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Protein

Translocating chain-associated membrane protein 1-like 1

Gene

TRAM1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stimulatory or required for the translocation of secretory proteins across the ER membrane.By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Translocating chain-associated membrane protein 1-like 1
Gene namesi
Name:TRAM1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000174599.5
HGNCiHGNC:28371 TRAM1L1
MIMi617505 gene
neXtProtiNX_Q8N609

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 81LumenalSequence analysisAdd BLAST31
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 121CytoplasmicSequence analysisAdd BLAST19
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 164LumenalSequence analysisAdd BLAST22
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 196CytoplasmicSequence analysisAdd BLAST11
Transmembranei197 – 215HelicalSequence analysisAdd BLAST19
Topological domaini216 – 219LumenalSequence analysis4
Transmembranei220 – 242HelicalSequence analysisAdd BLAST23
Topological domaini243 – 249CytoplasmicSequence analysis7
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Topological domaini271 – 297LumenalSequence analysisAdd BLAST27
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 369CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi133022
OpenTargetsiENSG00000174599
PharmGKBiPA134911361

Polymorphism and mutation databases

BioMutaiTRAM1L1
DMDMi166231532

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003137061 – 369Translocating chain-associated membrane protein 1-like 1Add BLAST369

Proteomic databases

PaxDbiQ8N609
PeptideAtlasiQ8N609
PRIDEiQ8N609

PTM databases

iPTMnetiQ8N609
PhosphoSitePlusiQ8N609

Expressioni

Gene expression databases

BgeeiENSG00000174599
CleanExiHS_TRAM1L1
GenevisibleiQ8N609 HS

Organism-specific databases

HPAiHPA044560

Interactioni

Protein-protein interaction databases

BioGridi126347, 2 interactors
IntActiQ8N609, 8 interactors
STRINGi9606.ENSP00000309402

Structurei

3D structure databases

ProteinModelPortaliQ8N609
SMRiQ8N609
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 326TLCPROSITE-ProRule annotationAdd BLAST210

Sequence similaritiesi

Belongs to the TRAM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1608 Eukaryota
ENOG410XSB3 LUCA
GeneTreeiENSGT00510000046470
HOGENOMiHOG000007494
HOVERGENiHBG054402
InParanoidiQ8N609
OMAiAIIIHAT
OrthoDBiEOG091G077N
PhylomeDBiQ8N609
TreeFamiTF314319

Family and domain databases

InterProiView protein in InterPro
IPR006634 TLC-dom
IPR013599 TRAM1
IPR016447 Translocation_assoc_membrane
PfamiView protein in Pfam
PF08390 TRAM1, 1 hit
PF03798 TRAM_LAG1_CLN8, 1 hit
PIRSFiPIRSF005449 Translocation_assoc_membrane, 1 hit
SMARTiView protein in SMART
SM00724 TLC, 1 hit
PROSITEiView protein in PROSITE
PS50922 TLC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRKKSTKN PPVLSQEFIL QNHADIVSCV GMFFLLGLVF EGTAEASIVF
60 70 80 90 100
LTLQHSVAVP AAEEQATGSK SLYYYGVKDL ATVFFYMLVA IIIHATIQEY
110 120 130 140 150
VLDKINKRMQ FTKAKQNKFN ESGQFSVFYF FSCIWGTFIL ISENCLSDPT
160 170 180 190 200
LIWKARPHSM MTFQMKFFYI SQLAYWFHAF PELYFQKTKK QDIPRQLVYI
210 220 230 240 250
GLHLFHITGA YLLYLNHLGL LLLVLHYFVE LLSHMCGLFY FSDEKYQKGI
260 270 280 290 300
SLWAIVFILG RLVTLIVSVL TVGFHLAGSQ NRNPDALTGN VNVLAAKIAV
310 320 330 340 350
LSSSCTIQAY VTWNLITLWL QRWVEDSNIQ ASCMKKKRSR SSKKRTENGV
360
GVETSNRVDC PPKRKEKSS
Length:369
Mass (Da):42,162
Last modified:January 15, 2008 - v2
Checksum:i95E2A5D82BEECF72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59V → A in AAH30831 (PubMed:15489334).Curated1
Sequence conflicti170I → V in BAC11091 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074617 mRNA Translation: BAC11091.1
BC030831 mRNA Translation: AAH30831.1
CCDSiCCDS3707.1
RefSeqiNP_689615.2, NM_152402.2
UniGeneiHs.570737

Genome annotation databases

EnsembliENST00000310754; ENSP00000309402; ENSG00000174599
GeneIDi133022
KEGGihsa:133022
UCSCiuc003ibv.5 human

Similar proteinsi

Entry informationi

Entry nameiTR1L1_HUMAN
AccessioniPrimary (citable) accession number: Q8N609
Secondary accession number(s): Q8N2L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 25, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health