases

MaxQBiQ8N680.
PaxDbiQ8N680.
PRIDEiQ8N680.

PTM databases

PhosphoSiteiQ8N680.

Expressioni

Gene expression databases

BgeeiQ8N680.
CleanExiHS_ZBTB2.
ExpressionAtlasiQ8N680. baseline and differential.
GenevestigatoriQ8N680.

Organism-specific databases

HPAiHPA023136.
HPA023137.
HPA023458.
HPA023487.

Interactioni

Protein-protein interaction databases

BioGridi121667. 19 interactions.
IntActiQ8N680. 2 interactions.
MINTiMINT-4658354.
STRINGi9606.ENSP00000323183.

Structurei

3D structure databases

ProteinModelPortaliQ8N680.
SMRiQ8N680. Positions 3-104, 248-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 8966BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri254 – 27623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41021C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 46821C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG255202.
GeneTreeiENSGT00690000102095.
HOGENOMiHOG000013138.
HOVERGENiHBG058134.
InParanoidiQ8N680.
KOiK10489.
OMAiQGTFSHP.
OrthoDBiEOG747PHK.
PhylomeDBiQ8N680.
TreeFamiTF332229.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N680-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLANHGLIL LQQLNAQREF GFLCDCTVAI GDVYFKAHKS VLASFSNYFK
60 70 80 90 100
MLFVHQTSEC VRLKPTDIQP DIFSYLLHLM YTGKMAPQLI DPVRLEQGIK
110 120 130 140 150
FLHAYPLIQE ASLASQGAFS HPDQVFPLAS SLYGIQIADH QLRQATKIAS
160 170 180 190 200
APEKLGRDPR PQTSRISQEQ VPEASQLSQL TSNLAQVNRT NMTPSDPLQT
210 220 230 240 250
SLSPELVSTP VPPPPPGEET NLEASSSDEQ PASLTIAHVK PSIMKRNGSF
260 270 280 290 300
PKYYACHLCG RRFTLRSSLR EHLQIHTGVP FTSSQQGESR VPLTLCSNAA
310 320 330 340 350
DLGKDAMEVP EAGMISDSEL QHISDSPIID GQQQSETPPP SDIADIDNLE
360 370 380 390 400
QADQEREVKR RKYECTICGR KFIQKSHWRE HMYIHTGKPF KCSTCDKSFC
410 420 430 440 450
RANQAARHVC LNQSIDTYTM VDKQTLELCT FEEGSQMDNM LVQTNKPYKC
460 470 480 490 500
NLCDKTFSTP NEVVKHSCQN QNSDVFALDE GRSILLGSGD SEVTEPDHPV
510
LASIKKEQET VLLD
Length:514
Mass (Da):57,337
Last modified:October 1, 2002 - v1
Checksum:i2087A104CCA3DD85
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti466 – 4661H → L in BAA96007. (PubMed:10819331)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK291942 mRNA. Translation: BAF84631.1.
AL590413 Genomic DNA. Translation: CAI13589.1.
CH471051 Genomic DNA. Translation: EAW47751.1.
BC020172 mRNA. Translation: AAH20172.1.
AB040916 mRNA. Translation: BAA96007.1.
CCDSiCCDS5231.1.
RefSeqiNP_065912.1. NM_020861.1.
XP_005267133.1. XM_005267076.1.
UniGeneiHs.520073.

Genome annotation databases

EnsembliENST00000325144; ENSP00000323183; ENSG00000181472.
GeneIDi57621.
KEGGihsa:57621.
UCSCiuc003qoh.3. human.

Polymorphism databases

DMDMi30316315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK291942 mRNA. Translation: BAF84631.1 .
AL590413 Genomic DNA. Translation: CAI13589.1 .
CH471051 Genomic DNA. Translation: EAW47751.1 .
BC020172 mRNA. Translation: AAH20172.1 .
AB040916 mRNA. Translation: BAA96007.1 .
CCDSi CCDS5231.1.
RefSeqi NP_065912.1. NM_020861.1.
XP_005267133.1. XM_005267076.1.
UniGenei Hs.520073.

3D structure databases

ProteinModelPortali Q8N680.
SMRi Q8N680. Positions 3-104, 248-466.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121667. 19 interactions.
IntActi Q8N680. 2 interactions.
MINTi MINT-4658354.
STRINGi 9606.ENSP00000323183.

PTM databases

PhosphoSitei Q8N680.

Polymorphism databases

DMDMi 30316315.

Proteomic databases

MaxQBi Q8N680.
PaxDbi Q8N680.
PRIDEi Q8N680.

Protocols and materials databases

DNASUi 57621.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000325144 ; ENSP00000323183 ; ENSG00000181472 .
GeneIDi 57621.
KEGGi hsa:57621.
UCSCi uc003qoh.3. human.

Organism-specific databases

CTDi 57621.
GeneCardsi GC06M151685.
HGNCi HGNC:20868. ZBTB2.
HPAi HPA023136.
HPA023137.
HPA023458.
HPA023487.
neXtProti NX_Q8N680.
PharmGKBi PA134949885.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG255202.
GeneTreei ENSGT00690000102095.
HOGENOMi HOG000013138.
HOVERGENi HBG058134.
InParanoidi Q8N680.
KOi K10489.
OMAi QGTFSHP.
OrthoDBi EOG747PHK.
PhylomeDBi Q8N680.
TreeFami TF332229.

Miscellaneous databases

ChiTaRSi ZBTB2. human.
GenomeRNAii 57621.
NextBioi 64298.
PROi Q8N680.

Gene expression databases

Bgeei Q8N680.
CleanExi HS_ZBTB2.
ExpressionAtlasi Q8N680. baseline and differential.
Genevestigatori Q8N680.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Melanoma.
  5. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-514.
    Tissue: Brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.

Entry informationi

Entry nameiZBTB2_HUMAN
AccessioniPrimary (citable) accession number: Q8N680
Secondary accession number(s): A8K7C7, Q5SZ81, Q9P245
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3