Q8N5M9 (JAGN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein jagunal homolog 1

Gene names

Name:

JAGN1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be required for endoplasmic reticulum organization By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the jagunal family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 183	183	Protein jagunal homolog 1		PRO_0000313608
Regions
	Topological domain	1 – 39	39	Cytoplasmic Potential
	Transmembrane	40 – 60	21	Helical; Potential
	Topological domain	61 – 71	11	Lumenal Potential
	Transmembrane	72 – 92	21	Helical; Potential
	Topological domain	93 – 96	4	Cytoplasmic Potential
	Transmembrane	97 – 117	21	Helical; Potential
	Topological domain	118 – 137	20	Lumenal Potential
	Transmembrane	138 – 158	21	Helical; Potential
	Topological domain	159 – 183	25	Cytoplasmic Potential
Experimental info
	Sequence conflict	9	1	A → T in BAC11188. Ref.1
	Sequence conflict	58	1	G → E in BAB55163. Ref.1
	Sequence conflict	61	1	R → G in BAB55163. Ref.1
	Sequence conflict	149	1	Y → H in BAB55163. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8N5M9 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 5F203B99E670D7A7	FASTA	183	21,125
	10 20 30 40 50 60 MASRAGPRAA GTDGSDFQHR ERVAMHYQMS VTLKYEIKKL IYVHLVIWLL LVAKMSVGHL 70 80 90 100 110 120 RLLSHDQVAM PYQWEYPYLL SILPSLLGLL SFPRNNISYL VLSMISMGLF SIAPLIYGSM 130 140 150 160 170 180 EMFPAAQQLY RHGKAYRFLF GFSAVSIMYL VLVLAVQVHA WQLYYSKKLL DSWFTSTQEK KHK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[4]	"Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis." Lee S., Cooley L. J. Cell Biol. 176:941-952(2007) [PubMed: 17389229] [Abstract] Cited for: IDENTIFICATION.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK027508 mRNA. Translation: BAB55163.1. AK074760 mRNA. Translation: BAC11188.1. CH471055 Genomic DNA. Translation: EAW64015.1. BC032101 mRNA. Translation: AAH32101.1.
IPI	IPI00329025.
RefSeq	NP_115881.3. NM_032492.3.
UniGene	Hs.24054.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q8N5M9.
Polymorphism databases
DMDM	74729022.
Proteomic databases
PRIDE	Q8N5M9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307768; ENSP00000306106; ENSG00000171135.
GeneID	84522.
KEGG	hsa:84522.
UCSC	uc003btt.2. human.
Organism-specific databases
CTD	84522.
GeneCards	GC03P009932.
H-InvDB	HIX0003036.
HGNC	HGNC:26926. JAGN1.
neXtProt	NX_Q8N5M9.
PharmGKB	PA134954931.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000005596.
HOGENOM	HBG283192.
HOVERGEN	HBG056502.
InParanoid	Q8N5M9.
OMA	IFVLEIE.
OrthoDB	EOG4CVG80.
PhylomeDB	Q8N5M9.
Gene expression databases
ArrayExpress	Q8N5M9.
Bgee	Q8N5M9.
CleanEx	HS_JAGN1.
Genevestigator	Q8N5M9.
Family and domain databases
InterPro	IPR009787. DUF1352. [Graphical view]
PANTHER	PTHR20955. DUF1352. 1 hit.
Pfam	PF07086. DUF1352. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	74343.

Entry information

Entry name

JAGN1_HUMAN

Accession

Primary (citable) accession number: Q8N5M9
Secondary accession number(s): Q8NCF6, Q96SW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.