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Q8N612

- F16A2_HUMAN

UniProt

Q8N612 - F16A2_HUMAN

Protein

FTS and Hook-interacting protein

Gene

FAM160A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 3 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. early endosome to late endosome transport Source: UniProtKB
    2. endosome organization Source: UniProtKB
    3. endosome to lysosome transport Source: UniProtKB
    4. lysosome organization Source: UniProtKB
    5. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FTS and Hook-interacting protein
    Short name:
    FHIP
    Alternative name(s):
    Protein FAM160A2
    Gene namesi
    Name:FAM160A2
    Synonyms:C11orf56, KIAA1759
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:25378. FAM160A2.

    Subcellular locationi

    GO - Cellular componenti

    1. FHF complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162386769.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 972972FTS and Hook-interacting proteinPRO_0000253859Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei510 – 5101PhosphoserineBy similarity
    Modified residuei523 – 5231PhosphoserineBy similarity
    Modified residuei897 – 8971Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8N612.
    PaxDbiQ8N612.
    PRIDEiQ8N612.

    PTM databases

    PhosphoSiteiQ8N612.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N612.
    BgeeiQ8N612.
    CleanExiHS_FAM160A2.
    GenevestigatoriQ8N612.

    Organism-specific databases

    HPAiHPA055994.

    Interactioni

    Subunit structurei

    Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex).1 Publication

    Protein-protein interaction databases

    BioGridi123862. 8 interactions.
    IntActiQ8N612. 4 interactions.
    MINTiMINT-1459470.
    STRINGi9606.ENSP00000265978.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N612.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0518 family.Curated

    Phylogenomic databases

    eggNOGiNOG318159.
    HOGENOMiHOG000112444.
    HOVERGENiHBG107874.
    InParanoidiQ8N612.
    OMAiVRRVPQE.
    OrthoDBiEOG757CWX.
    PhylomeDBiQ8N612.
    TreeFamiTF313941.

    Family and domain databases

    InterProiIPR019384. RetinoicA-induced_16-like.
    [Graphical view]
    PfamiPF10257. RAI16-like. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N612-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERMNWLSRL ASRGPGHRIP QGANLQTPVM ADPETCLMVF KNHWSQVVRI    50
    LERQGPRAAP GGADDLSAVR NHTYQMLTLL AEDRAVPSAP TGPGPLLEFA 100
    LHEDLLTRVL TWQLQWDELG DGVEERRAEQ LKLFEMLVSE ARQPLLRHGP 150
    VREALLTLLD ACGRPVPSSP ALDEGLVLLL SQLCVCVAQE PSLLEFFLQP 200
    PPEPGAAPRL LLFSRLVPFV HREGTLGQQA RDALLLLMAL SAGSPTVGRY 250
    IADHSYFCPV LATGLSALYS SLPRKIEVPG DDWHCLRRED WLGVPALALF 300
    MSSLEFCNAV IQVAHPLVQK QLVDYIHNGF LVPVMGPALH KTSVEEMIAS 350
    TAYLELFLRS ISEPALLRTF LRFLLLHRHD THTILDTLVA RIGSNSRLCM 400
    VSLSLFRTLL NLSCEDVLLQ LVLRYLVPCN HVMLSQKPAV RDVDLYGRAA 450
    DKFLSLIPRC CRHHAPSPPR PEHASWARGP GSPSVDSSSV TTVPRPSTPS 500
    RLALFLRQQS LGGSESPGPA PCSPGLSASP ASSPGRRPTP AEEPGELEDN 550
    YLEYLREARR GVDRCVRACR TWSAPYDGER PSPEPSPFGS RTKKRSLLPE 600
    EDRNNVGEGE EEELGRRGRA GGAGEGPGHL PPPQLNGVPG SWPEGAKKVR 650
    LVPKEGAGEL LEGISEGMAG LEGFGQELRE LEVALSNGGT GSESPLEPPL 700
    PLEEEEAYES FTCPPEPPGP FLSSPLRTLN QLPSQPFTGP FMAVLFAKLE 750
    NMLQNSVYVN FLLTGLVAQL ACHPQPLLRS FLLNTNMVFQ PSVKSLLQVL 800
    GSVKNKIENF AASQEDFPAL LSKAKKYLIA RGKLDWAEGP AAGPAPRRSD 850
    PLVKSRRPSL GELLLRHAHS PTRARQAAQL VLQPGRDGAG LGLSGGSPGA 900
    STPVLLTRGG APERQGEALR VKNAVYCAVI FPEFLKELAA ISQAHAVTSP 950
    FLLETSEEGS GPLISGCGPL NP 972
    Length:972
    Mass (Da):105,568
    Last modified:July 7, 2009 - v3
    Checksum:iF1CC45667E1B6811
    GO
    Isoform 2 (identifier: Q8N612-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         479-479: G → GGPSRETGRREDITG

    Note: No experimental confirmation available.

    Show »
    Length:986
    Mass (Da):107,081
    Checksum:i18C2DACC61A49115
    GO
    Isoform 3 (identifier: Q8N612-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-75: Missing.
         757-780: VYVNFLLTGLVAQLACHPQPLLRS → ALSCSTPTWSSSPVSSPCCRCWAL
         781-972: Missing.

    Show »
    Length:705
    Mass (Da):76,834
    Checksum:iA1F02608EBBE8B11
    GO

    Sequence cautioni

    The sequence BAB21850.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 951P → S in CAB66657. (PubMed:11230166)Curated
    Sequence conflicti136 – 1361M → V in CAB66657. (PubMed:11230166)Curated
    Sequence conflicti186 – 1861C → Y in BAB15443. (PubMed:14702039)Curated
    Sequence conflicti503 – 5031A → V in CAB66657. (PubMed:11230166)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti462 – 4621R → W.
    Corresponds to variant rs35932378 [ dbSNP | Ensembl ].
    VAR_057805
    Natural varianti491 – 4911T → M.2 Publications
    Corresponds to variant rs3750944 [ dbSNP | Ensembl ].
    VAR_028739
    Natural varianti619 – 6191R → L.
    Corresponds to variant rs3750943 [ dbSNP | Ensembl ].
    VAR_028740
    Natural varianti754 – 7541Q → H.
    Corresponds to variant rs11040808 [ dbSNP | Ensembl ].
    VAR_028741

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7575Missing in isoform 3. 1 PublicationVSP_021128Add
    BLAST
    Alternative sequencei479 – 4791G → GGPSRETGRREDITG in isoform 2. 1 PublicationVSP_021129
    Alternative sequencei757 – 78024VYVNF…PLLRS → ALSCSTPTWSSSPVSSPCCR CWAL in isoform 3. 1 PublicationVSP_021130Add
    BLAST
    Alternative sequencei781 – 972192Missing in isoform 3. 1 PublicationVSP_021131Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051546 mRNA. Translation: BAB21850.1. Different initiation.
    AK026318 mRNA. Translation: BAB15443.1.
    AL136723 mRNA. Translation: CAB66657.1.
    BC030825 mRNA. Translation: AAH30825.1.
    CCDSiCCDS44530.1. [Q8N612-1]
    CCDS7760.1. [Q8N612-2]
    RefSeqiNP_001092264.1. NM_001098794.1. [Q8N612-1]
    NP_115503.2. NM_032127.3. [Q8N612-2]
    XP_006718405.1. XM_006718342.1. [Q8N612-2]
    XP_006718406.1. XM_006718343.1. [Q8N612-2]
    UniGeneiHs.501793.

    Genome annotation databases

    EnsembliENST00000265978; ENSP00000265978; ENSG00000051009. [Q8N612-2]
    ENST00000449352; ENSP00000416918; ENSG00000051009. [Q8N612-1]
    GeneIDi84067.
    KEGGihsa:84067.
    UCSCiuc001mck.4. human. [Q8N612-2]
    uc001mcl.4. human. [Q8N612-1]

    Polymorphism databases

    DMDMi251757473.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051546 mRNA. Translation: BAB21850.1 . Different initiation.
    AK026318 mRNA. Translation: BAB15443.1 .
    AL136723 mRNA. Translation: CAB66657.1 .
    BC030825 mRNA. Translation: AAH30825.1 .
    CCDSi CCDS44530.1. [Q8N612-1 ]
    CCDS7760.1. [Q8N612-2 ]
    RefSeqi NP_001092264.1. NM_001098794.1. [Q8N612-1 ]
    NP_115503.2. NM_032127.3. [Q8N612-2 ]
    XP_006718405.1. XM_006718342.1. [Q8N612-2 ]
    XP_006718406.1. XM_006718343.1. [Q8N612-2 ]
    UniGenei Hs.501793.

    3D structure databases

    ProteinModelPortali Q8N612.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123862. 8 interactions.
    IntActi Q8N612. 4 interactions.
    MINTi MINT-1459470.
    STRINGi 9606.ENSP00000265978.

    PTM databases

    PhosphoSitei Q8N612.

    Polymorphism databases

    DMDMi 251757473.

    Proteomic databases

    MaxQBi Q8N612.
    PaxDbi Q8N612.
    PRIDEi Q8N612.

    Protocols and materials databases

    DNASUi 84067.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265978 ; ENSP00000265978 ; ENSG00000051009 . [Q8N612-2 ]
    ENST00000449352 ; ENSP00000416918 ; ENSG00000051009 . [Q8N612-1 ]
    GeneIDi 84067.
    KEGGi hsa:84067.
    UCSCi uc001mck.4. human. [Q8N612-2 ]
    uc001mcl.4. human. [Q8N612-1 ]

    Organism-specific databases

    CTDi 84067.
    GeneCardsi GC11M006232.
    HGNCi HGNC:25378. FAM160A2.
    HPAi HPA055994.
    neXtProti NX_Q8N612.
    PharmGKBi PA162386769.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG318159.
    HOGENOMi HOG000112444.
    HOVERGENi HBG107874.
    InParanoidi Q8N612.
    OMAi VRRVPQE.
    OrthoDBi EOG757CWX.
    PhylomeDBi Q8N612.
    TreeFami TF313941.

    Miscellaneous databases

    ChiTaRSi FAM160A2. human.
    GeneWikii C11orf56.
    GenomeRNAii 84067.
    NextBioi 73247.
    PROi Q8N612.

    Gene expression databases

    ArrayExpressi Q8N612.
    Bgeei Q8N612.
    CleanExi HS_FAM160A2.
    Genevestigatori Q8N612.

    Family and domain databases

    InterProi IPR019384. RetinoicA-induced_16-like.
    [Graphical view ]
    Pfami PF10257. RAI16-like. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-491.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT MET-491.
      Tissue: Small intestine.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex."
      Xu L., Sowa M.E., Chen J., Li X., Gygi S.P., Harper J.W.
      Mol. Biol. Cell 19:5059-5071(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE FHF COMPLEX, FUNCTION, ASSOCIATION WITH THE HOPS COMPLEX.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-897, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiF16A2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N612
    Secondary accession number(s): Q9C0A4, Q9H0N3, Q9H624
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 82 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families
    5. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3