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Q8N5R6

- CCD33_HUMAN

UniProt

Q8N5R6 - CCD33_HUMAN

Protein

Coiled-coil domain-containing protein 33

Gene

CCDC33

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 3 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 33
    Alternative name(s):
    Cancer/testis antigen 61
    Short name:
    CT61
    Gene namesi
    Name:CCDC33
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:26552. CCDC33.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672188.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 958958Coiled-coil domain-containing protein 33PRO_0000307643Add
    BLAST

    Proteomic databases

    PaxDbiQ8N5R6.
    PRIDEiQ8N5R6.

    PTM databases

    PhosphoSiteiQ8N5R6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N5R6.
    BgeeiQ8N5R6.
    CleanExiHS_CCDC33.
    GenevestigatoriQ8N5R6.

    Organism-specific databases

    HPAiHPA038628.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HOOK2Q96ED92EBI-740841,EBI-743290

    Protein-protein interaction databases

    BioGridi123126. 25 interactions.
    IntActiQ8N5R6. 32 interactions.
    MINTiMINT-1467824.
    STRINGi9606.ENSP00000381795.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N5R6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini225 – 329105C2Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili632 – 774143Sequence AnalysisAdd
    BLAST
    Coiled coili859 – 89941Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C2 domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG133362.
    HOVERGENiHBG107614.
    OMAiCHIAVIV.
    OrthoDBiEOG79W95F.
    PhylomeDBiQ8N5R6.
    TreeFamiTF328975.

    Family and domain databases

    Gene3Di2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N5R6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFRGPEPWV SASLLRQRLK AEEKTLDLEF EVLSVGFNEA GRYALRLSAE    50
    NPLQVGSGAG VQLQVNDGDP FPACSAITDV IEQQEPGQSL TLTRSKFIFT 100
    LPKGFCKNDG QHDAQLHVEA LRLDEPLGRA AQRVGEAIFP IYPRPDQPRM 150
    NPKAQDHEDL YRYCGNLALL RASTDPTARH CGSLAYSVAF HVHRGPQPPV 200
    SDSPPRAGQP ELMSPEEPLI ASQSTEPEIG HLSPSKKETI MVTLHGATNL 250
    PACKDGSEPW PYVVVKSTSE EKNNQSSKAV TSVTSEPTRA PIWGDTVNVE 300
    IQAEDAGQED VILKVVDNRK KQELLSYKIP IKYLRVFHPY HFELVKPTES 350
    GKADEATAKT QLYATVVRKS SFIPRYIGCN HMALEIFLRG VNEPLANNPN 400
    PIVVIARVVP NYKEFKVSQA NRDLASVGLP ITPLSFPIPS MMNFDVPRVS 450
    QNGCPQLSKP GGPPEQPLWN QSFLFQGRDG ATSFSEDTAL VLEYYSSTSM 500
    KGSQPWTLNQ PLGISVLPLK SRLYQKMLTG KGLDGLHVER LPIMDTSLKT 550
    INDEAPTVAL SFQLLSSERP ENFLTPNNSK ALPTLDPKIL DKKLRTIQES 600
    WSKDTVSSTM DLSTSTPREA EEEPLVPEMS HDTEMNNYRR AMQKMAEDIL 650
    SLRRQASILE GENRILRSRL AQQEEEEGQG KASEAQNTVS MKQKLLLSEL 700
    DMKKLRDRVQ HLQNELIRKN DREKELLLLY QAQQPQAALL KQYQGKLQKM 750
    KALEETVRHQ EKVIEKMERV LEDRLQDRSK PPPLNRQQGK PYTGFPMLSA 800
    SGLPLGSMGE NLPVELYSVL LAENAKLRTE LDKNRHQQAP IILQQQALPD 850
    LLSGTSDKFN LLAKLEHAQS RILSLESQLE DSARRWGREK QDLATRLQEQ 900
    EKGFRHPSNS IIIEQPSALT HSMDLKQPSE LEPLLPSSDS KLNKPLSPQK 950
    ETANSQQT 958
    Length:958
    Mass (Da):107,216
    Last modified:July 22, 2008 - v3
    Checksum:i1F8A9284396424CA
    GO
    Isoform 2 (identifier: Q8N5R6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         849-849: P → PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ
         917-958: SALTHSMDLK...QKETANSQQT → PYSLPPAPGA...FHLPQNIYHV

