Q8N608 (DPP10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inactive dipeptidyl peptidase 10

Alternative name(s):
Dipeptidyl peptidase IV-related protein 3
Short name=DPRP-3
Dipeptidyl peptidase X
Short name=DPP X
Dipeptidyl peptidase-like protein 2
Short name=DPL2

Gene names

Name:	DPP10
Synonyms:	DPRP3, KIAA1492

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	796 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has no dipeptidyl aminopeptidase activity. May modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. Ref.2 Ref.9 Ref.10
Subunit structure	May form oligomers. Interacts with KCND1 Probable. Interacts with KCND2. Ref.3 Ref.9
Subcellular location	Membrane; Single-pass type II membrane protein Ref.2 Ref.3.
Tissue specificity	Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands. Ref.2 Ref.3
Post-translational modification	N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.
Involvement in disease	Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.3 Ref.12
Sequence similarities	Belongs to the peptidase S9B family. DPPIV subfamily.
Caution	Gly-651 is present instead of the conserved Ser which is expected to be an active site residue suggesting that this protein has no peptidase activity.
Sequence caution	The sequence BAA96016.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Asthma
Domain	Signal-anchor Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from direct assay Ref.2. Source: MGI
Molecular_function	serine-type peptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist, which may have different subcellular locations.

Isoform 1 (identifier: Q8N608-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N608-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNQTASVSHHIKCQPSKTIK → MRKVESRGEGGRE

Isoform 3 (identifier: Q8N608-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNQTASVSHHIKCQPSKTIK → MTAAKQEPQPTPGARASQAQPADQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 796	796	Inactive dipeptidyl peptidase 10		PRO_0000122417
Regions
	Topological domain	1 – 34	34	Cytoplasmic Potential
	Transmembrane	35 – 55	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	56 – 796	741	Extracellular Potential
	Region	1 – 56	56	Mediates effects on KCND2
Amino acid modifications
	Modified residue	138	1	Phosphotyrosine Ref.11
	Modified residue	143	1	Phosphotyrosine Ref.11
	Glycosylation	90	1	N-linked (GlcNAc...) Ref.13
	Glycosylation	111	1	N-linked (GlcNAc...) Ref.13
	Glycosylation	119	1	N-linked (GlcNAc...) Ref.13
	Glycosylation	257	1	N-linked (GlcNAc...) Ref.13
	Glycosylation	342	1	N-linked (GlcNAc...) Ref.13
	Glycosylation	748	1	N-linked (GlcNAc...) Ref.13
Natural variations
	Alternative sequence	1 – 20	20	MNQTA…SKTIK → MRKVESRGEGGRE in isoform 2.		VSP_013873
	Alternative sequence	1 – 20	20	MNQTA…SKTIK → MTAAKQEPQPTPGARASQAQ PADQ in isoform 3.		VSP_044466
	Natural variant	340	1	A → P. Ref.1 Ref.5 Corresponds to variant rs2053724 [ dbSNP | Ensembl ].		VAR_057061
	Natural variant	401	1	V → I. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.8 Corresponds to variant rs1446495 [ dbSNP | Ensembl ].		VAR_059759
	Natural variant	517	1	S → N. Corresponds to variant rs13421193 [ dbSNP | Ensembl ].		VAR_057062
Experimental info
	Mutagenesis	257	1	N → Q: Abolishes sorting to the cell surface and dimerization. Ref.13
	Sequence conflict	288	1	V → M in AAO17263. Ref.2
	Sequence conflict	288	1	V → M in BAF82656. Ref.5
	Sequence conflict	288	1	V → M in AAH30832. Ref.7
	Sequence conflict	687	1	F → L in AAQ91190. Ref.1
Isoform 3:
	Sequence conflict	4	1	A → M in ABI16086. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 072CBD67D1FB478E	FASTA	796	90,888
	10 20 30 40 50 60 MNQTASVSHH IKCQPSKTIK ELGSNSPPQR NWKGIAIALL VILVVCSLIT MSVILLTPDE 70 80 90 100 110 120 LTNSSETRLS LEDLFRKDFV LHDPEARWIN DTDVVYKSEN GHVIKLNIET NATTLLLENT 130 140 150 160 170 180 TFVTFKASRH SVSPDLKYVL LAYDVKQIFH YSYTASYVIY NIHTREVWEL NPPEVEDSVL 190 200 210 220 230 240 QYAAWGVQGQ QLIYIFENNI YYQPDIKSSS LRLTSSGKEE IIFNGIADWL YEEELLHSHI 250 260 270 280 290 300 AHWWSPDGER LAFLMINDSL VPTMVIPRFT GALYPKGKQY PYPKAGQVNP TIKLYVVNLY 310 320 330 340 350 360 GPTHTLELMP PDSFKSREYY ITMVKWVSNT KTVVRWLNRA QNISILTVCE TTTGACSKKY 370 380 390 400 410 420 EMTSDTWLSQ QNEEPVFSRD GSKFFMTVPV KQGGRGEFHH VAMFLIQSKS EQITVRHLTS 430 440 450 460 470 480 GNWEVIKILA YDETTQKIYF LSTESSPRGR QLYSASTEGL LNRQCISCNF MKEQCTYFDA 490 500 510 520 530 540 SFSPMNQHFL LFCEGPRVPV VSLHSTDNPA KYFILESNSM LKEAILKKKI GKPEIKILHI 550 560 570 580 590 600 DDYELPLQLS LPKDFMDRNQ YALLLIMDEE PGGQLVTDKF HIDWDSVLID MDNVIVARFD 610 620 630 640 650 660 GRGSGFQGLK ILQEIHRRLG SVEVKDQITA VKFLLKLPYI DSKRLSIFGK GYGGYIASMI 670 680 690 700 710 720 LKSDEKLFKC GSVVAPITDL KLYASAFSER YLGMPSKEES TYQAASVLHN VHGLKEENIL 730 740 750 760 770 780 IIHGTADTKV HFQHSAELIK HLIKAGVNYT MQVYPDEGHN VSEKSKYHLY STILKFFSDC 790 LKEEISVLPQ EPEEDE
	Isoform 2 [UniParc]. Checksum: F1746DDCA46C0744	FASTA	789	90,140
	10 20 30 40 50 60 MRKVESRGEG GREELGSNSP PQRNWKGIAI ALLVILVVCS LITMSVILLT PDELTNSSET 70 80 90 100 110 120 RLSLEDLFRK DFVLHDPEAR WINDTDVVYK SENGHVIKLN IETNATTLLL ENTTFVTFKA 130 140 150 160 170 180 SRHSVSPDLK YVLLAYDVKQ IFHYSYTASY VIYNIHTREV WELNPPEVED SVLQYAAWGV 190 200 210 220 230 240 QGQQLIYIFE NNIYYQPDIK SSSLRLTSSG KEEIIFNGIA DWLYEEELLH SHIAHWWSPD 250 260 270 280 290 300 GERLAFLMIN DSLVPTMVIP RFTGALYPKG KQYPYPKAGQ VNPTIKLYVV NLYGPTHTLE 310 320 330 340 350 360 LMPPDSFKSR EYYITMVKWV SNTKTVVRWL NRAQNISILT VCETTTGACS KKYEMTSDTW 370 380 390 400 410 420 LSQQNEEPVF SRDGSKFFMT VPVKQGGRGE FHHVAMFLIQ SKSEQITVRH LTSGNWEVIK 430 440 450 460 470 480 ILAYDETTQK IYFLSTESSP RGRQLYSAST EGLLNRQCIS CNFMKEQCTY FDASFSPMNQ 490 500 510 520 530 540 HFLLFCEGPR VPVVSLHSTD NPAKYFILES NSMLKEAILK KKIGKPEIKI LHIDDYELPL 550 560 570 580 590 600 QLSLPKDFMD RNQYALLLIM DEEPGGQLVT DKFHIDWDSV LIDMDNVIVA RFDGRGSGFQ 610 620 630 640 650 660 GLKILQEIHR RLGSVEVKDQ ITAVKFLLKL PYIDSKRLSI FGKGYGGYIA SMILKSDEKL 670 680 690 700 710 720 FKCGSVVAPI TDLKLYASAF SERYLGMPSK EESTYQAASV LHNVHGLKEE NILIIHGTAD 730 740 750 760 770 780 TKVHFQHSAE LIKHLIKAGV NYTMQVYPDE GHNVSEKSKY HLYSTILKFF SDCLKEEISV LPQEPEEDE
	Isoform 3 [UniParc]. Checksum: C837D61773C3E890	FASTA	800	91,129
	10 20 30 40 50 60 MTAAKQEPQP TPGARASQAQ PADQELGSNS PPQRNWKGIA IALLVILVVC SLITMSVILL 70 80 90 100 110 120 TPDELTNSSE TRLSLEDLFR KDFVLHDPEA RWINDTDVVY KSENGHVIKL NIETNATTLL 130 140 150 160 170 180 LENTTFVTFK ASRHSVSPDL KYVLLAYDVK QIFHYSYTAS YVIYNIHTRE VWELNPPEVE 190 200 210 220 230 240 DSVLQYAAWG VQGQQLIYIF ENNIYYQPDI KSSSLRLTSS GKEEIIFNGI ADWLYEEELL 250 260 270 280 290 300 HSHIAHWWSP DGERLAFLMI NDSLVPTMVI PRFTGALYPK GKQYPYPKAG QVNPTIKLYV 310 320 330 340 350 360 VNLYGPTHTL ELMPPDSFKS REYYITMVKW VSNTKTVVRW LNRAQNISIL TVCETTTGAC 370 380 390 400 410 420 SKKYEMTSDT WLSQQNEEPV FSRDGSKFFM TVPVKQGGRG EFHHVAMFLI QSKSEQITVR 430 440 450 460 470 480 HLTSGNWEVI KILAYDETTQ KIYFLSTESS PRGRQLYSAS TEGLLNRQCI SCNFMKEQCT 490 500 510 520 530 540 YFDASFSPMN QHFLLFCEGP RVPVVSLHST DNPAKYFILE SNSMLKEAIL KKKIGKPEIK 550 560 570 580 590 600 ILHIDDYELP LQLSLPKDFM DRNQYALLLI MDEEPGGQLV TDKFHIDWDS VLIDMDNVIV 610 620 630 640 650 660 ARFDGRGSGF QGLKILQEIH RRLGSVEVKD QITAVKFLLK LPYIDSKRLS IFGKGYGGYI 670 680 690 700 710 720 ASMILKSDEK LFKCGSVVAP ITDLKLYASA FSERYLGMPS KEESTYQAAS VLHNVHGLKE 730 740 750 760 770 780 ENILIIHGTA DTKVHFQHSA ELIKHLIKAG VNYTMQVYPD EGHNVSEKSK YHLYSTILKF 790 800 FSDCLKEEIS VLPQEPEEDE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Dipeptidyl peptidase IV gene family. The DPIV family." Chen T., Ajami K., McCaughan G.W., Gorrell M.D., Abbott C.A. Adv. Exp. Med. Biol. 524:79-86(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS PRO-340 AND ILE-401. Tissue: Brain.
[2]	"Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases." Qi S.Y., Riviere P.J., Trojnar J., Junien J.-L., Akinsanya K.O. Biochem. J. 373:179-189(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT ILE-401. Tissue: Hypothalamus.
[3]	"Positional cloning of a novel gene influencing asthma from chromosome 2q14." Allen M., Heinzmann A., Noguchi E., Abecasis G., Broxholme J., Ponting C.P., Bhattacharyya S., Tinsley J., Zhang Y., Holt R., Jones E.Y., Lench N., Carey A., Jones H., Dickens N.J., Dimon C., Nicholls R., Baker C. , Xue L., Townsend E., Kabesch M., Weiland S.K., Carr D., von Mutius E., Adcock I.M., Barnes P.J., Lathrop G.M., Edwards M., Moffatt M.F., Cookson W.O.C.M. Nat. Genet. 35:258-263(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INVOLVEMENT IN ASTHMA, VARIANT ILE-401.
[4]	"Species and tissue differences in the expression of DPPY splicing variants." Takimoto K., Hayashi Y., Ren X., Yoshimura N. Biochem. Biophys. Res. Commun. 348:1094-1100(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT ILE-401, ALTERNATIVE SPLICING.
[5]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS PRO-340 AND ILE-401. Tissue: Brain.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-401. Tissue: Hippocampus.
[7]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-401. Tissue: Brain.
[9]	"Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)." Jerng H.H., Qian Y., Pfaffinger P.J. Biophys. J. 87:2380-2396(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, GLYCOSYLATION, INTERACTION WITH KCND1 AND KCND2.
[10]	"DPP10 modulates Kv4-mediated A-type potassium channels." Zagha E., Ozaita A., Chang S.Y., Nadal M.S., Lin U., Saganich M.J., McCormack T., Akinsanya K.O., Qi S.Y., Rudy B. J. Biol. Chem. 280:18853-18861(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-138 AND TYR-143, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort." Blakey J.D., Sayers I., Ring S.M., Strachan D.P., Hall I.P. Thorax 64:381-387(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA.
[13]	"N-glycosylation of the mammalian dipeptidyl aminopeptidase-like protein 10 (DPP10) regulates trafficking and interaction with Kv4 channels." Cotella D., Radicke S., Cipriani V., Cavaletto M., Merlin S., Follenzi A., Ravens U., Wettwer E., Santoro C., Sblattero D. Int. J. Biochem. Cell Biol. 44:876-885(2012) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT ASN-90; ASN-111; ASN-119; ASN-257; ASN-342 AND ASN-748, MUTAGENESIS OF ASN-257.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY387785 mRNA. Translation: AAQ91190.1. AY172661 mRNA. Translation: AAO17263.2. AB040925 mRNA. Translation: BAA96016.2. Different initiation. DQ857322 mRNA. Translation: ABI16086.1. AK289967 mRNA. Translation: BAF82656.1. AC010885 Genomic DNA. No translation available. AC012071 Genomic DNA. No translation available. AC016721 Genomic DNA. Translation: AAY15025.1. AC017040 Genomic DNA. Translation: AAY15032.1. AC066593 Genomic DNA. No translation available. AC067947 Genomic DNA. Translation: AAY14685.1. AC068542 Genomic DNA. No translation available. AC093610 Genomic DNA. No translation available. AC105422 Genomic DNA. Translation: AAY24120.1. AC116620 Genomic DNA. No translation available. AC118276 Genomic DNA. No translation available. AC118664 Genomic DNA. No translation available. BC030832 mRNA. Translation: AAH30832.1.
IPI	IPI00166892. IPI00873846. IPI00917254.
RefSeq	NP_001004360.2. NM_001004360.3. NP_001171505.1. NM_001178034.1. NP_065919.2. NM_020868.3.
UniGene	Hs.580539.
3D structure databases
ProteinModelPortal	Q8N608.
SMR	Q8N608. Positions 66-782.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N608. 1 interaction.
STRING	9606.ENSP00000386565.
Protein family/group databases
MEROPS	S09.974.
PTM databases
PhosphoSite	Q8N608.
Polymorphism databases
DMDM	296434483.
Proteomic databases
PaxDb	Q8N608.
PRIDE	Q8N608.
Protocols and materials databases
DNASU	57628.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000310323; ENSP00000309066; ENSG00000175497. ENST00000393147; ENSP00000376855; ENSG00000175497. ENST00000410059; ENSP00000386565; ENSG00000175497.
GeneID	57628.
KEGG	hsa:57628.
Organism-specific databases
CTD	57628.
GeneCards	GC02P115295.
HGNC	HGNC:20823. DPP10.
HPA	HPA048767.
MIM	600807. phenotype. 608209. gene.
neXtProt	NX_Q8N608.
PharmGKB	PA134991647.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1506.
HOVERGEN	HBG105877.
OMA	ASMILKS.
OrthoDB	EOG42RD6N.
PhylomeDB	Q8N608.
Gene expression databases
ArrayExpress	Q8N608.
Bgee	Q8N608.
CleanEx	HS_DPP10.
Genevestigator	Q8N608.
GermOnline	ENSG00000175497. Homo sapiens.
Family and domain databases
InterPro	IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view]
Pfam	PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DPP10. human.
GenomeRNAi	57628.
NextBio	35535176.
SOURCE	Search...

Entry information

Entry name

DPP10_HUMAN

Accession

Primary (citable) accession number: Q8N608
Secondary accession number(s): A8K1Q2 , J3KPP2, Q0GLB8, Q53QT3, Q53S86, Q53SL8, Q53SS4, Q6TTV4, Q86YR9, Q9P236

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.