Q8N5R6 (CCD33_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 33

Alternative name(s):
Cancer/testis antigen 61
Short name=CT61

Gene names

Name:

CCDC33

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	958 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HOOK2	Q96ED9	2	EBI-740841,EBI-743290

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N5R6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N5R6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     849-849: P → PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ
     917-958: SALTHSMDLK...QKETANSQQT → PYSLPPAPGA...FHLPQNIYHV

Isoform 4 (identifier: Q8N5R6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-610: Missing.
     611-633: DLSTSTPREAEEEPLVPEMSHDT → MGEPGPPSPPAPKAAPGLIDSFS
     917-958: SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT → VSDPPGVAPRGSGGGAGSHRTPKVTGP

Isoform 5 (identifier: Q8N5R6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-610: Missing.
     611-633: DLSTSTPREAEEEPLVPEMSHDT → MGEPGPPSPPAPKAAPGLIDSFS
     849-849: P → PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ
     917-958: SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT → VSDPPGVAPRGSGGGAGSHRTPKVTGP

Isoform 6 (identifier: Q8N5R6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     204-214: PPRAGQPELMS → MGLKNKKNTED

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 958	958	Coiled-coil domain-containing protein 33		PRO_0000307643
Regions
	Domain	225 – 329	105	C2
	Coiled coil	632 – 774	143	Potential
	Coiled coil	859 – 899	41	Potential
Natural variations
	Alternative sequence	1 – 610	610	Missing in isoform 4 and isoform 5.		VSP_028755
	Alternative sequence	1 – 203	203	Missing in isoform 6.		VSP_040258
	Alternative sequence	204 – 214	11	PPRAGQPELMS → MGLKNKKNTED in isoform 6.		VSP_040259
	Alternative sequence	611 – 633	23	DLSTS…MSHDT → MGEPGPPSPPAPKAAPGLID SFS in isoform 4 and isoform 5.		VSP_028756
	Alternative sequence	849	1	P → PVDPGELGAGGDLTERLQET HGPGHSECTETLPAQ in isoform 2 and isoform 5.		VSP_028757
	Alternative sequence	917 – 958	42	SALTH…NSQQT → PYSLPPAPGASIFGKPRATV DPGGWREEAFQSRGQGDGPL PDPEKKQGHQRPALLGNTRE ACPFHLPQNIYHV in isoform 2.		VSP_028758
	Alternative sequence	917 – 958	42	SALTH…NSQQT → VSDPPGVAPRGSGGGAGSHR TPKVTGP in isoform 4 and isoform 5.		VSP_028759
	Natural variant	635	1	M → V. Corresponds to variant rs2277603 [ dbSNP | Ensembl ].		VAR_045602
	Natural variant	640	1	R → L. Corresponds to variant rs2277604 [ dbSNP | Ensembl ].		VAR_045603
	Natural variant	683	1	S → N. Ref.1 Corresponds to variant rs1564782 [ dbSNP | Ensembl ].		VAR_036625
	Natural variant	940	1	S → Y. Corresponds to variant rs4887136 [ dbSNP | Ensembl ].		VAR_045604
Experimental info
	Sequence conflict	237	1	Missing in BAG51911. Ref.1
	Sequence conflict	531	1	K → E in BAG51911. Ref.1
	Sequence conflict	775	1	L → P in BAF83398. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 22, 2008. Version 3. Checksum: 1F8A9284396424CA	FASTA	958	107,216
	10 20 30 40 50 60 MAFRGPEPWV SASLLRQRLK AEEKTLDLEF EVLSVGFNEA GRYALRLSAE NPLQVGSGAG 70 80 90 100 110 120 VQLQVNDGDP FPACSAITDV IEQQEPGQSL TLTRSKFIFT LPKGFCKNDG QHDAQLHVEA 130 140 150 160 170 180 LRLDEPLGRA AQRVGEAIFP IYPRPDQPRM NPKAQDHEDL YRYCGNLALL RASTDPTARH 190 200 210 220 230 240 CGSLAYSVAF HVHRGPQPPV SDSPPRAGQP ELMSPEEPLI ASQSTEPEIG HLSPSKKETI 250 260 270 280 290 300 MVTLHGATNL PACKDGSEPW PYVVVKSTSE EKNNQSSKAV TSVTSEPTRA PIWGDTVNVE 310 320 330 340 350 360 IQAEDAGQED VILKVVDNRK KQELLSYKIP IKYLRVFHPY HFELVKPTES GKADEATAKT 370 380 390 400 410 420 QLYATVVRKS SFIPRYIGCN HMALEIFLRG VNEPLANNPN PIVVIARVVP NYKEFKVSQA 430 440 450 460 470 480 NRDLASVGLP ITPLSFPIPS MMNFDVPRVS QNGCPQLSKP GGPPEQPLWN QSFLFQGRDG 490 500 510 520 530 540 ATSFSEDTAL VLEYYSSTSM KGSQPWTLNQ PLGISVLPLK SRLYQKMLTG KGLDGLHVER 550 560 570 580 590 600 LPIMDTSLKT INDEAPTVAL SFQLLSSERP ENFLTPNNSK ALPTLDPKIL DKKLRTIQES 610 620 630 640 650 660 WSKDTVSSTM DLSTSTPREA EEEPLVPEMS HDTEMNNYRR AMQKMAEDIL SLRRQASILE 670 680 690 700 710 720 GENRILRSRL AQQEEEEGQG KASEAQNTVS MKQKLLLSEL DMKKLRDRVQ HLQNELIRKN 730 740 750 760 770 780 DREKELLLLY QAQQPQAALL KQYQGKLQKM KALEETVRHQ EKVIEKMERV LEDRLQDRSK 790 800 810 820 830 840 PPPLNRQQGK PYTGFPMLSA SGLPLGSMGE NLPVELYSVL LAENAKLRTE LDKNRHQQAP 850 860 870 880 890 900 IILQQQALPD LLSGTSDKFN LLAKLEHAQS RILSLESQLE DSARRWGREK QDLATRLQEQ 910 920 930 940 950 EKGFRHPSNS IIIEQPSALT HSMDLKQPSE LEPLLPSSDS KLNKPLSPQK ETANSQQT
	Isoform 2 [UniParc]. Checksum: 0B1233CF38EDC0F1	FASTA	1,023	114,065
	10 20 30 40 50 60 MAFRGPEPWV SASLLRQRLK AEEKTLDLEF EVLSVGFNEA GRYALRLSAE NPLQVGSGAG 70 80 90 100 110 120 VQLQVNDGDP FPACSAITDV IEQQEPGQSL TLTRSKFIFT LPKGFCKNDG QHDAQLHVEA 130 140 150 160 170 180 LRLDEPLGRA AQRVGEAIFP IYPRPDQPRM NPKAQDHEDL YRYCGNLALL RASTDPTARH 190 200 210 220 230 240 CGSLAYSVAF HVHRGPQPPV SDSPPRAGQP ELMSPEEPLI ASQSTEPEIG HLSPSKKETI 250 260 270 280 290 300 MVTLHGATNL PACKDGSEPW PYVVVKSTSE EKNNQSSKAV TSVTSEPTRA PIWGDTVNVE 310 320 330 340 350 360 IQAEDAGQED VILKVVDNRK KQELLSYKIP IKYLRVFHPY HFELVKPTES GKADEATAKT 370 380 390 400 410 420 QLYATVVRKS SFIPRYIGCN HMALEIFLRG VNEPLANNPN PIVVIARVVP NYKEFKVSQA 430 440 450 460 470 480 NRDLASVGLP ITPLSFPIPS MMNFDVPRVS QNGCPQLSKP GGPPEQPLWN QSFLFQGRDG 490 500 510 520 530 540 ATSFSEDTAL VLEYYSSTSM KGSQPWTLNQ PLGISVLPLK SRLYQKMLTG KGLDGLHVER 550 560 570 580 590 600 LPIMDTSLKT INDEAPTVAL SFQLLSSERP ENFLTPNNSK ALPTLDPKIL DKKLRTIQES 610 620 630 640 650 660 WSKDTVSSTM DLSTSTPREA EEEPLVPEMS HDTEMNNYRR AMQKMAEDIL SLRRQASILE 670 680 690 700 710 720 GENRILRSRL AQQEEEEGQG KASEAQNTVS MKQKLLLSEL DMKKLRDRVQ HLQNELIRKN 730 740 750 760 770 780 