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Protein

Coiled-coil domain-containing protein 33

Gene

CCDC33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 33
Alternative name(s):
Cancer/testis antigen 61
Short name:
CT61
Gene namesi
Name:CCDC33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:26552. CCDC33.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672188.

Polymorphism and mutation databases

DMDMi205646145.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Coiled-coil domain-containing protein 33PRO_0000307643Add
BLAST

Proteomic databases

PaxDbiQ8N5R6.
PRIDEiQ8N5R6.

PTM databases

PhosphoSiteiQ8N5R6.

Expressioni

Gene expression databases

BgeeiQ8N5R6.
CleanExiHS_CCDC33.
ExpressionAtlasiQ8N5R6. baseline and differential.
GenevestigatoriQ8N5R6.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HOOK2Q96ED92EBI-740841,EBI-743290

Protein-protein interaction databases

BioGridi123126. 93 interactions.
IntActiQ8N5R6. 33 interactions.
MINTiMINT-1467824.
STRINGi9606.ENSP00000381795.

Structurei

3D structure databases

ProteinModelPortaliQ8N5R6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 329105C2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili632 – 774143Sequence AnalysisAdd
BLAST
Coiled coili859 – 89941Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG133362.
GeneTreeiENSGT00390000017366.
HOVERGENiHBG107614.
InParanoidiQ8N5R6.
OrthoDBiEOG79W95F.
PhylomeDBiQ8N5R6.
TreeFamiTF328975.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N5R6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFRGPEPWV SASLLRQRLK AEEKTLDLEF EVLSVGFNEA GRYALRLSAE
60 70 80 90 100
NPLQVGSGAG VQLQVNDGDP FPACSAITDV IEQQEPGQSL TLTRSKFIFT
110 120 130 140 150
LPKGFCKNDG QHDAQLHVEA LRLDEPLGRA AQRVGEAIFP IYPRPDQPRM
160 170 180 190 200
NPKAQDHEDL YRYCGNLALL RASTDPTARH CGSLAYSVAF HVHRGPQPPV
210 220 230 240 250
SDSPPRAGQP ELMSPEEPLI ASQSTEPEIG HLSPSKKETI MVTLHGATNL
260 270 280 290 300
PACKDGSEPW PYVVVKSTSE EKNNQSSKAV TSVTSEPTRA PIWGDTVNVE
310 320 330 340 350
IQAEDAGQED VILKVVDNRK KQELLSYKIP IKYLRVFHPY HFELVKPTES
360 370 380 390 400
GKADEATAKT QLYATVVRKS SFIPRYIGCN HMALEIFLRG VNEPLANNPN
410 420 430 440 450
PIVVIARVVP NYKEFKVSQA NRDLASVGLP ITPLSFPIPS MMNFDVPRVS
460 470 480 490 500
QNGCPQLSKP GGPPEQPLWN QSFLFQGRDG ATSFSEDTAL VLEYYSSTSM
510 520 530 540 550
KGSQPWTLNQ PLGISVLPLK SRLYQKMLTG KGLDGLHVER LPIMDTSLKT
560 570 580 590 600
INDEAPTVAL SFQLLSSERP ENFLTPNNSK ALPTLDPKIL DKKLRTIQES
610 620 630 640 650
WSKDTVSSTM DLSTSTPREA EEEPLVPEMS HDTEMNNYRR AMQKMAEDIL
660 670 680 690 700
SLRRQASILE GENRILRSRL AQQEEEEGQG KASEAQNTVS MKQKLLLSEL
710 720 730 740 750
DMKKLRDRVQ HLQNELIRKN DREKELLLLY QAQQPQAALL KQYQGKLQKM
760 770 780 790 800
KALEETVRHQ EKVIEKMERV LEDRLQDRSK PPPLNRQQGK PYTGFPMLSA
810 820 830 840 850
SGLPLGSMGE NLPVELYSVL LAENAKLRTE LDKNRHQQAP IILQQQALPD
860 870 880 890 900
LLSGTSDKFN LLAKLEHAQS RILSLESQLE DSARRWGREK QDLATRLQEQ
910 920 930 940 950
EKGFRHPSNS IIIEQPSALT HSMDLKQPSE LEPLLPSSDS KLNKPLSPQK

ETANSQQT
Length:958
Mass (Da):107,216
Last modified:July 22, 2008 - v3
Checksum:i1F8A9284396424CA
GO
Isoform 2 (identifier: Q8N5R6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     849-849: P → PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ
     917-958: SALTHSMDLK...QKETANSQQT → PYSLPPAPGA...FHLPQNIYHV

Show »
Length:1,023
Mass (Da):114,065
Checksum:i0B1233CF38EDC0F1
GO
Isoform 4 (identifier: Q8N5R6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-610: Missing.
     611-633: DLSTSTPREAEEEPLVPEMSHDT → MGEPGPPSPPAPKAAPGLIDSFS
     917-958: SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT → VSDPPGVAPRGSGGGAGSHRTPKVTGP

Show »
Length:333
Mass (Da):37,440
Checksum:i540C809CD62CEF28
GO
Isoform 5 (identifier: Q8N5R6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-610: Missing.
     611-633: DLSTSTPREAEEEPLVPEMSHDT → MGEPGPPSPPAPKAAPGLIDSFS
     849-849: P → PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ
     917-958: SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT → VSDPPGVAPRGSGGGAGSHRTPKVTGP

Show »
Length:367
Mass (Da):40,924
Checksum:iCD44E943A7C40A79
GO
Isoform 6 (identifier: Q8N5R6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     204-214: PPRAGQPELMS → MGLKNKKNTED

Show »
Length:755
Mass (Da):84,952
Checksum:i13B4BCF196C06C44
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371Missing in BAG51911 (PubMed:14702039).Curated
Sequence conflicti531 – 5311K → E in BAG51911 (PubMed:14702039).Curated
Sequence conflicti775 – 7751L → P in BAF83398 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti635 – 6351M → V.
Corresponds to variant rs2277603 [ dbSNP | Ensembl ].
VAR_045602
Natural varianti640 – 6401R → L.
Corresponds to variant rs2277604 [ dbSNP | Ensembl ].
VAR_045603
Natural varianti683 – 6831S → N.1 Publication
Corresponds to variant rs1564782 [ dbSNP | Ensembl ].
VAR_036625
Natural varianti940 – 9401S → Y.
Corresponds to variant rs4887136 [ dbSNP | Ensembl ].
VAR_045604

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 610610Missing in isoform 4 and isoform 5. 1 PublicationVSP_028755Add
BLAST
Alternative sequencei1 – 203203Missing in isoform 6. 1 PublicationVSP_040258Add
BLAST
Alternative sequencei204 – 21411PPRAGQPELMS → MGLKNKKNTED in isoform 6. 1 PublicationVSP_040259Add
BLAST
Alternative sequencei611 – 63323DLSTS…MSHDT → MGEPGPPSPPAPKAAPGLID SFS in isoform 4 and isoform 5. 1 PublicationVSP_028756Add
BLAST
Alternative sequencei849 – 8491P → PVDPGELGAGGDLTERLQET HGPGHSECTETLPAQ in isoform 2 and isoform 5. 1 PublicationVSP_028757
Alternative sequencei917 – 95842SALTH…NSQQT → PYSLPPAPGASIFGKPRATV DPGGWREEAFQSRGQGDGPL PDPEKKQGHQRPALLGNTRE ACPFHLPQNIYHV in isoform 2. 1 PublicationVSP_028758Add
BLAST
Alternative sequencei917 – 95842SALTH…NSQQT → VSDPPGVAPRGSGGGAGSHR TPKVTGP in isoform 4 and isoform 5. 1 PublicationVSP_028759Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057417 mRNA. Translation: BAG51911.1.
AK026821 mRNA. Translation: BAB15564.1.
AK290709 mRNA. Translation: BAF83398.1.
AC023300 Genomic DNA. No translation available.
AC090826 Genomic DNA. No translation available.
BC031684 mRNA. Translation: AAH31684.1.
CCDSiCCDS42058.1. [Q8N5R6-6]
CCDS42059.1. [Q8N5R6-5]
CCDS73753.1. [Q8N5R6-4]
RefSeqiNP_001274110.1. NM_001287181.1. [Q8N5R6-4]
NP_079331.3. NM_025055.4. [Q8N5R6-6]
NP_877592.2. NM_182791.3. [Q8N5R6-5]
UniGeneiHs.383206.
Hs.621342.

Genome annotation databases

EnsembliENST00000268082; ENSP00000268082; ENSG00000140481. [Q8N5R6-5]
ENST00000321374; ENSP00000325661; ENSG00000140481. [Q8N5R6-4]
ENST00000398814; ENSP00000381795; ENSG00000140481. [Q8N5R6-6]
ENST00000558821; ENSP00000452817; ENSG00000140481. [Q8N5R6-4]
GeneIDi80125.
KEGGihsa:80125.
UCSCiuc002axo.4. human. [Q8N5R6-6]
uc002axq.4. human. [Q8N5R6-5]
uc002axr.4. human. [Q8N5R6-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057417 mRNA. Translation: BAG51911.1.
AK026821 mRNA. Translation: BAB15564.1.
AK290709 mRNA. Translation: BAF83398.1.
AC023300 Genomic DNA. No translation available.
AC090826 Genomic DNA. No translation available.
BC031684 mRNA. Translation: AAH31684.1.
CCDSiCCDS42058.1. [Q8N5R6-6]
CCDS42059.1. [Q8N5R6-5]
CCDS73753.1. [Q8N5R6-4]
RefSeqiNP_001274110.1. NM_001287181.1. [Q8N5R6-4]
NP_079331.3. NM_025055.4. [Q8N5R6-6]
NP_877592.2. NM_182791.3. [Q8N5R6-5]
UniGeneiHs.383206.
Hs.621342.

3D structure databases

ProteinModelPortaliQ8N5R6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123126. 93 interactions.
IntActiQ8N5R6. 33 interactions.
MINTiMINT-1467824.
STRINGi9606.ENSP00000381795.

PTM databases

PhosphoSiteiQ8N5R6.

Polymorphism and mutation databases

DMDMi205646145.

Proteomic databases

PaxDbiQ8N5R6.
PRIDEiQ8N5R6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268082; ENSP00000268082; ENSG00000140481. [Q8N5R6-5]
ENST00000321374; ENSP00000325661; ENSG00000140481. [Q8N5R6-4]
ENST00000398814; ENSP00000381795; ENSG00000140481. [Q8N5R6-6]
ENST00000558821; ENSP00000452817; ENSG00000140481. [Q8N5R6-4]
GeneIDi80125.
KEGGihsa:80125.
UCSCiuc002axo.4. human. [Q8N5R6-6]
uc002axq.4. human. [Q8N5R6-5]
uc002axr.4. human. [Q8N5R6-4]

Organism-specific databases

CTDi80125.
GeneCardsiGC15P074509.
HGNCiHGNC:26552. CCDC33.
neXtProtiNX_Q8N5R6.
PharmGKBiPA142672188.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG133362.
GeneTreeiENSGT00390000017366.
HOVERGENiHBG107614.
InParanoidiQ8N5R6.
OrthoDBiEOG79W95F.
PhylomeDBiQ8N5R6.
TreeFamiTF328975.

Miscellaneous databases

GenomeRNAii80125.
NextBioi70364.
PROiQ8N5R6.

Gene expression databases

BgeeiQ8N5R6.
CleanExiHS_CCDC33.
ExpressionAtlasiQ8N5R6. baseline and differential.
GenevestigatoriQ8N5R6.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6), VARIANT ASN-683.
    Tissue: Lung and Testis.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 324-958 (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiCCD33_HUMAN
AccessioniPrimary (citable) accession number: Q8N5R6
Secondary accession number(s): A8K3U4
, A8MPQ6, A8MV61, A8MVU9, B3KQ49, Q8TAX6, Q9H5Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 22, 2008
Last modified: May 27, 2015
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.