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Protein

FTS and Hook-interacting protein

Gene

FAM160A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).1 Publication

GO - Biological processi

  • early endosome to late endosome transport Source: UniProtKB
  • endosome organization Source: UniProtKB
  • endosome to lysosome transport Source: UniProtKB
  • lysosome organization Source: UniProtKB
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
FTS and Hook-interacting protein
Short name:
FHIP
Alternative name(s):
Protein FAM160A2
Gene namesi
Name:FAM160A2
Synonyms:C11orf56, KIAA1759
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25378. FAM160A2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • FHF complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000051009.
PharmGKBiPA162386769.

Polymorphism and mutation databases

BioMutaiFAM160A2.
DMDMi251757473.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002538591 – 972FTS and Hook-interacting proteinAdd BLAST972

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei467PhosphoserineCombined sources1
Modified residuei510PhosphoserineBy similarity1
Modified residuei523PhosphoserineBy similarity1
Modified residuei529PhosphoserineBy similarity1
Modified residuei533PhosphoserineBy similarity1
Modified residuei859PhosphoserineCombined sources1
Modified residuei897PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N612.
MaxQBiQ8N612.
PaxDbiQ8N612.
PeptideAtlasiQ8N612.
PRIDEiQ8N612.

PTM databases

iPTMnetiQ8N612.
PhosphoSitePlusiQ8N612.

Expressioni

Gene expression databases

BgeeiENSG00000051009.
CleanExiHS_FAM160A2.
ExpressionAtlasiQ8N612. baseline and differential.
GenevisibleiQ8N612. HS.

Organism-specific databases

HPAiHPA055994.
HPA063987.

Interactioni

Subunit structurei

Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-742137,EBI-741181
REEP6Q96HR94EBI-742137,EBI-750345

Protein-protein interaction databases

BioGridi123862. 10 interactors.
IntActiQ8N612. 5 interactors.
MINTiMINT-1459470.
STRINGi9606.ENSP00000265978.

Structurei

3D structure databases

ProteinModelPortaliQ8N612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0518 family.Curated

Phylogenomic databases

eggNOGiKOG3695. Eukaryota.
ENOG410XY4X. LUCA.
GeneTreeiENSGT00760000119270.
HOGENOMiHOG000112444.
HOVERGENiHBG107874.
InParanoidiQ8N612.
OMAiCRSWSAP.
OrthoDBiEOG091G0189.
PhylomeDBiQ8N612.
TreeFamiTF313941.

Family and domain databases

InterProiIPR019384. RetinoicA-induced_16-like.
[Graphical view]
PfamiPF10257. RAI16-like. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N612-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERMNWLSRL ASRGPGHRIP QGANLQTPVM ADPETCLMVF KNHWSQVVRI
60 70 80 90 100
LERQGPRAAP GGADDLSAVR NHTYQMLTLL AEDRAVPSAP TGPGPLLEFA
110 120 130 140 150
LHEDLLTRVL TWQLQWDELG DGVEERRAEQ LKLFEMLVSE ARQPLLRHGP
160 170 180 190 200
VREALLTLLD ACGRPVPSSP ALDEGLVLLL SQLCVCVAQE PSLLEFFLQP
210 220 230 240 250
PPEPGAAPRL LLFSRLVPFV HREGTLGQQA RDALLLLMAL SAGSPTVGRY
260 270 280 290 300
IADHSYFCPV LATGLSALYS SLPRKIEVPG DDWHCLRRED WLGVPALALF
310 320 330 340 350
MSSLEFCNAV IQVAHPLVQK QLVDYIHNGF LVPVMGPALH KTSVEEMIAS
360 370 380 390 400
TAYLELFLRS ISEPALLRTF LRFLLLHRHD THTILDTLVA RIGSNSRLCM
410 420 430 440 450
VSLSLFRTLL NLSCEDVLLQ LVLRYLVPCN HVMLSQKPAV RDVDLYGRAA
460 470 480 490 500
DKFLSLIPRC CRHHAPSPPR PEHASWARGP GSPSVDSSSV TTVPRPSTPS
510 520 530 540 550
RLALFLRQQS LGGSESPGPA PCSPGLSASP ASSPGRRPTP AEEPGELEDN
560 570 580 590 600
YLEYLREARR GVDRCVRACR TWSAPYDGER PSPEPSPFGS RTKKRSLLPE
610 620 630 640 650
EDRNNVGEGE EEELGRRGRA GGAGEGPGHL PPPQLNGVPG SWPEGAKKVR
660 670 680 690 700
LVPKEGAGEL LEGISEGMAG LEGFGQELRE LEVALSNGGT GSESPLEPPL
710 720 730 740 750
PLEEEEAYES FTCPPEPPGP FLSSPLRTLN QLPSQPFTGP FMAVLFAKLE
760 770 780 790 800
NMLQNSVYVN FLLTGLVAQL ACHPQPLLRS FLLNTNMVFQ PSVKSLLQVL
810 820 830 840 850
GSVKNKIENF AASQEDFPAL LSKAKKYLIA RGKLDWAEGP AAGPAPRRSD
860 870 880 890 900
PLVKSRRPSL GELLLRHAHS PTRARQAAQL VLQPGRDGAG LGLSGGSPGA
910 920 930 940 950
STPVLLTRGG APERQGEALR VKNAVYCAVI FPEFLKELAA ISQAHAVTSP
960 970
FLLETSEEGS GPLISGCGPL NP
Length:972
Mass (Da):105,568
Last modified:July 7, 2009 - v3
Checksum:iF1CC45667E1B6811
GO
Isoform 2 (identifier: Q8N612-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     479-479: G → GGPSRETGRREDITG

Note: No experimental confirmation available.
Show »
Length:986
Mass (Da):107,081
Checksum:i18C2DACC61A49115
GO
Isoform 3 (identifier: Q8N612-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     757-780: VYVNFLLTGLVAQLACHPQPLLRS → ALSCSTPTWSSSPVSSPCCRCWAL
     781-972: Missing.

