Q8N655 (CJ012_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C10orf12

Gene names

Name:

C10orf12

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1247 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9
Sequence caution	The sequence BAB14396.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1247	1247	Uncharacterized protein C10orf12		PRO_0000089783
Amino acid modifications
	Modified residue	273	1	Phosphoserine Ref.7 Ref.9
	Modified residue	428	1	Phosphothreonine Ref.5
	Modified residue	449	1	Phosphoserine Ref.8
	Modified residue	451	1	Phosphothreonine Ref.8
	Modified residue	767	1	Phosphoserine Ref.9
	Modified residue	993	1	Phosphothreonine Ref.7
	Modified residue	996	1	Phosphoserine Ref.7
	Modified residue	1077	1	Phosphoserine Ref.6
	Modified residue	1121	1	Phosphothreonine Ref.6
Natural variations
	Natural variant	49	1	N → S. Corresponds to variant rs11188980 [ dbSNP | Ensembl ].		VAR_033687
	Natural variant	314	1	L → P. Corresponds to variant rs7082522 [ dbSNP | Ensembl ].		VAR_033688
	Natural variant	396	1	E → G. Corresponds to variant rs35128733 [ dbSNP | Ensembl ].		VAR_050846
	Natural variant	401	1	P → A. Corresponds to variant rs34104025 [ dbSNP | Ensembl ].		VAR_033689
	Natural variant	535	1	I → L. Corresponds to variant rs3829856 [ dbSNP | Ensembl ].		VAR_033690
	Natural variant	556	1	T → P. Corresponds to variant rs7894200 [ dbSNP | Ensembl ].		VAR_050847
	Natural variant	579	1	N → S. Corresponds to variant rs7894315 [ dbSNP | Ensembl ].		VAR_059605
	Natural variant	614	1	R → G. Corresponds to variant rs7894545 [ dbSNP | Ensembl ].		VAR_059606
	Natural variant	716	1	A → P. Corresponds to variant rs7895159 [ dbSNP | Ensembl ].		VAR_059607
Experimental info
	Sequence conflict	612	1	E → G in BAB14396. Ref.3
	Sequence conflict	899	1	D → G in BAB14396. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8N655 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 8D54C9ACE489CEE8	FASTA	1,247	137,223
	10 20 30 40 50 60 MQSSALVESL ITVKMAAENS EEGNTCIIPQ RNLFKALSEE AWNSGFMGNS SRTADKENTL 70 80 90 100 110 120 QCPKTPLRQD LEANEQDARP KQENHLHSLG RNKVGYHLHP SDKGQFDHSK DGWLGPGPMP 130 140 150 160 170 180 AVHKAANGHS RTKMISTSIK TARKSKRASG LRINDYDNQC DVVYISQPIT ECHFENQKSI 190 200 210 220 230 240 LSSRKTARKS TRGYFFNGDC CELPTVRTLA RNLHSQEKAS CSALASEAVF TPKQTLTIPA 250 260 270 280 290 300 PRHTVDVQLP REDNPEEPSK EITSHEEGGG DVSPRKEPQE PEVCPTKIKP NLSSSPRSEE 310 320 330 340 350 360 TTASSLVWPL PAHLPEEDLP EGGSTVSAPT ASGMSSPEHN QPPVALLDTE EMSVPQDCHL 370 380 390 400 410 420 LPSTESFSGG VSEDVISRPH SPPEIVSREE SPQCSENQSS PMGLEPPMSL GKAEDNQSIS 430 440 450 460 470 480 AEVESGDTQE LNVDPLLKES STFTDENPSE TEESEAAGGI GKLEGEDGDV KCLSEKDTYD 490 500 510 520 530 540 TSIDSLEENL DKKKKGKKFP EASDRCLRSQ LSDSSSADRC LRNQSSDSSS ACLEIKVPKN 550 560 570 580 590 600 PSAKRSKKEG HPGGTTPKGL LPDSFHTETL EDTEKPSVNE RPSEKDAEQE GEGGGIITRQ 610 620 630 640 650 660 TLKNMLDKEV KELRGEIFPS RDPITTAGQP LPGERLEIYV QSKMDEKNAH IPSESIACKR 670 680 690 700 710 720 DPEQAKEEPG HIPTQHVEEA VNEVDNENTQ QKDDESDAPC SSLGLSSSGS GDAARAPKSV 730 740 750 760 770 780 PRPKRLTSST YNLRHAHSLG SLDASKVTSE KEAAQVNPIM PKENGASESG DPLDEDDVDT 790 800 810 820 830 840 VVDEQPKFME WCAEEENQEL IANFNAQYMK VQKGWIQLEK EGQPTPRARN KSDKLKEIWK 850 860 870 880 890 900 SKKRSRKCRS SLESQKCSPV QMLFMTNFKL SNVCKWFLET TETRSLVIVK KLNTRLPGDV 910 920 930 940 950 960 PPVKHPLQKY APSSLYPSSL QAERLKKHLK KFPGATPAKN NWKMQKLWAK FRENPDQVEP 970 980 990 1000 1010 1020 EDGSDVSPGP NSEDSIEEVK EDRNSHPPAN LPTPASTRIL RKYSNIRGKL RAQQRLIKNE 1030 1040 1050 1060 1070 1080 KMECPDALAV ESKPSRKSVC INPLMSPKLA LQVDADGFPV KPKSTEGMKG RKGKQVSEIL 1090 1100 1110 1120 1130 1140 PKAEVQSKRK RTEGSSPPDS KNKGPTVKAS KEKHADGATK TPAAKRPAAR DRSSQPPKKT 1150 1160 1170 1180 1190 1200 SLKENKVKIP KKSAGKSCPP SRKEKENTNK RPSQSIASET LTKPAKQKGA GESSSRPQKA 1210 1220 1230 1240 TNRKQSSGKT RARPSTKTPE SSAAQRKRKL KAKLDCSHSK RRRLDAK

References

[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 236-1247.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1025-1247. Tissue: Brain.
[5]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-428, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[6]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1077 AND THR-1121, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; THR-993 AND SER-996, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-449 AND THR-451, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273 AND SER-767, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL442123 Genomic DNA. Translation: CAH70916.1. BC024315 mRNA. Translation: AAH24315.1. AK023084 mRNA. Translation: BAB14396.1. Different initiation. AL049938 mRNA. Translation: CAB43214.1.
IPI	IPI00166933.
PIR	T08672.
RefSeq	NP_056467.2. NM_015652.2.
UniGene	Hs.14555. Hs.427927.
3D structure databases
ProteinModelPortal	Q8N655.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N655. 2 interactions.
MINT	MINT-1484880.
PTM databases
PhosphoSite	Q8N655.
Polymorphism databases
DMDM	68565212.
Proteomic databases
PRIDE	Q8N655.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000286067; ENSP00000286067; ENSG00000155640.
GeneID	26148.
KEGG	hsa:26148.
UCSC	uc001kmv.1. human.
Organism-specific databases
CTD	26148.
GeneCards	GC10P098731.
HGNC	HGNC:23420. C10orf12.
HPA	HPA038954.
neXtProt	NX_Q8N655.
PharmGKB	PA134866687.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000064232.
HOVERGEN	HBG081176.
InParanoid	Q8N655.
OMA	CINPLMS.
OrthoDB	EOG42JNQN.
PhylomeDB	Q8N655.
Gene expression databases
ArrayExpress	Q8N655.
Bgee	Q8N655.
CleanEx	HS_C10orf12.
Genevestigator	Q8N655.
GermOnline	ENSG00000155640. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	48211.

Entry information

Entry name

CJ012_HUMAN

Accession

Primary (citable) accession number: Q8N655
Secondary accession number(s): Q9H945, Q9Y457

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.