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Q8N608

- DPP10_HUMAN

UniProt

Q8N608 - DPP10_HUMAN

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Protein

Inactive dipeptidyl peptidase 10

Gene

DPP10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has no dipeptidyl aminopeptidase activity. May modulate cell surface expression and activity of the potassium channels KCND1 and KCND2.3 Publications

GO - Molecular functioni

  1. serine-type peptidase activity Source: InterPro
Complete GO annotation...

Protein family/group databases

MEROPSiS09.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive dipeptidyl peptidase 10
Alternative name(s):
Dipeptidyl peptidase IV-related protein 3
Short name:
DPRP-3
Dipeptidyl peptidase X
Short name:
DPP X
Dipeptidyl peptidase-like protein 2
Short name:
DPL2
Gene namesi
Name:DPP10
Synonyms:DPRP3, KIAA1492
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:20823. DPP10.

Subcellular locationi

Membrane 2 Publications; Single-pass type II membrane protein 2 Publications

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.2 Publications
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi257 – 2571N → Q: Abolishes sorting to the cell surface and dimerization. 1 Publication

Keywords - Diseasei

Asthma

Organism-specific databases

MIMi600807. phenotype.
PharmGKBiPA134991647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 796796Inactive dipeptidyl peptidase 10PRO_0000122417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...)1 Publication
Glycosylationi111 – 1111N-linked (GlcNAc...)1 Publication
Glycosylationi119 – 1191N-linked (GlcNAc...)1 Publication
Modified residuei138 – 1381Phosphotyrosine1 Publication
Modified residuei143 – 1431Phosphotyrosine1 Publication
Glycosylationi257 – 2571N-linked (GlcNAc...)1 Publication
Glycosylationi342 – 3421N-linked (GlcNAc...)1 Publication
Glycosylationi748 – 7481N-linked (GlcNAc...)1 Publication

Post-translational modificationi

N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8N608.
PaxDbiQ8N608.
PRIDEiQ8N608.

PTM databases

PhosphoSiteiQ8N608.

Expressioni

Tissue specificityi

Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.2 Publications

Gene expression databases

BgeeiQ8N608.
CleanExiHS_DPP10.
ExpressionAtlasiQ8N608. baseline and differential.
GenevestigatoriQ8N608.

Organism-specific databases

HPAiHPA048767.

Interactioni

Subunit structurei

May form oligomers. Interacts with KCND1 (Probable). Interacts with KCND2.2 PublicationsCurated

Protein-protein interaction databases

BioGridi121672. 4 interactions.
IntActiQ8N608. 1 interaction.
STRINGi9606.ENSP00000386565.

Structurei

3D structure databases

ProteinModelPortaliQ8N608.
SMRiQ8N608. Positions 66-782.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini56 – 796741ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5656Mediates effects on KCND2Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S9B family. DPPIV subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1506.
GeneTreeiENSGT00760000119233.
HOVERGENiHBG105877.
InParanoidiQ8N608.
OMAiNWEVIKI.
OrthoDBiEOG7H791M.
PhylomeDBiQ8N608.
TreeFamiTF313309.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist, which may have different subcellular locations.

Isoform 1 (identifier: Q8N608-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNQTASVSHH IKCQPSKTIK ELGSNSPPQR NWKGIAIALL VILVVCSLIT
60 70 80 90 100
MSVILLTPDE LTNSSETRLS LEDLFRKDFV LHDPEARWIN DTDVVYKSEN
110 120 130 140 150
GHVIKLNIET NATTLLLENT TFVTFKASRH SVSPDLKYVL LAYDVKQIFH
160 170 180 190 200
YSYTASYVIY NIHTREVWEL NPPEVEDSVL QYAAWGVQGQ QLIYIFENNI
210 220 230 240 250
YYQPDIKSSS LRLTSSGKEE IIFNGIADWL YEEELLHSHI AHWWSPDGER
260 270 280 290 300
LAFLMINDSL VPTMVIPRFT GALYPKGKQY PYPKAGQVNP TIKLYVVNLY
310 320 330 340 350
GPTHTLELMP PDSFKSREYY ITMVKWVSNT KTVVRWLNRA QNISILTVCE
360 370 380 390 400
TTTGACSKKY EMTSDTWLSQ QNEEPVFSRD GSKFFMTVPV KQGGRGEFHH
410 420 430 440 450
VAMFLIQSKS EQITVRHLTS GNWEVIKILA YDETTQKIYF LSTESSPRGR
460 470 480 490 500
QLYSASTEGL LNRQCISCNF MKEQCTYFDA SFSPMNQHFL LFCEGPRVPV
510 520 530 540 550
VSLHSTDNPA KYFILESNSM LKEAILKKKI GKPEIKILHI DDYELPLQLS
560 570 580 590 600
LPKDFMDRNQ YALLLIMDEE PGGQLVTDKF HIDWDSVLID MDNVIVARFD
610 620 630 640 650
GRGSGFQGLK ILQEIHRRLG SVEVKDQITA VKFLLKLPYI DSKRLSIFGK
660 670 680 690 700
GYGGYIASMI LKSDEKLFKC GSVVAPITDL KLYASAFSER YLGMPSKEES
710 720 730 740 750
TYQAASVLHN VHGLKEENIL IIHGTADTKV HFQHSAELIK HLIKAGVNYT
760 770 780 790
MQVYPDEGHN VSEKSKYHLY STILKFFSDC LKEEISVLPQ EPEEDE
Length:796
Mass (Da):90,888
Last modified:May 18, 2010 - v2
Checksum:i072CBD67D1FB478E
GO
Isoform 2 (identifier: Q8N608-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNQTASVSHHIKCQPSKTIK → MRKVESRGEGGRE

Show »
Length:789
Mass (Da):90,140
Checksum:iF1746DDCA46C0744
GO
Isoform 3 (identifier: Q8N608-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNQTASVSHHIKCQPSKTIK → MTAAKQEPQPTPGARASQAQPADQ

Show »
Length:800
Mass (Da):91,129
Checksum:iC837D61773C3E890
GO
Isoform 4 (identifier: Q8N608-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Note: Gene prediction based on EST data.

Show »
Length:746
Mass (Da):85,480
Checksum:iF71826F40623C64D
GO

Sequence cautioni

The sequence BAA96016.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti288 – 2881V → M in AAO17263. (PubMed:12662155)Curated
Sequence conflicti288 – 2881V → M in BAF82656. (PubMed:10819331)Curated
Sequence conflicti288 – 2881V → M in AAH30832. (PubMed:15815621)Curated
Sequence conflicti687 – 6871F → L in AAQ91190. (PubMed:12675227)Curated
Isoform 3 (identifier: Q8N608-3)
Sequence conflicti4 – 41A → M in ABI16086. (PubMed:16899223)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti340 – 3401A → P.2 Publications
Corresponds to variant rs2053724 [ dbSNP | Ensembl ].
VAR_057061
Natural varianti401 – 4011V → I.7 Publications
Corresponds to variant rs1446495 [ dbSNP | Ensembl ].
VAR_059759
Natural varianti517 – 5171S → N.
Corresponds to variant rs13421193 [ dbSNP | Ensembl ].
VAR_057062

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5050Missing in isoform 4. CuratedVSP_047152Add
BLAST
Alternative sequencei1 – 2020MNQTA…SKTIK → MRKVESRGEGGRE in isoform 2. 2 PublicationsVSP_013873Add
BLAST
Alternative sequencei1 – 2020MNQTA…SKTIK → MTAAKQEPQPTPGARASQAQ PADQ in isoform 3. 1 PublicationVSP_044466Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY387785 mRNA. Translation: AAQ91190.1.
AY172661 mRNA. Translation: AAO17263.2.
AB040925 mRNA. Translation: BAA96016.2. Different initiation.
DQ857322 mRNA. Translation: ABI16086.1.
AK289967 mRNA. Translation: BAF82656.1.
AC010885 Genomic DNA. No translation available.
AC012071 Genomic DNA. No translation available.
AC016721 Genomic DNA. Translation: AAY15025.1.
AC017040 Genomic DNA. Translation: AAY15032.1.
AC066593 Genomic DNA. No translation available.
AC067947 Genomic DNA. Translation: AAY14685.1.
AC068542 Genomic DNA. No translation available.
AC093610 Genomic DNA. No translation available.
AC105422 Genomic DNA. Translation: AAY24120.1.
AC116620 Genomic DNA. No translation available.
AC118276 Genomic DNA. No translation available.
AC118664 Genomic DNA. No translation available.
BC030832 mRNA. Translation: AAH30832.1.
CCDSiCCDS33278.1. [Q8N608-2]
CCDS46400.1. [Q8N608-1]
CCDS54388.1. [Q8N608-3]
CCDS54389.1. [Q8N608-4]
RefSeqiNP_001004360.2. NM_001004360.3.
NP_001171505.1. NM_001178034.1.
NP_065919.2. NM_020868.3.
UniGeneiHs.580539.

Genome annotation databases

EnsembliENST00000310323; ENSP00000309066; ENSG00000175497. [Q8N608-2]
ENST00000393147; ENSP00000376855; ENSG00000175497. [Q8N608-3]
ENST00000409163; ENSP00000387038; ENSG00000175497. [Q8N608-4]
ENST00000410059; ENSP00000386565; ENSG00000175497. [Q8N608-1]
GeneIDi57628.
KEGGihsa:57628.
UCSCiuc002tle.3. human. [Q8N608-3]

Polymorphism databases

DMDMi296434483.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY387785 mRNA. Translation: AAQ91190.1 .
AY172661 mRNA. Translation: AAO17263.2 .
AB040925 mRNA. Translation: BAA96016.2 . Different initiation.
DQ857322 mRNA. Translation: ABI16086.1 .
AK289967 mRNA. Translation: BAF82656.1 .
AC010885 Genomic DNA. No translation available.
AC012071 Genomic DNA. No translation available.
AC016721 Genomic DNA. Translation: AAY15025.1 .
AC017040 Genomic DNA. Translation: AAY15032.1 .
AC066593 Genomic DNA. No translation available.
AC067947 Genomic DNA. Translation: AAY14685.1 .
AC068542 Genomic DNA. No translation available.
AC093610 Genomic DNA. No translation available.
AC105422 Genomic DNA. Translation: AAY24120.1 .
AC116620 Genomic DNA. No translation available.
AC118276 Genomic DNA. No translation available.
AC118664 Genomic DNA. No translation available.
BC030832 mRNA. Translation: AAH30832.1 .
CCDSi CCDS33278.1. [Q8N608-2 ]
CCDS46400.1. [Q8N608-1 ]
CCDS54388.1. [Q8N608-3 ]
CCDS54389.1. [Q8N608-4 ]
RefSeqi NP_001004360.2. NM_001004360.3.
NP_001171505.1. NM_001178034.1.
NP_065919.2. NM_020868.3.
UniGenei Hs.580539.

3D structure databases

ProteinModelPortali Q8N608.
SMRi Q8N608. Positions 66-782.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121672. 4 interactions.
IntActi Q8N608. 1 interaction.
STRINGi 9606.ENSP00000386565.

Protein family/group databases

MEROPSi S09.974.

PTM databases

PhosphoSitei Q8N608.

Polymorphism databases

DMDMi 296434483.

Proteomic databases

MaxQBi Q8N608.
PaxDbi Q8N608.
PRIDEi Q8N608.

Protocols and materials databases

DNASUi 57628.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310323 ; ENSP00000309066 ; ENSG00000175497 . [Q8N608-2 ]
ENST00000393147 ; ENSP00000376855 ; ENSG00000175497 . [Q8N608-3 ]
ENST00000409163 ; ENSP00000387038 ; ENSG00000175497 . [Q8N608-4 ]
ENST00000410059 ; ENSP00000386565 ; ENSG00000175497 . [Q8N608-1 ]
GeneIDi 57628.
KEGGi hsa:57628.
UCSCi uc002tle.3. human. [Q8N608-3 ]

Organism-specific databases

CTDi 57628.
GeneCardsi GC02P115295.
HGNCi HGNC:20823. DPP10.
HPAi HPA048767.
MIMi 600807. phenotype.
608209. gene.
neXtProti NX_Q8N608.
PharmGKBi PA134991647.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1506.
GeneTreei ENSGT00760000119233.
HOVERGENi HBG105877.
InParanoidi Q8N608.
OMAi NWEVIKI.
OrthoDBi EOG7H791M.
PhylomeDBi Q8N608.
TreeFami TF313309.

Miscellaneous databases

ChiTaRSi DPP10. human.
GeneWikii DPP10.
GenomeRNAii 57628.
NextBioi 35535176.
PROi Q8N608.
SOURCEi Search...

Gene expression databases

Bgeei Q8N608.
CleanExi HS_DPP10.
ExpressionAtlasi Q8N608. baseline and differential.
Genevestigatori Q8N608.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dipeptidyl peptidase IV gene family. The DPIV family."
    Chen T., Ajami K., McCaughan G.W., Gorrell M.D., Abbott C.A.
    Adv. Exp. Med. Biol. 524:79-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS PRO-340 AND ILE-401.
    Tissue: Brain.
  2. "Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases."
    Qi S.Y., Riviere P.J., Trojnar J., Junien J.-L., Akinsanya K.O.
    Biochem. J. 373:179-189(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT ILE-401.
    Tissue: Hypothalamus.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INVOLVEMENT IN ASTHMA, VARIANT ILE-401.
  4. "Species and tissue differences in the expression of DPPY splicing variants."
    Takimoto K., Hayashi Y., Ren X., Yoshimura N.
    Biochem. Biophys. Res. Commun. 348:1094-1100(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT ILE-401, ALTERNATIVE SPLICING.
  5. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS PRO-340 AND ILE-401.
    Tissue: Brain.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-401.
    Tissue: Hippocampus.
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-401.
    Tissue: Brain.
  9. "Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)."
    Jerng H.H., Qian Y., Pfaffinger P.J.
    Biophys. J. 87:2380-2396(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GLYCOSYLATION, INTERACTION WITH KCND1 AND KCND2.
  10. Cited for: FUNCTION.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-138 AND TYR-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort."
    Blakey J.D., Sayers I., Ring S.M., Strachan D.P., Hall I.P.
    Thorax 64:381-387(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA.
  13. "N-glycosylation of the mammalian dipeptidyl aminopeptidase-like protein 10 (DPP10) regulates trafficking and interaction with Kv4 channels."
    Cotella D., Radicke S., Cipriani V., Cavaletto M., Merlin S., Follenzi A., Ravens U., Wettwer E., Santoro C., Sblattero D.
    Int. J. Biochem. Cell Biol. 44:876-885(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-90; ASN-111; ASN-119; ASN-257; ASN-342 AND ASN-748, MUTAGENESIS OF ASN-257.

Entry informationi

Entry nameiDPP10_HUMAN
AccessioniPrimary (citable) accession number: Q8N608
Secondary accession number(s): A8K1Q2
, J3KPP2, J3KQ46, Q0GLB8, Q53QT3, Q53S86, Q53SL8, Q53SS4, Q6TTV4, Q86YR9, Q9P236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3