ID TM86B_HUMAN Reviewed; 226 AA. AC Q8N661; DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot. DT 18-MAY-2010, sequence version 2. DT 24-JAN-2024, entry version 137. DE RecName: Full=Lysoplasmalogenase TMEM86B; DE EC=3.3.2.2 {ECO:0000269|PubMed:21515882}; DE AltName: Full=Transmembrane protein 86B; GN Name=TMEM86B; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-199. RC TISSUE=Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, ACTIVITY RP REGULATION, SUBUNIT, AND SUBCELLULAR LOCATION. RX PubMed=21515882; DOI=10.1074/jbc.m111.247163; RA Wu L.C., Pfeiffer D.R., Calhoon E.A., Madiai F., Marcucci G., Liu S., RA Jurkowitz M.S.; RT "Purification, identification, and cloning of lysoplasmalogenase, the RT enzyme that catalyzes hydrolysis of the vinyl ether bond of RT lysoplasmalogen."; RL J. Biol. Chem. 286:24916-24930(2011). CC -!- FUNCTION: Catalyzes the hydrolysis of the vinyl ether bond of choline CC or ethanolamine lysoplasmalogens, forming fatty aldehyde and CC glycerophosphocholine or glycerophosphoethanolamine, respectively and CC is specific for the sn-2-deacylated (lyso) form of plasmalogen. CC {ECO:0000269|PubMed:21515882}. CC -!- CATALYTIC ACTIVITY: CC Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3- CC saturated aldehyde + sn-glycerol 3-phosphocholine; CC Xref=Rhea:RHEA:22544, ChEBI:CHEBI:15377, ChEBI:CHEBI:16870, CC ChEBI:CHEBI:73359, ChEBI:CHEBI:77287; EC=3.3.2.2; CC Evidence={ECO:0000269|PubMed:21515882}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a CC 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine; CC Xref=Rhea:RHEA:16905, ChEBI:CHEBI:15377, ChEBI:CHEBI:73359, CC ChEBI:CHEBI:77288, ChEBI:CHEBI:143890; EC=3.3.2.2; CC Evidence={ECO:0000269|PubMed:21515882}; CC -!- ACTIVITY REGULATION: Competitively inhibited by lysophosphatidic acid. CC {ECO:0000269|PubMed:21515882}. CC -!- BIOPHYSICOCHEMICAL PROPERTIES: CC Kinetic parameters: CC KM=45 uM for lysoplasmenyl-choline {ECO:0000269|PubMed:21515882}; CC KM=53 uM for lysoplasmenyl-ethanolamine CC {ECO:0000269|PubMed:21515882}; CC pH dependence: CC Optimum pH is 6.95 and 7.05 with lysoplasmenyl-ethanolamine and CC lysoplasmenyl-choline as substrates, respectively. CC {ECO:0000269|PubMed:21515882}; CC -!- SUBUNIT: Homodimer. {ECO:0000305}. CC -!- INTERACTION: CC Q8N661; Q13520: AQP6; NbExp=3; IntAct=EBI-2548832, EBI-13059134; CC Q8N661; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-2548832, EBI-11343438; CC Q8N661; Q8N6S5: ARL6IP6; NbExp=3; IntAct=EBI-2548832, EBI-2808844; CC Q8N661; P07307-3: ASGR2; NbExp=3; IntAct=EBI-2548832, EBI-12808270; CC Q8N661; Q9BXK5: BCL2L13; NbExp=6; IntAct=EBI-2548832, EBI-747430; CC Q8N661; Q13323: BIK; NbExp=3; IntAct=EBI-2548832, EBI-700794; CC Q8N661; O95393: BMP10; NbExp=3; IntAct=EBI-2548832, EBI-3922513; CC Q8N661; O14523: C2CD2L; NbExp=3; IntAct=EBI-2548832, EBI-12822627; CC Q8N661; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-2548832, EBI-9083477; CC Q8N661; Q96HJ3-2: CCDC34; NbExp=3; IntAct=EBI-2548832, EBI-17641690; CC Q8N661; P13236: CCL4; NbExp=3; IntAct=EBI-2548832, EBI-2873970; CC Q8N661; P19397: CD53; NbExp=3; IntAct=EBI-2548832, EBI-6657396; CC Q8N661; P11912: CD79A; NbExp=3; IntAct=EBI-2548832, EBI-7797864; CC Q8N661; P58418: CLRN1; NbExp=3; IntAct=EBI-2548832, EBI-17274839; CC Q8N661; O43169: CYB5B; NbExp=3; IntAct=EBI-2548832, EBI-1058710; CC Q8N661; Q8N5I4: DHRSX; NbExp=3; IntAct=EBI-2548832, EBI-3923585; CC Q8N661; Q96LL9: DNAJC30; NbExp=3; IntAct=EBI-2548832, EBI-8639143; CC Q8N661; Q15125: EBP; NbExp=3; IntAct=EBI-2548832, EBI-3915253; CC Q8N661; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-2548832, EBI-781551; CC Q8N661; P30040: ERP29; NbExp=3; IntAct=EBI-2548832, EBI-946830; CC Q8N661; P34910-2: EVI2B; NbExp=3; IntAct=EBI-2548832, EBI-17640610; CC Q8N661; Q9Y624: F11R; NbExp=3; IntAct=EBI-2548832, EBI-742600; CC Q8N661; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-2548832, EBI-18304435; CC Q8N661; Q96IV6: FAXDC2; NbExp=3; IntAct=EBI-2548832, EBI-12142299; CC Q8N661; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-2548832, EBI-3918971; CC Q8N661; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-2548832, EBI-713304; CC Q8N661; P17302: GJA1; NbExp=3; IntAct=EBI-2548832, EBI-1103439; CC Q8N661; P35212: GJA4; NbExp=3; IntAct=EBI-2548832, EBI-6918707; CC Q8N661; P48165: GJA8; NbExp=3; IntAct=EBI-2548832, EBI-17458373; CC Q8N661; Q8NBJ4: GOLM1; NbExp=3; IntAct=EBI-2548832, EBI-712073; CC Q8N661; O60883: GPR37L1; NbExp=3; IntAct=EBI-2548832, EBI-2927498; CC Q8N661; Q8TED1: GPX8; NbExp=3; IntAct=EBI-2548832, EBI-11721746; CC Q8N661; Q02747: GUCA2A; NbExp=3; IntAct=EBI-2548832, EBI-12244272; CC Q8N661; P31937: HIBADH; NbExp=3; IntAct=EBI-2548832, EBI-11427100; CC Q8N661; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-2548832, EBI-18053395; CC Q8N661; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-2548832, EBI-725665; CC Q8N661; Q01628: IFITM3; NbExp=3; IntAct=EBI-2548832, EBI-7932862; CC Q8N661; P43628: KIR2DL3; NbExp=3; IntAct=EBI-2548832, EBI-8632435; CC Q8N661; Q86VI4: LAPTM4B; NbExp=3; IntAct=EBI-2548832, EBI-3267258; CC Q8N661; Q9H400: LIME1; NbExp=3; IntAct=EBI-2548832, EBI-2830566; CC Q8N661; P48449: LSS; NbExp=3; IntAct=EBI-2548832, EBI-3930711; CC Q8N661; Q14210: LY6D; NbExp=3; IntAct=EBI-2548832, EBI-1965225; CC Q8N661; Q9P0N8: MARCHF2; NbExp=3; IntAct=EBI-2548832, EBI-10317612; CC Q8N661; Q9GZY8-5: MFF; NbExp=6; IntAct=EBI-2548832, EBI-11956541; CC Q8N661; O14880: MGST3; NbExp=3; IntAct=EBI-2548832, EBI-724754; CC Q8N661; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-2548832, EBI-6163737; CC Q8N661; Q96JA4: MS4A14; NbExp=3; IntAct=EBI-2548832, EBI-12839612; CC Q8N661; Q15800: MSMO1; NbExp=3; IntAct=EBI-2548832, EBI-949102; CC Q8N661; P15941-11: MUC1; NbExp=3; IntAct=EBI-2548832, EBI-17263240; CC Q8N661; Q9Y375: NDUFAF1; NbExp=3; IntAct=EBI-2548832, EBI-741874; CC Q8N661; O14524-2: NEMP1; NbExp=3; IntAct=EBI-2548832, EBI-10969203; CC Q8N661; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-2548832, EBI-10317425; CC Q8N661; Q53FV1: ORMDL2; NbExp=3; IntAct=EBI-2548832, EBI-11075081; CC Q8N661; Q9NUU6: OTULINL; NbExp=3; IntAct=EBI-2548832, EBI-6916492; CC Q8N661; Q96HA9: PEX11G; NbExp=3; IntAct=EBI-2548832, EBI-17284886; CC Q8N661; O15173: PGRMC2; NbExp=3; IntAct=EBI-2548832, EBI-1050125; CC Q8N661; Q07326: PIGF; NbExp=3; IntAct=EBI-2548832, EBI-17180304; CC Q8N661; P26678: PLN; NbExp=3; IntAct=EBI-2548832, EBI-692836; CC Q8N661; P18031: PTPN1; NbExp=3; IntAct=EBI-2548832, EBI-968788; CC Q8N661; P43378: PTPN9; NbExp=3; IntAct=EBI-2548832, EBI-742898; CC Q8N661; Q8TEB9: RHBDD1; NbExp=3; IntAct=EBI-2548832, EBI-9916444; CC Q8N661; Q8IXI1: RHOT2; NbExp=3; IntAct=EBI-2548832, EBI-1396563; CC Q8N661; Q9NS64: RPRM; NbExp=3; IntAct=EBI-2548832, EBI-1052363; CC Q8N661; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-2548832, EBI-10244780; CC Q8N661; O75396: SEC22B; NbExp=3; IntAct=EBI-2548832, EBI-1058865; CC Q8N661; Q8N474: SFRP1; NbExp=3; IntAct=EBI-2548832, EBI-3940687; CC Q8N661; Q8WV19: SFT2D1; NbExp=3; IntAct=EBI-2548832, EBI-2854842; CC Q8N661; Q8TD22: SFXN5; NbExp=3; IntAct=EBI-2548832, EBI-17274136; CC Q8N661; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-2548832, EBI-18159983; CC Q8N661; Q8TBE7: SLC35G2; NbExp=3; IntAct=EBI-2548832, EBI-727304; CC Q8N661; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-2548832, EBI-2823239; CC Q8N661; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-2548832, EBI-12188413; CC Q8N661; Q6UX34: SNORC; NbExp=3; IntAct=EBI-2548832, EBI-11957067; CC Q8N661; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-2548832, EBI-17280858; CC Q8N661; P27105: STOM; NbExp=3; IntAct=EBI-2548832, EBI-1211440; CC Q8N661; Q86Y82: STX12; NbExp=3; IntAct=EBI-2548832, EBI-2691717; CC Q8N661; O43752: STX6; NbExp=3; IntAct=EBI-2548832, EBI-2695795; CC Q8N661; Q9UNK0: STX8; NbExp=3; IntAct=EBI-2548832, EBI-727240; CC Q8N661; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-2548832, EBI-19027521; CC Q8N661; Q8WY91: THAP4; NbExp=3; IntAct=EBI-2548832, EBI-726691; CC Q8N661; P07204: THBD; NbExp=3; IntAct=EBI-2548832, EBI-941422; CC Q8N661; O14925: TIMM23; NbExp=3; IntAct=EBI-2548832, EBI-1047996; CC Q8N661; Q96A25: TMEM106A; NbExp=3; IntAct=EBI-2548832, EBI-3915978; CC Q8N661; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-2548832, EBI-12845616; CC Q8N661; Q9BXJ8: TMEM120A; NbExp=3; IntAct=EBI-2548832, EBI-727322; CC Q8N661; Q9Y6G1: TMEM14A; NbExp=3; IntAct=EBI-2548832, EBI-2800360; CC Q8N661; Q9P0S9: TMEM14C; NbExp=3; IntAct=EBI-2548832, EBI-2339195; CC Q8N661; Q969S6: TMEM203; NbExp=3; IntAct=EBI-2548832, EBI-12274070; CC Q8N661; Q96Q45-2: TMEM237; NbExp=5; IntAct=EBI-2548832, EBI-10982110; CC Q8N661; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-2548832, EBI-10314986; CC Q8N661; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-2548832, EBI-18178701; CC Q8N661; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-2548832, EBI-2852148; CC Q8N661; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-2548832, EBI-2548832; CC Q8N661; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-2548832, EBI-12345267; CC Q8N661; Q9Y320: TMX2; NbExp=3; IntAct=EBI-2548832, EBI-6447886; CC Q8N661; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-2548832, EBI-16746122; CC Q8N661; A0AVG3: TSNARE1; NbExp=3; IntAct=EBI-2548832, EBI-12003468; CC Q8N661; Q9NZ43: USE1; NbExp=3; IntAct=EBI-2548832, EBI-742842; CC Q8N661; P63027: VAMP2; NbExp=3; IntAct=EBI-2548832, EBI-520113; CC Q8N661; Q15836: VAMP3; NbExp=3; IntAct=EBI-2548832, EBI-722343; CC Q8N661; O95183: VAMP5; NbExp=3; IntAct=EBI-2548832, EBI-10191195; CC Q8N661; Q9P0L0: VAPA; NbExp=3; IntAct=EBI-2548832, EBI-1059156; CC Q8N661; Q8N966: ZDHHC22; NbExp=3; IntAct=EBI-2548832, EBI-10268111; CC Q8N661; Q96FB2; NbExp=3; IntAct=EBI-2548832, EBI-2857623; CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000250|UniProtKB:Q9D8N3}; Multi-pass membrane protein CC {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:21515882}. CC -!- SIMILARITY: Belongs to the TMEM86 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC010327; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC023000; AAH23000.1; -; mRNA. DR CCDS; CCDS12920.1; -. DR RefSeq; NP_776165.3; NM_173804.4. DR AlphaFoldDB; Q8N661; -. DR BioGRID; 129071; 106. DR IntAct; Q8N661; 104. DR STRING; 9606.ENSP00000321038; -. DR SwissLipids; SLP:000000632; -. DR PhosphoSitePlus; Q8N661; -. DR BioMuta; TMEM86B; -. DR DMDM; 296452936; -. DR MassIVE; Q8N661; -. DR PaxDb; 9606-ENSP00000321038; -. DR PeptideAtlas; Q8N661; -. DR ProteomicsDB; 72134; -. DR Antibodypedia; 33044; 15 antibodies from 9 providers. DR DNASU; 255043; -. DR Ensembl; ENST00000327042.5; ENSP00000321038.3; ENSG00000180089.6. DR GeneID; 255043; -. DR KEGG; hsa:255043; -. DR MANE-Select; ENST00000327042.5; ENSP00000321038.3; NM_173804.5; NP_776165.3. DR UCSC; uc002qju.4; human. DR AGR; HGNC:28448; -. DR CTD; 255043; -. DR DisGeNET; 255043; -. DR GeneCards; TMEM86B; -. DR HGNC; HGNC:28448; TMEM86B. DR HPA; ENSG00000180089; Tissue enhanced (gallbladder, liver). DR MIM; 617806; gene. DR neXtProt; NX_Q8N661; -. DR OpenTargets; ENSG00000180089; -. DR PharmGKB; PA142670738; -. DR VEuPathDB; HostDB:ENSG00000180089; -. DR eggNOG; KOG4804; Eukaryota. DR GeneTree; ENSGT00390000007101; -. DR HOGENOM; CLU_079086_1_0_1; -. DR InParanoid; Q8N661; -. DR OMA; WPETFLH; -. DR OrthoDB; 3030862at2759; -. DR PhylomeDB; Q8N661; -. DR TreeFam; TF324663; -. DR BioCyc; MetaCyc:ENSG00000180089-MONOMER; -. DR PathwayCommons; Q8N661; -. DR Reactome; R-HSA-1482788; Acyl chain