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Q8N628 (OR2C3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2C3
Alternative name(s):
Olfactory receptor 2C4
Olfactory receptor 2C5
Olfactory receptor OR1-30
Gene names
Name:OR2C3
Synonyms:OR2C4, OR2C5P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.

Sequence caution

The sequence AAH30717.1 differs from that shown. Reason: Erroneous initiation.

The sequence DAA04869.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Olfactory receptor 2C3
PRO_0000150466

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 5024Helical; Name=1; Potential
Topological domain51 – 588Cytoplasmic Potential
Transmembrane59 – 8022Helical; Name=2; Potential
Topological domain81 – 10121Extracellular Potential
Transmembrane102 – 12120Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 15919Helical; Name=4; Potential
Topological domain160 – 19637Extracellular Potential
Transmembrane197 – 22024Helical; Name=5; Potential
Topological domain221 – 23717Cytoplasmic Potential
Transmembrane238 – 26023Helical; Name=6; Potential
Topological domain261 – 27313Extracellular Potential
Transmembrane274 – 29320Helical; Name=7; Potential
Topological domain294 – 32027Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant201T → A. Ref.3
Corresponds to variant rs6697472 [ dbSNP | Ensembl ].
VAR_025540
Natural variant681P → S. Ref.3
Corresponds to variant rs6657127 [ dbSNP | Ensembl ].
VAR_025541
Natural variant1291R → S.
Corresponds to variant rs34220133 [ dbSNP | Ensembl ].
VAR_046378
Natural variant2891L → V.
Corresponds to variant rs6702693 [ dbSNP | Ensembl ].
VAR_062016

Sequences

Sequence LengthMass (Da)Tools
Q8N628 [UniParc].

Last modified December 16, 2008. Version 3.
Checksum: 52C8143CB927E2FF

FASTA32035,376
        10         20         30         40         50         60 
MMEIANVSSP EVFVLLGFST RPSLETVLFI VVLSFYMVSI LGNGIIILVS HTDVHLHTPM 

        70         80         90        100        110        120 
YFFLANLPFL DMSFTTSIVP QLLANLWGPQ KTISYGGCVV QFYISHWLGA TECVLLATMS 

       130        140        150        160        170        180 
YDRYAAICRP LHYTVIMHPQ LCLGLALASW LGGLTTSMVG STLTMLLPLC GNNCIDHFFC 

       190        200        210        220        230        240 
EMPLIMQLAC VDTSLNEMEM YLASFVFVVL PLGLILVSYG HIARAVLKIR SAEGRRKAFN 

       250        260        270        280        290        300 
TCSSHVAVVS LFYGSIIFMY LQPAKSTSHE QGKFIALFYT VVTPALNPLI YTLRNTEVKS 

       310        320 
ALRHMVLENC CGSAGKLAQI 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-20 AND SER-68.
Tissue: Melanoma.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065649 Genomic DNA. Translation: BAC05875.1.
AL606804 Genomic DNA. Translation: CAI17147.2.
BC030717 mRNA. Translation: AAH30717.1. Different initiation.
BK004471 Genomic DNA. Translation: DAA04869.1. Different initiation.
RefSeqNP_932340.3. NM_198074.4.
UniGeneHs.730218.

3D structure databases

ProteinModelPortalQ8N628.
SMRQ8N628. Positions 110-141, 280-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000355443.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM218512126.

Proteomic databases

PaxDbQ8N628.
PRIDEQ8N628.

Protocols and materials databases

DNASU81472.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000366487; ENSP00000355443; ENSG00000196242.
GeneID81472.
KEGGhsa:81472.
UCSCuc009xgy.3. human.

Organism-specific databases

CTD81472.
GeneCardsGC01M247693.
HGNCHGNC:15005. OR2C3.
HPAHPA053920.
neXtProtNX_Q8N628.
PharmGKBPA32149.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG135087.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8N628.
KOK04257.
OMALVSCMDV.
OrthoDBEOG71K63J.
PhylomeDBQ8N628.
TreeFamTF336512.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8N628.
CleanExHS_OR2C3.
GenevestigatorQ8N628.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2C3.
GenomeRNAi81472.
NextBio71700.
PROQ8N628.

Entry information

Entry nameOR2C3_HUMAN
AccessionPrimary (citable) accession number: Q8N628
Secondary accession number(s): Q5JQS4, Q6IEZ1, Q8NGW7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries