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Protein

Solute carrier family 25 member 41

Gene

SLC25A41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.23.6. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 41
Gene namesi
Name:SLC25A41Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28533. SLC25A41.

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei96 – 11318Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei151 – 17020Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei194 – 20714Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei245 – 26319Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei282 – 30625Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei342 – 36120Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403684.

Polymorphism and mutation databases

BioMutaiSLC25A41.
DMDMi172046142.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Solute carrier family 25 member 41PRO_0000319990Add
BLAST

Proteomic databases

MaxQBiQ8N5S1.
PaxDbiQ8N5S1.
PRIDEiQ8N5S1.

PTM databases

PhosphoSiteiQ8N5S1.

Expressioni

Gene expression databases

BgeeiQ8N5S1.
CleanExiHS_SLC25A41.
GenevisibleiQ8N5S1. HS.

Organism-specific databases

HPAiHPA043591.

Interactioni

Protein-protein interaction databases

BioGridi129873. 84 interactions.
STRINGi9606.ENSP00000322649.

Structurei

3D structure databases

ProteinModelPortaliQ8N5S1.
SMRiQ8N5S1. Positions 87-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati90 – 17687Solcar 1Sequence analysisAdd
BLAST
Repeati184 – 26986Solcar 2Sequence analysisAdd
BLAST
Repeati280 – 36788Solcar 3Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 4415Pro-richSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ8N5S1.
KOiK14684.
OMAiYMQVYSS.
OrthoDBiEOG7V7661.
PhylomeDBiQ8N5S1.
TreeFamiTF313492.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q8N5S1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAQPGEPQN TCSRIQTLFR RVKTLLIKAP PPPQPPPPPP SWNPGCTHVY
60 70 80 90 100
GYAFGHMHDN NLEHLPSQQV LDTGEQLMVP VEVLEVDNKE ALWKFLLSGA
110 120 130 140 150
MAGAVSRTGT APLDRAKVYM QVYSSKTNFT NLLGGLQSMV QEGGFRSLWR
160 170 180 190 200
GNGINVLKIA PEYAIKFSVF EQCKNYFCGI QGSPPFQERL LAGSLAVAIS
210 220 230 240 250
QTLINPMEVL KTRLTLRRTG QYKGLLDCAR QILQREGTRA LYRGYLPNML
260 270 280 290 300
GIIPYACTDL AVYEMLQCFW VKSGRDMGDP SGLVSLSSVT LSTTCGQMAS
310 320 330 340 350
YPLTLVRTRM QAQDTVEGSN PTMRGVLQRI LAQQGWLGLY RGMTPTLLKV
360 370
LPAGGISYVV YEAMKKTLGI
Length:370
Mass (Da):40,795
Last modified:February 26, 2008 - v2
Checksum:i818C9FC7CD5F6041
GO
Isoform 21 Publication (identifier: Q8N5S1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-242: QVYSSKTNFT...LQREGTRALY → QLLGRLRQEN...PRPSSTPWRC
     243-370: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:242
Mass (Da):26,397
Checksum:i0C76E27DF28893AE
GO

Sequence cautioni

The sequence AAH31671.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC05163.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti144 – 1441G → S.
Corresponds to variant rs34488963 [ dbSNP | Ensembl ].
VAR_050132
Natural varianti258 – 2581T → S.
Corresponds to variant rs11883242 [ dbSNP | Ensembl ].
VAR_050133

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei121 – 242122QVYSS…TRALY → QLLGRLRQENRLNLGGGGCS EPRSPDRTPAWATESTPPRR TSPTCWGGYRAWSRRAASAP CGGATASTCSRLLLSMPSSS PYSSSARITSVEYKGPRPSR SVSLLAPWLWPSPRPSSTPW RC in isoform 2. 1 PublicationVSP_052690Add
BLAST
Alternative sequencei243 – 370128Missing in isoform 2. 1 PublicationVSP_035524Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097761 mRNA. Translation: BAC05163.1. Sequence problems.
AC011539 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69092.1.
CH471139 Genomic DNA. Translation: EAW69094.1.
CH471139 Genomic DNA. Translation: EAW69093.1.
BC031671 mRNA. Translation: AAH31671.1. Different initiation.
CCDSiCCDS45937.1. [Q8N5S1-1]
RefSeqiNP_775908.2. NM_173637.3. [Q8N5S1-1]
UniGeneiHs.375135.

Genome annotation databases

EnsembliENST00000321510; ENSP00000322649; ENSG00000181240. [Q8N5S1-1]
ENST00000458275; ENSP00000405411; ENSG00000181240. [Q8N5S1-2]
ENST00000597558; ENSP00000471238; ENSG00000181240. [Q8N5S1-1]
GeneIDi284427.
KEGGihsa:284427.
UCSCiuc010dus.4. human. [Q8N5S1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097761 mRNA. Translation: BAC05163.1. Sequence problems.
AC011539 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69092.1.
CH471139 Genomic DNA. Translation: EAW69094.1.
CH471139 Genomic DNA. Translation: EAW69093.1.
BC031671 mRNA. Translation: AAH31671.1. Different initiation.
CCDSiCCDS45937.1. [Q8N5S1-1]
RefSeqiNP_775908.2. NM_173637.3. [Q8N5S1-1]
UniGeneiHs.375135.

3D structure databases

ProteinModelPortaliQ8N5S1.
SMRiQ8N5S1. Positions 87-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129873. 84 interactions.
STRINGi9606.ENSP00000322649.

Protein family/group databases

TCDBi2.A.29.23.6. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteiQ8N5S1.

Polymorphism and mutation databases

BioMutaiSLC25A41.
DMDMi172046142.

Proteomic databases

MaxQBiQ8N5S1.
PaxDbiQ8N5S1.
PRIDEiQ8N5S1.

Protocols and materials databases

DNASUi284427.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321510; ENSP00000322649; ENSG00000181240. [Q8N5S1-1]
ENST00000458275; ENSP00000405411; ENSG00000181240. [Q8N5S1-2]
ENST00000597558; ENSP00000471238; ENSG00000181240. [Q8N5S1-1]
GeneIDi284427.
KEGGihsa:284427.
UCSCiuc010dus.4. human. [Q8N5S1-1]

Organism-specific databases

CTDi284427.
GeneCardsiSLC25A41.
HGNCiHGNC:28533. SLC25A41.
HPAiHPA043591.
MIMi610822. gene.
neXtProtiNX_Q8N5S1.
PharmGKBiPA162403684.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ8N5S1.
KOiK14684.
OMAiYMQVYSS.
OrthoDBiEOG7V7661.
PhylomeDBiQ8N5S1.
TreeFamiTF313492.

Miscellaneous databases

GenomeRNAii284427.
NextBioi94874.
PROiQ8N5S1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N5S1.
CleanExiHS_SLC25A41.
GenevisibleiQ8N5S1. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: TestisImported.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: BrainImported.
  5. "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system."
    Haitina T., Lindblom J., Renstroem T., Fredriksson R.
    Genomics 88:779-790(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiS2541_HUMAN
AccessioniPrimary (citable) accession number: Q8N5S1
Secondary accession number(s): A8MQ40, D6W642, Q8N7R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: March 16, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.