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Protein

Refilin-B

Gene

RFLNB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements.By similarity

GO - Molecular functioni

  • filamin binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Refilin-B
Alternative name(s):
Regulator of filamin protein B
Short name:
RefilinB
Gene namesi
Name:RFLNBImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000183688.4.
HGNCiHGNC:28705. RFLNB.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi359845.
PharmGKBiPA143485463.

Polymorphism and mutation databases

BioMutaiFAM101B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002646311 – 214Refilin-BAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei26PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N5W9.
MaxQBiQ8N5W9.
PaxDbiQ8N5W9.
PeptideAtlasiQ8N5W9.
PRIDEiQ8N5W9.

PTM databases

iPTMnetiQ8N5W9.
PhosphoSitePlusiQ8N5W9.

Miscellaneous databases

PMAP-CutDBiQ8N5W9.

Expressioni

Gene expression databases

BgeeiENSG00000183688.
CleanExiHS_FAM101B.
GenevisibleiQ8N5W9. HS.

Organism-specific databases

HPAiHPA030879.

Interactioni

Subunit structurei

Interacts with FLNA and FLNB.By similarity

GO - Molecular functioni

  • filamin binding Source: MGI

Protein-protein interaction databases

BioGridi131787. 10 interactors.
IntActiQ8N5W9. 4 interactors.
MINTiMINT-1391671.
STRINGi9606.ENSP00000331915.

Structurei

3D structure databases

ProteinModelPortaliQ8N5W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 49Poly-Gly5

Sequence similaritiesi

Belongs to the Refilin family.Curated

Phylogenomic databases

eggNOGiENOG410IXFT. Eukaryota.
ENOG410ZFEH. LUCA.
HOGENOMiHOG000112422.
HOVERGENiHBG064959.
InParanoidiQ8N5W9.
OrthoDBiEOG091G13B3.
PhylomeDBiQ8N5W9.
TreeFamiTF332387.

Family and domain databases

InterProiView protein in InterPro
IPR028215. Refilin.
PfamiView protein in Pfam
PF15068. FAM101. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N5W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGRLSLQDV PELVDAKKKG DGVLDSPDSG LPPSPSPSHW GLAAGGGGGE
60 70 80 90 100
RAAAPGTLEP DAAAATPAAP SPASLPLAPG CALRLCPLSF GEGVEFDPLP
110 120 130 140 150
PKEVRYTSLV KYDSERHFID DVQLPLGLAV ASCSQTVTCV PNGTWRNYKA
160 170 180 190 200
EVRFEPRHRP TRFLSTTIVY PKYPKAVYTT TLDYNCRKTL RRFLSSVELE
210
AAELPGSDDL SDEC
Length:214
Mass (Da):22,882
Last modified:October 1, 2002 - v1
Checksum:i2A51A58D8A6CB0D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031341 mRNA. Translation: AAH31341.1.
RefSeqiNP_874364.1. NM_182705.2.
UniGeneiHs.345588.
Hs.723693.
Hs.741149.

Genome annotation databases

EnsembliENST00000329099; ENSP00000331915; ENSG00000183688.
GeneIDi359845.
KEGGihsa:359845.
UCSCiuc002frj.4. human.

Similar proteinsi

Entry informationi

Entry nameiRFLB_HUMAN
AccessioniPrimary (citable) accession number: Q8N5W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families