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Protein

Uncharacterized protein C2orf73

Gene

C2orf73

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177994-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C2orf73
Gene namesi
Name:C2orf73
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26861. C2orf73.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177994.
PharmGKBiPA162379532.

Polymorphism and mutation databases

BioMutaiC2orf73.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322131 – 287Uncharacterized protein C2orf73Add BLAST287

Proteomic databases

PaxDbiQ8N5S3.
PRIDEiQ8N5S3.

PTM databases

PhosphoSitePlusiQ8N5S3.

Expressioni

Gene expression databases

BgeeiENSG00000177994.
CleanExiHS_C2orf73.
ExpressionAtlasiQ8N5S3. baseline and differential.
GenevisibleiQ8N5S3. HS.

Organism-specific databases

HPAiHPA055221.
HPA059596.

Interactioni

Protein-protein interaction databases

BioGridi126212. 3 interactors.
IntActiQ8N5S3. 3 interactors.
STRINGi9606.ENSP00000381631.

Structurei

3D structure databases

ProteinModelPortaliQ8N5S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IGYZ. Eukaryota.
ENOG4111RPT. LUCA.
GeneTreeiENSGT00390000005045.
HOGENOMiHOG000111332.
HOVERGENiHBG107582.
InParanoidiQ8N5S3.
OMAiINTNART.
OrthoDBiEOG091G10EZ.
PhylomeDBiQ8N5S3.
TreeFamiTF337686.

Family and domain databases

InterProiIPR031365. GDWWSH.
[Graphical view]
PfamiPF15667. GDWWSH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N5S3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEKEDKHQQ HKIEDAAITY VSENEEIKHE EKPGKSIHHS KSHVGRGRIY
60 70 80 90 100
YAKFINTNAR TYNEPFPYID PKKGPEIQGD WWSHGKALEP VFLPPYDSKS
110 120 130 140 150
TQRSDFQKPS CPLVLPVKHS KMQKPSCGIV PLASPGTSAE LQNNFIEYIS
160 170 180 190 200
FIHQYDARKT PNEPLQGKRH GAFVQREIKP GSRPTVPKGA EVLLNTPGSR
210 220 230 240 250
SSEQSKKTEK GNSAESRMIS PGLCQQNSQE LLEPKTHLSE TDVRQAAKAC
260 270 280
PSTPESREKT SGATQTTVGD ALFTRHKPLN PPIKKSE
Length:287
Mass (Da):32,142
Last modified:January 11, 2011 - v3
Checksum:i9AFD7EBA65BCE7C0
GO
Isoform 2 (identifier: Q8N5S3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.

Show »
Length:166
Mass (Da):18,091
Checksum:i3E753058BB0C4526
GO

Sequence cautioni

The sequence AAH31669 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06157129H → N.Corresponds to variant rs55714450dbSNPEnsembl.1
Natural variantiVAR_042973254P → L.3 PublicationsCorresponds to variant rs2280718dbSNPEnsembl.1
Natural variantiVAR_042974275R → T.2 PublicationsCorresponds to variant rs13184dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0333531 – 121Missing in isoform 2. 2 PublicationsAdd BLAST121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097617 mRNA. Translation: BAC05122.1.
AC108929 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00150.1.
BC031669 mRNA. Translation: AAH31669.1. Different initiation.
BC126244 mRNA. Translation: AAI26245.1.
BC126246 mRNA. Translation: AAI26247.1.
CCDSiCCDS46285.1. [Q8N5S3-1]
RefSeqiNP_001093866.1. NM_001100396.1. [Q8N5S3-1]
XP_005264190.1. XM_005264133.1. [Q8N5S3-2]
XP_005264191.1. XM_005264134.3. [Q8N5S3-2]
XP_011530812.1. XM_011532510.2. [Q8N5S3-1]
XP_011530815.1. XM_011532513.2. [Q8N5S3-2]
UniGeneiHs.732626.

Genome annotation databases

EnsembliENST00000398634; ENSP00000381631; ENSG00000177994. [Q8N5S3-1]
GeneIDi129852.
KEGGihsa:129852.
UCSCiuc002rxt.1. human. [Q8N5S3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097617 mRNA. Translation: BAC05122.1.
AC108929 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00150.1.
BC031669 mRNA. Translation: AAH31669.1. Different initiation.
BC126244 mRNA. Translation: AAI26245.1.
BC126246 mRNA. Translation: AAI26247.1.
CCDSiCCDS46285.1. [Q8N5S3-1]
RefSeqiNP_001093866.1. NM_001100396.1. [Q8N5S3-1]
XP_005264190.1. XM_005264133.1. [Q8N5S3-2]
XP_005264191.1. XM_005264134.3. [Q8N5S3-2]
XP_011530812.1. XM_011532510.2. [Q8N5S3-1]
XP_011530815.1. XM_011532513.2. [Q8N5S3-2]
UniGeneiHs.732626.

3D structure databases

ProteinModelPortaliQ8N5S3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126212. 3 interactors.
IntActiQ8N5S3. 3 interactors.
STRINGi9606.ENSP00000381631.

PTM databases

PhosphoSitePlusiQ8N5S3.

Polymorphism and mutation databases

BioMutaiC2orf73.

Proteomic databases

PaxDbiQ8N5S3.
PRIDEiQ8N5S3.

Protocols and materials databases

DNASUi129852.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398634; ENSP00000381631; ENSG00000177994. [Q8N5S3-1]
GeneIDi129852.
KEGGihsa:129852.
UCSCiuc002rxt.1. human. [Q8N5S3-1]

Organism-specific databases

CTDi129852.
GeneCardsiC2orf73.
HGNCiHGNC:26861. C2orf73.
HPAiHPA055221.
HPA059596.
neXtProtiNX_Q8N5S3.
OpenTargetsiENSG00000177994.
PharmGKBiPA162379532.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGYZ. Eukaryota.
ENOG4111RPT. LUCA.
GeneTreeiENSGT00390000005045.
HOGENOMiHOG000111332.
HOVERGENiHBG107582.
InParanoidiQ8N5S3.
OMAiINTNART.
OrthoDBiEOG091G10EZ.
PhylomeDBiQ8N5S3.
TreeFamiTF337686.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177994-MONOMER.

Miscellaneous databases

GenomeRNAii129852.
PROiQ8N5S3.

Gene expression databases

BgeeiENSG00000177994.
CleanExiHS_C2orf73.
ExpressionAtlasiQ8N5S3. baseline and differential.
GenevisibleiQ8N5S3. HS.

Family and domain databases

InterProiIPR031365. GDWWSH.
[Graphical view]
PfamiPF15667. GDWWSH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCB073_HUMAN
AccessioniPrimary (citable) accession number: Q8N5S3
Secondary accession number(s): A0AV79, A0AV81, Q8N7V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.