DREKELLLLY QAQQPQAALL KQYQGKLQKM KALEETVRHQ EKVIEKMERV LEDRLQDRSK 790 800 810 820 830 840 PPPLNRQQGK PYTGFPMLSA SGLPLGSMGE NLPVELYSVL LAENAKLRTE LDKNRHQQAP 850 860 870 880 890 900 IILQQQALPV DPGELGAGGD LTERLQETHG PGHSECTETL PAQDLLSGTS DKFNLLAKLE 910 920 930 940 950 960 HAQSRILSLE SQLEDSARRW GREKQDLATR LQEQEKGFRH PSNSIIIEQP PYSLPPAPGA 970 980 990 1000 1010 1020 SIFGKPRATV DPGGWREEAF QSRGQGDGPL PDPEKKQGHQ RPALLGNTRE ACPFHLPQNI YHV
	Isoform 4 [UniParc]. Checksum: 540C809CD62CEF28	FASTA	333	37,440
	10 20 30 40 50 60 MGEPGPPSPP APKAAPGLID SFSEMNNYRR AMQKMAEDIL SLRRQASILE GENRILRSRL 70 80 90 100 110 120 AQQEEEEGQG KASEAQNTVS MKQKLLLSEL DMKKLRDRVQ HLQNELIRKN DREKELLLLY 130 140 150 160 170 180 QAQQPQAALL KQYQGKLQKM KALEETVRHQ EKVIEKMERV LEDRLQDRSK PPPLNRQQGK 190 200 210 220 230 240 PYTGFPMLSA SGLPLGSMGE NLPVELYSVL LAENAKLRTE LDKNRHQQAP IILQQQALPD 250 260 270 280 290 300 LLSGTSDKFN LLAKLEHAQS RILSLESQLE DSARRWGREK QDLATRLQEQ EKGFRHPSNS 310 320 330 IIIEQPVSDP PGVAPRGSGG GAGSHRTPKV TGP
	Isoform 5 [UniParc]. Checksum: CD44E943A7C40A79	FASTA	367	40,924
	10 20 30 40 50 60 MGEPGPPSPP APKAAPGLID SFSEMNNYRR AMQKMAEDIL SLRRQASILE GENRILRSRL 70 80 90 100 110 120 AQQEEEEGQG KASEAQNTVS MKQKLLLSEL DMKKLRDRVQ HLQNELIRKN DREKELLLLY 130 140 150 160 170 180 QAQQPQAALL KQYQGKLQKM KALEETVRHQ EKVIEKMERV LEDRLQDRSK PPPLNRQQGK 190 200 210 220 230 240 PYTGFPMLSA SGLPLGSMGE NLPVELYSVL LAENAKLRTE LDKNRHQQAP IILQQQALPV 250 260 270 280 290 300 DPGELGAGGD LTERLQETHG PGHSECTETL PAQDLLSGTS DKFNLLAKLE HAQSRILSLE 310 320 330 340 350 360 SQLEDSARRW GREKQDLATR LQEQEKGFRH PSNSIIIEQP VSDPPGVAPR GSGGGAGSHR TPKVTGP
	Isoform 6 [UniParc]. Checksum: 13B4BCF196C06C44	FASTA	755	84,952
	10 20 30 40 50 60 MGLKNKKNTE DPEEPLIASQ STEPEIGHLS PSKKETIMVT LHGATNLPAC KDGSEPWPYV 70 80 90 100 110 120 VVKSTSEEKN NQSSKAVTSV TSEPTRAPIW GDTVNVEIQA EDAGQEDVIL KVVDNRKKQE 130 140 150 160 170 180 LLSYKIPIKY LRVFHPYHFE LVKPTESGKA DEATAKTQLY ATVVRKSSFI PRYIGCNHMA 190 200 210 220 230 240 LEIFLRGVNE PLANNPNPIV VIARVVPNYK EFKVSQANRD LASVGLPITP LSFPIPSMMN 250 260 270 280 290 300 FDVPRVSQNG CPQLSKPGGP PEQPLWNQSF LFQGRDGATS FSEDTALVLE YYSSTSMKGS 310 320 330 340 350 360 QPWTLNQPLG ISVLPLKSRL YQKMLTGKGL DGLHVERLPI MDTSLKTIND EAPTVALSFQ 370 380 390 400 410 420 LLSSERPENF LTPNNSKALP TLDPKILDKK LRTIQESWSK DTVSSTMDLS TSTPREAEEE 430 440 450 460 470 480 PLVPEMSHDT EMNNYRRAMQ KMAEDILSLR RQASILEGEN RILRSRLAQQ EEEEGQGKAS 490 500 510 520 530 540 EAQNTVSMKQ KLLLSELDMK KLRDRVQHLQ NELIRKNDRE KELLLLYQAQ QPQAALLKQY 550 560 570 580 590 600 QGKLQKMKAL EETVRHQEKV IEKMERVLED RLQDRSKPPP LNRQQGKPYT GFPMLSASGL 610 620 630 640 650 660 PLGSMGENLP VELYSVLLAE NAKLRTELDK NRHQQAPIIL QQQALPDLLS GTSDKFNLLA 670 680 690 700 710 720 KLEHAQSRIL SLESQLEDSA RRWGREKQDL ATRLQEQEKG FRHPSNSIII EQPSALTHSM 730 740 750 DLKQPSELEP LLPSSDSKLN KPLSPQKETA NSQQT

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6), VARIANT ASN-683. Tissue: Lung and Testis.
[2]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 324-958 (ISOFORM 2). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK057417 mRNA. Translation: BAG51911.1. AK026821 mRNA. Translation: BAB15564.1. AK290709 mRNA. Translation: BAF83398.1. AC023300 Genomic DNA. No translation available. AC090826 Genomic DNA. No translation available. BC031684 mRNA. Translation: AAH31684.1.
IPI	IPI00152152. IPI00177882. IPI00376874. IPI00869100. IPI00941163.
RefSeq	NP_079331.3. NM_025055.4.
UniGene	Hs.383206. Hs.621342.
3D structure databases
ProteinModelPortal	Q8N5R6.
SMR	Q8N5R6. Positions 236-334.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N5R6. 25 interactions.
MINT	MINT-1467824.
STRING	9606.ENSP00000381795.
PTM databases
PhosphoSite	Q8N5R6.
Polymorphism databases
DMDM	205646145.
Proteomic databases
PaxDb	Q8N5R6.
PRIDE	Q8N5R6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000268082; ENSP00000268082; ENSG00000140481. ENST00000321374; ENSP00000325661; ENSG00000140481. ENST00000398814; ENSP00000381795; ENSG00000140481. ENST00000558821; ENSP00000452817; ENSG00000140481.
GeneID	80125.
KEGG	hsa:80125.
UCSC	uc002axo.3. human. uc002axq.3. human. uc002axr.3. human.
Organism-specific databases
CTD	80125.
GeneCards	GC15P074509.
HGNC	HGNC:26552. CCDC33.
HPA	HPA038628.
neXtProt	NX_Q8N5R6.
PharmGKB	PA142672188.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG133362.
HOVERGEN	HBG107614.
Gene expression databases
ArrayExpress	Q8N5R6.
Bgee	Q8N5R6.
CleanEx	HS_CCDC33.
Genevestigator	Q8N5R6.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. [Graphical view]
Pfam	PF00168. C2. 1 hit. [Graphical view]
SMART	SM00239. C2. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit.
PROSITE	PS50004. C2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	80125.
NextBio	70364.

Entry information

Entry name

CCD33_HUMAN

Accession

Primary (citable) accession number: Q8N5R6
Secondary accession number(s): A8K3U4 , A8MPQ6, A8MV61, A8MVU9, B3KQ49, Q8TAX6, Q9H5Q6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	July 22, 2008
Last modified:	May 1, 2013
This is version 73 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.