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Protein

Olfactory receptor 2C3

Gene

OR2C3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2C3
Alternative name(s):
Olfactory receptor 2C4
Olfactory receptor 2C5
Olfactory receptor OR1-30
Gene namesi
Name:OR2C3
Synonyms:OR2C4, OR2C5P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15005. OR2C3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 5024Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 588CytoplasmicSequence Analysis
Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 10121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 15919Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 22024Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 26023Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei274 – 29320Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 32027CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Olfactory receptor 2C3PRO_0000150466Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N628.
PRIDEiQ8N628.

Expressioni

Gene expression databases

BgeeiQ8N628.
CleanExiHS_OR2C3.
GenevestigatoriQ8N628.

Organism-specific databases

HPAiHPA053920.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355443.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG135087.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8N628.
KOiK04257.
OMAiLVSCMDV.
OrthoDBiEOG71K63J.
PhylomeDBiQ8N628.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEIANVSSP EVFVLLGFST RPSLETVLFI VVLSFYMVSI LGNGIIILVS
60 70 80 90 100
HTDVHLHTPM YFFLANLPFL DMSFTTSIVP QLLANLWGPQ KTISYGGCVV
110 120 130 140 150
QFYISHWLGA TECVLLATMS YDRYAAICRP LHYTVIMHPQ LCLGLALASW
160 170 180 190 200
LGGLTTSMVG STLTMLLPLC GNNCIDHFFC EMPLIMQLAC VDTSLNEMEM
210 220 230 240 250
YLASFVFVVL PLGLILVSYG HIARAVLKIR SAEGRRKAFN TCSSHVAVVS
260 270 280 290 300
LFYGSIIFMY LQPAKSTSHE QGKFIALFYT VVTPALNPLI YTLRNTEVKS
310 320
ALRHMVLENC CGSAGKLAQI
Length:320
Mass (Da):35,376
Last modified:December 16, 2008 - v3
Checksum:i52C8143CB927E2FF
GO

Sequence cautioni

The sequence AAH30717.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence DAA04869.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201T → A.1 Publication
Corresponds to variant rs6697472 [ dbSNP | Ensembl ].
VAR_025540
Natural varianti68 – 681P → S.1 Publication
Corresponds to variant rs6657127 [ dbSNP | Ensembl ].
VAR_025541
Natural varianti129 – 1291R → S.
Corresponds to variant rs34220133 [ dbSNP | Ensembl ].
VAR_046378
Natural varianti289 – 2891L → V.
Corresponds to variant rs6702693 [ dbSNP | Ensembl ].
VAR_062016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065649 Genomic DNA. Translation: BAC05875.1.
AL606804 Genomic DNA. Translation: CAI17147.2.
BC030717 mRNA. Translation: AAH30717.1. Different initiation.
BK004471 Genomic DNA. Translation: DAA04869.1. Different initiation.
CCDSiCCDS1634.2.
RefSeqiNP_932340.3. NM_198074.4.
UniGeneiHs.730218.

Genome annotation databases

EnsembliENST00000366487; ENSP00000355443; ENSG00000196242.
ENST00000617752; ENSP00000479757; ENSG00000196242.
GeneIDi81472.
KEGGihsa:81472.
UCSCiuc009xgy.3. human.

Polymorphism databases

DMDMi218512126.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065649 Genomic DNA. Translation: BAC05875.1.
AL606804 Genomic DNA. Translation: CAI17147.2.
BC030717 mRNA. Translation: AAH30717.1. Different initiation.
BK004471 Genomic DNA. Translation: DAA04869.1. Different initiation.
CCDSiCCDS1634.2.
RefSeqiNP_932340.3. NM_198074.4.
UniGeneiHs.730218.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355443.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi218512126.

Proteomic databases

PaxDbiQ8N628.
PRIDEiQ8N628.

Protocols and materials databases

DNASUi81472.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366487; ENSP00000355443; ENSG00000196242.
ENST00000617752; ENSP00000479757; ENSG00000196242.
GeneIDi81472.
KEGGihsa:81472.
UCSCiuc009xgy.3. human.

Organism-specific databases

CTDi81472.
GeneCardsiGC01M247693.
HGNCiHGNC:15005. OR2C3.
HPAiHPA053920.
neXtProtiNX_Q8N628.
PharmGKBiPA32149.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG135087.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8N628.
KOiK04257.
OMAiLVSCMDV.
OrthoDBiEOG71K63J.
PhylomeDBiQ8N628.
TreeFamiTF336512.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2C3.
GenomeRNAii81472.
NextBioi71700.
PROiQ8N628.

Gene expression databases

BgeeiQ8N628.
CleanExiHS_OR2C3.
GenevestigatoriQ8N628.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-20 AND SER-68.
    Tissue: Melanoma.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2003)

Entry informationi

Entry nameiOR2C3_HUMAN
AccessioniPrimary (citable) accession number: Q8N628
Secondary accession number(s): Q5JQS4, Q6IEZ1, Q8NGW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 16, 2008
Last modified: April 1, 2015
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.