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Q8N661

- TM86B_HUMAN

UniProt

Q8N661 - TM86B_HUMAN

Protein

Lysoplasmalogenase

Gene

TMEM86B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.1 Publication

    Catalytic activityi

    1-(1-alkenyl)-sn-glycero-3-phosphocholine + H2O = an aldehyde + sn-glycero-3-phosphocholine.1 Publication
    1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = an aldehyde + sn-glycero-3-phosphoethanolamine.1 Publication

    Enzyme regulationi

    Competitively inhibited by lysophosphatidic acid.1 Publication

    Kineticsi

    1. KM=45 µM for lysoplasmenyl-choline1 Publication
    2. KM=53 µM for lysoplasmenyl-ethanolamine1 Publication

    pH dependencei

    Optimum pH is 6.95 and 7.05 with lysoplasmenyl-ethanolamine and lysoplasmenyl-choline as substrates, respectively.1 Publication

    GO - Molecular functioni

    1. alkenylglycerophosphocholine hydrolase activity Source: UniProtKB
    2. alkenylglycerophosphoethanolamine hydrolase activity Source: UniProtKB

    GO - Biological processi

    1. ether lipid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysoplasmalogenase (EC:3.3.2.2, EC:3.3.2.5)
    Alternative name(s):
    Transmembrane protein 86B
    Gene namesi
    Name:TMEM86B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:28448. TMEM86B.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670738.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226LysoplasmalogenasePRO_0000201841Add
    BLAST

    Proteomic databases

    PRIDEiQ8N661.

    Expressioni

    Gene expression databases

    BgeeiQ8N661.
    CleanExiHS_TMEM86B.
    GenevestigatoriQ8N661.

    Organism-specific databases

    HPAiHPA057689.

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Protein-protein interaction databases

    BioGridi129071. 1 interaction.
    IntActiQ8N661. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N661.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM86 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74425.
    HOGENOMiHOG000204433.
    HOVERGENiHBG055092.
    InParanoidiQ8N661.
    OMAiMLWRGLA.
    OrthoDBiEOG7J9VQD.
    PhylomeDBiQ8N661.
    TreeFamiTF324663.

    Family and domain databases

    InterProiIPR012506. YhhN.
    [Graphical view]
    PfamiPF07947. YhhN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N661-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAGKAGQTL KTHCSAQRPD VCRWLSPFIL SCCVYFCLWI PEDQLSWFAA    50
    LVKCLPVLCL AGFLWVMSPS GGYTQLLQGA LVCSAVGDAC LIWPAAFVPG 100
    MAAFATAHLL YVWAFGFSPL QPGLLLLIIL APGPYLSLVL QHLEPDMVLP 150
    VAAYGLILMA MLWRGLAQGG SAGWGALLFT LSDGVLAWDT FAQPLPHAHL 200
    VIMTTYYAAQ LLITLSALRS PVPKTD 226
    Length:226
    Mass (Da):24,352
    Last modified:May 18, 2010 - v2
    Checksum:iBD5344268F221275
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti176 – 1761A → T.
    Corresponds to variant rs35608872 [ dbSNP | Ensembl ].
    VAR_052343
    Natural varianti199 – 1991H → R.1 Publication
    Corresponds to variant rs4644955 [ dbSNP | Ensembl ].
    VAR_052344

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010327 Genomic DNA. No translation available.
    BC023000 mRNA. Translation: AAH23000.1.
    CCDSiCCDS12920.1.
    RefSeqiNP_776165.3. NM_173804.4.
    UniGeneiHs.135215.

    Genome annotation databases

    EnsembliENST00000327042; ENSP00000321038; ENSG00000180089.
    GeneIDi255043.
    KEGGihsa:255043.
    UCSCiuc002qjt.3. human.

    Polymorphism databases

    DMDMi296452936.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010327 Genomic DNA. No translation available.
    BC023000 mRNA. Translation: AAH23000.1 .
    CCDSi CCDS12920.1.
    RefSeqi NP_776165.3. NM_173804.4.
    UniGenei Hs.135215.

    3D structure databases

    ProteinModelPortali Q8N661.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129071. 1 interaction.
    IntActi Q8N661. 1 interaction.

    Polymorphism databases

    DMDMi 296452936.

    Proteomic databases

    PRIDEi Q8N661.

    Protocols and materials databases

    DNASUi 255043.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000327042 ; ENSP00000321038 ; ENSG00000180089 .
    GeneIDi 255043.
    KEGGi hsa:255043.
    UCSCi uc002qjt.3. human.

    Organism-specific databases

    CTDi 255043.
    GeneCardsi GC19M055738.
    H-InvDB HIX0174302.
    HIX0202856.
    HGNCi HGNC:28448. TMEM86B.
    HPAi HPA057689.
    neXtProti NX_Q8N661.
    PharmGKBi PA142670738.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74425.
    HOGENOMi HOG000204433.
    HOVERGENi HBG055092.
    InParanoidi Q8N661.
    OMAi MLWRGLA.
    OrthoDBi EOG7J9VQD.
    PhylomeDBi Q8N661.
    TreeFami TF324663.

    Miscellaneous databases

    GenomeRNAii 255043.
    NextBioi 92454.
    PROi Q8N661.

    Gene expression databases

    Bgeei Q8N661.
    CleanExi HS_TMEM86B.
    Genevestigatori Q8N661.

    Family and domain databases

    InterProi IPR012506. YhhN.
    [Graphical view ]
    Pfami PF07947. YhhN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-199.
      Tissue: Placenta.
    3. "Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen."
      Wu L.C., Pfeiffer D.R., Calhoon E.A., Madiai F., Marcucci G., Liu S., Jurkowitz M.S.
      J. Biol. Chem. 286:24916-24930(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, DIMERIZATION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiTM86B_HUMAN
    AccessioniPrimary (citable) accession number: Q8N661
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3