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Q8N5U6

- RNF10_HUMAN

UniProt

Q8N5U6 - RNF10_HUMAN

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Protein

RING finger protein 10

Gene

RNF10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional factor involved in the regulation of MAG expression. Participates in the peripheral nerve development and Schawnn cell differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri225 – 26743RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. transcription regulatory region DNA binding Source: UniProtKB
  2. ubiquitin-protein transferase activity Source: FlyBase
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. negative regulation of Schwann cell proliferation Source: UniProtKB
  2. positive regulation of myelination Source: UniProtKB
  3. positive regulation of transcription, DNA-templated Source: UniProtKB
  4. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  5. protein autoubiquitination Source: FlyBase
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 10
Gene namesi
Name:RNF10
Synonyms:KIAA0262, RIE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:10055. RNF10.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 811811RING finger protein 10PRO_0000259585Add
BLAST

Proteomic databases

MaxQBiQ8N5U6.
PaxDbiQ8N5U6.
PRIDEiQ8N5U6.

PTM databases

PhosphoSiteiQ8N5U6.

Expressioni

Gene expression databases

BgeeiQ8N5U6.
CleanExiHS_RNF10.
ExpressionAtlasiQ8N5U6. baseline and differential.
GenevestigatoriQ8N5U6.

Organism-specific databases

HPAiHPA017135.
HPA052643.

Interactioni

Subunit structurei

Interacts with MEOX2.1 Publication

Protein-protein interaction databases

BioGridi115249. 32 interactions.
IntActiQ8N5U6. 28 interactions.
MINTiMINT-1381793.
STRINGi9606.ENSP00000322242.

Structurei

3D structure databases

ProteinModelPortaliQ8N5U6.
SMRiQ8N5U6. Positions 220-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni101 – 18585Interaction with MEOX2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi19 – 11092Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the RNF10 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri225 – 26743RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG330884.
GeneTreeiENSGT00390000001731.
HOVERGENiHBG059523.
InParanoidiQ8N5U6.
OMAiEGTICTE.
OrthoDBiEOG747PHT.
PhylomeDBiQ8N5U6.
TreeFamiTF323455.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N5U6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP
60 70 80 90 100
KSDGKNSSGS KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG
110 120 130 140 150
GGSSKLFSSS FNGGRRDEVA EAQRAEFSPA QFSGPKKINL NHLLNFTFEP
160 170 180 190 200
RGQTGHFEGS GHGSWGKRNK WGHKPFNKEL FLQANCQFVV SEDQDYTAHF
210 220 230 240 250
ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC GHIFCWACIL
260 270 280 290 300
HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESHQYVVGD TITMQLMKRE
310 320 330 340 350
KGVLVALPKS KWMNVDHPIH LGDEQHSQYS KLLLASKEQV LHRVVLEEKV
360 370 380 390 400
ALEQQLAEEK HTPESCFIEA AIQELKTREE ALSGLAGSRR EVTGVVAALE
410 420 430 440 450
QLVLMAPLAK ESVFQPRKGV LEYLSAFDEE TTEVCSLDTP SRPLALPLVE
460 470 480 490 500
EEEAVSEPEP EGLPEACDDL ELADDNLKEG TICTESSQQE PITKSGFTRL
510 520 530 540 550
SSSPCYYFYQ AEDGQHMFLH PVNVRCLVRE YGSLERSPEK ISATVVEIAG
560 570 580 590 600
YSMSEDVRQR HRYLSHLPLT CEFSICELAL QPPVVSKETL EMFSDDIEKR
610 620 630 640 650
KRQRQKKARE ERRRERRIEI EENKKQGKYP EVHIPLENLQ QFPAFNSYTC
660 670 680 690 700
SSDSALGPTS TEGHGALSIS PLSRSPGSHA DFLLTPLSPT ASQGSPSFCV
710 720 730 740 750
GSLEEDSPFP SFAQMLRVGK AKADVWPKTA PKKDENSLVP PAPVDSDGES
760 770 780 790 800
DNSDRVPVPS FQNSFSQAIE AAFMKLDTPA TSDPLSEEKG GKKRKKQKQK
810
LLFSTSVVHT K
Length:811
Mass (Da):89,927
Last modified:October 31, 2006 - v2
Checksum:i54BCB1F7D59AE1BA
GO
Isoform 2 (identifier: Q8N5U6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     418-418: K → KSLLQQ

Note: No experimental confirmation available.

