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Protein

Inactive dipeptidyl peptidase 10

Gene

DPP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

ESTHERihuman-DPP10. DPP4N_Peptidase_S9.
MEROPSiS09.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive dipeptidyl peptidase 10
Alternative name(s):
Dipeptidyl peptidase IV-related protein 3
Short name:
DPRP-3
Dipeptidyl peptidase X
Short name:
DPP X
Dipeptidyl peptidase-like protein 2
Short name:
DPL2
Gene namesi
Name:DPP10
Synonyms:DPRP3, KIAA1492
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20823. DPP10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei35 – 5521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini56 – 796741ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Asthma (ASTHMA)2 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionThe most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.

See also OMIM:600807

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi257 – 2571N → Q: Abolishes sorting to the cell surface and dimerization. 1 Publication

Keywords - Diseasei

Asthma

Organism-specific databases

MIMi600807. phenotype.
PharmGKBiPA134991647.

Polymorphism and mutation databases

BioMutaiDPP10.
DMDMi296434483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 796796Inactive dipeptidyl peptidase 10PRO_0000122417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...)1 Publication
Glycosylationi111 – 1111N-linked (GlcNAc...)1 Publication
Glycosylationi119 – 1191N-linked (GlcNAc...)1 Publication
Modified residuei138 – 1381Phosphotyrosine1 Publication
Modified residuei143 – 1431Phosphotyrosine1 Publication
Glycosylationi257 – 2571N-linked (GlcNAc...)1 Publication
Glycosylationi342 – 3421N-linked (GlcNAc...)1 Publication
Glycosylationi748 – 7481N-linked (GlcNAc...)1 Publication

Post-translational modificationi

N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8N608.
PaxDbiQ8N608.
PRIDEiQ8N608.

PTM databases

PhosphoSiteiQ8N608.

Expressioni

Tissue specificityi

Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.2 Publications

Gene expression databases

BgeeiQ8N608.
CleanExiHS_DPP10.
ExpressionAtlasiQ8N608. baseline and differential.
GenevisibleiQ8N608. HS.

Organism-specific databases

HPAiHPA048767.

Interactioni

Subunit structurei

May form oligomers. Interacts with KCND1 (Probable). Interacts with KCND2.Curated2 Publications

Protein-protein interaction databases

BioGridi121672. 4 interactions.
IntActiQ8N608. 1 interaction.
STRINGi9606.ENSP00000376855.

Structurei

Secondary structure

1
796
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi71 – 744Combined sources
Beta strandi90 – 945Combined sources
Beta strandi99 – 1013Combined sources
Beta strandi103 – 1075Combined sources
Turni108 – 1103Combined sources
Beta strandi113 – 1175Combined sources
Turni119 – 1257Combined sources
Beta strandi129 – 1324Combined sources
Beta strandi136 – 14712Combined sources
Beta strandi149 – 1513Combined sources
Beta strandi153 – 16412Combined sources
Beta strandi167 – 1704Combined sources
Beta strandi180 – 1823Combined sources
Beta strandi192 – 1965Combined sources
Beta strandi199 – 20810Combined sources
Turni219 – 2213Combined sources
Beta strandi222 – 2265Combined sources
Helixi229 – 2335Combined sources
Turni234 – 2363Combined sources
Beta strandi237 – 2404Combined sources
Beta strandi242 – 2443Combined sources
Beta strandi248 – 25710Combined sources
Beta strandi263 – 2653Combined sources
Beta strandi270 – 2745Combined sources
Beta strandi279 – 2813Combined sources
Beta strandi291 – 30010Combined sources
Turni312 – 3165Combined sources
Beta strandi319 – 33820Combined sources
Beta strandi343 – 3508Combined sources
Turni351 – 3544Combined sources
Beta strandi355 – 3639Combined sources
Beta strandi379 – 39012Combined sources
Beta strandi398 – 4025Combined sources
Beta strandi408 – 4114Combined sources
Beta strandi421 – 4233Combined sources
Beta strandi425 – 4317Combined sources
Beta strandi435 – 4439Combined sources
Beta strandi447 – 46014Combined sources
Beta strandi463 – 4664Combined sources
Turni467 – 4737Combined sources
Beta strandi479 – 4824Combined sources
Beta strandi487 – 4926Combined sources
Beta strandi495 – 4984Combined sources
Beta strandi501 – 5077Combined sources
Beta strandi513 – 5164Combined sources
Helixi519 – 5279Combined sources
Beta strandi534 – 5407Combined sources
Beta strandi543 – 5508Combined sources
Beta strandi557 – 5593Combined sources
Beta strandi561 – 5666Combined sources
Helixi584 – 5907Combined sources
Turni591 – 5933Combined sources
Beta strandi594 – 5996Combined sources
Beta strandi605 – 6073Combined sources
Turni608 – 6114Combined sources
Helixi612 – 6154Combined sources
Helixi621 – 63515Combined sources
Beta strandi637 – 65014Combined sources
Helixi651 – 66010Combined sources
Beta strandi669 – 6757Combined sources
Helixi680 – 6823Combined sources
Helixi685 – 6928Combined sources
Turni696 – 6983Combined sources
Helixi701 – 7044Combined sources
Beta strandi705 – 7084Combined sources
Beta strandi718 – 7247Combined sources
Beta strandi728 – 7303Combined sources
Helixi733 – 74412Combined sources
Beta strandi749 – 7546Combined sources
Helixi763 – 78018Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4WJLX-ray3.40A/B65-783[»]
ProteinModelPortaliQ8N608.
SMRiQ8N608. Positions 66-782.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5656Mediates effects on KCND2Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S9B family. DPPIV subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1506.
GeneTreeiENSGT00760000119233.
HOGENOMiHOG000231875.
HOVERGENiHBG105877.
InParanoidiQ8N608.
OMAiKEGIIFN.
OrthoDBiEOG7H791M.
PhylomeDBiQ8N608.
TreeFamiTF313309.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist, which may have different subcellular locations.

Isoform 1 (identifier: Q8N608-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNQTASVSHH IKCQPSKTIK ELGSNSPPQR NWKGIAIALL VILVVCSLIT
60 70 80 90 100
MSVILLTPDE LTNSSETRLS LEDLFRKDFV LHDPEARWIN DTDVVYKSEN
110 120 130 140 150
GHVIKLNIET NATTLLLENT TFVTFKASRH SVSPDLKYVL LAYDVKQIFH
160 170 180 190 200
YSYTASYVIY NIHTREVWEL NPPEVEDSVL QYAAWGVQGQ QLIYIFENNI
210 220 230 240 250
YYQPDIKSSS LRLTSSGKEE IIFNGIADWL YEEELLHSHI AHWWSPDGER
260 270 280 290 300
LAFLMINDSL VPTMVIPRFT GALYPKGKQY PYPKAGQVNP TIKLYVVNLY
310 320 330 340 350
GPTHTLELMP PDSFKSREYY ITMVKWVSNT KTVVRWLNRA QNISILTVCE
360 370 380 390 400
TTTGACSKKY EMTSDTWLSQ QNEEPVFSRD GSKFFMTVPV KQGGRGEFHH
410 420 430 440 450
VAMFLIQSKS EQITVRHLTS GNWEVIKILA YDETTQKIYF LSTESSPRGR
460 470 480 490 500
QLYSASTEGL LNRQCISCNF MKEQCTYFDA SFSPMNQHFL LFCEGPRVPV
510 520 530 540 550
VSLHSTDNPA KYFILESNSM LKEAILKKKI GKPEIKILHI DDYELPLQLS
560 570 580 590 600
LPKDFMDRNQ YALLLIMDEE PGGQLVTDKF HIDWDSVLID MDNVIVARFD
610 620 630 640 650
GRGSGFQGLK ILQEIHRRLG SVEVKDQITA VKFLLKLPYI DSKRLSIFGK
660 670 680 690 700
GYGGYIASMI LKSDEKLFKC GSVVAPITDL KLYASAFSER YLGMPSKEES
710 720 730 740 750
TYQAASVLHN VHGLKEENIL IIHGTADTKV HFQHSAELIK HLIKAGVNYT
760 770 780 790
MQVYPDEGHN VSEKSKYHLY STILKFFSDC LKEEISVLPQ EPEEDE
Length:796
Mass (Da):90,888
Last modified:May 18, 2010 - v2
Checksum:i072CBD67D1FB478E
GO
Isoform 2 (identifier: Q8N608-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNQTASVSHHIKCQPSKTIK → MRKVESRGEGGRE

Show »
Length:789
Mass (Da):90,140
Checksum:iF1746DDCA46C0744
GO
Isoform 3 (identifier: Q8N608-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNQTASVSHHIKCQPSKTIK → MTAAKQEPQPTPGARASQAQPADQ

Show »
Length:800
Mass (Da):91,129
Checksum:iC837D61773C3E890
GO
Isoform 4 (identifier: Q8N608-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Note: Gene prediction based on EST data.
Show »
Length:746
Mass (Da):85,480
Checksum:iF71826F40623C64D
GO

Sequence cautioni

The sequence BAA96016.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti288 – 2881V → M in AAO17263 (PubMed:12662155).Curated
Sequence conflicti288 – 2881V → M in BAF82656 (PubMed:10819331).Curated
Sequence conflicti288 – 2881V → M in AAH30832 (PubMed:15815621).Curated
Sequence conflicti687 – 6871F → L in AAQ91190 (PubMed:12675227).Curated
Isoform 3 (identifier: Q8N608-3)
Sequence conflicti4 – 41A → M in ABI16086 (PubMed:16899223).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti340 – 3401A → P.2 Publications
Corresponds to variant rs2053724 [ dbSNP | Ensembl ].
VAR_057061
Natural varianti401 – 4011V → I.7 Publications
Corresponds to variant rs1446495 [ dbSNP | Ensembl ].
VAR_059759
Natural varianti517 – 5171S → N.
Corresponds to variant rs13421193 [ dbSNP | Ensembl ].
VAR_057062

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5050Missing in isoform 4. CuratedVSP_047152Add
BLAST
Alternative sequencei1 – 2020MNQTA…SKTIK → MRKVESRGEGGRE in isoform 2. 2 PublicationsVSP_013873Add
BLAST
Alternative sequencei1 – 2020MNQTA…SKTIK → MTAAKQEPQPTPGARASQAQ PADQ in isoform 3. 1 PublicationVSP_044466Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY387785 mRNA. Translation: AAQ91190.1.
AY172661 mRNA. Translation: AAO17263.2.
AB040925 mRNA. Translation: BAA96016.2. Different initiation.
DQ857322 mRNA. Translation: ABI16086.1.
AK289967 mRNA. Translation: BAF82656.1.
AC010885 Genomic DNA. No translation available.
AC012071 Genomic DNA. No translation available.
AC016721 Genomic DNA. Translation: AAY15025.1.
AC017040 Genomic DNA. Translation: AAY15032.1.
AC066593 Genomic DNA. No translation available.
AC067947 Genomic DNA. Translation: AAY14685.1.
AC068542 Genomic DNA. No translation available.
AC093610 Genomic DNA. No translation available.
AC105422 Genomic DNA. Translation: AAY24120.1.
AC116620 Genomic DNA. No translation available.
AC118276 Genomic DNA. No translation available.
AC118664 Genomic DNA. No translation available.
BC030832 mRNA. Translation: AAH30832.1.
CCDSiCCDS33278.1. [Q8N608-2]
CCDS46400.1. [Q8N608-1]
CCDS54388.1. [Q8N608-3]
CCDS54389.1. [Q8N608-4]
RefSeqiNP_001004360.2. NM_001004360.3.
NP_001171505.1. NM_001178034.1.
NP_065919.2. NM_020868.3.
UniGeneiHs.580539.

Genome annotation databases

EnsembliENST00000310323; ENSP00000309066; ENSG00000175497. [Q8N608-2]
ENST00000393147; ENSP00000376855; ENSG00000175497. [Q8N608-3]
ENST00000409163; ENSP00000387038; ENSG00000175497. [Q8N608-4]
ENST00000410059; ENSP00000386565; ENSG00000175497. [Q8N608-1]
GeneIDi57628.
KEGGihsa:57628.
UCSCiuc002tle.3. human. [Q8N608-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY387785 mRNA. Translation: AAQ91190.1.
AY172661 mRNA. Translation: AAO17263.2.
AB040925 mRNA. Translation: BAA96016.2. Different initiation.
DQ857322 mRNA. Translation: ABI16086.1.
AK289967 mRNA. Translation: BAF82656.1.
AC010885 Genomic DNA. No translation available.
AC012071 Genomic DNA. No translation available.
AC016721 Genomic DNA. Translation: AAY15025.1.
AC017040 Genomic DNA. Translation: AAY15032.1.
AC066593 Genomic DNA. No translation available.
AC067947 Genomic DNA. Translation: AAY14685.1.
AC068542 Genomic DNA. No translation available.
AC093610 Genomic DNA. No translation available.
AC105422 Genomic DNA. Translation: AAY24120.1.
AC116620 Genomic DNA. No translation available.
AC118276 Genomic DNA. No translation available.
AC118664 Genomic DNA. No translation available.
BC030832 mRNA. Translation: AAH30832.1.
CCDSiCCDS33278.1. [Q8N608-2]
CCDS46400.1. [Q8N608-1]
CCDS54388.1. [Q8N608-3]
CCDS54389.1. [Q8N608-4]
RefSeqiNP_001004360.2. NM_001004360.3.
NP_001171505.1. NM_001178034.1.
NP_065919.2. NM_020868.3.
UniGeneiHs.580539.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4WJLX-ray3.40A/B65-783[»]
ProteinModelPortaliQ8N608.
SMRiQ8N608. Positions 66-782.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121672. 4 interactions.
IntActiQ8N608. 1 interaction.
STRINGi9606.ENSP00000376855.

Protein family/group databases

ESTHERihuman-DPP10. DPP4N_Peptidase_S9.
MEROPSiS09.974.

PTM databases

PhosphoSiteiQ8N608.

Polymorphism and mutation databases

BioMutaiDPP10.
DMDMi296434483.

Proteomic databases

MaxQBiQ8N608.
PaxDbiQ8N608.
PRIDEiQ8N608.

Protocols and materials databases

DNASUi57628.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310323; ENSP00000309066; ENSG00000175497. [Q8N608-2]
ENST00000393147; ENSP00000376855; ENSG00000175497. [Q8N608-3]
ENST00000409163; ENSP00000387038; ENSG00000175497. [Q8N608-4]
ENST00000410059; ENSP00000386565; ENSG00000175497. [Q8N608-1]
GeneIDi57628.
KEGGihsa:57628.
UCSCiuc002tle.3. human. [Q8N608-3]

Organism-specific databases

CTDi57628.
GeneCardsiGC02P115295.
HGNCiHGNC:20823. DPP10.
HPAiHPA048767.
MIMi600807. phenotype.
608209. gene.
neXtProtiNX_Q8N608.
PharmGKBiPA134991647.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1506.
GeneTreeiENSGT00760000119233.
HOGENOMiHOG000231875.
HOVERGENiHBG105877.
InParanoidiQ8N608.
OMAiKEGIIFN.
OrthoDBiEOG7H791M.
PhylomeDBiQ8N608.
TreeFamiTF313309.

Miscellaneous databases

ChiTaRSiDPP10. human.
GeneWikiiDPP10.
GenomeRNAii57628.
NextBioi35535176.
PROiQ8N608.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N608.
CleanExiHS_DPP10.
ExpressionAtlasiQ8N608. baseline and differential.
GenevisibleiQ8N608. HS.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Dipeptidyl peptidase IV gene family. The DPIV family."
    Chen T., Ajami K., McCaughan G.W., Gorrell M.D., Abbott C.A.
    Adv. Exp. Med. Biol. 524:79-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS PRO-340 AND ILE-401.
    Tissue: Brain.
  2. "Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases."
    Qi S.Y., Riviere P.J., Trojnar J., Junien J.-L., Akinsanya K.O.
    Biochem. J. 373:179-189(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, LACK OF ENZYME ACTIVITY, VARIANT ILE-401.
    Tissue: Hypothalamus.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INVOLVEMENT IN ASTHMA, VARIANT ILE-401.
  4. "Species and tissue differences in the expression of DPPY splicing variants."
    Takimoto K., Hayashi Y., Ren X., Yoshimura N.
    Biochem. Biophys. Res. Commun. 348:1094-1100(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT ILE-401, ALTERNATIVE SPLICING.
  5. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS PRO-340 AND ILE-401.
    Tissue: Brain.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-401.
    Tissue: Hippocampus.
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-401.
    Tissue: Brain.
  9. "Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)."
    Jerng H.H., Qian Y., Pfaffinger P.J.
    Biophys. J. 87:2380-2396(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GLYCOSYLATION, INTERACTION WITH KCND1 AND KCND2.
  10. Cited for: FUNCTION.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-138 AND TYR-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort."
    Blakey J.D., Sayers I., Ring S.M., Strachan D.P., Hall I.P.
    Thorax 64:381-387(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA.
  13. "N-glycosylation of the mammalian dipeptidyl aminopeptidase-like protein 10 (DPP10) regulates trafficking and interaction with Kv4 channels."
    Cotella D., Radicke S., Cipriani V., Cavaletto M., Merlin S., Follenzi A., Ravens U., Wettwer E., Santoro C., Sblattero D.
    Int. J. Biochem. Cell Biol. 44:876-885(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-90; ASN-111; ASN-119; ASN-257; ASN-342 AND ASN-748, MUTAGENESIS OF ASN-257.

Entry informationi

Entry nameiDPP10_HUMAN
AccessioniPrimary (citable) accession number: Q8N608
Secondary accession number(s): A8K1Q2
, J3KPP2, J3KQ46, Q0GLB8, Q53QT3, Q53S86, Q53SL8, Q53SS4, Q6TTV4, Q86YR9, Q9P236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 18, 2010
Last modified: June 24, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Gly-651 is present instead of the conserved Ser which is expected to be an active site residue suggesting that this protein has no peptidase activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.