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Protein

Inactive dipeptidyl peptidase 10

Gene

DPP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

ESTHERihuman-DPP10. DPP4N_Peptidase_S9.
MEROPSiS09.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive dipeptidyl peptidase 10
Alternative name(s):
Dipeptidyl peptidase IV-related protein 3
Short name:
DPRP-3
Dipeptidyl peptidase X
Short name:
DPP X
Dipeptidyl peptidase-like protein 2
Short name:
DPL2
Gene namesi
Name:DPP10
Synonyms:DPRP3, KIAA1492
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20823. DPP10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini56 – 796ExtracellularSequence analysisAdd BLAST741

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Asthma (ASTHMA)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionThe most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
See also OMIM:600807

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi257N → Q: Abolishes sorting to the cell surface and dimerization. 1 Publication1

Keywords - Diseasei

Asthma

Organism-specific databases

DisGeNETi57628.
MIMi600807. phenotype.
OpenTargetsiENSG00000175497.
PharmGKBiPA134991647.

Polymorphism and mutation databases

BioMutaiDPP10.
DMDMi296434483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224171 – 796Inactive dipeptidyl peptidase 10Add BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...)1 Publication1
Glycosylationi111N-linked (GlcNAc...)1 Publication1
Glycosylationi119N-linked (GlcNAc...)1 Publication1
Modified residuei138PhosphotyrosineCombined sources1
Modified residuei143PhosphotyrosineCombined sources1
Glycosylationi257N-linked (GlcNAc...)1 Publication1
Glycosylationi342N-linked (GlcNAc...)1 Publication1
Glycosylationi748N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8N608.
PaxDbiQ8N608.
PeptideAtlasiQ8N608.
PRIDEiQ8N608.

PTM databases

iPTMnetiQ8N608.
PhosphoSitePlusiQ8N608.

Expressioni

Tissue specificityi

Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.2 Publications

Gene expression databases

BgeeiENSG00000175497.
CleanExiHS_DPP10.
ExpressionAtlasiQ8N608. baseline and differential.
GenevisibleiQ8N608. HS.

Organism-specific databases

HPAiHPA048767.

Interactioni

Subunit structurei

May form oligomers. Interacts with KCND1 (Probable). Interacts with KCND2.Curated2 Publications

Protein-protein interaction databases

BioGridi121672. 4 interactors.
IntActiQ8N608. 1 interactor.
STRINGi9606.ENSP00000376855.

Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi71 – 74Combined sources4
Beta strandi90 – 94Combined sources5
Beta strandi99 – 101Combined sources3
Beta strandi103 – 107Combined sources5
Turni108 – 110Combined sources3
Beta strandi113 – 117Combined sources5
Turni119 – 125Combined sources7
Beta strandi129 – 132Combined sources4
Beta strandi136 – 147Combined sources12
Beta strandi149 – 151Combined sources3
Beta strandi153 – 164Combined sources12
Beta strandi167 – 170Combined sources4
Beta strandi180 – 182Combined sources3
Beta strandi192 – 196Combined sources5
Beta strandi199 – 208Combined sources10
Turni219 – 221Combined sources3
Beta strandi222 – 226Combined sources5
Helixi229 – 233Combined sources5
Turni234 – 236Combined sources3
Beta strandi237 – 240Combined sources4
Beta strandi242 – 244Combined sources3
Beta strandi248 – 257Combined sources10
Beta strandi263 – 265Combined sources3
Beta strandi270 – 274Combined sources5
Beta strandi279 – 281Combined sources3
Beta strandi291 – 300Combined sources10
Turni312 – 316Combined sources5
Beta strandi319 – 338Combined sources20
Beta strandi343 – 350Combined sources8
Turni351 – 354Combined sources4
Beta strandi355 – 363Combined sources9
Beta strandi379 – 390Combined sources12
Beta strandi398 – 402Combined sources5
Beta strandi408 – 411Combined sources4
Beta strandi421 – 423Combined sources3
Beta strandi425 – 431Combined sources7
Beta strandi435 – 443Combined sources9
Beta strandi447 – 460Combined sources14
Beta strandi463 – 466Combined sources4
Turni467 – 473Combined sources7
Beta strandi479 – 482Combined sources4
Beta strandi487 – 492Combined sources6
Beta strandi495 – 498Combined sources4
Beta strandi501 – 507Combined sources7
Beta strandi513 – 516Combined sources4
Helixi519 – 527Combined sources9
Beta strandi534 – 540Combined sources7
Beta strandi543 – 550Combined sources8
Beta strandi557 – 559Combined sources3
Beta strandi561 – 566Combined sources6
Helixi584 – 590Combined sources7
Turni591 – 593Combined sources3
Beta strandi594 – 599Combined sources6
Beta strandi605 – 607Combined sources3
Turni608 – 611Combined sources4
Helixi612 – 615Combined sources4
Helixi621 – 635Combined sources15
Beta strandi637 – 650Combined sources14
Helixi651 – 660Combined sources10
Beta strandi669 – 675Combined sources7
Helixi680 – 682Combined sources3
Helixi685 – 692Combined sources8
Turni696 – 698Combined sources3
Helixi701 – 704Combined sources4
Beta strandi705 – 708Combined sources4
Beta strandi718 – 724Combined sources7
Beta strandi728 – 730Combined sources3
Helixi733 – 744Combined sources12
Beta strandi749 – 754Combined sources6
Helixi763 – 780Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WJLX-ray3.40A/B65-783[»]
ProteinModelPortaliQ8N608.
SMRiQ8N608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 56Mediates effects on KCND2Add BLAST56

Sequence similaritiesi

Belongs to the peptidase S9B family. DPPIV subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2100. Eukaryota.
COG1506. LUCA.
GeneTreeiENSGT00760000119233.
HOGENOMiHOG000231875.
HOVERGENiHBG105877.
InParanoidiQ8N608.
OMAiVIYNIHT.
OrthoDBiEOG091G0GBJ.
PhylomeDBiQ8N608.
TreeFamiTF313309.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist, which may have different subcellular locations.
Isoform 1 (identifier: Q8N608-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNQTASVSHH IKCQPSKTIK ELGSNSPPQR NWKGIAIALL VILVVCSLIT
60 70 80 90 100
MSVILLTPDE LTNSSETRLS LEDLFRKDFV LHDPEARWIN DTDVVYKSEN
110 120 130 140 150
GHVIKLNIET NATTLLLENT TFVTFKASRH SVSPDLKYVL LAYDVKQIFH
160 170 180 190 200
YSYTASYVIY NIHTREVWEL NPPEVEDSVL QYAAWGVQGQ QLIYIFENNI
210 220 230 240 250
YYQPDIKSSS LRLTSSGKEE IIFNGIADWL YEEELLHSHI AHWWSPDGER
260 270 280 290 300
LAFLMINDSL VPTMVIPRFT GALYPKGKQY PYPKAGQVNP TIKLYVVNLY
310 320 330 340 350
GPTHTLELMP PDSFKSREYY ITMVKWVSNT KTVVRWLNRA QNISILTVCE
360 370 380 390 400
TTTGACSKKY EMTSDTWLSQ QNEEPVFSRD GSKFFMTVPV KQGGRGEFHH
410 420 430 440 450
VAMFLIQSKS EQITVRHLTS GNWEVIKILA YDETTQKIYF LSTESSPRGR
460 470 480 490 500
QLYSASTEGL LNRQCISCNF MKEQCTYFDA SFSPMNQHFL LFCEGPRVPV
510 520 530 540 550
VSLHSTDNPA KYFILESNSM LKEAILKKKI GKPEIKILHI DDYELPLQLS
560 570 580 590 600
LPKDFMDRNQ YALLLIMDEE PGGQLVTDKF HIDWDSVLID MDNVIVARFD
610 620 630 640 650
GRGSGFQGLK ILQEIHRRLG SVEVKDQITA VKFLLKLPYI DSKRLSIFGK
660 670 680 690 700
GYGGYIASMI LKSDEKLFKC GSVVAPITDL KLYASAFSER YLGMPSKEES
710 720 730 740 750
TYQAASVLHN VHGLKEENIL IIHGTADTKV HFQHSAELIK HLIKAGVNYT
760 770 780 790
MQVYPDEGHN VSEKSKYHLY STILKFFSDC LKEEISVLPQ EPEEDE
Length:796
Mass (Da):90,888
Last modified:May 18, 2010 - v2
Checksum:i072CBD67D1FB478E
GO
Isoform 2 (identifier: Q8N608-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNQTASVSHHIKCQPSKTIK → MRKVESRGEGGRE

Show »
Length:789
Mass (Da):90,140
Checksum:iF1746DDCA46C0744
GO
Isoform 3 (identifier: Q8N608-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNQTASVSHHIKCQPSKTIK → MTAAKQEPQPTPGARASQAQPADQ

Show »
Length:800
Mass (Da):91,129
Checksum:iC837D61773C3E890
GO
Isoform 4 (identifier: Q8N608-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Note: Gene prediction based on EST data.
Show »
Length:746
Mass (Da):85,480
Checksum:iF71826F40623C64D
GO

Sequence cautioni

The sequence BAA96016 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288V → M in AAO17263 (PubMed:12662155).Curated1
Sequence conflicti288V → M in BAF82656 (PubMed:10819331).Curated1
Sequence conflicti288V → M in AAH30832 (PubMed:15815621).Curated1
Sequence conflicti687F → L in AAQ91190 (PubMed:12675227).Curated1
Isoform 3 (identifier: Q8N608-3)
Sequence conflicti4A → M in ABI16086 (PubMed:16899223).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057061340A → P.2 PublicationsCorresponds to variant rs2053724dbSNPEnsembl.1
Natural variantiVAR_059759401V → I.7 PublicationsCorresponds to variant rs1446495dbSNPEnsembl.1
Natural variantiVAR_057062517S → N.Corresponds to variant rs13421193dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0471521 – 50Missing in isoform 4. CuratedAdd BLAST50
Alternative sequenceiVSP_0138731 – 20MNQTA…SKTIK → MRKVESRGEGGRE in isoform 2. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_0444661 – 20MNQTA…SKTIK → MTAAKQEPQPTPGARASQAQ PADQ in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY387785 mRNA. Translation: AAQ91190.1.
AY172661 mRNA. Translation: AAO17263.2.
AB040925 mRNA. Translation: BAA96016.2. Different initiation.
DQ857322 mRNA. Translation: ABI16086.1.
AK289967 mRNA. Translation: BAF82656.1.
AC010885 Genomic DNA. No translation available.
AC012071 Genomic DNA. No translation available.
AC016721 Genomic DNA. Translation: AAY15025.1.
AC017040 Genomic DNA. Translation: AAY15032.1.
AC066593 Genomic DNA. No translation available.
AC067947 Genomic DNA. Translation: AAY14685.1.
AC068542 Genomic DNA. No translation available.
AC093610 Genomic DNA. No translation available.
AC105422 Genomic DNA. Translation: AAY24120.1.
AC116620 Genomic DNA. No translation available.
AC118276 Genomic DNA. No translation available.
AC118664 Genomic DNA. No translation available.
BC030832 mRNA. Translation: AAH30832.1.
CCDSiCCDS33278.1. [Q8N608-2]
CCDS46400.1. [Q8N608-1]
CCDS54388.1. [Q8N608-3]
CCDS54389.1. [Q8N608-4]
RefSeqiNP_001004360.2. NM_001004360.3.
NP_001171505.1. NM_001178034.1.
NP_001308835.1. NM_001321906.1.
NP_001308840.1. NM_001321911.1.
NP_001308841.1. NM_001321912.1.
NP_001308842.1. NM_001321913.1.
NP_001308843.1. NM_001321914.1.
NP_065919.2. NM_020868.4.
UniGeneiHs.580539.
Hs.657379.

Genome annotation databases

EnsembliENST00000310323; ENSP00000309066; ENSG00000175497. [Q8N608-2]
ENST00000393147; ENSP00000376855; ENSG00000175497. [Q8N608-3]
ENST00000409163; ENSP00000387038; ENSG00000175497. [Q8N608-4]
ENST00000410059; ENSP00000386565; ENSG00000175497. [Q8N608-1]
GeneIDi57628.
KEGGihsa:57628.
UCSCiuc002tla.3. human. [Q8N608-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY387785 mRNA. Translation: AAQ91190.1.
AY172661 mRNA. Translation: AAO17263.2.
AB040925 mRNA. Translation: BAA96016.2. Different initiation.
DQ857322 mRNA. Translation: ABI16086.1.
AK289967 mRNA. Translation: BAF82656.1.
AC010885 Genomic DNA. No translation available.
AC012071 Genomic DNA. No translation available.
AC016721 Genomic DNA. Translation: AAY15025.1.
AC017040 Genomic DNA. Translation: AAY15032.1.
AC066593 Genomic DNA. No translation available.
AC067947 Genomic DNA. Translation: AAY14685.1.
AC068542 Genomic DNA. No translation available.
AC093610 Genomic DNA. No translation available.
AC105422 Genomic DNA. Translation: AAY24120.1.
AC116620 Genomic DNA. No translation available.
AC118276 Genomic DNA. No translation available.
AC118664 Genomic DNA. No translation available.
BC030832 mRNA. Translation: AAH30832.1.
CCDSiCCDS33278.1. [Q8N608-2]
CCDS46400.1. [Q8N608-1]
CCDS54388.1. [Q8N608-3]
CCDS54389.1. [Q8N608-4]
RefSeqiNP_001004360.2. NM_001004360.3.
NP_001171505.1. NM_001178034.1.
NP_001308835.1. NM_001321906.1.
NP_001308840.1. NM_001321911.1.
NP_001308841.1. NM_001321912.1.
NP_001308842.1. NM_001321913.1.
NP_001308843.1. NM_001321914.1.
NP_065919.2. NM_020868.4.
UniGeneiHs.580539.
Hs.657379.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WJLX-ray3.40A/B65-783[»]
ProteinModelPortaliQ8N608.
SMRiQ8N608.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121672. 4 interactors.
IntActiQ8N608. 1 interactor.
STRINGi9606.ENSP00000376855.

Protein family/group databases

ESTHERihuman-DPP10. DPP4N_Peptidase_S9.
MEROPSiS09.974.

PTM databases

iPTMnetiQ8N608.
PhosphoSitePlusiQ8N608.

Polymorphism and mutation databases

BioMutaiDPP10.
DMDMi296434483.

Proteomic databases

MaxQBiQ8N608.
PaxDbiQ8N608.
PeptideAtlasiQ8N608.
PRIDEiQ8N608.

Protocols and materials databases

DNASUi57628.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310323; ENSP00000309066; ENSG00000175497. [Q8N608-2]
ENST00000393147; ENSP00000376855; ENSG00000175497. [Q8N608-3]
ENST00000409163; ENSP00000387038; ENSG00000175497. [Q8N608-4]
ENST00000410059; ENSP00000386565; ENSG00000175497. [Q8N608-1]
GeneIDi57628.
KEGGihsa:57628.
UCSCiuc002tla.3. human. [Q8N608-1]

Organism-specific databases

CTDi57628.
DisGeNETi57628.
GeneCardsiDPP10.
HGNCiHGNC:20823. DPP10.
HPAiHPA048767.
MIMi600807. phenotype.
608209. gene.
neXtProtiNX_Q8N608.
OpenTargetsiENSG00000175497.
PharmGKBiPA134991647.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2100. Eukaryota.
COG1506. LUCA.
GeneTreeiENSGT00760000119233.
HOGENOMiHOG000231875.
HOVERGENiHBG105877.
InParanoidiQ8N608.
OMAiVIYNIHT.
OrthoDBiEOG091G0GBJ.
PhylomeDBiQ8N608.
TreeFamiTF313309.

Miscellaneous databases

ChiTaRSiDPP10. human.
GeneWikiiDPP10.
GenomeRNAii57628.
PROiQ8N608.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175497.
CleanExiHS_DPP10.
ExpressionAtlasiQ8N608. baseline and differential.
GenevisibleiQ8N608. HS.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPP10_HUMAN
AccessioniPrimary (citable) accession number: Q8N608
Secondary accession number(s): A8K1Q2
, J3KPP2, J3KQ46, Q0GLB8, Q53QT3, Q53S86, Q53SL8, Q53SS4, Q6TTV4, Q86YR9, Q9P236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Gly-651 is present instead of the conserved Ser which is expected to be an active site residue suggesting that this protein has no peptidase activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.