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Q8N628

- OR2C3_HUMAN

UniProt

Q8N628 - OR2C3_HUMAN

Protein

Olfactory receptor 2C3

Gene

OR2C3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2C3
    Alternative name(s):
    Olfactory receptor 2C4
    Olfactory receptor 2C5
    Olfactory receptor OR1-30
    Gene namesi
    Name:OR2C3
    Synonyms:OR2C4, OR2C5P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:15005. OR2C3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32149.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Olfactory receptor 2C3PRO_0000150466Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8N628.
    PRIDEiQ8N628.

    Expressioni

    Gene expression databases

    BgeeiQ8N628.
    CleanExiHS_OR2C3.
    GenevestigatoriQ8N628.

    Organism-specific databases

    HPAiHPA053920.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000355443.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N628.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 588CytoplasmicSequence Analysis
    Topological domaini81 – 10121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 32027CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 5024Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 15919Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 22024Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 26023Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29320Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG135087.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8N628.
    KOiK04257.
    OMAiLVSCMDV.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8N628.
    TreeFamiTF336512.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N628-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMEIANVSSP EVFVLLGFST RPSLETVLFI VVLSFYMVSI LGNGIIILVS    50
    HTDVHLHTPM YFFLANLPFL DMSFTTSIVP QLLANLWGPQ KTISYGGCVV 100
    QFYISHWLGA TECVLLATMS YDRYAAICRP LHYTVIMHPQ LCLGLALASW 150
    LGGLTTSMVG STLTMLLPLC GNNCIDHFFC EMPLIMQLAC VDTSLNEMEM 200
    YLASFVFVVL PLGLILVSYG HIARAVLKIR SAEGRRKAFN TCSSHVAVVS 250
    LFYGSIIFMY LQPAKSTSHE QGKFIALFYT VVTPALNPLI YTLRNTEVKS 300
    ALRHMVLENC CGSAGKLAQI 320
    Length:320
    Mass (Da):35,376
    Last modified:December 16, 2008 - v3
    Checksum:i52C8143CB927E2FF
    GO

    Sequence cautioni

    The sequence AAH30717.1 differs from that shown. Reason: Erroneous initiation.
    The sequence DAA04869.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti20 – 201T → A.1 Publication
    Corresponds to variant rs6697472 [ dbSNP | Ensembl ].
    VAR_025540
    Natural varianti68 – 681P → S.1 Publication
    Corresponds to variant rs6657127 [ dbSNP | Ensembl ].
    VAR_025541
    Natural varianti129 – 1291R → S.
    Corresponds to variant rs34220133 [ dbSNP | Ensembl ].
    VAR_046378
    Natural varianti289 – 2891L → V.
    Corresponds to variant rs6702693 [ dbSNP | Ensembl ].
    VAR_062016

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065649 Genomic DNA. Translation: BAC05875.1.
    AL606804 Genomic DNA. Translation: CAI17147.2.
    BC030717 mRNA. Translation: AAH30717.1. Different initiation.
    BK004471 Genomic DNA. Translation: DAA04869.1. Different initiation.
    CCDSiCCDS1634.2.
    RefSeqiNP_932340.3. NM_198074.4.
    UniGeneiHs.730218.

    Genome annotation databases

    EnsembliENST00000366487; ENSP00000355443; ENSG00000196242.
    GeneIDi81472.
    KEGGihsa:81472.
    UCSCiuc009xgy.3. human.

    Polymorphism databases

    DMDMi218512126.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065649 Genomic DNA. Translation: BAC05875.1 .
    AL606804 Genomic DNA. Translation: CAI17147.2 .
    BC030717 mRNA. Translation: AAH30717.1 . Different initiation.
    BK004471 Genomic DNA. Translation: DAA04869.1 . Different initiation.
    CCDSi CCDS1634.2.
    RefSeqi NP_932340.3. NM_198074.4.
    UniGenei Hs.730218.

    3D structure databases

    ProteinModelPortali Q8N628.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000355443.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 218512126.

    Proteomic databases

    PaxDbi Q8N628.
    PRIDEi Q8N628.

    Protocols and materials databases

    DNASUi 81472.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366487 ; ENSP00000355443 ; ENSG00000196242 .
    GeneIDi 81472.
    KEGGi hsa:81472.
    UCSCi uc009xgy.3. human.

    Organism-specific databases

    CTDi 81472.
    GeneCardsi GC01M247693.
    HGNCi HGNC:15005. OR2C3.
    HPAi HPA053920.
    neXtProti NX_Q8N628.
    PharmGKBi PA32149.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG135087.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8N628.
    KOi K04257.
    OMAi LVSCMDV.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8N628.
    TreeFami TF336512.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2C3.
    GenomeRNAii 81472.
    NextBioi 71700.
    PROi Q8N628.

    Gene expression databases

    Bgeei Q8N628.
    CleanExi HS_OR2C3.
    Genevestigatori Q8N628.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-20 AND SER-68.
      Tissue: Melanoma.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2C3_HUMAN
    AccessioniPrimary (citable) accession number: Q8N628
    Secondary accession number(s): Q5JQS4, Q6IEZ1, Q8NGW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-2 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3