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Q8N612

- F16A2_HUMAN

UniProt

Q8N612 - F16A2_HUMAN

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Protein

FTS and Hook-interacting protein

Gene

FAM160A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).1 Publication

GO - Biological processi

  1. early endosome to late endosome transport Source: UniProtKB
  2. endosome organization Source: UniProtKB
  3. endosome to lysosome transport Source: UniProtKB
  4. lysosome organization Source: UniProtKB
  5. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
FTS and Hook-interacting protein
Short name:
FHIP
Alternative name(s):
Protein FAM160A2
Gene namesi
Name:FAM160A2
Synonyms:C11orf56, KIAA1759
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:25378. FAM160A2.

Subcellular locationi

GO - Cellular componenti

  1. FHF complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 972972FTS and Hook-interacting proteinPRO_0000253859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei510 – 5101PhosphoserineBy similarity
Modified residuei523 – 5231PhosphoserineBy similarity
Modified residuei897 – 8971Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N612.
PaxDbiQ8N612.
PRIDEiQ8N612.

PTM databases

PhosphoSiteiQ8N612.

Expressioni

Gene expression databases

BgeeiQ8N612.
CleanExiHS_FAM160A2.
ExpressionAtlasiQ8N612. baseline and differential.
GenevestigatoriQ8N612.

Organism-specific databases

HPAiHPA055994.

Interactioni

Subunit structurei

Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex).1 Publication

Protein-protein interaction databases

BioGridi123862. 9 interactions.
IntActiQ8N612. 4 interactions.
MINTiMINT-1459470.
STRINGi9606.ENSP00000265978.

Structurei

3D structure databases

ProteinModelPortaliQ8N612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0518 family.Curated

Phylogenomic databases

eggNOGiNOG318159.
GeneTreeiENSGT00760000119270.
HOGENOMiHOG000112444.
HOVERGENiHBG107874.
InParanoidiQ8N612.
OMAiVRRVPQE.
OrthoDBiEOG757CWX.
PhylomeDBiQ8N612.
TreeFamiTF313941.

Family and domain databases

InterProiIPR019384. RetinoicA-induced_16-like.
[Graphical view]
PfamiPF10257. RAI16-like. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N612-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERMNWLSRL ASRGPGHRIP QGANLQTPVM ADPETCLMVF KNHWSQVVRI
60 70 80 90 100
LERQGPRAAP GGADDLSAVR NHTYQMLTLL AEDRAVPSAP TGPGPLLEFA
110 120 130 140 150
LHEDLLTRVL TWQLQWDELG DGVEERRAEQ LKLFEMLVSE ARQPLLRHGP
160 170 180 190 200
VREALLTLLD ACGRPVPSSP ALDEGLVLLL SQLCVCVAQE PSLLEFFLQP
210 220 230 240 250
PPEPGAAPRL LLFSRLVPFV HREGTLGQQA RDALLLLMAL SAGSPTVGRY
260 270 280 290 300
IADHSYFCPV LATGLSALYS SLPRKIEVPG DDWHCLRRED WLGVPALALF
310 320 330 340 350
MSSLEFCNAV IQVAHPLVQK QLVDYIHNGF LVPVMGPALH KTSVEEMIAS
360 370 380 390 400
TAYLELFLRS ISEPALLRTF LRFLLLHRHD THTILDTLVA RIGSNSRLCM
410 420 430 440 450
VSLSLFRTLL NLSCEDVLLQ LVLRYLVPCN HVMLSQKPAV RDVDLYGRAA
460 470 480 490 500
DKFLSLIPRC CRHHAPSPPR PEHASWARGP GSPSVDSSSV TTVPRPSTPS
510 520 530 540 550
RLALFLRQQS LGGSESPGPA PCSPGLSASP ASSPGRRPTP AEEPGELEDN
560 570 580 590 600
YLEYLREARR GVDRCVRACR TWSAPYDGER PSPEPSPFGS RTKKRSLLPE
610 620 630 640 650
EDRNNVGEGE EEELGRRGRA GGAGEGPGHL PPPQLNGVPG SWPEGAKKVR
660 670 680 690 700
LVPKEGAGEL LEGISEGMAG LEGFGQELRE LEVALSNGGT GSESPLEPPL
710 720 730 740 750
PLEEEEAYES FTCPPEPPGP FLSSPLRTLN QLPSQPFTGP FMAVLFAKLE
760 770 780 790 800
NMLQNSVYVN FLLTGLVAQL ACHPQPLLRS FLLNTNMVFQ PSVKSLLQVL
810 820 830 840 850
GSVKNKIENF AASQEDFPAL LSKAKKYLIA RGKLDWAEGP AAGPAPRRSD
860 870 880 890 900
PLVKSRRPSL GELLLRHAHS PTRARQAAQL VLQPGRDGAG LGLSGGSPGA
910 920 930 940 950
STPVLLTRGG APERQGEALR VKNAVYCAVI FPEFLKELAA ISQAHAVTSP
960 970
FLLETSEEGS GPLISGCGPL NP
Length:972
Mass (Da):105,568
Last modified:July 7, 2009 - v3
Checksum:iF1CC45667E1B6811
GO
Isoform 2 (identifier: Q8N612-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     479-479: G → GGPSRETGRREDITG

Note: No experimental confirmation available.

Show »
Length:986
Mass (Da):107,081
Checksum:i18C2DACC61A49115
GO
Isoform 3 (identifier: Q8N612-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     757-780: VYVNFLLTGLVAQLACHPQPLLRS → ALSCSTPTWSSSPVSSPCCRCWAL
     781-972: Missing.

