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Q8N5U6

- RNF10_HUMAN

UniProt

Q8N5U6 - RNF10_HUMAN

Protein

RING finger protein 10

Gene

RNF10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Transcriptional factor involved in the regulation of MAG expression. Participates in the peripheral nerve development and Schawnn cell differentiation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri225 – 26743RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. transcription regulatory region DNA binding Source: UniProtKB
    3. ubiquitin-protein transferase activity Source: FlyBase
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. negative regulation of Schwann cell proliferation Source: UniProtKB
    2. positive regulation of myelination Source: UniProtKB
    3. positive regulation of transcription, DNA-templated Source: UniProtKB
    4. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    5. protein autoubiquitination Source: FlyBase
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RING finger protein 10
    Gene namesi
    Name:RNF10
    Synonyms:KIAA0262, RIE2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:10055. RNF10.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34419.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 811811RING finger protein 10PRO_0000259585Add
    BLAST

    Proteomic databases

    MaxQBiQ8N5U6.
    PaxDbiQ8N5U6.
    PRIDEiQ8N5U6.

    PTM databases

    PhosphoSiteiQ8N5U6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N5U6.
    BgeeiQ8N5U6.
    CleanExiHS_RNF10.
    GenevestigatoriQ8N5U6.

    Organism-specific databases

    HPAiHPA017135.
    HPA052643.

    Interactioni

    Subunit structurei

    Interacts with MEOX2.1 Publication

    Protein-protein interaction databases

    BioGridi115249. 32 interactions.
    IntActiQ8N5U6. 28 interactions.
    MINTiMINT-1381793.
    STRINGi9606.ENSP00000322242.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N5U6.
    SMRiQ8N5U6. Positions 221-270.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni101 – 18585Interaction with MEOX2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi19 – 11092Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RNF10 family.Curated
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri225 – 26743RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG330884.
    HOVERGENiHBG059523.
    InParanoidiQ8N5U6.
    OMAiEGTICTE.
    OrthoDBiEOG747PHT.
    PhylomeDBiQ8N5U6.
    TreeFamiTF323455.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N5U6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP    50
    KSDGKNSSGS KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG 100
    GGSSKLFSSS FNGGRRDEVA EAQRAEFSPA QFSGPKKINL NHLLNFTFEP 150
    RGQTGHFEGS GHGSWGKRNK WGHKPFNKEL FLQANCQFVV SEDQDYTAHF 200
    ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC GHIFCWACIL 250
    HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESHQYVVGD TITMQLMKRE 300
    KGVLVALPKS KWMNVDHPIH LGDEQHSQYS KLLLASKEQV LHRVVLEEKV 350
    ALEQQLAEEK HTPESCFIEA AIQELKTREE ALSGLAGSRR EVTGVVAALE 400
    QLVLMAPLAK ESVFQPRKGV LEYLSAFDEE TTEVCSLDTP SRPLALPLVE 450
    EEEAVSEPEP EGLPEACDDL ELADDNLKEG TICTESSQQE PITKSGFTRL 500
    SSSPCYYFYQ AEDGQHMFLH PVNVRCLVRE YGSLERSPEK ISATVVEIAG 550
    YSMSEDVRQR HRYLSHLPLT CEFSICELAL QPPVVSKETL EMFSDDIEKR 600
    KRQRQKKARE ERRRERRIEI EENKKQGKYP EVHIPLENLQ QFPAFNSYTC 650
    SSDSALGPTS TEGHGALSIS PLSRSPGSHA DFLLTPLSPT ASQGSPSFCV 700
    GSLEEDSPFP SFAQMLRVGK AKADVWPKTA PKKDENSLVP PAPVDSDGES 750
    DNSDRVPVPS FQNSFSQAIE AAFMKLDTPA TSDPLSEEKG GKKRKKQKQK 800
    LLFSTSVVHT K 811
    Length:811
    Mass (Da):89,927
    Last modified:October 31, 2006 - v2
    Checksum:i54BCB1F7D59AE1BA
    GO
    Isoform 2 (identifier: Q8N5U6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         418-418: K → KSLLQQ

    Note: No experimental confirmation available.

