Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Eukaryotic translation initiation factor 4E type 3

Gene

EIF4E3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Translation regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E type 3
Short name:
eIF-4E type 3
Short name:
eIF-4E3
Short name:
eIF4E type 3
Short name:
eIF4E-3
Gene namesi
Name:EIF4E3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:31837. EIF4E3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961880.

Polymorphism and mutation databases

BioMutaiEIF4E3.
DMDMi156633293.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Eukaryotic translation initiation factor 4E type 3PRO_0000287697Add
BLAST

Proteomic databases

MaxQBiQ8N5X7.
PaxDbiQ8N5X7.
PRIDEiQ8N5X7.

PTM databases

iPTMnetiQ8N5X7.
PhosphoSiteiQ8N5X7.

Expressioni

Gene expression databases

BgeeiQ8N5X7.
CleanExiHS_EIF4E3.
ExpressionAtlasiQ8N5X7. baseline and differential.
GenevisibleiQ8N5X7. HS.

Organism-specific databases

HPAiHPA053106.

Interactioni

Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity). EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi130428. 5 interactions.
IntActiQ8N5X7. 2 interactions.
STRINGi9606.ENSP00000393324.

Structurei

3D structure databases

ProteinModelPortaliQ8N5X7.
SMRiQ8N5X7. Positions 35-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 11627-methylguanosine-containing mRNA cap bindingBy similarity
Regioni169 – 17467-methylguanosine-containing mRNA cap bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IHHQ. Eukaryota.
COG5053. LUCA.
GeneTreeiENSGT00520000055549.
HOGENOMiHOG000059588.
HOVERGENiHBG107990.
InParanoidiQ8N5X7.
OMAiGTWRLKC.
OrthoDBiEOG7X6M1B.
PhylomeDBiQ8N5X7.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiIPR023398. TIF_eIF4e-like.
IPR001040. TIF_eIF_4E.
[Graphical view]
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMiSSF55418. SSF55418. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N5X7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPPAAAPP AGAREPPGSR AAAAAAAPEP PLGLQQLSAL QPEPGGVPLH
60 70 80 90 100
SSWTFWLDRS LPGATAAECA SNLKKIYTVQ TVQIFWSVYN NIPPVTSLPL
110 120 130 140 150
RCSYHLMRGE RRPLWEEESN AKGGVWKMKV PKDSTSTVWK ELLLATIGEQ
160 170 180 190 200
FTDCAAADDE VIGVSVSVRD REDVVQVWNV NASLVGEATV LEKIYELLPH
210 220
ITFKAVFYKP HEEHHAFEGG RGKH
Length:224
Mass (Da):24,441
Last modified:July 24, 2007 - v4
Checksum:iC724BF3A6438D728
GO
Isoform 2 (identifier: Q8N5X7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:118
Mass (Da):13,333
Checksum:i8CD9AFBAD53D0E01
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 106106Missing in isoform 2. 2 PublicationsVSP_025602Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126999 mRNA. Translation: BAG54418.1.
AK313656 mRNA. Translation: BAG36410.1.
AC134770 Genomic DNA. No translation available.
BC031289 mRNA. Translation: AAH31289.3.
BC068443 mRNA. Translation: AAH68443.1.
CCDSiCCDS33786.1. [Q8N5X7-2]
CCDS46867.1. [Q8N5X7-1]
RefSeqiNP_001128121.1. NM_001134649.2. [Q8N5X7-2]
NP_001128122.1. NM_001134650.1. [Q8N5X7-2]
NP_001128123.1. NM_001134651.1. [Q8N5X7-1]
NP_001269815.1. NM_001282886.1. [Q8N5X7-2]
NP_775495.1. NM_173359.4. [Q8N5X7-2]
UniGeneiHs.581355.

Genome annotation databases

EnsembliENST00000295612; ENSP00000295612; ENSG00000163412. [Q8N5X7-2]
ENST00000389826; ENSP00000374476; ENSG00000163412. [Q8N5X7-2]
ENST00000421769; ENSP00000411762; ENSG00000163412. [Q8N5X7-2]
ENST00000425534; ENSP00000393324; ENSG00000163412. [Q8N5X7-1]
ENST00000448225; ENSP00000410350; ENSG00000163412. [Q8N5X7-2]
GeneIDi317649.
KEGGihsa:317649.
UCSCiuc003dov.5. human. [Q8N5X7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126999 mRNA. Translation: BAG54418.1.
AK313656 mRNA. Translation: BAG36410.1.
AC134770 Genomic DNA. No translation available.
BC031289 mRNA. Translation: AAH31289.3.
BC068443 mRNA. Translation: AAH68443.1.
CCDSiCCDS33786.1. [Q8N5X7-2]
CCDS46867.1. [Q8N5X7-1]
RefSeqiNP_001128121.1. NM_001134649.2. [Q8N5X7-2]
NP_001128122.1. NM_001134650.1. [Q8N5X7-2]
NP_001128123.1. NM_001134651.1. [Q8N5X7-1]
NP_001269815.1. NM_001282886.1. [Q8N5X7-2]
NP_775495.1. NM_173359.4. [Q8N5X7-2]
UniGeneiHs.581355.

3D structure databases

ProteinModelPortaliQ8N5X7.
SMRiQ8N5X7. Positions 35-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130428. 5 interactions.
IntActiQ8N5X7. 2 interactions.
STRINGi9606.ENSP00000393324.

PTM databases

iPTMnetiQ8N5X7.
PhosphoSiteiQ8N5X7.

Polymorphism and mutation databases

BioMutaiEIF4E3.
DMDMi156633293.

Proteomic databases

MaxQBiQ8N5X7.
PaxDbiQ8N5X7.
PRIDEiQ8N5X7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295612; ENSP00000295612; ENSG00000163412. [Q8N5X7-2]
ENST00000389826; ENSP00000374476; ENSG00000163412. [Q8N5X7-2]
ENST00000421769; ENSP00000411762; ENSG00000163412. [Q8N5X7-2]
ENST00000425534; ENSP00000393324; ENSG00000163412. [Q8N5X7-1]
ENST00000448225; ENSP00000410350; ENSG00000163412. [Q8N5X7-2]
GeneIDi317649.
KEGGihsa:317649.
UCSCiuc003dov.5. human. [Q8N5X7-1]

Organism-specific databases

CTDi317649.
GeneCardsiEIF4E3.
HGNCiHGNC:31837. EIF4E3.
HPAiHPA053106.
MIMi609896. gene.
neXtProtiNX_Q8N5X7.
PharmGKBiPA134961880.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHHQ. Eukaryota.
COG5053. LUCA.
GeneTreeiENSGT00520000055549.
HOGENOMiHOG000059588.
HOVERGENiHBG107990.
InParanoidiQ8N5X7.
OMAiGTWRLKC.
OrthoDBiEOG7X6M1B.
PhylomeDBiQ8N5X7.

Enzyme and pathway databases

ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.

Miscellaneous databases

ChiTaRSiEIF4E3. human.
GeneWikiiEIF4E3.
GenomeRNAii317649.
PROiQ8N5X7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N5X7.
CleanExiHS_EIF4E3.
ExpressionAtlasiQ8N5X7. baseline and differential.
GenevisibleiQ8N5X7. HS.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiIPR023398. TIF_eIF4e-like.
IPR001040. TIF_eIF_4E.
[Graphical view]
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMiSSF55418. SSF55418. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain and Cerebellum.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-224 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiIF4E3_HUMAN
AccessioniPrimary (citable) accession number: Q8N5X7
Secondary accession number(s): B2R963, Q6NUT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: June 8, 2016
This is version 102 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.