Q8N5Y8 (PAR16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly [ADP-ribose] polymerase 16
Short name=PARP-16
EC=2.4.2.30

Gene names

Name:	PARP16
Synonyms:	C15orf30

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Contains 1 PARP catalytic domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	NAD
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N5Y8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N5Y8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     59-173: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8N5Y8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     277-277: K → KS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Poly [ADP-ribose] polymerase 16		PRO_0000252437
Regions
	Transmembrane	288 – 308	21	Helical; Potential
	Domain	77 – 280	204	PARP catalytic
	Compositional bias	297 – 303	7	Poly-Leu
Natural variations
	Alternative sequence	59 – 173	115	Missing in isoform 2.		VSP_020973
	Alternative sequence	277	1	K → KS in isoform 3.		VSP_020974
	Natural variant	280	1	S → P. Ref.2 Corresponds to variant rs17852901 [ dbSNP | Ensembl ].		VAR_027864

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: DA1C99E8A1305982	FASTA	322	36,383
	10 20 30 40 50 60 MQPSGWAAAR EAAGRDMLAA DLRCSLFASA LQSYKRDSVL RPFPASYARG DCKDFEALLA 70 80 90 100 110 120 DASKLPNLKE LLQSSGDNHK RAWDLVSWIL SSKVLTIHSA GKAEFEKIQK LTGAPHTPVP 130 140 150 160 170 180 APDFLFEIEY FDPANAKFYE TKGERDLIYA FHGSRLENFH SIIHNGLHCH LNKTSLFGEG 190 200 210 220 230 240 TYLTSDLSLA LIYSPHGHGW QHSLLGPILS CVAVCEVIDH PDVKCQTKKK DSKEIDRRRA 250 260 270 280 290 300 RIKHSEGGDI PPKYFVVTNN QLLRVKYLLV YSQKPPKRAS SQLSWFSSHW FTVMISLYLL 310 320 LLLIVSVINS SAFQHFWNRA KR
	Isoform 2 [UniParc]. Checksum: 5D9F59FCAFBBBA13	FASTA	207	23,378
	10 20 30 40 50 60 MQPSGWAAAR EAAGRDMLAA DLRCSLFASA LQSYKRDSVL RPFPASYARG DCKDFEALTS 70 80 90 100 110 120 LFGEGTYLTS DLSLALIYSP HGHGWQHSLL GPILSCVAVC EVIDHPDVKC QTKKKDSKEI 130 140 150 160 170 180 DRRRARIKHS EGGDIPPKYF VVTNNQLLRV KYLLVYSQKP PKRASSQLSW FSSHWFTVMI 190 200 SLYLLLLLIV SVINSSAFQH FWNRAKR
	Isoform 3 [UniParc]. Checksum: 3F3ED063887CB0EE	FASTA	323	36,470
	10 20 30 40 50 60 MQPSGWAAAR EAAGRDMLAA DLRCSLFASA LQSYKRDSVL RPFPASYARG DCKDFEALLA 70 80 90 100 110 120 DASKLPNLKE LLQSSGDNHK RAWDLVSWIL SSKVLTIHSA GKAEFEKIQK LTGAPHTPVP 130 140 150 160 170 180 APDFLFEIEY FDPANAKFYE TKGERDLIYA FHGSRLENFH SIIHNGLHCH LNKTSLFGEG 190 200 210 220 230 240 TYLTSDLSLA LIYSPHGHGW QHSLLGPILS CVAVCEVIDH PDVKCQTKKK DSKEIDRRRA 250 260 270 280 290 300 RIKHSEGGDI PPKYFVVTNN QLLRVKYLLV YSQKPPKSRA SSQLSWFSSH WFTVMISLYL 310 320 LLLLIVSVIN SSAFQHFWNR AKR

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Carcinoma.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT PRO-280. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000516 mRNA. Translation: BAA91222.1. BC006389 mRNA. Translation: AAH06389.1. BC031074 mRNA. Translation: AAH31074.1.
IPI	IPI00016479. IPI00297151. IPI00794653.
RefSeq	NP_060321.3. NM_017851.4.
UniGene	Hs.30634.
3D structure databases
ProteinModelPortal	Q8N5Y8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8N5Y8.
PTM databases
PhosphoSite	Q8N5Y8.
Polymorphism databases
DMDM	116248565.
Proteomic databases
PRIDE	Q8N5Y8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000432843; ENSP00000399999; ENSG00000138617.
GeneID	54956.
KEGG	hsa:54956.
UCSC	uc002aoo.2. human. uc002aop.2. human. uc002aoq.1. human.
Organism-specific databases
CTD	54956.
GeneCards	GC15M065550.
HGNC	HGNC:26040. PARP16.
HPA	HPA017081.
neXtProt	NX_Q8N5Y8.
PharmGKB	PA134984504.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10390.
GeneTree	ENSGT00390000014077.
HOVERGEN	HBG058859.
InParanoid	Q8N5Y8.
OMA	AVCEIID.
Enzyme and pathway databases
BRENDA	2.4.2.30. 2681.
Gene expression databases
ArrayExpress	Q8N5Y8.
Bgee	Q8N5Y8.
CleanEx	HS_PARP16.
Genevestigator	Q8N5Y8.
GermOnline	ENSG00000138617. Homo sapiens.
Family and domain databases
InterPro	IPR012317. Poly(ADP-ribose)pol_cat_dom. [Graphical view]
KO	K00774.
Pfam	PF00644. PARP. 1 hit. [Graphical view]
PROSITE	PS51059. PARP_CATALYTIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	58144.

Entry information

Entry name

PAR16_HUMAN

Accession

Primary (citable) accession number: Q8N5Y8
Secondary accession number(s): Q6PK64, Q9NX03

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.