Show »
Length:705
Mass (Da):76,834
Checksum:iA1F02608EBBE8B11
GO

Sequence cautioni

The sequence BAB21850 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95P → S in CAB66657 (PubMed:11230166).Curated1
Sequence conflicti136M → V in CAB66657 (PubMed:11230166).Curated1
Sequence conflicti186C → Y in BAB15443 (PubMed:14702039).Curated1
Sequence conflicti503A → V in CAB66657 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057805462R → W.Corresponds to variant rs35932378dbSNPEnsembl.1
Natural variantiVAR_028739491T → M.2 PublicationsCorresponds to variant rs3750944dbSNPEnsembl.1
Natural variantiVAR_028740619R → L.Corresponds to variant rs3750943dbSNPEnsembl.1
Natural variantiVAR_028741754Q → H.Corresponds to variant rs11040808dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0211281 – 75Missing in isoform 3. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_021129479G → GGPSRETGRREDITG in isoform 2. 1 Publication1
Alternative sequenceiVSP_021130757 – 780VYVNF…PLLRS → ALSCSTPTWSSSPVSSPCCR CWAL in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_021131781 – 972Missing in isoform 3. 1 PublicationAdd BLAST192

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051546 mRNA. Translation: BAB21850.1. Different initiation.
AK026318 mRNA. Translation: BAB15443.1.
AL136723 mRNA. Translation: CAB66657.1.
BC030825 mRNA. Translation: AAH30825.1.
CCDSiCCDS44530.1. [Q8N612-1]
CCDS7760.1. [Q8N612-2]
RefSeqiNP_001092264.1. NM_001098794.1. [Q8N612-1]
NP_115503.2. NM_032127.3. [Q8N612-2]
XP_006718406.1. XM_006718343.2. [Q8N612-2]
XP_011518699.1. XM_011520397.2. [Q8N612-2]
UniGeneiHs.501793.

Genome annotation databases

EnsembliENST00000265978; ENSP00000265978; ENSG00000051009. [Q8N612-2]
ENST00000449352; ENSP00000416918; ENSG00000051009. [Q8N612-1]
GeneIDi84067.
KEGGihsa:84067.
UCSCiuc001mck.5. human. [Q8N612-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051546 mRNA. Translation: BAB21850.1. Different initiation.
AK026318 mRNA. Translation: BAB15443.1.
AL136723 mRNA. Translation: CAB66657.1.
BC030825 mRNA. Translation: AAH30825.1.
CCDSiCCDS44530.1. [Q8N612-1]
CCDS7760.1. [Q8N612-2]
RefSeqiNP_001092264.1. NM_001098794.1. [Q8N612-1]
NP_115503.2. NM_032127.3. [Q8N612-2]
XP_006718406.1. XM_006718343.2. [Q8N612-2]
XP_011518699.1. XM_011520397.2. [Q8N612-2]
UniGeneiHs.501793.

3D structure databases

ProteinModelPortaliQ8N612.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123862. 10 interactors.
IntActiQ8N612. 5 interactors.
MINTiMINT-1459470.
STRINGi9606.ENSP00000265978.

PTM databases

iPTMnetiQ8N612.
PhosphoSitePlusiQ8N612.

Polymorphism and mutation databases

BioMutaiFAM160A2.
DMDMi251757473.

Proteomic databases

EPDiQ8N612.
MaxQBiQ8N612.
PaxDbiQ8N612.
PeptideAtlasiQ8N612.
PRIDEiQ8N612.

Protocols and materials databases

DNASUi84067.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265978; ENSP00000265978; ENSG00000051009. [Q8N612-2]
ENST00000449352; ENSP00000416918; ENSG00000051009. [Q8N612-1]
GeneIDi84067.
KEGGihsa:84067.
UCSCiuc001mck.5. human. [Q8N612-1]

Organism-specific databases

CTDi84067.
GeneCardsiFAM160A2.
HGNCiHGNC:25378. FAM160A2.
HPAiHPA055994.
HPA063987.
neXtProtiNX_Q8N612.
OpenTargetsiENSG00000051009.
PharmGKBiPA162386769.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3695. Eukaryota.
ENOG410XY4X. LUCA.
GeneTreeiENSGT00760000119270.
HOGENOMiHOG000112444.
HOVERGENiHBG107874.
InParanoidiQ8N612.
OMAiCRSWSAP.
OrthoDBiEOG091G0189.
PhylomeDBiQ8N612.
TreeFamiTF313941.

Miscellaneous databases

ChiTaRSiFAM160A2. human.
GeneWikiiC11orf56.
GenomeRNAii84067.
PROiQ8N612.

Gene expression databases

BgeeiENSG00000051009.
CleanExiHS_FAM160A2.
ExpressionAtlasiQ8N612. baseline and differential.
GenevisibleiQ8N612. HS.

Family and domain databases

InterProiIPR019384. RetinoicA-induced_16-like.
[Graphical view]
PfamiPF10257. RAI16-like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF16A2_HUMAN
AccessioniPrimary (citable) accession number: Q8N612
Secondary accession number(s): Q9C0A4, Q9H0N3, Q9H624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 7, 2009
Last modified: November 2, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.