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Q8N5U6 (RNF10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RING finger protein 10
Gene names
Name:RNF10
Synonyms:KIAA0262, RIE2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length811 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional factor involved in the regulation of MAG expression. Participates in the peripheral nerve development and Schawnn cell differentiation By similarity.

Subunit structure

Interacts with MEOX2. Ref.7

Subcellular location

Cytoplasm By similarity. Nucleus By similarity Ref.7.

Sequence similarities

Belongs to the RNF10 family.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of Schwann cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of myelination

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from direct assay Ref.7. Source: UniProtKB

protein autoubiquitination

Inferred from direct assay PubMed 24105792. Source: FlyBase

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from direct assay Ref.7. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionprotein binding

Inferred from physical interaction Ref.7. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

ubiquitin-protein transferase activity

Inferred from direct assay PubMed 24105792. Source: FlyBase

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N5U6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N5U6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     418-418: K → KSLLQQ
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 811811RING finger protein 10
PRO_0000259585

Regions

Zinc finger225 – 26743RING-type
Region101 – 18585Interaction with MEOX2
Compositional bias19 – 11092Ser-rich

Natural variations

Alternative sequence4181K → KSLLQQ in isoform 2.
VSP_021478
Natural variant3321L → F. Ref.6
Corresponds to variant rs17852961 [ dbSNP | Ensembl ].
VAR_028967
Natural variant4331E → D.
Corresponds to variant rs16950277 [ dbSNP | Ensembl ].
VAR_028968

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: 54BCB1F7D59AE1BA

FASTA81189,927
        10         20         30         40         50         60 
MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP KSDGKNSSGS 

        70         80         90        100        110        120 
KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG GGSSKLFSSS FNGGRRDEVA 

       130        140        150        160        170        180 
EAQRAEFSPA QFSGPKKINL NHLLNFTFEP RGQTGHFEGS GHGSWGKRNK WGHKPFNKEL 

       190        200        210        220        230        240 
FLQANCQFVV SEDQDYTAHF ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC 

       250        260        270        280        290        300 
GHIFCWACIL HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESHQYVVGD TITMQLMKRE 

       310        320        330        340        350        360 
KGVLVALPKS KWMNVDHPIH LGDEQHSQYS KLLLASKEQV LHRVVLEEKV ALEQQLAEEK 

       370        380        390        400        410        420 
HTPESCFIEA AIQELKTREE ALSGLAGSRR EVTGVVAALE QLVLMAPLAK ESVFQPRKGV 

       430        440        450        460        470        480 
LEYLSAFDEE TTEVCSLDTP SRPLALPLVE EEEAVSEPEP EGLPEACDDL ELADDNLKEG 

       490        500        510        520        530        540 
TICTESSQQE PITKSGFTRL SSSPCYYFYQ AEDGQHMFLH PVNVRCLVRE YGSLERSPEK 

       550        560        570        580        590        600 
ISATVVEIAG YSMSEDVRQR HRYLSHLPLT CEFSICELAL QPPVVSKETL EMFSDDIEKR 

       610        620        630        640        650        660 
KRQRQKKARE ERRRERRIEI EENKKQGKYP EVHIPLENLQ QFPAFNSYTC SSDSALGPTS 

       670        680        690        700        710        720 
TEGHGALSIS PLSRSPGSHA DFLLTPLSPT ASQGSPSFCV GSLEEDSPFP SFAQMLRVGK 

       730        740        750        760        770        780 
AKADVWPKTA PKKDENSLVP PAPVDSDGES DNSDRVPVPS FQNSFSQAIE AAFMKLDTPA 

       790        800        810 
TSDPLSEEKG GKKRKKQKQK LLFSTSVVHT K 

« Hide

Isoform 2 [UniParc].

Checksum: B7018039E420F9C9
Show »

FASTA81690,497

References

« Hide 'large scale' references
[1]"cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein."
Seki N., Hattori A., Sugano S., Muramatsu M., Saito T.
J. Hum. Genet. 45:38-42(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Bone marrow.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain, Eye and Liver.
[6]The European IMAGE consortium
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-811 (ISOFORM 2), VARIANT PHE-332.
[7]"Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10."
Lin J., Friesen M.T., Bocangel P., Cheung D., Rawszer K., Wigle J.T.
Mol. Cell. Biochem. 275:75-84(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MEOX2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB027196 mRNA. Translation: BAA84708.1.
D87451 mRNA. Translation: BAA13392.2.
BT006974 mRNA. Translation: AAP35620.1.
BC016622 mRNA. Translation: AAH16622.1.
BC031596 mRNA. Translation: AAH31596.1.
BC101709 mRNA. Translation: AAI01710.1.
BC101715 mRNA. Translation: AAI01716.1.
AL389976 mRNA. Translation: CAB97533.1.
CCDSCCDS9201.1. [Q8N5U6-1]
RefSeqNP_055683.3. NM_014868.4. [Q8N5U6-1]
XP_006719780.1. XM_006719717.1. [Q8N5U6-2]
UniGeneHs.442798.

3D structure databases

ProteinModelPortalQ8N5U6.
SMRQ8N5U6. Positions 221-270.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115249. 32 interactions.
IntActQ8N5U6. 28 interactions.
MINTMINT-1381793.
STRING9606.ENSP00000322242.

PTM databases

PhosphoSiteQ8N5U6.

Polymorphism databases

DMDM117949776.

Proteomic databases

MaxQBQ8N5U6.
PaxDbQ8N5U6.
PRIDEQ8N5U6.

Protocols and materials databases

DNASU9921.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000325954; ENSP00000322242; ENSG00000022840. [Q8N5U6-1]
ENST00000413266; ENSP00000415682; ENSG00000022840. [Q8N5U6-2]
GeneID9921.
KEGGhsa:9921.
UCSCuc001typ.4. human. [Q8N5U6-1]
uc001tyq.4. human. [Q8N5U6-2]

Organism-specific databases

CTD9921.
GeneCardsGC12P120972.
HGNCHGNC:10055. RNF10.
HPAHPA017135.
HPA052643.
neXtProtNX_Q8N5U6.
PharmGKBPA34419.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG330884.
HOVERGENHBG059523.
InParanoidQ8N5U6.
OMAEGTICTE.
OrthoDBEOG747PHT.
PhylomeDBQ8N5U6.
TreeFamTF323455.

Gene expression databases

ArrayExpressQ8N5U6.
BgeeQ8N5U6.
CleanExHS_RNF10.
GenevestigatorQ8N5U6.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTSM00184. RING. 1 hit.
[Graphical view]
PROSITEPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRNF10. human.
GeneWikiRNF10.
GenomeRNAi9921.
NextBio37428.
PROQ8N5U6.

Entry information

Entry nameRNF10_HUMAN
AccessionPrimary (citable) accession number: Q8N5U6
Secondary accession number(s): Q92550, Q9NPP8, Q9ULW4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM