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Protein

Uncharacterized protein C10orf12

Gene

C10orf12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C10orf12
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23420. C10orf12.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866687.

Polymorphism and mutation databases

BioMutaiC10orf12.
DMDMi68565212.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12471247Uncharacterized protein C10orf12PRO_0000089783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731PhosphoserineCombined sources
Modified residuei295 – 2951PhosphoserineCombined sources
Modified residuei482 – 4821PhosphoserineCombined sources
Modified residuei738 – 7381PhosphoserineCombined sources
Modified residuei767 – 7671PhosphoserineCombined sources
Modified residuei964 – 9641PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N655.
MaxQBiQ8N655.
PaxDbiQ8N655.
PeptideAtlasiQ8N655.
PRIDEiQ8N655.

PTM databases

iPTMnetiQ8N655.
PhosphoSiteiQ8N655.

Expressioni

Gene expression databases

BgeeiQ8N655.
CleanExiHS_C10orf12.
GenevisibleiQ8N655. HS.

Organism-specific databases

HPAiHPA038954.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EHMT2A2ABF93EBI-746045,EBI-10174566

Protein-protein interaction databases

BioGridi117579. 31 interactions.
IntActiQ8N655. 30 interactions.
MINTiMINT-1484880.
STRINGi9606.ENSP00000286067.

Structurei

3D structure databases

ProteinModelPortaliQ8N655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHUE. Eukaryota.
ENOG4111MRK. LUCA.
GeneTreeiENSGT00530000064232.
HOGENOMiHOG000111679.
HOVERGENiHBG081176.
InParanoidiQ8N655.
OMAiPKQENHL.
OrthoDBiEOG776SP3.
PhylomeDBiQ8N655.
TreeFamiTF332137.

Family and domain databases

InterProiIPR028104. DUF4553.
[Graphical view]
PfamiPF15090. DUF4553. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSSALVESL ITVKMAAENS EEGNTCIIPQ RNLFKALSEE AWNSGFMGNS
60 70 80 90 100
SRTADKENTL QCPKTPLRQD LEANEQDARP KQENHLHSLG RNKVGYHLHP
110 120 130 140 150
SDKGQFDHSK DGWLGPGPMP AVHKAANGHS RTKMISTSIK TARKSKRASG
160 170 180 190 200
LRINDYDNQC DVVYISQPIT ECHFENQKSI LSSRKTARKS TRGYFFNGDC
210 220 230 240 250
CELPTVRTLA RNLHSQEKAS CSALASEAVF TPKQTLTIPA PRHTVDVQLP
260 270 280 290 300
REDNPEEPSK EITSHEEGGG DVSPRKEPQE PEVCPTKIKP NLSSSPRSEE
310 320 330 340 350
TTASSLVWPL PAHLPEEDLP EGGSTVSAPT ASGMSSPEHN QPPVALLDTE
360 370 380 390 400
EMSVPQDCHL LPSTESFSGG VSEDVISRPH SPPEIVSREE SPQCSENQSS
410 420 430 440 450
PMGLEPPMSL GKAEDNQSIS AEVESGDTQE LNVDPLLKES STFTDENPSE
460 470 480 490 500
TEESEAAGGI GKLEGEDGDV KCLSEKDTYD TSIDSLEENL DKKKKGKKFP
510 520 530 540 550
EASDRCLRSQ LSDSSSADRC LRNQSSDSSS ACLEIKVPKN PSAKRSKKEG
560 570 580 590 600
HPGGTTPKGL LPDSFHTETL EDTEKPSVNE RPSEKDAEQE GEGGGIITRQ
610 620 630 640 650
TLKNMLDKEV KELRGEIFPS RDPITTAGQP LPGERLEIYV QSKMDEKNAH
660 670 680 690 700
IPSESIACKR DPEQAKEEPG HIPTQHVEEA VNEVDNENTQ QKDDESDAPC
710 720 730 740 750
SSLGLSSSGS GDAARAPKSV PRPKRLTSST YNLRHAHSLG SLDASKVTSE
760 770 780 790 800
KEAAQVNPIM PKENGASESG DPLDEDDVDT VVDEQPKFME WCAEEENQEL
810 820 830 840 850
IANFNAQYMK VQKGWIQLEK EGQPTPRARN KSDKLKEIWK SKKRSRKCRS
860 870 880 890 900
SLESQKCSPV QMLFMTNFKL SNVCKWFLET TETRSLVIVK KLNTRLPGDV
910 920 930 940 950
PPVKHPLQKY APSSLYPSSL QAERLKKHLK KFPGATPAKN NWKMQKLWAK
960 970 980 990 1000
FRENPDQVEP EDGSDVSPGP NSEDSIEEVK EDRNSHPPAN LPTPASTRIL
1010 1020 1030 1040 1050
RKYSNIRGKL RAQQRLIKNE KMECPDALAV ESKPSRKSVC INPLMSPKLA
1060 1070 1080 1090 1100
LQVDADGFPV KPKSTEGMKG RKGKQVSEIL PKAEVQSKRK RTEGSSPPDS
1110 1120 1130 1140 1150
KNKGPTVKAS KEKHADGATK TPAAKRPAAR DRSSQPPKKT SLKENKVKIP
1160 1170 1180 1190 1200
KKSAGKSCPP SRKEKENTNK RPSQSIASET LTKPAKQKGA GESSSRPQKA
1210 1220 1230 1240
TNRKQSSGKT RARPSTKTPE SSAAQRKRKL KAKLDCSHSK RRRLDAK
Length:1,247
Mass (Da):137,223
Last modified:October 1, 2002 - v1
Checksum:i8D54C9ACE489CEE8
GO

Sequence cautioni

The sequence BAB14396.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti612 – 6121E → G in BAB14396 (PubMed:14702039).Curated
Sequence conflicti899 – 8991D → G in BAB14396 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491N → S.
Corresponds to variant rs11188980 [ dbSNP | Ensembl ].
VAR_033687
Natural varianti314 – 3141L → P.
Corresponds to variant rs7082522 [ dbSNP | Ensembl ].
VAR_033688
Natural varianti396 – 3961E → G.
Corresponds to variant rs35128733 [ dbSNP | Ensembl ].
VAR_050846
Natural varianti401 – 4011P → A.
Corresponds to variant rs34104025 [ dbSNP | Ensembl ].
VAR_033689
Natural varianti535 – 5351I → L.
Corresponds to variant rs3829856 [ dbSNP | Ensembl ].
VAR_033690
Natural varianti556 – 5561T → P.
Corresponds to variant rs7894200 [ dbSNP | Ensembl ].
VAR_050847
Natural varianti579 – 5791N → S.
Corresponds to variant rs7894315 [ dbSNP | Ensembl ].
VAR_059605
Natural varianti614 – 6141R → G.
Corresponds to variant rs7894545 [ dbSNP | Ensembl ].
VAR_059606
Natural varianti716 – 7161A → P.
Corresponds to variant rs7895159 [ dbSNP | Ensembl ].
VAR_059607

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL442123 Genomic DNA. Translation: CAH70916.1.
BC024315 mRNA. Translation: AAH24315.1.
AK023084 mRNA. Translation: BAB14396.1. Different initiation.
AL049938 mRNA. Translation: CAB43214.1.
CCDSiCCDS7452.1.
PIRiT08672.
RefSeqiNP_056467.2. NM_015652.2.
UniGeneiHs.427927.

Genome annotation databases

EnsembliENST00000286067; ENSP00000286067; ENSG00000155640.
GeneIDi26148.
KEGGihsa:26148.
UCSCiuc001kmv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL442123 Genomic DNA. Translation: CAH70916.1.
BC024315 mRNA. Translation: AAH24315.1.
AK023084 mRNA. Translation: BAB14396.1. Different initiation.
AL049938 mRNA. Translation: CAB43214.1.
CCDSiCCDS7452.1.
PIRiT08672.
RefSeqiNP_056467.2. NM_015652.2.
UniGeneiHs.427927.

3D structure databases

ProteinModelPortaliQ8N655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117579. 31 interactions.
IntActiQ8N655. 30 interactions.
MINTiMINT-1484880.
STRINGi9606.ENSP00000286067.

PTM databases

iPTMnetiQ8N655.
PhosphoSiteiQ8N655.

Polymorphism and mutation databases

BioMutaiC10orf12.
DMDMi68565212.

Proteomic databases

EPDiQ8N655.
MaxQBiQ8N655.
PaxDbiQ8N655.
PeptideAtlasiQ8N655.
PRIDEiQ8N655.

Protocols and materials databases

DNASUi26148.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286067; ENSP00000286067; ENSG00000155640.
GeneIDi26148.
KEGGihsa:26148.
UCSCiuc001kmv.4. human.

Organism-specific databases

CTDi26148.
GeneCardsiC10orf12.
H-InvDBHIX0170441.
HGNCiHGNC:23420. C10orf12.
HPAiHPA038954.
neXtProtiNX_Q8N655.
PharmGKBiPA134866687.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHUE. Eukaryota.
ENOG4111MRK. LUCA.
GeneTreeiENSGT00530000064232.
HOGENOMiHOG000111679.
HOVERGENiHBG081176.
InParanoidiQ8N655.
OMAiPKQENHL.
OrthoDBiEOG776SP3.
PhylomeDBiQ8N655.
TreeFamiTF332137.

Miscellaneous databases

ChiTaRSiC10orf12. human.
GenomeRNAii26148.
PROiQ8N655.

Gene expression databases

BgeeiQ8N655.
CleanExiHS_C10orf12.
GenevisibleiQ8N655. HS.

Family and domain databases

InterProiIPR028104. DUF4553.
[Graphical view]
PfamiPF15090. DUF4553. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 236-1247.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1025-1247.
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-767, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-482; SER-738 AND SER-964, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273 AND SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiCJ012_HUMAN
AccessioniPrimary (citable) accession number: Q8N655
Secondary accession number(s): Q9H945, Q9Y457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.