    Show »
    Length:1,023
    Mass (Da):114,065
    Checksum:i0B1233CF38EDC0F1
    GO
    Isoform 4 (identifier: Q8N5R6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-610: Missing.
         611-633: DLSTSTPREAEEEPLVPEMSHDT → MGEPGPPSPPAPKAAPGLIDSFS
         917-958: SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT → VSDPPGVAPRGSGGGAGSHRTPKVTGP

    Show »
    Length:333
    Mass (Da):37,440
    Checksum:i540C809CD62CEF28
    GO
    Isoform 5 (identifier: Q8N5R6-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-610: Missing.
         611-633: DLSTSTPREAEEEPLVPEMSHDT → MGEPGPPSPPAPKAAPGLIDSFS
         849-849: P → PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ
         917-958: SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT → VSDPPGVAPRGSGGGAGSHRTPKVTGP

    Show »
    Length:367
    Mass (Da):40,924
    Checksum:iCD44E943A7C40A79
    GO
    Isoform 6 (identifier: Q8N5R6-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-203: Missing.
         204-214: PPRAGQPELMS → MGLKNKKNTED

    Show »
    Length:755
    Mass (Da):84,952
    Checksum:i13B4BCF196C06C44
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti237 – 2371Missing in BAG51911. (PubMed:14702039)Curated
    Sequence conflicti531 – 5311K → E in BAG51911. (PubMed:14702039)Curated
    Sequence conflicti775 – 7751L → P in BAF83398. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti635 – 6351M → V.
    Corresponds to variant rs2277603 [ dbSNP | Ensembl ].
    VAR_045602
    Natural varianti640 – 6401R → L.
    Corresponds to variant rs2277604 [ dbSNP | Ensembl ].
    VAR_045603
    Natural varianti683 – 6831S → N.1 Publication
    Corresponds to variant rs1564782 [ dbSNP | Ensembl ].
    VAR_036625
    Natural varianti940 – 9401S → Y.
    Corresponds to variant rs4887136 [ dbSNP | Ensembl ].
    VAR_045604

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 610610Missing in isoform 4 and isoform 5. 1 PublicationVSP_028755Add
    BLAST
    Alternative sequencei1 – 203203Missing in isoform 6. 1 PublicationVSP_040258Add
    BLAST
    Alternative sequencei204 – 21411PPRAGQPELMS → MGLKNKKNTED in isoform 6. 1 PublicationVSP_040259Add
    BLAST
    Alternative sequencei611 – 63323DLSTS…MSHDT → MGEPGPPSPPAPKAAPGLID SFS in isoform 4 and isoform 5. 1 PublicationVSP_028756Add
    BLAST
    Alternative sequencei849 – 8491P → PVDPGELGAGGDLTERLQET HGPGHSECTETLPAQ in isoform 2 and isoform 5. 1 PublicationVSP_028757
    Alternative sequencei917 – 95842SALTH…NSQQT → PYSLPPAPGASIFGKPRATV DPGGWREEAFQSRGQGDGPL PDPEKKQGHQRPALLGNTRE ACPFHLPQNIYHV in isoform 2. 1 PublicationVSP_028758Add
    BLAST
    Alternative sequencei917 – 95842SALTH…NSQQT → VSDPPGVAPRGSGGGAGSHR TPKVTGP in isoform 4 and isoform 5. 1 PublicationVSP_028759Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057417 mRNA. Translation: BAG51911.1.
    AK026821 mRNA. Translation: BAB15564.1.
    AK290709 mRNA. Translation: BAF83398.1.
    AC023300 Genomic DNA. No translation available.
    AC090826 Genomic DNA. No translation available.
    BC031684 mRNA. Translation: AAH31684.1.
    CCDSiCCDS42058.1. [Q8N5R6-6]
    RefSeqiNP_001274110.1. NM_001287181.1. [Q8N5R6-4]
    NP_079331.3. NM_025055.4. [Q8N5R6-6]
    NP_877592.2. NM_182791.3. [Q8N5R6-5]
    UniGeneiHs.383206.
    Hs.621342.

