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Q8N5R6

- CCD33_HUMAN

UniProt

Q8N5R6 - CCD33_HUMAN

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Protein
Coiled-coil domain-containing protein 33
Gene
CCDC33
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 33
Alternative name(s):
Cancer/testis antigen 61
Short name:
CT61
Gene namesi
Name:CCDC33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:26552. CCDC33.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Coiled-coil domain-containing protein 33
PRO_0000307643Add
BLAST

Proteomic databases

PaxDbiQ8N5R6.
PRIDEiQ8N5R6.

PTM databases

PhosphoSiteiQ8N5R6.

Expressioni

Gene expression databases

ArrayExpressiQ8N5R6.
BgeeiQ8N5R6.
CleanExiHS_CCDC33.
GenevestigatoriQ8N5R6.

Organism-specific databases

HPAiHPA038628.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HOOK2Q96ED92EBI-740841,EBI-743290

Protein-protein interaction databases

BioGridi123126. 25 interactions.
IntActiQ8N5R6. 32 interactions.
MINTiMINT-1467824.
STRINGi9606.ENSP00000381795.

Structurei

3D structure databases

ProteinModelPortaliQ8N5R6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 329105C2
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili632 – 774143 Reviewed prediction
Add
BLAST
Coiled coili859 – 89941 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 C2 domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG133362.
HOVERGENiHBG107614.
OMAiCHIAVIV.
OrthoDBiEOG79W95F.
PhylomeDBiQ8N5R6.
TreeFamiTF328975.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N5R6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAFRGPEPWV SASLLRQRLK AEEKTLDLEF EVLSVGFNEA GRYALRLSAE    50
NPLQVGSGAG VQLQVNDGDP FPACSAITDV IEQQEPGQSL TLTRSKFIFT 100
LPKGFCKNDG QHDAQLHVEA LRLDEPLGRA AQRVGEAIFP IYPRPDQPRM 150
NPKAQDHEDL YRYCGNLALL RASTDPTARH CGSLAYSVAF HVHRGPQPPV 200
SDSPPRAGQP ELMSPEEPLI ASQSTEPEIG HLSPSKKETI MVTLHGATNL 250
PACKDGSEPW PYVVVKSTSE EKNNQSSKAV TSVTSEPTRA PIWGDTVNVE 300
IQAEDAGQED VILKVVDNRK KQELLSYKIP IKYLRVFHPY HFELVKPTES 350
GKADEATAKT QLYATVVRKS SFIPRYIGCN HMALEIFLRG VNEPLANNPN 400
PIVVIARVVP NYKEFKVSQA NRDLASVGLP ITPLSFPIPS MMNFDVPRVS 450
QNGCPQLSKP GGPPEQPLWN QSFLFQGRDG ATSFSEDTAL VLEYYSSTSM 500
KGSQPWTLNQ PLGISVLPLK SRLYQKMLTG KGLDGLHVER LPIMDTSLKT 550
INDEAPTVAL SFQLLSSERP ENFLTPNNSK ALPTLDPKIL DKKLRTIQES 600
WSKDTVSSTM DLSTSTPREA EEEPLVPEMS HDTEMNNYRR AMQKMAEDIL 650
SLRRQASILE GENRILRSRL AQQEEEEGQG KASEAQNTVS MKQKLLLSEL 700
DMKKLRDRVQ HLQNELIRKN DREKELLLLY QAQQPQAALL KQYQGKLQKM 750
KALEETVRHQ EKVIEKMERV LEDRLQDRSK PPPLNRQQGK PYTGFPMLSA 800
SGLPLGSMGE NLPVELYSVL LAENAKLRTE LDKNRHQQAP IILQQQALPD 850
LLSGTSDKFN LLAKLEHAQS RILSLESQLE DSARRWGREK QDLATRLQEQ 900
EKGFRHPSNS IIIEQPSALT HSMDLKQPSE LEPLLPSSDS KLNKPLSPQK 950
ETANSQQT 958
Length:958
Mass (Da):107,216
Last modified:July 22, 2008 - v3
Checksum:i1F8A9284396424CA
GO
Isoform 2 (identifier: Q8N5R6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     849-849: P → PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ
     917-958: SALTHSMDLK...QKETANSQQT → PYSLPPAPGA...FHLPQNIYHV

Show »
Length:1,023
Mass (Da):114,065
Checksum:i0B1233CF38EDC0F1
GO
Isoform 4 (identifier: Q8N5R6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-610: Missing.
     611-633: DLSTSTPREAEEEPLVPEMSHDT → MGEPGPPSPPAPKAAPGLIDSFS
     917-958: SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT → VSDPPGVAPRGSGGGAGSHRTPKVTGP

Show »
Length:333
Mass (Da):37,440
Checksum:i540C809CD62CEF28
GO
Isoform 5 (identifier: Q8N5R6-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-610: Missing.
     611-633: DLSTSTPREAEEEPLVPEMSHDT → MGEPGPPSPPAPKAAPGLIDSFS
     849-849: P → PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ
     917-958: SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT → VSDPPGVAPRGSGGGAGSHRTPKVTGP

Show »
Length:367
Mass (Da):40,924
Checksum:iCD44E943A7C40A79
GO
Isoform 6 (identifier: Q8N5R6-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     204-214: PPRAGQPELMS → MGLKNKKNTED

Show »
Length:755
Mass (Da):84,952
Checksum:i13B4BCF196C06C44
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti635 – 6351M → V.
Corresponds to variant rs2277603 [ dbSNP | Ensembl ].
VAR_045602
Natural varianti640 – 6401R → L.
Corresponds to variant rs2277604 [ dbSNP | Ensembl ].
VAR_045603
Natural varianti683 – 6831S → N.1 Publication
Corresponds to variant rs1564782 [ dbSNP | Ensembl ].
VAR_036625
Natural varianti940 – 9401S → Y.
Corresponds to variant rs4887136 [ dbSNP | Ensembl ].
VAR_045604

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 610610Missing in isoform 4 and isoform 5.
VSP_028755Add
BLAST
Alternative sequencei1 – 203203Missing in isoform 6.
VSP_040258Add
BLAST
Alternative sequencei204 – 21411PPRAGQPELMS → MGLKNKKNTED in isoform 6.
VSP_040259Add
BLAST
Alternative sequencei611 – 63323DLSTS…MSHDT → MGEPGPPSPPAPKAAPGLID SFS in isoform 4 and isoform 5.
VSP_028756Add
BLAST
Alternative sequencei849 – 8491P → PVDPGELGAGGDLTERLQET HGPGHSECTETLPAQ in isoform 2 and isoform 5.
VSP_028757
Alternative sequencei917 – 95842SALTH…NSQQT → PYSLPPAPGASIFGKPRATV DPGGWREEAFQSRGQGDGPL PDPEKKQGHQRPALLGNTRE ACPFHLPQNIYHV in isoform 2.
VSP_028758Add
BLAST
Alternative sequencei917 – 95842SALTH…NSQQT → VSDPPGVAPRGSGGGAGSHR TPKVTGP in isoform 4 and isoform 5.
VSP_028759Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371Missing in BAG51911. 1 Publication
Sequence conflicti531 – 5311K → E in BAG51911. 1 Publication
Sequence conflicti775 – 7751L → P in BAF83398. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057417 mRNA. Translation: BAG51911.1.
AK026821 mRNA. Translation: BAB15564.1.
AK290709 mRNA. Translation: BAF83398.1.
AC023300 Genomic DNA. No translation available.
AC090826 Genomic DNA. No translation available.
BC031684 mRNA. Translation: AAH31684.1.
CCDSiCCDS42058.1. [Q8N5R6-6]
RefSeqiNP_001274110.1. NM_001287181.1. [Q8N5R6-4]
NP_079331.3. NM_025055.4. [Q8N5R6-6]
NP_877592.2. NM_182791.3. [Q8N5R6-5]
UniGeneiHs.383206.
Hs.621342.

Genome annotation databases

EnsembliENST00000268082; ENSP00000268082; ENSG00000140481. [Q8N5R6-5]
ENST00000321374; ENSP00000325661; ENSG00000140481. [Q8N5R6-4]
ENST00000398814; ENSP00000381795; ENSG00000140481. [Q8N5R6-6]
ENST00000558821; ENSP00000452817; ENSG00000140481. [Q8N5R6-4]
GeneIDi80125.
KEGGihsa:80125.
UCSCiuc002axo.4. human. [Q8N5R6-6]
uc002axq.4. human. [Q8N5R6-5]
uc002axr.4. human. [Q8N5R6-4]

Polymorphism databases

DMDMi205646145.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057417 mRNA. Translation: BAG51911.1 .
AK026821 mRNA. Translation: BAB15564.1 .
AK290709 mRNA. Translation: BAF83398.1 .
AC023300 Genomic DNA. No translation available.
AC090826 Genomic DNA. No translation available.
BC031684 mRNA. Translation: AAH31684.1 .
CCDSi CCDS42058.1. [Q8N5R6-6 ]
RefSeqi NP_001274110.1. NM_001287181.1. [Q8N5R6-4 ]
NP_079331.3. NM_025055.4. [Q8N5R6-6 ]
NP_877592.2. NM_182791.3. [Q8N5R6-5 ]
UniGenei Hs.383206.
Hs.621342.

3D structure databases

ProteinModelPortali Q8N5R6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123126. 25 interactions.
IntActi Q8N5R6. 32 interactions.
MINTi MINT-1467824.
STRINGi 9606.ENSP00000381795.

PTM databases

PhosphoSitei Q8N5R6.

Polymorphism databases

DMDMi 205646145.

Proteomic databases

PaxDbi Q8N5R6.
PRIDEi Q8N5R6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000268082 ; ENSP00000268082 ; ENSG00000140481 . [Q8N5R6-5 ]
ENST00000321374 ; ENSP00000325661 ; ENSG00000140481 . [Q8N5R6-4 ]
ENST00000398814 ; ENSP00000381795 ; ENSG00000140481 . [Q8N5R6-6 ]
ENST00000558821 ; ENSP00000452817 ; ENSG00000140481 . [Q8N5R6-4 ]
GeneIDi 80125.
KEGGi hsa:80125.
UCSCi uc002axo.4. human. [Q8N5R6-6 ]
uc002axq.4. human. [Q8N5R6-5 ]
uc002axr.4. human. [Q8N5R6-4 ]

Organism-specific databases

CTDi 80125.
GeneCardsi GC15P074509.
HGNCi HGNC:26552. CCDC33.
HPAi HPA038628.
neXtProti NX_Q8N5R6.
PharmGKBi PA142672188.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG133362.
HOVERGENi HBG107614.
OMAi CHIAVIV.
OrthoDBi EOG79W95F.
PhylomeDBi Q8N5R6.
TreeFami TF328975.

Miscellaneous databases

GenomeRNAii 80125.
NextBioi 70364.
PROi Q8N5R6.

Gene expression databases

ArrayExpressi Q8N5R6.
Bgeei Q8N5R6.
CleanExi HS_CCDC33.
Genevestigatori Q8N5R6.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
[Graphical view ]
Pfami PF00168. C2. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6), VARIANT ASN-683.
    Tissue: Lung and Testis.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 324-958 (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiCCD33_HUMAN
AccessioniPrimary (citable) accession number: Q8N5R6
Secondary accession number(s): A8K3U4
, A8MPQ6, A8MV61, A8MVU9, B3KQ49, Q8TAX6, Q9H5Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 22, 2008
Last modified: July 9, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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