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Protein

RING finger protein 10

Gene

RNF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 267RING-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000022840-MONOMER.
SIGNORiQ8N5U6.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 10
Gene namesi
Name:RNF10
Synonyms:KIAA0262, RIE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:10055. RNF10.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000022840.
PharmGKBiPA34419.

Polymorphism and mutation databases

BioMutaiRNF10.
DMDMi117949776.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595851 – 811RING finger protein 10Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei128PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N5U6.
MaxQBiQ8N5U6.
PaxDbiQ8N5U6.
PeptideAtlasiQ8N5U6.
PRIDEiQ8N5U6.

PTM databases

iPTMnetiQ8N5U6.
PhosphoSitePlusiQ8N5U6.

Expressioni

Gene expression databases

BgeeiENSG00000022840.
CleanExiHS_RNF10.
ExpressionAtlasiQ8N5U6. baseline and differential.
GenevisibleiQ8N5U6. HS.

Organism-specific databases

HPAiHPA052643.

Interactioni

Subunit structurei

Interacts with MEOX2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF1P542742EBI-714023,EBI-710997

Protein-protein interaction databases

BioGridi115249. 38 interactors.
IntActiQ8N5U6. 32 interactors.
MINTiMINT-1381793.
STRINGi9606.ENSP00000322242.

Structurei

3D structure databases

ProteinModelPortaliQ8N5U6.
SMRiQ8N5U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni101 – 185Interaction with MEOX21 PublicationAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi19 – 110Ser-richAdd BLAST92

Sequence similaritiesi

Belongs to the RNF10 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 267RING-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2164. Eukaryota.
ENOG410XTFS. LUCA.
GeneTreeiENSGT00390000001731.
HOVERGENiHBG059523.
InParanoidiQ8N5U6.
OMAiQQMFLHP.
OrthoDBiEOG091G05CI.
PhylomeDBiQ8N5U6.
TreeFamiTF323455.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N5U6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP
60 70 80 90 100
KSDGKNSSGS KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG
110 120 130 140 150
GGSSKLFSSS FNGGRRDEVA EAQRAEFSPA QFSGPKKINL NHLLNFTFEP
160 170 180 190 200
RGQTGHFEGS GHGSWGKRNK WGHKPFNKEL FLQANCQFVV SEDQDYTAHF
210 220 230 240 250
ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC GHIFCWACIL
260 270 280 290 300
HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESHQYVVGD TITMQLMKRE
310 320 330 340 350
KGVLVALPKS KWMNVDHPIH LGDEQHSQYS KLLLASKEQV LHRVVLEEKV
360 370 380 390 400
ALEQQLAEEK HTPESCFIEA AIQELKTREE ALSGLAGSRR EVTGVVAALE
410 420 430 440 450
QLVLMAPLAK ESVFQPRKGV LEYLSAFDEE TTEVCSLDTP SRPLALPLVE
460 470 480 490 500
EEEAVSEPEP EGLPEACDDL ELADDNLKEG TICTESSQQE PITKSGFTRL
510 520 530 540 550
SSSPCYYFYQ AEDGQHMFLH PVNVRCLVRE YGSLERSPEK ISATVVEIAG
560 570 580 590 600
YSMSEDVRQR HRYLSHLPLT CEFSICELAL QPPVVSKETL EMFSDDIEKR
610 620 630 640 650
KRQRQKKARE ERRRERRIEI EENKKQGKYP EVHIPLENLQ QFPAFNSYTC
660 670 680 690 700
SSDSALGPTS TEGHGALSIS PLSRSPGSHA DFLLTPLSPT ASQGSPSFCV
710 720 730 740 750
GSLEEDSPFP SFAQMLRVGK AKADVWPKTA PKKDENSLVP PAPVDSDGES
760 770 780 790 800
DNSDRVPVPS FQNSFSQAIE AAFMKLDTPA TSDPLSEEKG GKKRKKQKQK
810
LLFSTSVVHT K
Length:811
Mass (Da):89,927
Last modified:October 31, 2006 - v2
Checksum:i54BCB1F7D59AE1BA
GO
Isoform 2 (identifier: Q8N5U6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     418-418: K → KSLLQQ

Note: No experimental confirmation available.
Show »
Length:816
Mass (Da):90,497
Checksum:iB7018039E420F9C9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028967332L → F.1 PublicationCorresponds to variant rs17852961dbSNPEnsembl.1
Natural variantiVAR_028968433E → D.Corresponds to variant rs16950277dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021478418K → KSLLQQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027196 mRNA. Translation: BAA84708.1.
D87451 mRNA. Translation: BAA13392.2.
BT006974 mRNA. Translation: AAP35620.1.
BC016622 mRNA. Translation: AAH16622.1.
BC031596 mRNA. Translation: AAH31596.1.
BC101709 mRNA. Translation: AAI01710.1.
BC101715 mRNA. Translation: AAI01716.1.
AL389976 mRNA. Translation: CAB97533.1.
CCDSiCCDS81746.1. [Q8N5U6-2]
CCDS9201.1. [Q8N5U6-1]
RefSeqiNP_001317403.1. NM_001330474.1.
NP_055683.3. NM_014868.4. [Q8N5U6-1]
UniGeneiHs.442798.

Genome annotation databases

EnsembliENST00000325954; ENSP00000322242; ENSG00000022840. [Q8N5U6-1]
ENST00000413266; ENSP00000415682; ENSG00000022840. [Q8N5U6-2]
GeneIDi9921.
KEGGihsa:9921.
UCSCiuc001typ.5. human. [Q8N5U6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027196 mRNA. Translation: BAA84708.1.
D87451 mRNA. Translation: BAA13392.2.
BT006974 mRNA. Translation: AAP35620.1.
BC016622 mRNA. Translation: AAH16622.1.
BC031596 mRNA. Translation: AAH31596.1.
BC101709 mRNA. Translation: AAI01710.1.
BC101715 mRNA. Translation: AAI01716.1.
AL389976 mRNA. Translation: CAB97533.1.
CCDSiCCDS81746.1. [Q8N5U6-2]
CCDS9201.1. [Q8N5U6-1]
RefSeqiNP_001317403.1. NM_001330474.1.
NP_055683.3. NM_014868.4. [Q8N5U6-1]
UniGeneiHs.442798.

3D structure databases

ProteinModelPortaliQ8N5U6.
SMRiQ8N5U6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115249. 38 interactors.
IntActiQ8N5U6. 32 interactors.
MINTiMINT-1381793.
STRINGi9606.ENSP00000322242.

PTM databases

iPTMnetiQ8N5U6.
PhosphoSitePlusiQ8N5U6.

Polymorphism and mutation databases

BioMutaiRNF10.
DMDMi117949776.

Proteomic databases

EPDiQ8N5U6.
MaxQBiQ8N5U6.
PaxDbiQ8N5U6.
PeptideAtlasiQ8N5U6.
PRIDEiQ8N5U6.

Protocols and materials databases

DNASUi9921.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325954; ENSP00000322242; ENSG00000022840. [Q8N5U6-1]
ENST00000413266; ENSP00000415682; ENSG00000022840. [Q8N5U6-2]
GeneIDi9921.
KEGGihsa:9921.
UCSCiuc001typ.5. human. [Q8N5U6-1]

Organism-specific databases

CTDi9921.
GeneCardsiRNF10.
HGNCiHGNC:10055. RNF10.
HPAiHPA052643.
MIMi615998. gene.
neXtProtiNX_Q8N5U6.
OpenTargetsiENSG00000022840.
PharmGKBiPA34419.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2164. Eukaryota.
ENOG410XTFS. LUCA.
GeneTreeiENSGT00390000001731.
HOVERGENiHBG059523.
InParanoidiQ8N5U6.
OMAiQQMFLHP.
OrthoDBiEOG091G05CI.
PhylomeDBiQ8N5U6.
TreeFamiTF323455.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000022840-MONOMER.
SIGNORiQ8N5U6.

Miscellaneous databases

ChiTaRSiRNF10. human.
GeneWikiiRNF10.
GenomeRNAii9921.
PROiQ8N5U6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000022840.
CleanExiHS_RNF10.
ExpressionAtlasiQ8N5U6. baseline and differential.
GenevisibleiQ8N5U6. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNF10_HUMAN
AccessioniPrimary (citable) accession number: Q8N5U6
Secondary accession number(s): Q92550, Q9NPP8, Q9ULW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.