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Protein

Neuroblastoma breakpoint family member 15

Gene

NBPF15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 15Imported
Alternative name(s):
Neuroblastoma breakpoint family member 16Imported
Gene namesi
Name:NBPF15Imported
Synonyms:NBPF16Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28791. NBPF15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671274.

Polymorphism and mutation databases

DMDMi223590098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Neuroblastoma breakpoint family member 15PRO_0000288049Add
BLAST

Proteomic databases

PaxDbiQ8N660.
PRIDEiQ8N660.

Expressioni

Tissue specificityi

Ubiquitously expressed with a higher expression observed in breast and liver. Also expressed in neuroblastoma cell line.1 Publication

Gene expression databases

BgeeiQ8N660.
CleanExiHS_NBPF15.
GenevisibleiQ8N660. HS.

Organism-specific databases

HPAiHPA042595.
HPA043105.
HPA043692.
HPA044023.
HPA046971.
HPA058050.

Interactioni

Protein-protein interaction databases

BioGridi129901. 1 interaction.
IntActiQ8N660. 1 interaction.
MINTiMINT-8417699.
STRINGi9606.ENSP00000395369.

Structurei

3D structure databases

ProteinModelPortaliQ8N660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 25793NBPF 1PROSITE-ProRule annotationAdd
BLAST
Domaini258 – 32972NBPF 2PROSITE-ProRule annotationAdd
BLAST
Domaini330 – 42192NBPF 3PROSITE-ProRule annotationAdd
BLAST
Domaini424 – 47956NBPF 4PROSITE-ProRule annotationAdd
BLAST
Domaini480 – 57293NBPF 5PROSITE-ProRule annotationAdd
BLAST
Domaini573 – 67098NBPF 6PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili70 – 13061Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi264 – 2685Poly-Glu
Compositional biasi279 – 2846Poly-Glu
Compositional biasi486 – 4894Poly-Glu

Sequence similaritiesi

Belongs to the NBPF family.Curated
Contains 6 NBPF domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG116165.
GeneTreeiENSGT00420000029746.
HOGENOMiHOG000049041.
HOVERGENiHBG058300.
InParanoidiQ8N660.
OMAiHISFSLY.
OrthoDBiEOG7GBFWV.
PhylomeDBiQ8N660.
TreeFamiTF341151.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 6 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVSAGPLSS EKAEMNILEI NEKLRPQLAE KKQQFRNLKE KCFLTQLAGF
60 70 80 90 100
LANRQKKYKY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH
110 120 130 140 150
AQERELTQLR EKLREGRDAS RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE
160 170 180 190 200
GCRLTQHLVQ KLSPENDNDD DEDVQVEVAE KVQKSSAPRE MQKAEEKEVP
210 220 230 240 250
EDSLEECAIT CSNSHGPYDS NQPHKKTKIT FEEDKVDSTL IGSSSHVEWE
260 270 280 290 300
DAVHIIPENE SDDEEEEEKG PVSPRNLQES EEEEVPQESW DEGYSTLSIP
310 320 330 340 350
PEMLASYQSY SSTFHSLEEQ QVCMAVDIGR HRWDQVKKED QEATGPRLSR
360 370 380 390 400
ELLDEKEPEV LQDSLDRCYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA
410 420 430 440 450
IDMDEIEKYQ EVEEDQDPSC PRLSRELLDE KEPEVLQDSL DRCYSTPSDY
460 470 480 490 500
LELPDLGQPY SSAVYSLEEQ YLGLALDVDR IKKDQEEEED QGPPCPRLSR
510 520 530 540 550
ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS
560 570 580 590 600
LDVGEIEKKG KGKKRRGRRS KKKRRRGRKE GEDDNPPCPR LYGVLMEVEE
610 620 630 640 650
PEVLQDSLDR CYSTPSMYFE QPDSFQHYRS VFYSFEEEHI SFALYVDNRF
660 670
FTLTVTSLHL VFQMGVIFPQ
Length:670
Mass (Da):77,563
Last modified:February 10, 2009 - v2
Checksum:i80944E05C2FC4511
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti477 – 4771D → A in AAH23087 (PubMed:15489334).Curated
Sequence conflicti518 – 5181C → Y in CAI16654 (PubMed:16710414).Curated
Sequence conflicti592 – 5921Y → N in CAI16654 (PubMed:16710414).Curated
Sequence conflicti621 – 6211Q → L in CAI16654 (PubMed:16710414).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti615 – 6151P → Q.
Corresponds to variant rs6695216 [ dbSNP | Ensembl ].
VAR_032383

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF379630 mRNA. Translation: AAO15398.1.
AY894566 mRNA. Translation: AAX85105.1.
AC246785 Genomic DNA. No translation available.
AL592492 Genomic DNA. Translation: CAI16654.1.
AL954711 Genomic DNA. Translation: CAM22821.1.
BC023087 mRNA. Translation: AAH23087.1.
CCDSiCCDS72852.1.
RefSeqiNP_001164226.1. NM_001170755.2.
NP_775909.2. NM_173638.4.
XP_005245153.1. XM_005245096.3.
UniGeneiHs.523572.
Hs.656782.
Hs.714127.

Genome annotation databases

EnsembliENST00000488031; ENSP00000481835; ENSG00000266338.
ENST00000577412; ENSP00000462600; ENSG00000266338.
ENST00000581897; ENSP00000463178; ENSG00000266338.
GeneIDi284565.
KEGGihsa:284565.
UCSCiuc001esb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF379630 mRNA. Translation: AAO15398.1.
AY894566 mRNA. Translation: AAX85105.1.
AC246785 Genomic DNA. No translation available.
AL592492 Genomic DNA. Translation: CAI16654.1.
AL954711 Genomic DNA. Translation: CAM22821.1.
BC023087 mRNA. Translation: AAH23087.1.
CCDSiCCDS72852.1.
RefSeqiNP_001164226.1. NM_001170755.2.
NP_775909.2. NM_173638.4.
XP_005245153.1. XM_005245096.3.
UniGeneiHs.523572.
Hs.656782.
Hs.714127.

3D structure databases

ProteinModelPortaliQ8N660.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129901. 1 interaction.
IntActiQ8N660. 1 interaction.
MINTiMINT-8417699.
STRINGi9606.ENSP00000395369.

Polymorphism and mutation databases

DMDMi223590098.

Proteomic databases

PaxDbiQ8N660.
PRIDEiQ8N660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000488031; ENSP00000481835; ENSG00000266338.
ENST00000577412; ENSP00000462600; ENSG00000266338.
ENST00000581897; ENSP00000463178; ENSG00000266338.
GeneIDi284565.
KEGGihsa:284565.
UCSCiuc001esb.2. human.

Organism-specific databases

CTDi284565.
GeneCardsiGC01P148555.
H-InvDBHIX0023175.
HGNCiHGNC:28791. NBPF15.
HPAiHPA042595.
HPA043105.
HPA043692.
HPA044023.
HPA046971.
HPA058050.
MIMi610414. gene.
614005. gene.
neXtProtiNX_Q8N660.
PharmGKBiPA142671274.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG116165.
GeneTreeiENSGT00420000029746.
HOGENOMiHOG000049041.
HOVERGENiHBG058300.
InParanoidiQ8N660.
OMAiHISFSLY.
OrthoDBiEOG7GBFWV.
PhylomeDBiQ8N660.
TreeFamiTF341151.

Miscellaneous databases

ChiTaRSiNBPF15. human.
GenomeRNAii284565.
NextBioi94963.
PROiQ8N660.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N660.
CleanExiHS_NBPF15.
GenevisibleiQ8N660. HS.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 6 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution."
    Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.
    Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Mammary gland.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-615.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiNBPFF_HUMAN
AccessioniPrimary (citable) accession number: Q8N660
Secondary accession number(s): A8MPT6
, Q3BBV9, Q5SXJ2, Q8IX77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 10, 2009
Last modified: July 22, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.