Q8N653 (LZTR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine-zipper-like transcriptional regulator 1
Short name=LZTR-1

Gene names

Name:	LZTR1
Synonyms:	TCFL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	840 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable transcriptional regulator that may play a crucial role in embryogenesis.
Developmental stage	Expressed in fetal brain, heart, kidney, liver and lung.
Sequence similarities	Contains 2 BTB (POZ) domains. Contains 6 Kelch repeats.
Sequence caution	The sequence BAA07508.1 differs from that shown. Reason: Frameshift at positions 16, 69 and 222.

Ontologies

Keywords
Domain	Kelch repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anatomical structure morphogenesis Traceable author statement Ref.4. Source: ProtInc
Molecular_function	sequence-specific DNA binding transcription factor activity Traceable author statement Ref.4. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 840	840	Leucine-zipper-like transcriptional regulator 1		PRO_0000119135
Regions
	Repeat	79 – 128	50	Kelch 1
	Repeat	130 – 185	56	Kelch 2
	Repeat	187 – 238	52	Kelch 3
	Repeat	239 – 285	47	Kelch 4
	Repeat	295 – 341	47	Kelch 5
	Repeat	399 – 450	52	Kelch 6
	Domain	443 – 537	95	BTB 1
	Domain	667 – 736	70	BTB 2
Experimental info
	Sequence conflict	498	1	G → S in BAA07508. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q8N653 [UniParc]. Last modified April 11, 2003. Version 2. Checksum: AAF172940BAEA92B	FASTA	840	94,719
	10 20 30 40 50 60 MAGPGSTGGQ IGAAALAGGA RSKVAPSVDF DHSCSDSVEY LTLNFGPFET VHRWRRLPPC 70 80 90 100 110 120 DEFVGARRSK HTVVAYKDAI YVFGGDNGKT MLNDLLRFDV KDCSWCRAFT TGTPPAPRYH 130 140 150 160 170 180 HSAVVYGSSM FVFGGYTGDI YSNSNLKNKN DLFEYKFATG QWTEWKIEGR LPVARSAHGA 190 200 210 220 230 240 TVYSDKLWIF AGYDGNARLN DMWTIGLQDR ELTCWEEVAQ SGEIPPSCCN FPVAVCRDKM 250 260 270 280 290 300 FVFSGQSGAK ITNNLFQFEF KDKTWTRIPT EHLLRGSPPP PQRRYGHTMV AFDRHLYVFG 310 320 330 340 350 360 GAADNTLPNE LHCYDVDFQT WEVVQPSSDS EVGGAEVPER ACASEEVPTL TYEERVGFKK 370 380 390 400 410 420 SRDVFGLDFG TTSAKQPTQP ASELPSGRLF HAAAVISDAM YIFGGTVDNN IRSGEMYRFQ 430 440 450 460 470 480 FSCYPKCTLH EDYGRLWESR QFCDVEFVLG EKEECVQGHV AIVTARSRWL RRKITQARER 490 500 510 520 530 540 LAQKLEQEAA PVPREAPGVA AGGARPPLLH VAIREAEARP FEVLMQFLYT DKIKYPRKGH 550 560 570 580 590 600 VEDVLLIMDV YKLALSFQLC RLEQLCRQYI EASVDLQNVL VVCESAARLQ LSQLKEHCLN 610 620 630 640 650 660 FVVKESHFNQ VIMMKEFERL SSPLIVEIVR RKQQPPPRTP LDQPVDIGTS LIQDMKAYLE 670 680 690 700 710 720 GAGAEFCDIT LLLDGHPRPA HKAILAARSS YFEAMFRSFM PEDGQVNISI GEMVPSRQAF 730 740 750 760 770 780 ESMLRYIYYG EVNMPPEDSL YLFAAPYYYG FYNNRLQAYC KQNLEMNVTV QNVLQILEAA 790 800 810 820 830 840 DKTQALDMKR HCLHIIVHQF TKVSKLPTLR SLSQQLLLDI IDSLASHISD KQCAELGADI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Duodenal adenocarcinoma.
[4]	"Isolation and characterization of a novel gene deleted in DiGeorge syndrome." Kurahashi H., Akagi K., Inazawa J., Ohta T., Niikawa N., Kayatani F., Sano T., Okada S., Nishisho I. Hum. Mol. Genet. 4:541-549(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-840. Tissue: Fetal brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT841521 mRNA. Translation: CAJ86451.1. CH471176 Genomic DNA. Translation: EAX02923.1. BC026214 mRNA. Translation: AAH26214.2. D38496 mRNA. Translation: BAA07508.1. Frameshift.
IPI	IPI00024893.
PIR	I54388.
RefSeq	NP_006758.2. NM_006767.3.
UniGene	Hs.78788.
3D structure databases
ProteinModelPortal	Q8N653.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N653. 2 interactions.
STRING	9606.ENSP00000215739.
PTM databases
PhosphoSite	Q8N653.
Polymorphism databases
DMDM	29839558.
Proteomic databases
PaxDb	Q8N653.
PRIDE	Q8N653.
Protocols and materials databases
DNASU	8216.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000215739; ENSP00000215739; ENSG00000099949.
GeneID	8216.
KEGG	hsa:8216.
UCSC	uc002zto.3. human.
Organism-specific databases
CTD	8216.
GeneCards	GC22P021339.
HGNC	HGNC:6742. LZTR1.
MIM	600574. gene.
neXtProt	NX_Q8N653.
PharmGKB	PA30506.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG145020.
HOGENOM	HOG000007115.
HOVERGEN	HBG052380.
InParanoid	Q8N653.
OMA	GHPRPAH.
OrthoDB	EOG4GF3DH.
PhylomeDB	Q8N653.
Gene expression databases
ArrayExpress	Q8N653.
Bgee	Q8N653.
CleanEx	HS_LZTR1.
Genevestigator	Q8N653.
GermOnline	ENSG00000099949. Homo sapiens.
Family and domain databases
Gene3D	2.120.10.80. 2 hits. 3.30.710.10. 3 hits.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR015915. Kelch-typ_b-propeller. IPR006652. Kelch_1. [Graphical view]
Pfam	PF00651. BTB. 2 hits. PF01344. Kelch_1. 1 hit. [Graphical view]
SMART	SM00225. BTB. 2 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 2 hits.
PROSITE	PS50097. BTB. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LZTR1. human.
GenomeRNAi	8216.
NextBio	30937.
SOURCE	Search...

Entry information

Entry name

LZTR1_HUMAN

Accession

Primary (citable) accession number: Q8N653
Secondary accession number(s): Q14776, Q20WK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	April 11, 2003
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.