Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8N5S3 (CB073_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C2orf73
Gene names
Name:C2orf73
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence caution

The sequence AAH31669.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N5S3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N5S3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Uncharacterized protein C2orf73
PRO_0000332213

Natural variations

Alternative sequence1 – 121121Missing in isoform 2.
VSP_033353
Natural variant291H → N.
Corresponds to variant rs55714450 [ dbSNP | Ensembl ].
VAR_061571
Natural variant2541P → L. Ref.1 Ref.3 Ref.4
Corresponds to variant rs2280718 [ dbSNP | Ensembl ].
VAR_042973
Natural variant2751R → T. Ref.1 Ref.3
Corresponds to variant rs13184 [ dbSNP | Ensembl ].
VAR_042974

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 11, 2011. Version 3.
Checksum: 9AFD7EBA65BCE7C0

FASTA28732,142
        10         20         30         40         50         60 
MEEKEDKHQQ HKIEDAAITY VSENEEIKHE EKPGKSIHHS KSHVGRGRIY YAKFINTNAR 

        70         80         90        100        110        120 
TYNEPFPYID PKKGPEIQGD WWSHGKALEP VFLPPYDSKS TQRSDFQKPS CPLVLPVKHS 

       130        140        150        160        170        180 
KMQKPSCGIV PLASPGTSAE LQNNFIEYIS FIHQYDARKT PNEPLQGKRH GAFVQREIKP 

       190        200        210        220        230        240 
GSRPTVPKGA EVLLNTPGSR SSEQSKKTEK GNSAESRMIS PGLCQQNSQE LLEPKTHLSE 

       250        260        270        280 
TDVRQAAKAC PSTPESREKT SGATQTTVGD ALFTRHKPLN PPIKKSE 

« Hide

Isoform 2 [UniParc].

Checksum: 3E753058BB0C4526
Show »

FASTA16618,091

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS LEU-254 AND THR-275.
Tissue: Testis.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-254 AND THR-275.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-254.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK097617 mRNA. Translation: BAC05122.1.
AC108929 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00150.1.
BC031669 mRNA. Translation: AAH31669.1. Different initiation.
BC126244 mRNA. Translation: AAI26245.1.
BC126246 mRNA. Translation: AAI26247.1.
CCDSCCDS46285.1. [Q8N5S3-1]
RefSeqNP_001093866.1. NM_001100396.1. [Q8N5S3-1]
XP_005264190.1. XM_005264133.1. [Q8N5S3-2]
XP_005264191.1. XM_005264134.1. [Q8N5S3-2]
UniGeneHs.732626.

3D structure databases

ProteinModelPortalQ8N5S3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126212. 3 interactions.
IntActQ8N5S3. 2 interactions.
STRING9606.ENSP00000381631.

Proteomic databases

PaxDbQ8N5S3.
PRIDEQ8N5S3.

Protocols and materials databases

DNASU129852.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000398634; ENSP00000381631; ENSG00000177994. [Q8N5S3-1]
GeneID129852.
KEGGhsa:129852.
UCSCuc002rxs.1. human. [Q8N5S3-1]

Organism-specific databases

CTD129852.
GeneCardsGC02P054557.
HGNCHGNC:26861. C2orf73.
HPAHPA055221.
neXtProtNX_Q8N5S3.
PharmGKBPA162379532.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47758.
HOGENOMHOG000111332.
HOVERGENHBG107582.
InParanoidQ8N5S3.
OMAIHQYDAR.
PhylomeDBQ8N5S3.
TreeFamTF337686.

Gene expression databases

ArrayExpressQ8N5S3.
BgeeQ8N5S3.
CleanExHS_C2orf73.
GenevestigatorQ8N5S3.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi129852.
NextBio82655.

Entry information

Entry nameCB073_HUMAN
AccessionPrimary (citable) accession number: Q8N5S3
Secondary accession number(s): A0AV79, A0AV81, Q8N7V4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 59 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM