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Protein

Refilin-B

Gene

RFLNB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements.By similarity

GO - Molecular functioni

  • filamin binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Refilin-B
Alternative name(s):
Regulator of filamin protein B
Short name:
RefilinB
Gene namesi
Name:RFLNBImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000183688.4
HGNCiHGNC:28705 RFLNB
MIMi615928 gene
neXtProtiNX_Q8N5W9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi359845
PharmGKBiPA143485463

Polymorphism and mutation databases

BioMutaiFAM101B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002646311 – 214Refilin-BAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei26PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N5W9
MaxQBiQ8N5W9
PaxDbiQ8N5W9
PeptideAtlasiQ8N5W9
PRIDEiQ8N5W9

PTM databases

iPTMnetiQ8N5W9
PhosphoSitePlusiQ8N5W9

Miscellaneous databases

PMAP-CutDBQ8N5W9

Expressioni

Gene expression databases

BgeeiENSG00000183688
CleanExiHS_FAM101B
GenevisibleiQ8N5W9 HS

Organism-specific databases

HPAiHPA030879

Interactioni

Subunit structurei

Interacts with FLNA and FLNB.By similarity

GO - Molecular functioni

  • filamin binding Source: MGI

Protein-protein interaction databases

BioGridi131787, 10 interactors
IntActiQ8N5W9, 5 interactors
STRINGi9606.ENSP00000331915

Structurei

3D structure databases

ProteinModelPortaliQ8N5W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 49Poly-Gly5

Sequence similaritiesi

Belongs to the Refilin family.Curated

Phylogenomic databases

eggNOGiENOG410IXFT Eukaryota
ENOG410ZFEH LUCA
HOGENOMiHOG000112422
HOVERGENiHBG064959
InParanoidiQ8N5W9
OrthoDBiEOG091G13B3
PhylomeDBiQ8N5W9
TreeFamiTF332387

Family and domain databases

InterProiView protein in InterPro
IPR028215 Refilin
PfamiView protein in Pfam
PF15068 FAM101, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N5W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGRLSLQDV PELVDAKKKG DGVLDSPDSG LPPSPSPSHW GLAAGGGGGE
60 70 80 90 100
RAAAPGTLEP DAAAATPAAP SPASLPLAPG CALRLCPLSF GEGVEFDPLP
110 120 130 140 150
PKEVRYTSLV KYDSERHFID DVQLPLGLAV ASCSQTVTCV PNGTWRNYKA
160 170 180 190 200
EVRFEPRHRP TRFLSTTIVY PKYPKAVYTT TLDYNCRKTL RRFLSSVELE
210
AAELPGSDDL SDEC
Length:214
Mass (Da):22,882
Last modified:October 1, 2002 - v1
Checksum:i2A51A58D8A6CB0D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031341 mRNA Translation: AAH31341.1
RefSeqiNP_874364.1, NM_182705.2
UniGeneiHs.345588
Hs.723693
Hs.741149

Genome annotation databases

EnsembliENST00000329099; ENSP00000331915; ENSG00000183688
GeneIDi359845
KEGGihsa:359845
UCSCiuc002frj.4 human

Similar proteinsi

Entry informationi

Entry nameiRFLB_HUMAN
AccessioniPrimary (citable) accession number: Q8N5W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health