Show »
Length:705
Mass (Da):76,834
Checksum:iA1F02608EBBE8B11
GO

Sequence cautioni

The sequence BAB21850.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951P → S in CAB66657. (PubMed:11230166)Curated
Sequence conflicti136 – 1361M → V in CAB66657. (PubMed:11230166)Curated
Sequence conflicti186 – 1861C → Y in BAB15443. (PubMed:14702039)Curated
Sequence conflicti503 – 5031A → V in CAB66657. (PubMed:11230166)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti462 – 4621R → W.
Corresponds to variant rs35932378 [ dbSNP | Ensembl ].
VAR_057805
Natural varianti491 – 4911T → M.2 Publications
Corresponds to variant rs3750944 [ dbSNP | Ensembl ].
VAR_028739
Natural varianti619 – 6191R → L.
Corresponds to variant rs3750943 [ dbSNP | Ensembl ].
VAR_028740
Natural varianti754 – 7541Q → H.
Corresponds to variant rs11040808 [ dbSNP | Ensembl ].
VAR_028741

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7575Missing in isoform 3. 1 PublicationVSP_021128Add
BLAST
Alternative sequencei479 – 4791G → GGPSRETGRREDITG in isoform 2. 1 PublicationVSP_021129
Alternative sequencei757 – 78024VYVNF…PLLRS → ALSCSTPTWSSSPVSSPCCR CWAL in isoform 3. 1 PublicationVSP_021130Add
BLAST
Alternative sequencei781 – 972192Missing in isoform 3. 1 PublicationVSP_021131Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051546 mRNA. Translation: BAB21850.1. Different initiation.
AK026318 mRNA. Translation: BAB15443.1.
AL136723 mRNA. Translation: CAB66657.1.
BC030825 mRNA. Translation: AAH30825.1.
CCDSiCCDS44530.1. [Q8N612-1]
CCDS7760.1. [Q8N612-2]
RefSeqiNP_001092264.1. NM_001098794.1. [Q8N612-1]
NP_115503.2. NM_032127.3. [Q8N612-2]
XP_006718405.1. XM_006718342.1. [Q8N612-2]
XP_006718406.1. XM_006718343.1. [Q8N612-2]
UniGeneiHs.501793.

Genome annotation databases

EnsembliENST00000265978; ENSP00000265978; ENSG00000051009. [Q8N612-2]
ENST00000449352; ENSP00000416918; ENSG00000051009. [Q8N612-1]
GeneIDi84067.
KEGGihsa:84067.
UCSCiuc001mck.4. human. [Q8N612-2]
uc001mcl.4. human. [Q8N612-1]

Polymorphism databases

DMDMi251757473.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051546 mRNA. Translation: BAB21850.1 . Different initiation.
AK026318 mRNA. Translation: BAB15443.1 .
AL136723 mRNA. Translation: CAB66657.1 .
BC030825 mRNA. Translation: AAH30825.1 .
CCDSi CCDS44530.1. [Q8N612-1 ]
CCDS7760.1. [Q8N612-2 ]
RefSeqi NP_001092264.1. NM_001098794.1. [Q8N612-1 ]
NP_115503.2. NM_032127.3. [Q8N612-2 ]
XP_006718405.1. XM_006718342.1. [Q8N612-2 ]
XP_006718406.1. XM_006718343.1. [Q8N612-2 ]
UniGenei Hs.501793.

3D structure databases

ProteinModelPortali Q8N612.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123862. 9 interactions.
IntActi Q8N612. 4 interactions.
MINTi MINT-1459470.
STRINGi 9606.ENSP00000265978.

PTM databases

PhosphoSitei Q8N612.

Polymorphism databases

DMDMi 251757473.

Proteomic databases

MaxQBi Q8N612.
PaxDbi Q8N612.
PRIDEi Q8N612.

Protocols and materials databases

DNASUi 84067.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265978 ; ENSP00000265978 ; ENSG00000051009 . [Q8N612-2 ]
ENST00000449352 ; ENSP00000416918 ; ENSG00000051009 . [Q8N612-1 ]
GeneIDi 84067.
KEGGi hsa:84067.
UCSCi uc001mck.4. human. [Q8N612-2 ]
uc001mcl.4. human. [Q8N612-1 ]

Organism-specific databases

CTDi 84067.
GeneCardsi GC11M006232.
HGNCi HGNC:25378. FAM160A2.
HPAi HPA055994.
neXtProti NX_Q8N612.
PharmGKBi PA162386769.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG318159.
GeneTreei ENSGT00760000119270.
HOGENOMi HOG000112444.
HOVERGENi HBG107874.
InParanoidi Q8N612.
OMAi VRRVPQE.
OrthoDBi EOG757CWX.
PhylomeDBi Q8N612.
TreeFami TF313941.

Miscellaneous databases

ChiTaRSi FAM160A2. human.
GeneWikii C11orf56.
GenomeRNAii 84067.
NextBioi 73247.
PROi Q8N612.

Gene expression databases

Bgeei Q8N612.
CleanExi HS_FAM160A2.
ExpressionAtlasi Q8N612. baseline and differential.
Genevestigatori Q8N612.

Family and domain databases

InterProi IPR019384. RetinoicA-induced_16-like.
[Graphical view ]
Pfami PF10257. RAI16-like. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-491.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT MET-491.
    Tissue: Small intestine.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex."
    Xu L., Sowa M.E., Chen J., Li X., Gygi S.P., Harper J.W.
    Mol. Biol. Cell 19:5059-5071(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE FHF COMPLEX, FUNCTION, ASSOCIATION WITH THE HOPS COMPLEX.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-897, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiF16A2_HUMAN
AccessioniPrimary (citable) accession number: Q8N612
Secondary accession number(s): Q9C0A4, Q9H0N3, Q9H624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3