Q8N5U6 (RNF10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RING finger protein 10

Gene names

Name:	RNF10
Synonyms:	KIAA0262, RIE2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	811 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional factor involved in the regulation of MAG expression. Participates in the peripheral nerve development and Schawnn cell differentiation By similarity.
Subunit structure	Interacts with MEOX2. Ref.7
Subcellular location	Cytoplasm By similarity. Nucleus By similarity Ref.7.
Sequence similarities	Belongs to the RNF10 family. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of Schwann cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of myelination Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-templated Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay Ref.7. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	transcription regulatory region DNA binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N5U6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N5U6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     418-418: K → KSLLQQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 811	811	RING finger protein 10		PRO_0000259585
Regions
	Zinc finger	225 – 267	43	RING-type
	Region	101 – 185	85	Interaction with MEOX2
	Compositional bias	19 – 110	92	Ser-rich
Natural variations
	Alternative sequence	418	1	K → KSLLQQ in isoform 2.		VSP_021478
	Natural variant	332	1	L → F. Ref.6 Corresponds to variant rs17852961 [ dbSNP | Ensembl ].		VAR_028967
	Natural variant	433	1	E → D. Corresponds to variant rs16950277 [ dbSNP | Ensembl ].		VAR_028968

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: 54BCB1F7D59AE1BA	FASTA	811	89,927
	10 20 30 40 50 60 MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP KSDGKNSSGS 70 80 90 100 110 120 KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG GGSSKLFSSS FNGGRRDEVA 130 140 150 160 170 180 EAQRAEFSPA QFSGPKKINL NHLLNFTFEP RGQTGHFEGS GHGSWGKRNK WGHKPFNKEL 190 200 210 220 230 240 FLQANCQFVV SEDQDYTAHF ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC 250 260 270 280 290 300 GHIFCWACIL HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESHQYVVGD TITMQLMKRE 310 320 330 340 350 360 KGVLVALPKS KWMNVDHPIH LGDEQHSQYS KLLLASKEQV LHRVVLEEKV ALEQQLAEEK 370 380 390 400 410 420 HTPESCFIEA AIQELKTREE ALSGLAGSRR EVTGVVAALE QLVLMAPLAK ESVFQPRKGV 430 440 450 460 470 480 LEYLSAFDEE TTEVCSLDTP SRPLALPLVE EEEAVSEPEP EGLPEACDDL ELADDNLKEG 490 500 510 520 530 540 TICTESSQQE PITKSGFTRL SSSPCYYFYQ AEDGQHMFLH PVNVRCLVRE YGSLERSPEK 550 560 570 580 590 600 ISATVVEIAG YSMSEDVRQR HRYLSHLPLT CEFSICELAL QPPVVSKETL EMFSDDIEKR 610 620 630 640 650 660 KRQRQKKARE ERRRERRIEI EENKKQGKYP EVHIPLENLQ QFPAFNSYTC SSDSALGPTS 670 680 690 700 710 720 TEGHGALSIS PLSRSPGSHA DFLLTPLSPT ASQGSPSFCV GSLEEDSPFP SFAQMLRVGK 730 740 750 760 770 780 AKADVWPKTA PKKDENSLVP PAPVDSDGES DNSDRVPVPS FQNSFSQAIE AAFMKLDTPA 790 800 810 TSDPLSEEKG GKKRKKQKQK LLFSTSVVHT K
	Isoform 2 [UniParc]. Checksum: B7018039E420F9C9	FASTA	816	90,497
	10 20 30 40 50 60 MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP KSDGKNSSGS 70 80 90 100 110 120 KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG GGSSKLFSSS FNGGRRDEVA 130 140 150 160 170 180 EAQRAEFSPA QFSGPKKINL NHLLNFTFEP RGQTGHFEGS GHGSWGKRNK WGHKPFNKEL 190 200 210 220 230 240 FLQANCQFVV SEDQDYTAHF ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC 250 260 270 280 290 300 GHIFCWACIL HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESHQYVVGD TITMQLMKRE 310 320 330 340 350 360 KGVLVALPKS KWMNVDHPIH LGDEQHSQYS KLLLASKEQV LHRVVLEEKV ALEQQLAEEK 370 380 390 400 410 420 HTPESCFIEA AIQELKTREE ALSGLAGSRR EVTGVVAALE QLVLMAPLAK ESVFQPRKSL 430 440 450 460 470 480 LQQGVLEYLS AFDEETTEVC SLDTPSRPLA LPLVEEEEAV SEPEPEGLPE ACDDLELADD 490 500 510 520 530 540 NLKEGTICTE SSQQEPITKS GFTRLSSSPC YYFYQAEDGQ HMFLHPVNVR CLVREYGSLE 550 560 570 580 590 600 RSPEKISATV VEIAGYSMSE DVRQRHRYLS HLPLTCEFSI CELALQPPVV SKETLEMFSD 610 620 630 640 650 660 DIEKRKRQRQ KKAREERRRE RRIEIEENKK QGKYPEVHIP LENLQQFPAF NSYTCSSDSA 670 680 690 700 710 720 LGPTSTEGHG ALSISPLSRS PGSHADFLLT PLSPTASQGS PSFCVGSLEE DSPFPSFAQM 730 740 750 760 770 780 LRVGKAKADV WPKTAPKKDE NSLVPPAPVD SDGESDNSDR VPVPSFQNSF SQAIEAAFMK 790 800 810 LDTPATSDPL SEEKGGKKRK KQKQKLLFST SVVHTK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein." Seki N., Hattori A., Sugano S., Muramatsu M., Saito T. J. Hum. Genet. 45:38-42(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain, Eye and Liver.
[6]	The European IMAGE consortium Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-811 (ISOFORM 2), VARIANT PHE-332.
[7]	"Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10." Lin J., Friesen M.T., Bocangel P., Cheung D., Rawszer K., Wigle J.T. Mol. Cell. Biochem. 275:75-84(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MEOX2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB027196 mRNA. Translation: BAA84708.1. D87451 mRNA. Translation: BAA13392.2. BT006974 mRNA. Translation: AAP35620.1. BC016622 mRNA. Translation: AAH16622.1. BC031596 mRNA. Translation: AAH31596.1. BC101709 mRNA. Translation: AAI01710.1. BC101715 mRNA. Translation: AAI01716.1. AL389976 mRNA. Translation: CAB97533.1.
RefSeq	NP_055683.3. NM_014868.4.
UniGene	Hs.442798.
3D structure databases
ProteinModelPortal	Q8N5U6.
SMR	Q8N5U6. Positions 220-278.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	115249. 32 interactions.
IntAct	Q8N5U6. 28 interactions.
MINT	MINT-1381793.
STRING	9606.ENSP00000322242.
PTM databases
PhosphoSite	Q8N5U6.
Polymorphism databases
DMDM	117949776.
Proteomic databases
PaxDb	Q8N5U6.
PRIDE	Q8N5U6.
Protocols and materials databases
DNASU	9921.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000325954; ENSP00000322242; ENSG00000022840. ENST00000413266; ENSP00000415682; ENSG00000022840.
GeneID	9921.
KEGG	hsa:9921.
UCSC	uc001typ.4. human.
Organism-specific databases
CTD	9921.
GeneCards	GC12P120972.
HGNC	HGNC:10055. RNF10.
HPA	HPA017135. HPA052643.
neXtProt	NX_Q8N5U6.
PharmGKB	PA34419.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG330884.
HOVERGEN	HBG059523.
InParanoid	Q8N5U6.
OMA	EGTICTE.
OrthoDB	EOG747PHT.
TreeFam	TF323455.
Gene expression databases
ArrayExpress	Q8N5U6.
Bgee	Q8N5U6.
CleanEx	HS_RNF10.
Genevestigator	Q8N5U6.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RNF10. human.
GeneWiki	RNF10.
GenomeRNAi	9921.
NextBio	37428.
PRO	Q8N5U6.

Entry information

Entry name

RNF10_HUMAN

Accession

Primary (citable) accession number: Q8N5U6
Secondary accession number(s): Q92550, Q9NPP8, Q9ULW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	February 19, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.