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Q8N5R6 (CCD33_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 33
Alternative name(s):
Cancer/testis antigen 61
Short name=CT61
Gene names
Name:CCDC33
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length958 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HOOK2Q96ED92EBI-740841,EBI-743290

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N5R6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N5R6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     849-849: P → PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ
     917-958: SALTHSMDLK...QKETANSQQT → PYSLPPAPGA...FHLPQNIYHV
Isoform 4 (identifier: Q8N5R6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-610: Missing.
     611-633: DLSTSTPREAEEEPLVPEMSHDT → MGEPGPPSPPAPKAAPGLIDSFS
     917-958: SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT → VSDPPGVAPRGSGGGAGSHRTPKVTGP
Isoform 5 (identifier: Q8N5R6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-610: Missing.
     611-633: DLSTSTPREAEEEPLVPEMSHDT → MGEPGPPSPPAPKAAPGLIDSFS
     849-849: P → PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ
     917-958: SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT → VSDPPGVAPRGSGGGAGSHRTPKVTGP
Isoform 6 (identifier: Q8N5R6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     204-214: PPRAGQPELMS → MGLKNKKNTED

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 958958Coiled-coil domain-containing protein 33
PRO_0000307643

Regions

Domain225 – 329105C2
Coiled coil632 – 774143 Potential
Coiled coil859 – 89941 Potential

Natural variations

Alternative sequence1 – 610610Missing in isoform 4 and isoform 5.
VSP_028755
Alternative sequence1 – 203203Missing in isoform 6.
VSP_040258
Alternative sequence204 – 21411PPRAGQPELMS → MGLKNKKNTED in isoform 6.
VSP_040259
Alternative sequence611 – 63323DLSTS…MSHDT → MGEPGPPSPPAPKAAPGLID SFS in isoform 4 and isoform 5.
VSP_028756
Alternative sequence8491P → PVDPGELGAGGDLTERLQET HGPGHSECTETLPAQ in isoform 2 and isoform 5.
VSP_028757
Alternative sequence917 – 95842SALTH…NSQQT → PYSLPPAPGASIFGKPRATV DPGGWREEAFQSRGQGDGPL PDPEKKQGHQRPALLGNTRE ACPFHLPQNIYHV in isoform 2.
VSP_028758
Alternative sequence917 – 95842SALTH…NSQQT → VSDPPGVAPRGSGGGAGSHR TPKVTGP in isoform 4 and isoform 5.
VSP_028759
Natural variant6351M → V.
Corresponds to variant rs2277603 [ dbSNP | Ensembl ].
VAR_045602
Natural variant6401R → L.
Corresponds to variant rs2277604 [ dbSNP | Ensembl ].
VAR_045603
Natural variant6831S → N. Ref.1
Corresponds to variant rs1564782 [ dbSNP | Ensembl ].
VAR_036625
Natural variant9401S → Y.
Corresponds to variant rs4887136 [ dbSNP | Ensembl ].
VAR_045604

Experimental info

Sequence conflict2371Missing in BAG51911. Ref.1
Sequence conflict5311K → E in BAG51911. Ref.1
Sequence conflict7751L → P in BAF83398. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 22, 2008. Version 3.
Checksum: 1F8A9284396424CA

FASTA958107,216
        10         20         30         40         50         60 
MAFRGPEPWV SASLLRQRLK AEEKTLDLEF EVLSVGFNEA GRYALRLSAE NPLQVGSGAG 

        70         80         90        100        110        120 
VQLQVNDGDP FPACSAITDV IEQQEPGQSL TLTRSKFIFT LPKGFCKNDG QHDAQLHVEA 

       130        140        150        160        170        180 
LRLDEPLGRA AQRVGEAIFP IYPRPDQPRM NPKAQDHEDL YRYCGNLALL RASTDPTARH 

       190        200        210        220        230        240 
CGSLAYSVAF HVHRGPQPPV SDSPPRAGQP ELMSPEEPLI ASQSTEPEIG HLSPSKKETI 

       250        260        270        280        290        300 
MVTLHGATNL PACKDGSEPW PYVVVKSTSE EKNNQSSKAV TSVTSEPTRA PIWGDTVNVE 

       310        320        330        340        350        360 
IQAEDAGQED VILKVVDNRK KQELLSYKIP IKYLRVFHPY HFELVKPTES GKADEATAKT 

       370        380        390        400        410        420 
QLYATVVRKS SFIPRYIGCN HMALEIFLRG VNEPLANNPN PIVVIARVVP NYKEFKVSQA 

       430        440        450        460        470        480 
NRDLASVGLP ITPLSFPIPS MMNFDVPRVS QNGCPQLSKP GGPPEQPLWN QSFLFQGRDG 

       490        500        510        520        530        540 
ATSFSEDTAL VLEYYSSTSM KGSQPWTLNQ PLGISVLPLK SRLYQKMLTG KGLDGLHVER 

       550        560        570        580        590        600 
LPIMDTSLKT INDEAPTVAL SFQLLSSERP ENFLTPNNSK ALPTLDPKIL DKKLRTIQES 

       610        620        630        640        650        660 
WSKDTVSSTM DLSTSTPREA EEEPLVPEMS HDTEMNNYRR AMQKMAEDIL SLRRQASILE 

       670        680        690        700        710        720 
GENRILRSRL AQQEEEEGQG KASEAQNTVS MKQKLLLSEL DMKKLRDRVQ HLQNELIRKN 

       730        740        750        760        770        780 
DREKELLLLY QAQQPQAALL KQYQGKLQKM KALEETVRHQ EKVIEKMERV LEDRLQDRSK 

       790        800        810        820        830        840 
PPPLNRQQGK PYTGFPMLSA SGLPLGSMGE NLPVELYSVL LAENAKLRTE LDKNRHQQAP 

       850        860        870        880        890        900 
IILQQQALPD LLSGTSDKFN LLAKLEHAQS RILSLESQLE DSARRWGREK QDLATRLQEQ 

       910        920        930        940        950 
EKGFRHPSNS IIIEQPSALT HSMDLKQPSE LEPLLPSSDS KLNKPLSPQK ETANSQQT 

« Hide

Isoform 2 [UniParc].

Checksum: 0B1233CF38EDC0F1
Show »

FASTA1,023114,065
Isoform 4 [UniParc].

Checksum: 540C809CD62CEF28
Show »

FASTA33337,440
Isoform 5 [UniParc].

Checksum: CD44E943A7C40A79
Show »

FASTA36740,924
Isoform 6 [UniParc].

Checksum: 13B4BCF196C06C44
Show »

FASTA75584,952

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6), VARIANT ASN-683.
Tissue: Lung and Testis.
[2]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 324-958 (ISOFORM 2).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057417 mRNA. Translation: BAG51911.1.
AK026821 mRNA. Translation: BAB15564.1.
AK290709 mRNA. Translation: BAF83398.1.
AC023300 Genomic DNA. No translation available.
AC090826 Genomic DNA. No translation available.
BC031684 mRNA. Translation: AAH31684.1.
RefSeqNP_001274110.1. NM_001287181.1.
NP_079331.3. NM_025055.4.
NP_877592.2. NM_182791.3.
UniGeneHs.383206.
Hs.621342.

3D structure databases

ProteinModelPortalQ8N5R6.
SMRQ8N5R6. Positions 237-338.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123126. 25 interactions.
IntActQ8N5R6. 32 interactions.
MINTMINT-1467824.
STRING9606.ENSP00000381795.

PTM databases

PhosphoSiteQ8N5R6.

Polymorphism databases

DMDM205646145.

Proteomic databases

PaxDbQ8N5R6.
PRIDEQ8N5R6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000268082; ENSP00000268082; ENSG00000140481. [Q8N5R6-5]
ENST00000321374; ENSP00000325661; ENSG00000140481. [Q8N5R6-4]
ENST00000398814; ENSP00000381795; ENSG00000140481. [Q8N5R6-6]
ENST00000558821; ENSP00000452817; ENSG00000140481. [Q8N5R6-4]
GeneID80125.
KEGGhsa:80125.
UCSCuc002axo.4. human. [Q8N5R6-6]
uc002axq.4. human. [Q8N5R6-5]
uc002axr.4. human. [Q8N5R6-4]

Organism-specific databases

CTD80125.
GeneCardsGC15P074509.
HGNCHGNC:26552. CCDC33.
HPAHPA038628.
neXtProtNX_Q8N5R6.
PharmGKBPA142672188.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG133362.
HOVERGENHBG107614.
OrthoDBEOG79W95F.
PhylomeDBQ8N5R6.
TreeFamTF328975.

Gene expression databases

ArrayExpressQ8N5R6.
BgeeQ8N5R6.
CleanExHS_CCDC33.
GenevestigatorQ8N5R6.

Family and domain databases

Gene3D2.60.40.150. 1 hit.
InterProIPR000008. C2_dom.
[Graphical view]
PfamPF00168. C2. 1 hit.
[Graphical view]
SMARTSM00239. C2. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi80125.
NextBio70364.
PROQ8N5R6.

Entry information

Entry nameCCD33_HUMAN
AccessionPrimary (citable) accession number: Q8N5R6
Secondary accession number(s): A8K3U4 expand/collapse secondary AC list , A8MPQ6, A8MV61, A8MVU9, B3KQ49, Q8TAX6, Q9H5Q6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 22, 2008
Last modified: April 16, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM