Q8N628 (OR2C3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 2C3

Alternative name(s):
Olfactory receptor 2C4
Olfactory receptor 2C5
Olfactory receptor OR1-30

Gene names

Name:	OR2C3
Synonyms:	OR2C4, OR2C5P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	It is uncertain whether Met-1 or Met-2 is the initiator.
Sequence caution	The sequence AAH30717.1 differs from that shown. Reason: Erroneous initiation. The sequence DAA04869.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Olfactory receptor 2C3		PRO_0000150466
Regions
	Topological domain	1 – 26	26	Extracellular Potential
	Transmembrane	27 – 50	24	Helical; Name=1; Potential
	Topological domain	51 – 58	8	Cytoplasmic Potential
	Transmembrane	59 – 80	22	Helical; Name=2; Potential
	Topological domain	81 – 101	21	Extracellular Potential
	Transmembrane	102 – 121	20	Helical; Name=3; Potential
	Topological domain	122 – 140	19	Cytoplasmic Potential
	Transmembrane	141 – 159	19	Helical; Name=4; Potential
	Topological domain	160 – 196	37	Extracellular Potential
	Transmembrane	197 – 220	24	Helical; Name=5; Potential
	Topological domain	221 – 237	17	Cytoplasmic Potential
	Transmembrane	238 – 260	23	Helical; Name=6; Potential
	Topological domain	261 – 273	13	Extracellular Potential
	Transmembrane	274 – 293	20	Helical; Name=7; Potential
	Topological domain	294 – 320	27	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	6	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 190		By similarity
Natural variations
	Natural variant	20	1	T → A. Ref.3 Corresponds to variant rs6697472 [ dbSNP | Ensembl ].		VAR_025540
	Natural variant	68	1	P → S. Ref.3 Corresponds to variant rs6657127 [ dbSNP | Ensembl ].		VAR_025541
	Natural variant	129	1	R → S. Corresponds to variant rs34220133 [ dbSNP | Ensembl ].		VAR_046378
	Natural variant	289	1	L → V. Corresponds to variant rs6702693 [ dbSNP | Ensembl ].		VAR_062016

Sequences

	Sequence		Length	Mass (Da)
	Q8N628 [UniParc]. Last modified December 16, 2008. Version 3. Checksum: 52C8143CB927E2FF	FASTA	320	35,376
	10 20 30 40 50 60 MMEIANVSSP EVFVLLGFST RPSLETVLFI VVLSFYMVSI LGNGIIILVS HTDVHLHTPM 70 80 90 100 110 120 YFFLANLPFL DMSFTTSIVP QLLANLWGPQ KTISYGGCVV QFYISHWLGA TECVLLATMS 130 140 150 160 170 180 YDRYAAICRP LHYTVIMHPQ LCLGLALASW LGGLTTSMVG STLTMLLPLC GNNCIDHFFC 190 200 210 220 230 240 EMPLIMQLAC VDTSLNEMEM YLASFVFVVL PLGLILVSYG HIARAVLKIR SAEGRRKAFN 250 260 270 280 290 300 TCSSHVAVVS LFYGSIIFMY LQPAKSTSHE QGKFIALFYT VVTPALNPLI YTLRNTEVKS 310 320 ALRHMVLENC CGSAGKLAQI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-20 AND SER-68. Tissue: Melanoma.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+	Additional computationally mapped references.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065649 Genomic DNA. Translation: BAC05875.1. AL606804 Genomic DNA. Translation: CAI17147.2. BC030717 mRNA. Translation: AAH30717.1. Different initiation. BK004471 Genomic DNA. Translation: DAA04869.1. Different initiation.
IPI	IPI00935359.
RefSeq	NP_932340.3. NM_198074.4.
UniGene	Hs.730218.
3D structure databases
ProteinModelPortal	Q8N628.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000355443.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	218512126.
Proteomic databases
PaxDb	Q8N628.
PRIDE	Q8N628.
Protocols and materials databases
DNASU	81472.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366487; ENSP00000355443; ENSG00000196242.
GeneID	81472.
KEGG	hsa:81472.
UCSC	uc009xgy.3. human.
Organism-specific databases
CTD	81472.
GeneCards	GC01M247693.
HGNC	HGNC:15005. OR2C3.
HPA	HPA053920.
neXtProt	NX_Q8N628.
PharmGKB	PA32149.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG135087.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	Q8N628.
KO	K04257.
OMA	ANLWGPQ.
OrthoDB	EOG42JNRV.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q8N628.
CleanEx	HS_OR2C3.
Genevestigator	Q8N628.
GermOnline	ENSG00000196242. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	81472.
NextBio	71700.

Entry information

Entry name

OR2C3_HUMAN

Accession

Primary (citable) accession number: Q8N628
Secondary accession number(s): Q5JQS4, Q6IEZ1, Q8NGW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.