ID   CC022_HUMAN             Reviewed;         141 AA.
AC   Q8N5N4; B3KUS9;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 111.
DE   RecName: Full=Uncharacterized protein C3orf22;
GN   Name=C3orf22;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N5N4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N5N4-2; Sequence=VSP_056902;
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DR   EMBL; AK097841; BAG53541.1; -; mRNA.
DR   EMBL; AC024558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC032025; AAH32025.1; -; mRNA.
DR   CCDS; CCDS3040.1; -. [Q8N5N4-1]
DR   RefSeq; NP_689746.1; NM_152533.2. [Q8N5N4-1]
DR   RefSeq; XP_016861240.1; XM_017005751.1. [Q8N5N4-1]
DR   RefSeq; XP_016861241.1; XM_017005752.1. [Q8N5N4-1]
DR   RefSeq; XP_016861242.1; XM_017005753.1.
DR   AlphaFoldDB; Q8N5N4; -.
DR   STRING; 9606.ENSP00000316644; -.
DR   iPTMnet; Q8N5N4; -.
DR   PhosphoSitePlus; Q8N5N4; -.
DR   BioMuta; C3orf22; -.
DR   PaxDb; 9606-ENSP00000316644; -.
DR   PeptideAtlas; Q8N5N4; -.
DR   ProteomicsDB; 3731; -.
DR   ProteomicsDB; 72077; -. [Q8N5N4-1]
DR   Antibodypedia; 58182; 32 antibodies from 10 providers.
DR   DNASU; 152065; -.
DR   Ensembl; ENST00000318225.3; ENSP00000316644.2; ENSG00000180697.9. [Q8N5N4-1]
DR   Ensembl; ENST00000505070.5; ENSP00000422064.1; ENSG00000180697.9. [Q8N5N4-2]
DR   GeneID; 152065; -.
DR   KEGG; hsa:152065; -.
DR   MANE-Select; ENST00000318225.3; ENSP00000316644.2; NM_152533.3; NP_689746.1.
DR   UCSC; uc003ejb.4; human. [Q8N5N4-1]
DR   AGR; HGNC:28534; -.
DR   CTD; 152065; -.
DR   DisGeNET; 152065; -.
DR   GeneCards; C3orf22; -.
DR   HGNC; HGNC:28534; C3orf22.
DR   HPA; ENSG00000180697; Tissue enriched (testis).
DR   neXtProt; NX_Q8N5N4; -.
DR   OpenTargets; ENSG00000180697; -.
DR   PharmGKB; PA142672383; -.
DR   VEuPathDB; HostDB:ENSG00000180697; -.
DR   eggNOG; ENOG502TF7C; Eukaryota.
DR   GeneTree; ENSGT00390000004778; -.
DR   HOGENOM; CLU_2276506_0_0_1; -.
DR   InParanoid; Q8N5N4; -.
DR   OMA; HTEAACP; -.
DR   OrthoDB; 4822639at2759; -.
DR   PhylomeDB; Q8N5N4; -.
DR   TreeFam; TF338341; -.
DR   PathwayCommons; Q8N5N4; -.
DR   BioGRID-ORCS; 152065; 11 hits in 1120 CRISPR screens.
DR   GenomeRNAi; 152065; -.
DR   Pharos; Q8N5N4; Tdark.
DR   PRO; PR:Q8N5N4; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q8N5N4; Protein.
DR   Bgee; ENSG00000180697; Expressed in right testis and 33 other cell types or tissues.
DR   InterPro; IPR038782; C3orf22.
DR   PANTHER; PTHR37875; HYPOTHETICAL PROTEIN LOC685964; 1.
DR   PANTHER; PTHR37875:SF1; HYPOTHETICAL PROTEIN LOC685964; 1.
DR   Genevisible; Q8N5N4; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..141
FT                   /note="Uncharacterized protein C3orf22"
FT                   /id="PRO_0000234430"
FT   VAR_SEQ         73..141
FT                   /note="LGAPDFTSPSGSCPAPLPAPSPPPLCNLWELKLLSRRFPRQLAFLLSTRHTE
FT                   AACPQTSKAAGLSRGLS -> VGVRIKKSMNVTSRTLSQMYTHTGKWAPFH (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056902"
SQ   SEQUENCE   141 AA;  15686 MW;  FD27529309C1261A CRC64;
     MDSSACKKSH QSKKWRIQAQ ENFAKKFPYR LSWLTEPDPE PLQPWEVTND SNTVQLPLQK
     RLVPTRSIPV RGLGAPDFTS PSGSCPAPLP APSPPPLCNL WELKLLSRRF PRQLAFLLST
     RHTEAACPQT SKAAGLSRGL S
//