Reviewed,
UniProtKB/Swiss-Prot Q8N668 (COMD1_HUMAN)
Last modified
January 19, 2010.
Version 54.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: COMM domain-containing protein 1 Alternative name(s): Protein Murr1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 190 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Inhibits TNF-induced NFKB1 activation. May function to facilitate biliary copper excretion within hepatocytes. Ref.8 |
| Subunit structure | Interacts directly with COMMD6 and the N-terminal region of ATP7B. Interacts with NFKBIB and COMMD7. Ref.8 Ref.6 Ref.7 |
| Subcellular location | |
| Tissue specificity | Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta. Ref.8 Ref.5 |
| Sequence similarities | Contains 1 COMM domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| PTM | Acetylation |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | identical protein binding Ref.7 Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| itself | 2 | EBI-1550112,EBI-1550112 | ||
| COMMD10 | Q9Y6G5 | 1 | EBI-1550112,EBI-1550310 | |
| COMMD2 | Q86X83 | 1 | EBI-1550112,EBI-1550220 | |
| COMMD3 | Q9UBI1 | 2 | EBI-1550112,EBI-714979 | |
| COMMD4 | Q9H0A8 | 1 | EBI-1550112,EBI-1550064 | |
| COMMD5 | Q9GZQ3 | 1 | EBI-1550112,EBI-1550256 | |
| COMMD6 | Q7Z4G1 | 1 | EBI-1550112,EBI-1550081 | |
| COMMD7 | Q86VX2 | 1 | EBI-1550112,EBI-1550280 | |
| COMMD8 | Q9NX08 | 1 | EBI-1550112,EBI-725694 | |
| CUL1 | Q13616 | 1 | EBI-1550112,EBI-359390 | |
| NFKB1 | P19838-2 | 1 | EBI-1550112,EBI-1452242 | |
| NFKB2 | Q00653-2 | 1 | EBI-1550112,EBI-307345 | |
| NFKBIA | P25963 | 2 | EBI-1550112,EBI-307386 | |
| REL | Q04864 | 1 | EBI-1550112,EBI-307352 | |
| RELA | Q04206 | 2 | EBI-1550112,EBI-73886 | |
| RELB | Q01201 | 1 | EBI-1550112,EBI-357837 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed | |||||||||||||||||||||||||||
| Chain | 2 – 190 | 189 | COMM domain-containing protein 1 | PRO_0000077384 | ||||||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||||||
| Domain | 118 – 186 | 69 | COMM | |||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||
| Modified residue | 2 | 1 | N-acetylalanine Ref.9 | |||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||
| Turn | 16 – 19 | 4 | ||||||||||||||||||||||||||||
| Helix | 32 – 39 | 8 | ||||||||||||||||||||||||||||
| Beta strand | 41 – 43 | 3 | ||||||||||||||||||||||||||||
| Helix | 48 – 52 | 5 | ||||||||||||||||||||||||||||
| Turn | 53 – 55 | 3 | ||||||||||||||||||||||||||||
| Helix | 59 – 62 | 4 | ||||||||||||||||||||||||||||
| Turn | 63 – 65 | 3 | ||||||||||||||||||||||||||||
| Turn | 69 – 71 | 3 | ||||||||||||||||||||||||||||
| Turn | 73 – 75 | 3 | ||||||||||||||||||||||||||||
| Helix | 76 – 79 | 4 | ||||||||||||||||||||||||||||
| Helix | 88 – 94 | 7 | ||||||||||||||||||||||||||||
| Turn | 95 – 101 | 7 | ||||||||||||||||||||||||||||
| Beta strand | 102 – 106 | 5 | ||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis." Mueller T., van de Sluis B.A.J., Zhernakova A., van Binsbergen E., Janecke A.R., Bavdekar A., Pandit A., Weirich-Schwaiger H., Witt H., Ellemunter H., Deutsch J., Denk H., Mueller W., Sternlieb I., Tanner M.S., Wijmenga C. J. Hepatol. 38:164-168(2003) [PubMed: 12547404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Analysis of the human homologue of the canine copper toxicosis gene MURR1 in Wilson disease patients." Stuehler B., Reichert J., Stremmel W., Schaefer M. J. Mol. Med. 82:629-634(2004) [PubMed: 15205742] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Comparative analyses of gene imprinting and CpG island methylation around mouse Murr1 and human syntenic region identify the 5'-portion of U2af1-rs1 CpG island as an imprinting control region." Zhang Z., Yatsuki H., Wang Y., Joh K., Nabetani A., Hatada I., Soejima H., Iwasaka T., Mukai T. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Skin. |
| [5] | "Identification of a new copper metabolism gene by positional cloning in a purebred dog population." van De Sluis B.A.J., Rothuizen J., Pearson P.L., van Oost B.A., Wijmenga C. Hum. Mol. Genet. 11:165-173(2002) [PubMed: 11809725] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [6] | "The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein." Tao T.Y., Liu F., Klomp L., Wijmenga C., Gitlin J.D. J. Biol. Chem. 278:41593-41596(2003) [PubMed: 12968035] [Abstract] Cited for: INTERACTION WITH ATP7B. |
| [7] | "COMMD proteins, a novel family of structural and functional homologs of MURR1." Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S. J. Biol. Chem. 280:22222-22232(2005) [PubMed: 15799966] [Abstract] Cited for: INTERACTION WITH COMMD7. |
| [8] | "Characterization of COMMD protein-protein interactions in NF-kappaB signalling." de Bie P., van de Sluis B., Burstein E., Duran K.J., Berger R., Duckett C.S., Wijmenga C., Klomp L.W. Biochem. J. 398:63-71(2006) [PubMed: 16573520] [Abstract] Cited for: FUNCTION, INTERACTION WITH COMMD6 AND NFKBIB, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. |
| [9] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AB178811 mRNA. Translation: BAD18972.1. BC009266 mRNA. Translation: AAH09266.2. BC022046 mRNA. Translation: AAH22046.1. | ||||||||||||
| IPI | IPI00171117. | ||||||||||||
| RefSeq | NP_689729.1. | ||||||||||||
| UniGene | Hs.468702 | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q8N668. 19 interactions. | ||||||||||||
| STRING | Q8N668. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q8N668. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000311832; ENSP00000308236; ENSG00000173163; Homo sapiens. [Genome view] | ||||||||||||
| GeneID | 150684. | ||||||||||||
| KEGG | hsa:150684. | ||||||||||||
| UCSC | uc002sbp.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 150684. | ||||||||||||
| GeneCards | GC02P062044. | ||||||||||||
| H-InvDB | HIX0002085. | ||||||||||||
| HGNC | HGNC:23024. COMMD1. | ||||||||||||
| MIM | 607238. gene. | ||||||||||||
| PharmGKB | PA134891368. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | HBG445090. | ||||||||||||
| HOVERGEN | Q8N668. | ||||||||||||
| InParanoid | Q8N668. | ||||||||||||
| OMA | NQSRWDN. | ||||||||||||
| PhylomeDB | Q8N668. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q8N668. | ||||||||||||
| Bgee | Q8N668. | ||||||||||||
| CleanEx | HS_COMMD1. | ||||||||||||
| Genevestigator | Q8N668. | ||||||||||||
| GermOnline | ENSG00000173163. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR017920. COMM. IPR009886. HCaRG. [Graphical view] | ||||||||||||
| Pfam | PF07258. HCaRG. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS51269. COMM. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 86500. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | COMD1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8N668 Secondary accession number(s): Q96GS0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