Show »
Length:816
Mass (Da):90,497
Checksum:iB7018039E420F9C9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti332 – 3321L → F.1 Publication
Corresponds to variant rs17852961 [ dbSNP | Ensembl ].
VAR_028967
Natural varianti433 – 4331E → D.
Corresponds to variant rs16950277 [ dbSNP | Ensembl ].
VAR_028968

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei418 – 4181K → KSLLQQ in isoform 2. 1 PublicationVSP_021478

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027196 mRNA. Translation: BAA84708.1.
D87451 mRNA. Translation: BAA13392.2.
BT006974 mRNA. Translation: AAP35620.1.
BC016622 mRNA. Translation: AAH16622.1.
BC031596 mRNA. Translation: AAH31596.1.
BC101709 mRNA. Translation: AAI01710.1.
BC101715 mRNA. Translation: AAI01716.1.
AL389976 mRNA. Translation: CAB97533.1.
CCDSiCCDS9201.1. [Q8N5U6-1]
RefSeqiNP_055683.3. NM_014868.4. [Q8N5U6-1]
XP_006719780.1. XM_006719717.1. [Q8N5U6-2]
UniGeneiHs.442798.

Genome annotation databases

EnsembliENST00000325954; ENSP00000322242; ENSG00000022840. [Q8N5U6-1]
ENST00000413266; ENSP00000415682; ENSG00000022840. [Q8N5U6-2]
GeneIDi9921.
KEGGihsa:9921.
UCSCiuc001typ.4. human. [Q8N5U6-1]
uc001tyq.4. human. [Q8N5U6-2]

Polymorphism databases

DMDMi117949776.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027196 mRNA. Translation: BAA84708.1 .
D87451 mRNA. Translation: BAA13392.2 .
BT006974 mRNA. Translation: AAP35620.1 .
BC016622 mRNA. Translation: AAH16622.1 .
BC031596 mRNA. Translation: AAH31596.1 .
BC101709 mRNA. Translation: AAI01710.1 .
BC101715 mRNA. Translation: AAI01716.1 .
AL389976 mRNA. Translation: CAB97533.1 .
CCDSi CCDS9201.1. [Q8N5U6-1 ]
RefSeqi NP_055683.3. NM_014868.4. [Q8N5U6-1 ]
XP_006719780.1. XM_006719717.1. [Q8N5U6-2 ]
UniGenei Hs.442798.

3D structure databases

ProteinModelPortali Q8N5U6.
SMRi Q8N5U6. Positions 220-278.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115249. 32 interactions.
IntActi Q8N5U6. 28 interactions.
MINTi MINT-1381793.
STRINGi 9606.ENSP00000322242.

PTM databases

PhosphoSitei Q8N5U6.

Polymorphism databases

DMDMi 117949776.

Proteomic databases

MaxQBi Q8N5U6.
PaxDbi Q8N5U6.
PRIDEi Q8N5U6.

Protocols and materials databases

DNASUi 9921.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000325954 ; ENSP00000322242 ; ENSG00000022840 . [Q8N5U6-1 ]
ENST00000413266 ; ENSP00000415682 ; ENSG00000022840 . [Q8N5U6-2 ]
GeneIDi 9921.
KEGGi hsa:9921.
UCSCi uc001typ.4. human. [Q8N5U6-1 ]
uc001tyq.4. human. [Q8N5U6-2 ]

Organism-specific databases

CTDi 9921.
GeneCardsi GC12P120972.
HGNCi HGNC:10055. RNF10.
HPAi HPA017135.
HPA052643.
neXtProti NX_Q8N5U6.
PharmGKBi PA34419.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG330884.
GeneTreei ENSGT00390000001731.
HOVERGENi HBG059523.
InParanoidi Q8N5U6.
OMAi EGTICTE.
OrthoDBi EOG747PHT.
PhylomeDBi Q8N5U6.
TreeFami TF323455.

Miscellaneous databases

ChiTaRSi RNF10. human.
GeneWikii RNF10.
GenomeRNAii 9921.
NextBioi 37428.
PROi Q8N5U6.

Gene expression databases

Bgeei Q8N5U6.
CleanExi HS_RNF10.
ExpressionAtlasi Q8N5U6. baseline and differential.
Genevestigatori Q8N5U6.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein."
    Seki N., Hattori A., Sugano S., Muramatsu M., Saito T.
    J. Hum. Genet. 45:38-42(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Eye and Liver.
  6. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-811 (ISOFORM 2), VARIANT PHE-332.
  7. "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10."
    Lin J., Friesen M.T., Bocangel P., Cheung D., Rawszer K., Wigle J.T.
    Mol. Cell. Biochem. 275:75-84(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MEOX2.

Entry informationi

Entry nameiRNF10_HUMAN
AccessioniPrimary (citable) accession number: Q8N5U6
Secondary accession number(s): Q92550, Q9NPP8, Q9ULW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3