remodelling of PC. DR SignaLink; Q8N661; -. DR BioGRID-ORCS; 255043; 10 hits in 1160 CRISPR screens. DR GenomeRNAi; 255043; -. DR Pharos; Q8N661; Tbio. DR PRO; PR:Q8N661; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; Q8N661; Protein. DR Bgee; ENSG00000180089; Expressed in right lobe of liver and 91 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB. DR GO; GO:0016020; C:membrane; IDA:UniProtKB. DR GO; GO:0047408; F:alkenylglycerophosphocholine hydrolase activity; IDA:UniProtKB. DR GO; GO:0047409; F:alkenylglycerophosphoethanolamine hydrolase activity; IDA:UniProtKB. DR GO; GO:0016803; F:ether hydrolase activity; TAS:Reactome. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0046485; P:ether lipid metabolic process; IDA:UniProtKB. DR GO; GO:0036151; P:phosphatidylcholine acyl-chain remodeling; TAS:Reactome. DR InterPro; IPR012506; TMEM86B-like. DR PANTHER; PTHR31885; GH04784P; 1. DR PANTHER; PTHR31885:SF7; LYSOPLASMALOGENASE; 1. DR Pfam; PF07947; YhhN; 1. DR Genevisible; Q8N661; HS. PE 1: Evidence at protein level; KW Cytoplasm; Endoplasmic reticulum; Hydrolase; Lipid metabolism; Membrane; KW Reference proteome; Transmembrane; Transmembrane helix. FT CHAIN 1..226 FT /note="Lysoplasmalogenase TMEM86B" FT /id="PRO_0000201841" FT TOPO_DOM 1..23 FT /note="Cytoplasmic" FT /evidence="ECO:0000305" FT TRANSMEM 24..40 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 41..46 FT /note="Extracellular" FT /evidence="ECO:0000305" FT TRANSMEM 47..67 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 68..75 FT /note="Cytoplasmic" FT /evidence="ECO:0000305" FT TRANSMEM 76..93 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 94..100 FT /note="Extracellular" FT /evidence="ECO:0000305" FT TRANSMEM 101..117 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 118..123 FT /note="Cytoplasmic" FT /evidence="ECO:0000305" FT TRANSMEM 124..140 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 141..146 FT /note="Extracellular" FT /evidence="ECO:0000305" FT TRANSMEM 147..163 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 164..171 FT /note="Cytoplasmic" FT /evidence="ECO:0000305" FT TRANSMEM 172..188 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 189..199 FT /note="Extracellular" FT /evidence="ECO:0000305" FT TRANSMEM 200..218 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 219..226 FT /note="Cytoplasmic" FT /evidence="ECO:0000305" FT VARIANT 176 FT /note="A -> T (in dbSNP:rs35608872)" FT /id="VAR_052343" FT VARIANT 199 FT /note="H -> R (in dbSNP:rs4644955)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_052344" SQ SEQUENCE 226 AA; 24352 MW; BD5344268F221275 CRC64; MDAGKAGQTL KTHCSAQRPD VCRWLSPFIL SCCVYFCLWI PEDQLSWFAA LVKCLPVLCL AGFLWVMSPS GGYTQLLQGA LVCSAVGDAC LIWPAAFVPG MAAFATAHLL YVWAFGFSPL QPGLLLLIIL APGPYLSLVL QHLEPDMVLP VAAYGLILMA MLWRGLAQGG SAGWGALLFT LSDGVLAWDT FAQPLPHAHL VIMTTYYAAQ LLITLSALRS PVPKTD //