UniProtKB - Q8N5U6 (RNF10_HUMAN)
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Protein
RING finger protein 10
Gene
RNF10
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 225 – 267 | RING-typePROSITE-ProRule annotationAdd BLAST | 43 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- transcription regulatory region DNA binding Source: UniProtKB
- ubiquitin-protein transferase activity Source: FlyBase
GO - Biological processi
- negative regulation of Schwann cell proliferation Source: UniProtKB
- positive regulation of myelination Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- protein autoubiquitination Source: FlyBase
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
SIGNORi | Q8N5U6. |
Names & Taxonomyi
Protein namesi | Recommended name: RING finger protein 10 |
Gene namesi | Name:RNF10 Synonyms:KIAA0262, RIE2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000022840.15. |
HGNCi | HGNC:10055. RNF10. |
MIMi | 615998. gene. |
neXtProti | NX_Q8N5U6. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9921. |
OpenTargetsi | ENSG00000022840. |
PharmGKBi | PA34419. |
Polymorphism and mutation databases
BioMutai | RNF10. |
DMDMi | 117949776. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000259585 | 1 – 811 | RING finger protein 10Add BLAST | 811 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 5 | PhosphoserineCombined sources | 1 | |
Modified residuei | 110 | PhosphoserineCombined sources | 1 | |
Modified residuei | 128 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8N5U6. |
MaxQBi | Q8N5U6. |
PaxDbi | Q8N5U6. |
PeptideAtlasi | Q8N5U6. |
PRIDEi | Q8N5U6. |
PTM databases
iPTMneti | Q8N5U6. |
PhosphoSitePlusi | Q8N5U6. |
Expressioni
Gene expression databases
Bgeei | ENSG00000022840. |
CleanExi | HS_RNF10. |
ExpressionAtlasi | Q8N5U6. baseline and differential. |
Genevisiblei | Q8N5U6. HS. |
Organism-specific databases
HPAi | HPA052643. |
Interactioni
Subunit structurei
Interacts with MEOX2.1 Publication
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
TERF1 | P54274 | 2 | EBI-714023,EBI-710997 |
Protein-protein interaction databases
BioGridi | 115249. 56 interactors. |
IntActi | Q8N5U6. 32 interactors. |
MINTi | Q8N5U6. |
STRINGi | 9606.ENSP00000322242. |
Structurei
3D structure databases
ProteinModelPortali | Q8N5U6. |
SMRi | Q8N5U6. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 101 – 185 | Interaction with MEOX21 PublicationAdd BLAST | 85 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 19 – 110 | Ser-richAdd BLAST | 92 |
Sequence similaritiesi
Belongs to the RNF10 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 225 – 267 | RING-typePROSITE-ProRule annotationAdd BLAST | 43 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2164. Eukaryota. ENOG410XTFS. LUCA. |
GeneTreei | ENSGT00390000001731. |
HOVERGENi | HBG059523. |
InParanoidi | Q8N5U6. |
OMAi | SYPKNEN. |
OrthoDBi | EOG091G05CI. |
PhylomeDBi | Q8N5U6. |
TreeFami | TF323455. |
Family and domain databases
Gene3Di | 3.30.40.10. 1 hit. |
InterProi | View protein in InterPro IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. |
Pfami | View protein in Pfam PF13639. zf-RING_2. 1 hit. |
SMARTi | View protein in SMART SM00184. RING. 1 hit. |
PROSITEi | View protein in PROSITE PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N5U6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP
60 70 80 90 100
KSDGKNSSGS KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG
110 120 130 140 150
GGSSKLFSSS FNGGRRDEVA EAQRAEFSPA QFSGPKKINL NHLLNFTFEP
160 170 180 190 200
RGQTGHFEGS GHGSWGKRNK WGHKPFNKEL FLQANCQFVV SEDQDYTAHF
210 220 230 240 250
ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC GHIFCWACIL
260 270 280 290 300
HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESHQYVVGD TITMQLMKRE
310 320 330 340 350
KGVLVALPKS KWMNVDHPIH LGDEQHSQYS KLLLASKEQV LHRVVLEEKV
360 370 380 390 400
ALEQQLAEEK HTPESCFIEA AIQELKTREE ALSGLAGSRR EVTGVVAALE
410 420 430 440 450
QLVLMAPLAK ESVFQPRKGV LEYLSAFDEE TTEVCSLDTP SRPLALPLVE
460 470 480 490 500
EEEAVSEPEP EGLPEACDDL ELADDNLKEG TICTESSQQE PITKSGFTRL
510 520 530 540 550
SSSPCYYFYQ AEDGQHMFLH PVNVRCLVRE YGSLERSPEK ISATVVEIAG
560 570 580 590 600
YSMSEDVRQR HRYLSHLPLT CEFSICELAL QPPVVSKETL EMFSDDIEKR
610 620 630 640 650
KRQRQKKARE ERRRERRIEI EENKKQGKYP EVHIPLENLQ QFPAFNSYTC
660 670 680 690 700
SSDSALGPTS TEGHGALSIS PLSRSPGSHA DFLLTPLSPT ASQGSPSFCV
710 720 730 740 750
GSLEEDSPFP SFAQMLRVGK AKADVWPKTA PKKDENSLVP PAPVDSDGES
760 770 780 790 800
DNSDRVPVPS FQNSFSQAIE AAFMKLDTPA TSDPLSEEKG GKKRKKQKQK
810
LLFSTSVVHT K
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028967 | 332 | L → F1 PublicationCorresponds to variant dbSNP:rs17852961Ensembl. | 1 | |
Natural variantiVAR_028968 | 433 | E → D. Corresponds to variant dbSNP:rs16950277Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021478 | 418 | K → KSLLQQ in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB027196 mRNA. Translation: BAA84708.1. D87451 mRNA. Translation: BAA13392.2. BT006974 mRNA. Translation: AAP35620.1. BC016622 mRNA. Translation: AAH16622.1. BC031596 mRNA. Translation: AAH31596.1. BC101709 mRNA. Translation: AAI01710.1. BC101715 mRNA. Translation: AAI01716.1. AL389976 mRNA. Translation: CAB97533.1. |
CCDSi | CCDS81746.1. [Q8N5U6-2] CCDS9201.1. [Q8N5U6-1] |
RefSeqi | NP_001317403.1. NM_001330474.1. [Q8N5U6-2] NP_055683.3. NM_014868.4. [Q8N5U6-1] |
UniGenei | Hs.442798. |
Genome annotation databases
Ensembli | ENST00000325954; ENSP00000322242; ENSG00000022840. [Q8N5U6-1] ENST00000413266; ENSP00000415682; ENSG00000022840. [Q8N5U6-2] |
GeneIDi | 9921. |
KEGGi | hsa:9921. |
UCSCi | uc001typ.5. human. [Q8N5U6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | RNF10_HUMAN | |
Accessioni | Q8N5U6Primary (citable) accession number: Q8N5U6 Secondary accession number(s): Q92550, Q9NPP8, Q9ULW4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | October 31, 2006 | |
Last modified: | March 28, 2018 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |