Reviewed, UniProtKB/Swiss-Prot Q8N668 (COMD1_HUMAN)

Names and origin

Protein names

Recommended name:
    COMM domain-containing protein 1
Alternative name(s):
    Protein Murr1

Gene names

Name:	COMMD1
Synonyms:	C2orf5, MURR1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Inhibits TNF-induced NFKB1 activation. May function to facilitate biliary copper excretion within hepatocytes. Ref.8
Subunit structure	Interacts directly with COMMD6 and the N-terminal region of ATP7B. Interacts with NFKBIB and COMMD7. Ref.8 Ref.6 Ref.7
Subcellular location	Nucleus. Cytoplasm Ref.8.
Tissue specificity	Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta. Ref.8 Ref.5
Sequence similarities	Contains 1 COMM domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
PTM	Acetylation
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	identical protein binding Ref.7 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-1550112,EBI-1550112
COMMD10	Q9Y6G5	1	EBI-1550112,EBI-1550310
COMMD2	Q86X83	1	EBI-1550112,EBI-1550220
COMMD3	Q9UBI1	2	EBI-1550112,EBI-714979
COMMD4	Q9H0A8	1	EBI-1550112,EBI-1550064
COMMD5	Q9GZQ3	1	EBI-1550112,EBI-1550256
COMMD6	Q7Z4G1	1	EBI-1550112,EBI-1550081
COMMD7	Q86VX2	1	EBI-1550112,EBI-1550280
COMMD8	Q9NX08	1	EBI-1550112,EBI-725694
CUL1	Q13616	1	EBI-1550112,EBI-359390
NFKB1	P19838-2	1	EBI-1550112,EBI-1452242
NFKB2	Q00653-2	1	EBI-1550112,EBI-307345
NFKBIA	P25963	2	EBI-1550112,EBI-307386
REL	Q04864	1	EBI-1550112,EBI-307352
RELA	Q04206	2	EBI-1550112,EBI-73886
RELB	Q01201	1	EBI-1550112,EBI-357837

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed

Chain

2 – 190

189

COMM domain-containing protein 1

PRO_0000077384

Regions

Domain

118 – 186

69

COMM

Amino acid modifications

Modified residue

2

1

N-acetylalanine Ref.9

Secondary structure

1

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190

Helix Strand Turn

Details...

Turn

16 – 19

4

Helix

32 – 39

8

Beta strand

41 – 43

3

Helix

48 – 52

5

Turn

53 – 55

3

Helix

59 – 62

4

Turn

63 – 65

3

Turn

69 – 71

3

Turn

73 – 75

3

Helix

76 – 79

4

Helix

88 – 94

7

Turn

95 – 101

7

Beta strand

102 – 106

5

Sequences

	Sequence		Length	Mass (Da)
	Q8N668-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 9C810AECA67011DC	FASTA	190	21,178
	10 20 30 40 50 60 MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK 70 80 90 100 110 120 SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR 130 140 150 160 170 180 GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE 190 SISTLISQPN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis." Mueller T., van de Sluis B.A.J., Zhernakova A., van Binsbergen E., Janecke A.R., Bavdekar A., Pandit A., Weirich-Schwaiger H., Witt H., Ellemunter H., Deutsch J., Denk H., Mueller W., Sternlieb I., Tanner M.S., Wijmenga C. J. Hepatol. 38:164-168(2003) [PubMed: 12547404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Analysis of the human homologue of the canine copper toxicosis gene MURR1 in Wilson disease patients." Stuehler B., Reichert J., Stremmel W., Schaefer M. J. Mol. Med. 82:629-634(2004) [PubMed: 15205742] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Comparative analyses of gene imprinting and CpG island methylation around mouse Murr1 and human syntenic region identify the 5'-portion of U2af1-rs1 CpG island as an imprinting control region." Zhang Z., Yatsuki H., Wang Y., Joh K., Nabetani A., Hatada I., Soejima H., Iwasaka T., Mukai T. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Skin.
[5]	"Identification of a new copper metabolism gene by positional cloning in a purebred dog population." van De Sluis B.A.J., Rothuizen J., Pearson P.L., van Oost B.A., Wijmenga C. Hum. Mol. Genet. 11:165-173(2002) [PubMed: 11809725] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein." Tao T.Y., Liu F., Klomp L., Wijmenga C., Gitlin J.D. J. Biol. Chem. 278:41593-41596(2003) [PubMed: 12968035] [Abstract] Cited for: INTERACTION WITH ATP7B.
[7]	"COMMD proteins, a novel family of structural and functional homologs of MURR1." Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S. J. Biol. Chem. 280:22222-22232(2005) [PubMed: 15799966] [Abstract] Cited for: INTERACTION WITH COMMD7.
[8]	"Characterization of COMMD protein-protein interactions in NF-kappaB signalling." de Bie P., van de Sluis B., Burstein E., Duran K.J., Berger R., Duckett C.S., Wijmenga C., Klomp L.W. Biochem. J. 398:63-71(2006) [PubMed: 16573520] [Abstract] Cited for: FUNCTION, INTERACTION WITH COMMD6 AND NFKBIB, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[9]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB178811 mRNA. Translation: BAD18972.1.
BC009266 mRNA. Translation: AAH09266.2.
BC022046 mRNA. Translation: AAH22046.1.

IPI

IPI00171117.

RefSeq

NP_689729.1.

UniGene

Hs.468702

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2H2M	NMR	-	A	1-108	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8N668. 19 interactions.

STRING

Q8N668.

Proteomic databases

PRIDE

Q8N668.

Genome annotation databases

Ensembl

ENST00000311832; ENSP00000308236; ENSG00000173163; Homo sapiens. [Genome view]

GeneID

150684.

KEGG

hsa:150684.

UCSC

uc002sbp.1. human.

Organism-specific databases

CTD

150684.

GeneCards

GC02P062044.

H-InvDB

HIX0002085.

HGNC

HGNC:23024. COMMD1.

MIM

607238. gene.

PharmGKB

PA134891368.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

HBG445090.

HOVERGEN

Q8N668.

InParanoid

Q8N668.

OMA

NQSRWDN.

PhylomeDB

Q8N668.

Gene expression databases

ArrayExpress

Q8N668.

Bgee

Q8N668.

CleanEx

HS_COMMD1.

Genevestigator

Q8N668.

GermOnline

ENSG00000173163. Homo sapiens.

Family and domain databases

InterPro

IPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]

Pfam

PF07258. HCaRG. 1 hit.
[Graphical view]

PROSITE

PS51269. COMM. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

86500.

SOURCE

Search...

Entry information

Entry name

COMD1_HUMAN

Accession

Primary (citable) accession number: Q8N668
Secondary accession number(s): Q96GS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	October 1, 2002
Last modified:	January 19, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.