    Show »
    Length:816
    Mass (Da):90,497
    Checksum:iB7018039E420F9C9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti332 – 3321L → F.1 Publication
    Corresponds to variant rs17852961 [ dbSNP | Ensembl ].
    VAR_028967
    Natural varianti433 – 4331E → D.
    Corresponds to variant rs16950277 [ dbSNP | Ensembl ].
    VAR_028968

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei418 – 4181K → KSLLQQ in isoform 2. 1 PublicationVSP_021478

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027196 mRNA. Translation: BAA84708.1.
    D87451 mRNA. Translation: BAA13392.2.
    BT006974 mRNA. Translation: AAP35620.1.
    BC016622 mRNA. Translation: AAH16622.1.
    BC031596 mRNA. Translation: AAH31596.1.
    BC101709 mRNA. Translation: AAI01710.1.
    BC101715 mRNA. Translation: AAI01716.1.
    AL389976 mRNA. Translation: CAB97533.1.
    CCDSiCCDS9201.1. [Q8N5U6-1]
    RefSeqiNP_055683.3. NM_014868.4. [Q8N5U6-1]
    XP_006719780.1. XM_006719717.1. [Q8N5U6-2]
    UniGeneiHs.442798.

    Genome annotation databases

    EnsembliENST00000325954; ENSP00000322242; ENSG00000022840. [Q8N5U6-1]
    ENST00000413266; ENSP00000415682; ENSG00000022840. [Q8N5U6-2]
    GeneIDi9921.
    KEGGihsa:9921.
    UCSCiuc001typ.4. human. [Q8N5U6-1]
    uc001tyq.4. human. [Q8N5U6-2]

    Polymorphism databases

    DMDMi117949776.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027196 mRNA. Translation: BAA84708.1 .
    D87451 mRNA. Translation: BAA13392.2 .
    BT006974 mRNA. Translation: AAP35620.1 .
    BC016622 mRNA. Translation: AAH16622.1 .
    BC031596 mRNA. Translation: AAH31596.1 .
    BC101709 mRNA. Translation: AAI01710.1 .
    BC101715 mRNA. Translation: AAI01716.1 .
    AL389976 mRNA. Translation: CAB97533.1 .
    CCDSi CCDS9201.1. [Q8N5U6-1 ]
    RefSeqi NP_055683.3. NM_014868.4. [Q8N5U6-1 ]
    XP_006719780.1. XM_006719717.1. [Q8N5U6-2 ]
    UniGenei Hs.442798.

    3D structure databases

    ProteinModelPortali Q8N5U6.
    SMRi Q8N5U6. Positions 221-270.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115249. 32 interactions.
    IntActi Q8N5U6. 28 interactions.
    MINTi MINT-1381793.
    STRINGi 9606.ENSP00000322242.

    PTM databases

    PhosphoSitei Q8N5U6.

    Polymorphism databases

    DMDMi 117949776.

    Proteomic databases

    MaxQBi Q8N5U6.
    PaxDbi Q8N5U6.
    PRIDEi Q8N5U6.

    Protocols and materials databases

    DNASUi 9921.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325954 ; ENSP00000322242 ; ENSG00000022840 . [Q8N5U6-1 ]
    ENST00000413266 ; ENSP00000415682 ; ENSG00000022840 . [Q8N5U6-2 ]
    GeneIDi 9921.
    KEGGi hsa:9921.
    UCSCi uc001typ.4. human. [Q8N5U6-1 ]
    uc001tyq.4. human. [Q8N5U6-2 ]

    Organism-specific databases

    CTDi 9921.
    GeneCardsi GC12P120972.
    HGNCi HGNC:10055. RNF10.
    HPAi HPA017135.
    HPA052643.
    neXtProti NX_Q8N5U6.
    PharmGKBi PA34419.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG330884.
    HOVERGENi HBG059523.
    InParanoidi Q8N5U6.
    OMAi EGTICTE.
    OrthoDBi EOG747PHT.
    PhylomeDBi Q8N5U6.
    TreeFami TF323455.

    Miscellaneous databases

    ChiTaRSi RNF10. human.
    GeneWikii RNF10.
    GenomeRNAii 9921.
    NextBioi 37428.
    PROi Q8N5U6.

    Gene expression databases

    ArrayExpressi Q8N5U6.
    Bgeei Q8N5U6.
    CleanExi HS_RNF10.
    Genevestigatori Q8N5U6.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein."
      Seki N., Hattori A., Sugano S., Muramatsu M., Saito T.
      J. Hum. Genet. 45:38-42(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain, Eye and Liver.
    6. The European IMAGE consortium
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-811 (ISOFORM 2), VARIANT PHE-332.
    7. "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10."
      Lin J., Friesen M.T., Bocangel P., Cheung D., Rawszer K., Wigle J.T.
      Mol. Cell. Biochem. 275:75-84(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MEOX2.

    Entry informationi

    Entry nameiRNF10_HUMAN
    AccessioniPrimary (citable) accession number: Q8N5U6
    Secondary accession number(s): Q92550, Q9NPP8, Q9ULW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3