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Protein

Protein FAM71E2

Gene

FAM71E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33201-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM71E2
Gene namesi
Name:FAM71E2
Synonyms:C19orf16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25278. FAM71E2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180043.
PharmGKBiPA164719912.

Polymorphism and mutation databases

BioMutaiFAM71E2.
DMDMi332278208.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003413691 – 922Protein FAM71E2Add BLAST922

Proteomic databases

EPDiQ8N5Q1.
MaxQBiQ8N5Q1.
PaxDbiQ8N5Q1.
PeptideAtlasiQ8N5Q1.
PRIDEiQ8N5Q1.

PTM databases

iPTMnetiQ8N5Q1.
PhosphoSitePlusiQ8N5Q1.

Expressioni

Gene expression databases

BgeeiENSG00000180043.
CleanExiHS_FAM71E2.
ExpressionAtlasiQ8N5Q1. baseline and differential.
GenevisibleiQ8N5Q1. HS.

Organism-specific databases

HPAiHPA053781.

Interactioni

Protein-protein interaction databases

BioGridi129870. 4 interactors.
IntActiQ8N5Q1. 1 interactor.
STRINGi9606.ENSP00000398617.

Structurei

3D structure databases

ProteinModelPortaliQ8N5Q1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi364 – 554Pro-richAdd BLAST191
Compositional biasi442 – 497Ala-richAdd BLAST56

Sequence similaritiesi

Belongs to the FAM71 family.Curated

Phylogenomic databases

eggNOGiENOG410J1KZ. Eukaryota.
ENOG41118M4. LUCA.
GeneTreeiENSGT00530000063078.
HOGENOMiHOG000207887.
InParanoidiQ8N5Q1.
OMAiPWGEMKE.
OrthoDBiEOG091G0EE4.
PhylomeDBiQ8N5Q1.
TreeFamiTF337884.

Family and domain databases

InterProiIPR022168. DUF3699.
[Graphical view]
PfamiPF12480. DUF3699. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N5Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIWLRNRRCL EPLQGTPKWV PVLGELQKTL QKGEYLPLRP LPMFESNFVQ
60 70 80 90 100
VTHQGGPVFV NHRTNRLAMG VAASLPGLVL PDILLIGQPA EDRDCSGLVL
110 120 130 140 150
TRMIPLDLVH LCVHDLSAWR LKLRLVSGRQ YYLALDAPDN EVGFLFHCWV
160 170 180 190 200
RLINLLQEPA PTWTPRTTRT APLDMPLAEA PASTWHLQDQ PISRHAVRVA
210 220 230 240 250
ERNFPHKTVA AQRQRKAKAL KRSFKSQAVG DSVPLIWSQL EHADVRKKPA
260 270 280 290 300
EKKSHSDPRP DRTHTQIRLP EKTSITTWTI FSIISSTANQ TQSSPKACTS
310 320 330 340 350
ASDEATGQGH VVESPSHCVS ADSPDGFFLG SCSSLDPCLW HQDTEDLMDS
360 370 380 390 400
GGSTLSSAAS GLAPYPPAAC LSTPYSSIPR GREKAGPMGS HQGPGPPPCQ
410 420 430 440 450
KAPSGLVTSC KAPFLVDQSQ KLPAVPASSW KPPPGLAPPQ KAPAASAPPR
460 470 480 490 500
KAPAVPAPSQ KAPAVPAPSQ KAPAIPAPSR KASAASASPR KASAVPAPPQ
510 520 530 540 550
KTPPPSQKAP SVPTIPQKAV SPTAPKKKSL LLPAPSQKAL PTSPTEYQMA
560 570 580 590 600
LSPPASRGKL PGDFDVLPTG IPGRAVLERS QSGGKPEPVV TVRTQETDVV
610 620 630 640 650
EMTTQAKSPE SPFTVTKKES KDILISQTKE VTLEAFRGQG KLEDWAHWAK
660 670 680 690 700
LEERSPDLPG VRSKELEQRK RWVKAKELAV EGPSQEHSRP FSVEALTLTK
710 720 730 740 750
LMITANSKEQ PSKSALVSLP SWLLATPQAS ATSMMASVPS RPGQLSLLEG
760 770 780 790 800
KPVVVREQPE SHTWVKEGKR PWGEMKEQPW GEMKEPPWDP KGPPKVPFRS
810 820 830 840 850
KPTSASLKRE GISQAPIPLT ASPWEDLRPS PLSETLISKM EATARASQQP
860 870 880 890 900
KRVSQEPMRM PAQHPLATVG SSSEILLPML LELETVRNTA TKAEEIQEES
910 920
GVLNLLPSLQ HSQHSEWPDA GA
Length:922
Mass (Da):99,915
Last modified:May 3, 2011 - v3
Checksum:iEE358F3AC121E25D
GO

Sequence cautioni

The sequence AAH31875 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH31875 differs from that shown. Reason: Frameshift at position 198.Curated
The sequence CAD38986 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti406L → P in CAD38986 (PubMed:17974005).Curated1
Sequence conflicti546E → Q in CAD38986 (PubMed:17974005).Curated1
Sequence conflicti546E → Q in AK128284 (PubMed:14702039).Curated1
Sequence conflicti629K → E in CAD38986 (PubMed:17974005).Curated1
Sequence conflicti629K → E in AK128284 (PubMed:14702039).Curated1
Sequence conflicti711P → R in CAD38986 (PubMed:17974005).Curated1
Sequence conflicti711P → R in AK128284 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070950778 – 785Missing .2 PublicationsCorresponds to variant rs35996821dbSNPEnsembl.8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020922 Genomic DNA. No translation available.
BC031875 mRNA. Translation: AAH31875.1. Sequence problems.
AL834316 mRNA. Translation: CAD38986.2. Different initiation.
AK128284 mRNA. No translation available.
RefSeqiNP_001138874.1. NM_001145402.1.
UniGeneiHs.528319.

Genome annotation databases

EnsembliENST00000424985; ENSP00000398617; ENSG00000180043.
GeneIDi284418.
KEGGihsa:284418.
UCSCiuc002qkr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020922 Genomic DNA. No translation available.
BC031875 mRNA. Translation: AAH31875.1. Sequence problems.
AL834316 mRNA. Translation: CAD38986.2. Different initiation.
AK128284 mRNA. No translation available.
RefSeqiNP_001138874.1. NM_001145402.1.
UniGeneiHs.528319.

3D structure databases

ProteinModelPortaliQ8N5Q1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129870. 4 interactors.
IntActiQ8N5Q1. 1 interactor.
STRINGi9606.ENSP00000398617.

PTM databases

iPTMnetiQ8N5Q1.
PhosphoSitePlusiQ8N5Q1.

Polymorphism and mutation databases

BioMutaiFAM71E2.
DMDMi332278208.

Proteomic databases

EPDiQ8N5Q1.
MaxQBiQ8N5Q1.
PaxDbiQ8N5Q1.
PeptideAtlasiQ8N5Q1.
PRIDEiQ8N5Q1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000424985; ENSP00000398617; ENSG00000180043.
GeneIDi284418.
KEGGihsa:284418.
UCSCiuc002qkr.3. human.

Organism-specific databases

CTDi284418.
GeneCardsiFAM71E2.
HGNCiHGNC:25278. FAM71E2.
HPAiHPA053781.
neXtProtiNX_Q8N5Q1.
OpenTargetsiENSG00000180043.
PharmGKBiPA164719912.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1KZ. Eukaryota.
ENOG41118M4. LUCA.
GeneTreeiENSGT00530000063078.
HOGENOMiHOG000207887.
InParanoidiQ8N5Q1.
OMAiPWGEMKE.
OrthoDBiEOG091G0EE4.
PhylomeDBiQ8N5Q1.
TreeFamiTF337884.

Enzyme and pathway databases

BioCyciZFISH:G66-33201-MONOMER.

Miscellaneous databases

GenomeRNAii284418.
PROiQ8N5Q1.

Gene expression databases

BgeeiENSG00000180043.
CleanExiHS_FAM71E2.
ExpressionAtlasiQ8N5Q1. baseline and differential.
GenevisibleiQ8N5Q1. HS.

Family and domain databases

InterProiIPR022168. DUF3699.
[Graphical view]
PfamiPF12480. DUF3699. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF71E2_HUMAN
AccessioniPrimary (citable) accession number: Q8N5Q1
Secondary accession number(s): Q8ND99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 3, 2011
Last modified: November 2, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.