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Q8N608

- DPP10_HUMAN

UniProt

Q8N608 - DPP10_HUMAN

Protein

Inactive dipeptidyl peptidase 10

Gene

DPP10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Has no dipeptidyl aminopeptidase activity. May modulate cell surface expression and activity of the potassium channels KCND1 and KCND2.3 Publications

    GO - Molecular functioni

    1. serine-type peptidase activity Source: InterPro

    Protein family/group databases

    MEROPSiS09.974.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive dipeptidyl peptidase 10
    Alternative name(s):
    Dipeptidyl peptidase IV-related protein 3
    Short name:
    DPRP-3
    Dipeptidyl peptidase X
    Short name:
    DPP X
    Dipeptidyl peptidase-like protein 2
    Short name:
    DPL2
    Gene namesi
    Name:DPP10
    Synonyms:DPRP3, KIAA1492
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:20823. DPP10.

    Subcellular locationi

    Membrane 2 Publications; Single-pass type II membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.2 Publications
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi257 – 2571N → Q: Abolishes sorting to the cell surface and dimerization. 1 Publication

    Keywords - Diseasei

    Asthma

    Organism-specific databases

    MIMi600807. phenotype.
    PharmGKBiPA134991647.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 796796Inactive dipeptidyl peptidase 10PRO_0000122417Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi90 – 901N-linked (GlcNAc...)2 Publications
    Glycosylationi111 – 1111N-linked (GlcNAc...)2 Publications
    Glycosylationi119 – 1191N-linked (GlcNAc...)2 Publications
    Modified residuei138 – 1381Phosphotyrosine1 Publication
    Modified residuei143 – 1431Phosphotyrosine1 Publication
    Glycosylationi257 – 2571N-linked (GlcNAc...)2 Publications
    Glycosylationi342 – 3421N-linked (GlcNAc...)2 Publications
    Glycosylationi748 – 7481N-linked (GlcNAc...)2 Publications

    Post-translational modificationi

    N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.2 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ8N608.
    PaxDbiQ8N608.
    PRIDEiQ8N608.

    PTM databases

    PhosphoSiteiQ8N608.

    Expressioni

    Tissue specificityi

    Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.2 Publications

    Gene expression databases

    ArrayExpressiQ8N608.
    BgeeiQ8N608.
    CleanExiHS_DPP10.
    GenevestigatoriQ8N608.

    Organism-specific databases

    HPAiHPA048767.

    Interactioni

    Subunit structurei

    May form oligomers. Interacts with KCND1 Probable. Interacts with KCND2.2 PublicationsCurated

    Protein-protein interaction databases

    BioGridi121672. 4 interactions.
    IntActiQ8N608. 1 interaction.
    STRINGi9606.ENSP00000386565.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N608.
    SMRiQ8N608. Positions 66-782.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini56 – 796741ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5656Mediates effects on KCND2Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S9B family. DPPIV subfamily.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1506.
    HOVERGENiHBG105877.
    OMAiNWEVIKI.
    OrthoDBiEOG7H791M.
    PhylomeDBiQ8N608.
    TreeFamiTF313309.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist, which may have different subcellular locations.

    Isoform 1 (identifier: Q8N608-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNQTASVSHH IKCQPSKTIK ELGSNSPPQR NWKGIAIALL VILVVCSLIT    50
    MSVILLTPDE LTNSSETRLS LEDLFRKDFV LHDPEARWIN DTDVVYKSEN 100
    GHVIKLNIET NATTLLLENT TFVTFKASRH SVSPDLKYVL LAYDVKQIFH 150
    YSYTASYVIY NIHTREVWEL NPPEVEDSVL QYAAWGVQGQ QLIYIFENNI 200
    YYQPDIKSSS LRLTSSGKEE IIFNGIADWL YEEELLHSHI AHWWSPDGER 250
    LAFLMINDSL VPTMVIPRFT GALYPKGKQY PYPKAGQVNP TIKLYVVNLY 300
    GPTHTLELMP PDSFKSREYY ITMVKWVSNT KTVVRWLNRA QNISILTVCE 350
    TTTGACSKKY EMTSDTWLSQ QNEEPVFSRD GSKFFMTVPV KQGGRGEFHH 400
    VAMFLIQSKS EQITVRHLTS GNWEVIKILA YDETTQKIYF LSTESSPRGR 450
    QLYSASTEGL LNRQCISCNF MKEQCTYFDA SFSPMNQHFL LFCEGPRVPV 500
    VSLHSTDNPA KYFILESNSM LKEAILKKKI GKPEIKILHI DDYELPLQLS 550
    LPKDFMDRNQ YALLLIMDEE PGGQLVTDKF HIDWDSVLID MDNVIVARFD 600
    GRGSGFQGLK ILQEIHRRLG SVEVKDQITA VKFLLKLPYI DSKRLSIFGK 650
    GYGGYIASMI LKSDEKLFKC GSVVAPITDL KLYASAFSER YLGMPSKEES 700
    TYQAASVLHN VHGLKEENIL IIHGTADTKV HFQHSAELIK HLIKAGVNYT 750
    MQVYPDEGHN VSEKSKYHLY STILKFFSDC LKEEISVLPQ EPEEDE 796
    Length:796
    Mass (Da):90,888
    Last modified:May 18, 2010 - v2
    Checksum:i072CBD67D1FB478E
    GO
    Isoform 2 (identifier: Q8N608-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: MNQTASVSHHIKCQPSKTIK → MRKVESRGEGGRE

    Show »
    Length:789
    Mass (Da):90,140
    Checksum:iF1746DDCA46C0744
    GO
    Isoform 3 (identifier: Q8N608-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: MNQTASVSHHIKCQPSKTIK → MTAAKQEPQPTPGARASQAQPADQ

    Show »
    Length:800
    Mass (Da):91,129
    Checksum:iC837D61773C3E890
    GO
    Isoform 4 (identifier: Q8N608-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-50: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:746
    Mass (Da):85,480
    Checksum:iF71826F40623C64D
    GO

    Sequence cautioni

    The sequence BAA96016.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti288 – 2881V → M in AAO17263. (PubMed:12662155)Curated
    Sequence conflicti288 – 2881V → M in BAF82656. (PubMed:10819331)Curated
    Sequence conflicti288 – 2881V → M in AAH30832. (PubMed:15815621)Curated
    Sequence conflicti687 – 6871F → L in AAQ91190. (PubMed:12675227)Curated
    Isoform 3 (identifier: Q8N608-3)
    Sequence conflicti4 – 41A → M in ABI16086. (PubMed:16899223)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti340 – 3401A → P.2 Publications
    Corresponds to variant rs2053724 [ dbSNP | Ensembl ].
    VAR_057061
    Natural varianti401 – 4011V → I.7 Publications
    Corresponds to variant rs1446495 [ dbSNP | Ensembl ].
    VAR_059759
    Natural varianti517 – 5171S → N.
    Corresponds to variant rs13421193 [ dbSNP | Ensembl ].
    VAR_057062

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5050Missing in isoform 4. CuratedVSP_047152Add
    BLAST
    Alternative sequencei1 – 2020MNQTA…SKTIK → MRKVESRGEGGRE in isoform 2. 2 PublicationsVSP_013873Add
    BLAST
    Alternative sequencei1 – 2020MNQTA…SKTIK → MTAAKQEPQPTPGARASQAQ PADQ in isoform 3. 1 PublicationVSP_044466Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY387785 mRNA. Translation: AAQ91190.1.
    AY172661 mRNA. Translation: AAO17263.2.
    AB040925 mRNA. Translation: BAA96016.2. Different initiation.
    DQ857322 mRNA. Translation: ABI16086.1.
    AK289967 mRNA. Translation: BAF82656.1.
    AC010885 Genomic DNA. No translation available.
    AC012071 Genomic DNA. No translation available.
    AC016721 Genomic DNA. Translation: AAY15025.1.
    AC017040 Genomic DNA. Translation: AAY15032.1.
    AC066593 Genomic DNA. No translation available.
    AC067947 Genomic DNA. Translation: AAY14685.1.
    AC068542 Genomic DNA. No translation available.
    AC093610 Genomic DNA. No translation available.
    AC105422 Genomic DNA. Translation: AAY24120.1.
    AC116620 Genomic DNA. No translation available.
    AC118276 Genomic DNA. No translation available.
    AC118664 Genomic DNA. No translation available.
    BC030832 mRNA. Translation: AAH30832.1.
    CCDSiCCDS33278.1. [Q8N608-2]
    CCDS46400.1. [Q8N608-1]
    CCDS54388.1. [Q8N608-3]
    CCDS54389.1. [Q8N608-4]
    RefSeqiNP_001004360.2. NM_001004360.3.
    NP_001171505.1. NM_001178034.1.
    NP_065919.2. NM_020868.3.
    UniGeneiHs.580539.

    Genome annotation databases

    EnsembliENST00000310323; ENSP00000309066; ENSG00000175497. [Q8N608-2]
    ENST00000393147; ENSP00000376855; ENSG00000175497. [Q8N608-3]
    ENST00000409163; ENSP00000387038; ENSG00000175497. [Q8N608-4]
    ENST00000410059; ENSP00000386565; ENSG00000175497. [Q8N608-1]
    GeneIDi57628.
    KEGGihsa:57628.
    UCSCiuc002tle.3. human. [Q8N608-3]

    Polymorphism databases

    DMDMi296434483.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY387785 mRNA. Translation: AAQ91190.1 .
    AY172661 mRNA. Translation: AAO17263.2 .
    AB040925 mRNA. Translation: BAA96016.2 . Different initiation.
    DQ857322 mRNA. Translation: ABI16086.1 .
    AK289967 mRNA. Translation: BAF82656.1 .
    AC010885 Genomic DNA. No translation available.
    AC012071 Genomic DNA. No translation available.
    AC016721 Genomic DNA. Translation: AAY15025.1 .
    AC017040 Genomic DNA. Translation: AAY15032.1 .
    AC066593 Genomic DNA. No translation available.
    AC067947 Genomic DNA. Translation: AAY14685.1 .
    AC068542 Genomic DNA. No translation available.
    AC093610 Genomic DNA. No translation available.
    AC105422 Genomic DNA. Translation: AAY24120.1 .
    AC116620 Genomic DNA. No translation available.
    AC118276 Genomic DNA. No translation available.
    AC118664 Genomic DNA. No translation available.
    BC030832 mRNA. Translation: AAH30832.1 .
    CCDSi CCDS33278.1. [Q8N608-2 ]
    CCDS46400.1. [Q8N608-1 ]
    CCDS54388.1. [Q8N608-3 ]
    CCDS54389.1. [Q8N608-4 ]
    RefSeqi NP_001004360.2. NM_001004360.3.
    NP_001171505.1. NM_001178034.1.
    NP_065919.2. NM_020868.3.
    UniGenei Hs.580539.

    3D structure databases

    ProteinModelPortali Q8N608.
    SMRi Q8N608. Positions 66-782.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121672. 4 interactions.
    IntActi Q8N608. 1 interaction.
    STRINGi 9606.ENSP00000386565.

    Protein family/group databases

    MEROPSi S09.974.

    PTM databases

    PhosphoSitei Q8N608.

    Polymorphism databases

    DMDMi 296434483.

    Proteomic databases

    MaxQBi Q8N608.
    PaxDbi Q8N608.
    PRIDEi Q8N608.

    Protocols and materials databases

    DNASUi 57628.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310323 ; ENSP00000309066 ; ENSG00000175497 . [Q8N608-2 ]
    ENST00000393147 ; ENSP00000376855 ; ENSG00000175497 . [Q8N608-3 ]
    ENST00000409163 ; ENSP00000387038 ; ENSG00000175497 . [Q8N608-4 ]
    ENST00000410059 ; ENSP00000386565 ; ENSG00000175497 . [Q8N608-1 ]
    GeneIDi 57628.
    KEGGi hsa:57628.
    UCSCi uc002tle.3. human. [Q8N608-3 ]

    Organism-specific databases

    CTDi 57628.
    GeneCardsi GC02P115295.
    HGNCi HGNC:20823. DPP10.
    HPAi HPA048767.
    MIMi 600807. phenotype.
    608209. gene.
    neXtProti NX_Q8N608.
    PharmGKBi PA134991647.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1506.
    HOVERGENi HBG105877.
    OMAi NWEVIKI.
    OrthoDBi EOG7H791M.
    PhylomeDBi Q8N608.
    TreeFami TF313309.

    Miscellaneous databases

    ChiTaRSi DPP10. human.
    GeneWikii DPP10.
    GenomeRNAii 57628.
    NextBioi 35535176.
    PROi Q8N608.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N608.
    Bgeei Q8N608.
    CleanExi HS_DPP10.
    Genevestigatori Q8N608.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Dipeptidyl peptidase IV gene family. The DPIV family."
      Chen T., Ajami K., McCaughan G.W., Gorrell M.D., Abbott C.A.
      Adv. Exp. Med. Biol. 524:79-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS PRO-340 AND ILE-401.
      Tissue: Brain.
    2. "Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases."
      Qi S.Y., Riviere P.J., Trojnar J., Junien J.-L., Akinsanya K.O.
      Biochem. J. 373:179-189(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT ILE-401.
      Tissue: Hypothalamus.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INVOLVEMENT IN ASTHMA, VARIANT ILE-401.
    4. "Species and tissue differences in the expression of DPPY splicing variants."
      Takimoto K., Hayashi Y., Ren X., Yoshimura N.
      Biochem. Biophys. Res. Commun. 348:1094-1100(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT ILE-401, ALTERNATIVE SPLICING.
    5. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS PRO-340 AND ILE-401.
      Tissue: Brain.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-401.
      Tissue: Hippocampus.
    7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-401.
      Tissue: Brain.
    9. "Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)."
      Jerng H.H., Qian Y., Pfaffinger P.J.
      Biophys. J. 87:2380-2396(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, GLYCOSYLATION, INTERACTION WITH KCND1 AND KCND2.
    10. Cited for: FUNCTION.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-138 AND TYR-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort."
      Blakey J.D., Sayers I., Ring S.M., Strachan D.P., Hall I.P.
      Thorax 64:381-387(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA.
    13. "N-glycosylation of the mammalian dipeptidyl aminopeptidase-like protein 10 (DPP10) regulates trafficking and interaction with Kv4 channels."
      Cotella D., Radicke S., Cipriani V., Cavaletto M., Merlin S., Follenzi A., Ravens U., Wettwer E., Santoro C., Sblattero D.
      Int. J. Biochem. Cell Biol. 44:876-885(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-90; ASN-111; ASN-119; ASN-257; ASN-342 AND ASN-748, MUTAGENESIS OF ASN-257.

    Entry informationi

    Entry nameiDPP10_HUMAN
    AccessioniPrimary (citable) accession number: Q8N608
    Secondary accession number(s): A8K1Q2
    , J3KPP2, J3KQ46, Q0GLB8, Q53QT3, Q53S86, Q53SL8, Q53SS4, Q6TTV4, Q86YR9, Q9P236
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3