    Genome annotation databases

    EnsembliENST00000268082; ENSP00000268082; ENSG00000140481. [Q8N5R6-5]
    ENST00000321374; ENSP00000325661; ENSG00000140481. [Q8N5R6-4]
    ENST00000398814; ENSP00000381795; ENSG00000140481. [Q8N5R6-6]
    ENST00000558821; ENSP00000452817; ENSG00000140481. [Q8N5R6-4]
    GeneIDi80125.
    KEGGihsa:80125.
    UCSCiuc002axo.4. human. [Q8N5R6-6]
    uc002axq.4. human. [Q8N5R6-5]
    uc002axr.4. human. [Q8N5R6-4]

    Polymorphism databases

    DMDMi205646145.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057417 mRNA. Translation: BAG51911.1 .
    AK026821 mRNA. Translation: BAB15564.1 .
    AK290709 mRNA. Translation: BAF83398.1 .
    AC023300 Genomic DNA. No translation available.
    AC090826 Genomic DNA. No translation available.
    BC031684 mRNA. Translation: AAH31684.1 .
    CCDSi CCDS42058.1. [Q8N5R6-6 ]
    RefSeqi NP_001274110.1. NM_001287181.1. [Q8N5R6-4 ]
    NP_079331.3. NM_025055.4. [Q8N5R6-6 ]
    NP_877592.2. NM_182791.3. [Q8N5R6-5 ]
    UniGenei Hs.383206.
    Hs.621342.

    3D structure databases

    ProteinModelPortali Q8N5R6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123126. 25 interactions.
    IntActi Q8N5R6. 32 interactions.
    MINTi MINT-1467824.
    STRINGi 9606.ENSP00000381795.

    PTM databases

    PhosphoSitei Q8N5R6.

    Polymorphism databases

    DMDMi 205646145.

    Proteomic databases

    PaxDbi Q8N5R6.
    PRIDEi Q8N5R6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000268082 ; ENSP00000268082 ; ENSG00000140481 . [Q8N5R6-5 ]
    ENST00000321374 ; ENSP00000325661 ; ENSG00000140481 . [Q8N5R6-4 ]
    ENST00000398814 ; ENSP00000381795 ; ENSG00000140481 . [Q8N5R6-6 ]
    ENST00000558821 ; ENSP00000452817 ; ENSG00000140481 . [Q8N5R6-4 ]
    GeneIDi 80125.
    KEGGi hsa:80125.
    UCSCi uc002axo.4. human. [Q8N5R6-6 ]
    uc002axq.4. human. [Q8N5R6-5 ]
    uc002axr.4. human. [Q8N5R6-4 ]

    Organism-specific databases

    CTDi 80125.
    GeneCardsi GC15P074509.
    HGNCi HGNC:26552. CCDC33.
    HPAi HPA038628.
    neXtProti NX_Q8N5R6.
    PharmGKBi PA142672188.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG133362.
    HOVERGENi HBG107614.
    OMAi CHIAVIV.
    OrthoDBi EOG79W95F.
    PhylomeDBi Q8N5R6.
    TreeFami TF328975.

    Miscellaneous databases

    GenomeRNAii 80125.
    NextBioi 70364.
    PROi Q8N5R6.

    Gene expression databases

    ArrayExpressi Q8N5R6.
    Bgeei Q8N5R6.
    CleanExi HS_CCDC33.
    Genevestigatori Q8N5R6.

    Family and domain databases

    Gene3Di 2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6), VARIANT ASN-683.
      Tissue: Lung and Testis.
    2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 324-958 (ISOFORM 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiCCD33_HUMAN
    AccessioniPrimary (citable) accession number: Q8N5R6
    Secondary accession number(s): A8K3U4
    , A8MPQ6, A8MV61, A8MVU9, B3KQ49, Q8TAX6, Q9H5Q6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 85 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3