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Protein

Translocating chain-associated membrane protein 1-like 1

Gene

TRAM1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulatory or required for the translocation of secretory proteins across the ER membrane.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Translocating chain-associated membrane protein 1-like 1
Gene namesi
Name:TRAM1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:28371. TRAM1L1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 81LumenalSequence analysisAdd BLAST31
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 121CytoplasmicSequence analysisAdd BLAST19
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 164LumenalSequence analysisAdd BLAST22
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 196CytoplasmicSequence analysisAdd BLAST11
Transmembranei197 – 215HelicalSequence analysisAdd BLAST19
Topological domaini216 – 219LumenalSequence analysis4
Transmembranei220 – 242HelicalSequence analysisAdd BLAST23
Topological domaini243 – 249CytoplasmicSequence analysis7
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Topological domaini271 – 297LumenalSequence analysisAdd BLAST27
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 369CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi133022.
OpenTargetsiENSG00000174599.
PharmGKBiPA134911361.

Polymorphism and mutation databases

BioMutaiTRAM1L1.
DMDMi166231532.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003137061 – 369Translocating chain-associated membrane protein 1-like 1Add BLAST369

Proteomic databases

PaxDbiQ8N609.
PeptideAtlasiQ8N609.
PRIDEiQ8N609.

PTM databases

iPTMnetiQ8N609.
PhosphoSitePlusiQ8N609.

Expressioni

Gene expression databases

BgeeiENSG00000174599.
CleanExiHS_TRAM1L1.
GenevisibleiQ8N609. HS.

Organism-specific databases

HPAiHPA044560.

Interactioni

Protein-protein interaction databases

BioGridi126347. 1 interactor.
IntActiQ8N609. 2 interactors.
MINTiMINT-4722973.
STRINGi9606.ENSP00000309402.

Structurei

3D structure databases

ProteinModelPortaliQ8N609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 326TLCPROSITE-ProRule annotationAdd BLAST210

Sequence similaritiesi

Belongs to the TRAM family.Curated
Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1608. Eukaryota.
ENOG410XSB3. LUCA.
GeneTreeiENSGT00510000046470.
HOGENOMiHOG000007494.
HOVERGENiHBG054402.
InParanoidiQ8N609.
OMAiIIHATIQ.
OrthoDBiEOG091G077N.
PhylomeDBiQ8N609.
TreeFamiTF314319.

Family and domain databases

InterProiIPR006634. TLC-dom.
IPR013599. TRAM1.
IPR016447. Translocation_assoc_membrane.
[Graphical view]
PfamiPF08390. TRAM1. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005449. Translocation_assoc_membrane. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRKKSTKN PPVLSQEFIL QNHADIVSCV GMFFLLGLVF EGTAEASIVF
60 70 80 90 100
LTLQHSVAVP AAEEQATGSK SLYYYGVKDL ATVFFYMLVA IIIHATIQEY
110 120 130 140 150
VLDKINKRMQ FTKAKQNKFN ESGQFSVFYF FSCIWGTFIL ISENCLSDPT
160 170 180 190 200
LIWKARPHSM MTFQMKFFYI SQLAYWFHAF PELYFQKTKK QDIPRQLVYI
210 220 230 240 250
GLHLFHITGA YLLYLNHLGL LLLVLHYFVE LLSHMCGLFY FSDEKYQKGI
260 270 280 290 300
SLWAIVFILG RLVTLIVSVL TVGFHLAGSQ NRNPDALTGN VNVLAAKIAV
310 320 330 340 350
LSSSCTIQAY VTWNLITLWL QRWVEDSNIQ ASCMKKKRSR SSKKRTENGV
360
GVETSNRVDC PPKRKEKSS
Length:369
Mass (Da):42,162
Last modified:January 15, 2008 - v2
Checksum:i95E2A5D82BEECF72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59V → A in AAH30831 (PubMed:15489334).Curated1
Sequence conflicti170I → V in BAC11091 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074617 mRNA. Translation: BAC11091.1.
BC030831 mRNA. Translation: AAH30831.1.
CCDSiCCDS3707.1.
RefSeqiNP_689615.2. NM_152402.2.
UniGeneiHs.570737.

Genome annotation databases

EnsembliENST00000310754; ENSP00000309402; ENSG00000174599.
GeneIDi133022.
KEGGihsa:133022.
UCSCiuc003ibv.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074617 mRNA. Translation: BAC11091.1.
BC030831 mRNA. Translation: AAH30831.1.
CCDSiCCDS3707.1.
RefSeqiNP_689615.2. NM_152402.2.
UniGeneiHs.570737.

3D structure databases

ProteinModelPortaliQ8N609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126347. 1 interactor.
IntActiQ8N609. 2 interactors.
MINTiMINT-4722973.
STRINGi9606.ENSP00000309402.

PTM databases

iPTMnetiQ8N609.
PhosphoSitePlusiQ8N609.

Polymorphism and mutation databases

BioMutaiTRAM1L1.
DMDMi166231532.

Proteomic databases

PaxDbiQ8N609.
PeptideAtlasiQ8N609.
PRIDEiQ8N609.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310754; ENSP00000309402; ENSG00000174599.
GeneIDi133022.
KEGGihsa:133022.
UCSCiuc003ibv.5. human.

Organism-specific databases

CTDi133022.
DisGeNETi133022.
GeneCardsiTRAM1L1.
H-InvDBHIX0004455.
HGNCiHGNC:28371. TRAM1L1.
HPAiHPA044560.
neXtProtiNX_Q8N609.
OpenTargetsiENSG00000174599.
PharmGKBiPA134911361.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1608. Eukaryota.
ENOG410XSB3. LUCA.
GeneTreeiENSGT00510000046470.
HOGENOMiHOG000007494.
HOVERGENiHBG054402.
InParanoidiQ8N609.
OMAiIIHATIQ.
OrthoDBiEOG091G077N.
PhylomeDBiQ8N609.
TreeFamiTF314319.

Miscellaneous databases

GenomeRNAii133022.
PROiQ8N609.

Gene expression databases

BgeeiENSG00000174599.
CleanExiHS_TRAM1L1.
GenevisibleiQ8N609. HS.

Family and domain databases

InterProiIPR006634. TLC-dom.
IPR013599. TRAM1.
IPR016447. Translocation_assoc_membrane.
[Graphical view]
PfamiPF08390. TRAM1. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005449. Translocation_assoc_membrane. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTR1L1_HUMAN
AccessioniPrimary (citable) accession number: Q8N609
Secondary accession number(s): Q8N2L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.