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Protein

Transmembrane protein 156

Gene

TMEM156

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121895-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 156
Gene namesi
Name:TMEM156
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26260. TMEM156.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 211ExtracellularSequence analysisAdd BLAST186
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 296CytoplasmicSequence analysisAdd BLAST64

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121895.
PharmGKBiPA145007464.

Polymorphism and mutation databases

BioMutaiTMEM156.
DMDMi145566966.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845051 – 296Transmembrane protein 156Add BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N614.
PRIDEiQ8N614.

PTM databases

iPTMnetiQ8N614.
PhosphoSitePlusiQ8N614.

Expressioni

Gene expression databases

BgeeiENSG00000121895.
CleanExiHS_TMEM156.
ExpressionAtlasiQ8N614. baseline and differential.
GenevisibleiQ8N614. HS.

Organism-specific databases

HPAiHPA029348.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371364.

Structurei

3D structure databases

ProteinModelPortaliQ8N614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPSV. Eukaryota.
ENOG41116BG. LUCA.
GeneTreeiENSGT00390000017929.
HOGENOMiHOG000154613.
HOVERGENiHBG098801.
InParanoidiQ8N614.
OMAiCIHISLH.
OrthoDBiEOG091G0BTY.
PhylomeDBiQ8N614.
TreeFamiTF336964.

Family and domain databases

InterProiIPR029374. TMEM156.
[Graphical view]
PfamiPF15106. TMEM156. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTALLKLF VAIVITFILI LPEYFKTPKE RTLELSCLEV CLQSNFTYSL
60 70 80 90 100
SSLNFSFVTF LQPVRETQII MRIFLNPSNF RNFTRTCQDI TGEFKMCSSC
110 120 130 140 150
LVCESKGNMD FISQEQTSKV LIRRGSMEVK ANDFHSPCQH FNFSVAPLVD
160 170 180 190 200
HLEEYNTTCH LKNHTGRSTI MEDEPSKEKS INYTCRIMEY PNDCIHISLH
210 220 230 240 250
LEMDIKNITC SMKITWYILV LLVFIFLIIL TIRKILEGQR RVQKWQSHRD
260 270 280 290
KPTSVLLRGS DSEKLRALNV QVLSAETTQR LPLDQVQEVL PPIPEL
Length:296
Mass (Da):34,323
Last modified:April 17, 2007 - v2
Checksum:i54DE078ECC1BCE97
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03175648Y → C.Corresponds to variant rs35576563dbSNPEnsembl.1
Natural variantiVAR_051430105S → P.1 PublicationCorresponds to variant rs11542133dbSNPEnsembl.1
Natural variantiVAR_031757212M → T.Corresponds to variant rs2276887dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026888 mRNA. Translation: BAB15583.1.
BC030803 mRNA. Translation: AAH30803.1.
CCDSiCCDS3448.1.
RefSeqiNP_001290157.1. NM_001303228.1.
NP_079219.1. NM_024943.2.
XP_011512051.1. XM_011513749.2.
UniGeneiHs.374147.

Genome annotation databases

EnsembliENST00000381938; ENSP00000371364; ENSG00000121895.
GeneIDi80008.
KEGGihsa:80008.
UCSCiuc003gto.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026888 mRNA. Translation: BAB15583.1.
BC030803 mRNA. Translation: AAH30803.1.
CCDSiCCDS3448.1.
RefSeqiNP_001290157.1. NM_001303228.1.
NP_079219.1. NM_024943.2.
XP_011512051.1. XM_011513749.2.
UniGeneiHs.374147.

3D structure databases

ProteinModelPortaliQ8N614.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371364.

PTM databases

iPTMnetiQ8N614.
PhosphoSitePlusiQ8N614.

Polymorphism and mutation databases

BioMutaiTMEM156.
DMDMi145566966.

Proteomic databases

PaxDbiQ8N614.
PRIDEiQ8N614.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381938; ENSP00000371364; ENSG00000121895.
GeneIDi80008.
KEGGihsa:80008.
UCSCiuc003gto.4. human.

Organism-specific databases

CTDi80008.
GeneCardsiTMEM156.
HGNCiHGNC:26260. TMEM156.
HPAiHPA029348.
neXtProtiNX_Q8N614.
OpenTargetsiENSG00000121895.
PharmGKBiPA145007464.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPSV. Eukaryota.
ENOG41116BG. LUCA.
GeneTreeiENSGT00390000017929.
HOGENOMiHOG000154613.
HOVERGENiHBG098801.
InParanoidiQ8N614.
OMAiCIHISLH.
OrthoDBiEOG091G0BTY.
PhylomeDBiQ8N614.
TreeFamiTF336964.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121895-MONOMER.

Miscellaneous databases

GenomeRNAii80008.
PROiQ8N614.

Gene expression databases

BgeeiENSG00000121895.
CleanExiHS_TMEM156.
ExpressionAtlasiQ8N614. baseline and differential.
GenevisibleiQ8N614. HS.

Family and domain databases

InterProiIPR029374. TMEM156.
[Graphical view]
PfamiPF15106. TMEM156. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM156_HUMAN
AccessioniPrimary (citable) accession number: Q8N614
Secondary accession number(s): Q9H5N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.