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Q8N653 (LZTR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-zipper-like transcriptional regulator 1

Short name=LZTR-1
Gene names
Name:LZTR1
Synonyms:TCFL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length840 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable transcriptional regulator that may play a crucial role in embryogenesis.

Developmental stage

Expressed in fetal brain, heart, kidney, liver and lung.

Sequence similarities

Contains 2 BTB (POZ) domains.

Contains 6 Kelch repeats.

Sequence caution

The sequence BAA07508.1 differs from that shown. Reason: Frameshift at positions 16, 69 and 222.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 840839Leucine-zipper-like transcriptional regulator 1
PRO_0000119135

Regions

Repeat79 – 12850Kelch 1
Repeat130 – 18556Kelch 2
Repeat187 – 23852Kelch 3
Repeat239 – 28547Kelch 4
Repeat295 – 34147Kelch 5
Repeat399 – 45052Kelch 6
Domain443 – 53795BTB 1
Domain667 – 73670BTB 2

Amino acid modifications

Modified residue21N-acetylalanine Ref.5

Experimental info

Sequence conflict4981G → S in BAA07508. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q8N653 [UniParc].

Last modified April 11, 2003. Version 2.
Checksum: AAF172940BAEA92B

FASTA84094,719
        10         20         30         40         50         60 
MAGPGSTGGQ IGAAALAGGA RSKVAPSVDF DHSCSDSVEY LTLNFGPFET VHRWRRLPPC 

        70         80         90        100        110        120 
DEFVGARRSK HTVVAYKDAI YVFGGDNGKT MLNDLLRFDV KDCSWCRAFT TGTPPAPRYH 

       130        140        150        160        170        180 
HSAVVYGSSM FVFGGYTGDI YSNSNLKNKN DLFEYKFATG QWTEWKIEGR LPVARSAHGA 

       190        200        210        220        230        240 
TVYSDKLWIF AGYDGNARLN DMWTIGLQDR ELTCWEEVAQ SGEIPPSCCN FPVAVCRDKM 

       250        260        270        280        290        300 
FVFSGQSGAK ITNNLFQFEF KDKTWTRIPT EHLLRGSPPP PQRRYGHTMV AFDRHLYVFG 

       310        320        330        340        350        360 
GAADNTLPNE LHCYDVDFQT WEVVQPSSDS EVGGAEVPER ACASEEVPTL TYEERVGFKK 

       370        380        390        400        410        420 
SRDVFGLDFG TTSAKQPTQP ASELPSGRLF HAAAVISDAM YIFGGTVDNN IRSGEMYRFQ 

       430        440        450        460        470        480 
FSCYPKCTLH EDYGRLWESR QFCDVEFVLG EKEECVQGHV AIVTARSRWL RRKITQARER 

       490        500        510        520        530        540 
LAQKLEQEAA PVPREAPGVA AGGARPPLLH VAIREAEARP FEVLMQFLYT DKIKYPRKGH 

       550        560        570        580        590        600 
VEDVLLIMDV YKLALSFQLC RLEQLCRQYI EASVDLQNVL VVCESAARLQ LSQLKEHCLN 

       610        620        630        640        650        660 
FVVKESHFNQ VIMMKEFERL SSPLIVEIVR RKQQPPPRTP LDQPVDIGTS LIQDMKAYLE 

       670        680        690        700        710        720 
GAGAEFCDIT LLLDGHPRPA HKAILAARSS YFEAMFRSFM PEDGQVNISI GEMVPSRQAF 

       730        740        750        760        770        780 
ESMLRYIYYG EVNMPPEDSL YLFAAPYYYG FYNNRLQAYC KQNLEMNVTV QNVLQILEAA 

       790        800        810        820        830        840 
DKTQALDMKR HCLHIIVHQF TKVSKLPTLR SLSQQLLLDI IDSLASHISD KQCAELGADI 

« Hide

References

« Hide 'large scale' references
[1]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Duodenal adenocarcinoma.
[4]"Isolation and characterization of a novel gene deleted in DiGeorge syndrome."
Kurahashi H., Akagi K., Inazawa J., Ohta T., Niikawa N., Kayatani F., Sano T., Okada S., Nishisho I.
Hum. Mol. Genet. 4:541-549(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-840.
Tissue: Fetal brain.
[5]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT841521 mRNA. Translation: CAJ86451.1.
CH471176 Genomic DNA. Translation: EAX02923.1.
BC026214 mRNA. Translation: AAH26214.2.
D38496 mRNA. Translation: BAA07508.1. Frameshift.
PIRI54388.
RefSeqNP_006758.2. NM_006767.3.
UniGeneHs.78788.

3D structure databases

ProteinModelPortalQ8N653.
SMRQ8N653. Positions 52-324, 381-408, 422-630, 649-824.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113852. 52 interactions.
IntActQ8N653. 2 interactions.
STRING9606.ENSP00000215739.

PTM databases

PhosphoSiteQ8N653.

Polymorphism databases

DMDM29839558.

Proteomic databases

PaxDbQ8N653.
PRIDEQ8N653.

Protocols and materials databases

DNASU8216.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000215739; ENSP00000215739; ENSG00000099949.
GeneID8216.
KEGGhsa:8216.
UCSCuc002ztn.3. human.

Organism-specific databases

CTD8216.
GeneCardsGC22P021339.
HGNCHGNC:6742. LZTR1.
MIM600574. gene.
neXtProtNX_Q8N653.
Orphanet251579. Giant cell glioblastoma.
251576. Gliosarcoma.
PharmGKBPA30506.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145020.
HOGENOMHOG000007115.
HOVERGENHBG052380.
InParanoidQ8N653.
OMAGHPRPAH.
OrthoDBEOG7JDQWZ.
PhylomeDBQ8N653.
TreeFamTF314081.

Gene expression databases

ArrayExpressQ8N653.
BgeeQ8N653.
CleanExHS_LZTR1.
GenevestigatorQ8N653.

Family and domain databases

Gene3D2.120.10.80. 2 hits.
3.30.710.10. 3 hits.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamPF00651. BTB. 2 hits.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 2 hits.
[Graphical view]
SUPFAMSSF54695. SSF54695. 4 hits.
PROSITEPS50097. BTB. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLZTR1. human.
GeneWikiLZTR1.
GenomeRNAi8216.
NextBio30937.
PROQ8N653.
SOURCESearch...

Entry information

Entry nameLZTR1_HUMAN
AccessionPrimary (citable) accession number: Q8N653
Secondary accession number(s): Q14776, Q20WK0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: April 16, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM