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Protein

Filamin-interacting protein FAM101B

Gene

FAM101B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements.By similarity

GO - Molecular functioni

  • filamin binding Source: MGI

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Filamin-interacting protein FAM101B
Alternative name(s):
Protein FAM101B
Regulator of filamin protein B
Short name:
RefilinB
Gene namesi
Name:FAM101B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28705. FAM101B.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity

  • Note: Colocalizes with FLNA along actin bundle-like structures.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485463.

Polymorphism and mutation databases

BioMutaiFAM101B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Filamin-interacting protein FAM101BPRO_0000264631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N5W9.
MaxQBiQ8N5W9.
PaxDbiQ8N5W9.
PRIDEiQ8N5W9.

PTM databases

iPTMnetiQ8N5W9.
PhosphoSiteiQ8N5W9.

Miscellaneous databases

PMAP-CutDBQ8N5W9.

Expressioni

Gene expression databases

BgeeiQ8N5W9.
CleanExiHS_FAM101B.
GenevisibleiQ8N5W9. HS.

Organism-specific databases

HPAiHPA030879.

Interactioni

Subunit structurei

Interacts with FLNA and FLNB.By similarity

GO - Molecular functioni

  • filamin binding Source: MGI

Protein-protein interaction databases

BioGridi131787. 5 interactions.
IntActiQ8N5W9. 4 interactions.
MINTiMINT-1391671.
STRINGi9606.ENSP00000331915.

Structurei

3D structure databases

ProteinModelPortaliQ8N5W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi45 – 495Poly-Gly

Sequence similaritiesi

Belongs to the FAM101 family.Curated

Phylogenomic databases

eggNOGiENOG410IXFT. Eukaryota.
ENOG410ZFEH. LUCA.
HOGENOMiHOG000112422.
HOVERGENiHBG064959.
InParanoidiQ8N5W9.
OrthoDBiEOG73BVF7.
PhylomeDBiQ8N5W9.
TreeFamiTF332387.

Family and domain databases

InterProiIPR028215. FAM101.
[Graphical view]
PfamiPF15068. FAM101. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N5W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGRLSLQDV PELVDAKKKG DGVLDSPDSG LPPSPSPSHW GLAAGGGGGE
60 70 80 90 100
RAAAPGTLEP DAAAATPAAP SPASLPLAPG CALRLCPLSF GEGVEFDPLP
110 120 130 140 150
PKEVRYTSLV KYDSERHFID DVQLPLGLAV ASCSQTVTCV PNGTWRNYKA
160 170 180 190 200
EVRFEPRHRP TRFLSTTIVY PKYPKAVYTT TLDYNCRKTL RRFLSSVELE
210
AAELPGSDDL SDEC
Length:214
Mass (Da):22,882
Last modified:October 1, 2002 - v1
Checksum:i2A51A58D8A6CB0D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031341 mRNA. Translation: AAH31341.1.
RefSeqiNP_874364.1. NM_182705.2.
UniGeneiHs.345588.
Hs.723693.
Hs.741149.

Genome annotation databases

EnsembliENST00000329099; ENSP00000331915; ENSG00000183688.
GeneIDi359845.
KEGGihsa:359845.
UCSCiuc002frj.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031341 mRNA. Translation: AAH31341.1.
RefSeqiNP_874364.1. NM_182705.2.
UniGeneiHs.345588.
Hs.723693.
Hs.741149.

3D structure databases

ProteinModelPortaliQ8N5W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131787. 5 interactions.
IntActiQ8N5W9. 4 interactions.
MINTiMINT-1391671.
STRINGi9606.ENSP00000331915.

PTM databases

iPTMnetiQ8N5W9.
PhosphoSiteiQ8N5W9.

Polymorphism and mutation databases

BioMutaiFAM101B.

Proteomic databases

EPDiQ8N5W9.
MaxQBiQ8N5W9.
PaxDbiQ8N5W9.
PRIDEiQ8N5W9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329099; ENSP00000331915; ENSG00000183688.
GeneIDi359845.
KEGGihsa:359845.
UCSCiuc002frj.4. human.

Organism-specific databases

CTDi359845.
GeneCardsiFAM101B.
HGNCiHGNC:28705. FAM101B.
HPAiHPA030879.
MIMi615928. gene.
neXtProtiNX_Q8N5W9.
PharmGKBiPA143485463.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXFT. Eukaryota.
ENOG410ZFEH. LUCA.
HOGENOMiHOG000112422.
HOVERGENiHBG064959.
InParanoidiQ8N5W9.
OrthoDBiEOG73BVF7.
PhylomeDBiQ8N5W9.
TreeFamiTF332387.

Miscellaneous databases

GenomeRNAii359845.
NextBioi99959.
PMAP-CutDBQ8N5W9.
PROiQ8N5W9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N5W9.
CleanExiHS_FAM101B.
GenevisibleiQ8N5W9. HS.

Family and domain databases

InterProiIPR028215. FAM101.
[Graphical view]
PfamiPF15068. FAM101. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF101B_HUMAN
AccessioniPrimary (citable) accession number: Q8N5W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: April 13, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.