ID   TTC9C_HUMAN             Reviewed;         171 AA.
AC   Q8N5M4; Q8WYY7;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 162.
DE   RecName: Full=Tetratricopeptide repeat protein 9C;
DE            Short=TPR repeat protein 9C;
GN   Name=TTC9C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA   Zhou X.M., Zhang P.P., Jiang H.Q., Huang Y., Qin W.X., Zhao X.T., Wan D.F.,
RA   Gu J.R.;
RT   "Novel human cDNA clones with function of inhibiting cancer cell growth.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RA   Zan Q., Guo J.H., Yu L.;
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=B-cell, and Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- INTERACTION:
CC       Q8N5M4; Q9Y232-2: CDYL; NbExp=3; IntAct=EBI-2851213, EBI-10986891;
CC       Q8N5M4; Q08379: GOLGA2; NbExp=3; IntAct=EBI-2851213, EBI-618309;
CC       Q8N5M4; O75031: HSF2BP; NbExp=3; IntAct=EBI-2851213, EBI-7116203;
CC       Q8N5M4; Q15323: KRT31; NbExp=3; IntAct=EBI-2851213, EBI-948001;
CC       Q8N5M4; O76011: KRT34; NbExp=3; IntAct=EBI-2851213, EBI-1047093;
CC       Q8N5M4; Q6A162: KRT40; NbExp=3; IntAct=EBI-2851213, EBI-10171697;
CC       Q8N5M4; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-2851213, EBI-1216080;
CC       Q8N5M4; P50222: MEOX2; NbExp=3; IntAct=EBI-2851213, EBI-748397;
CC       Q8N5M4; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-2851213, EBI-16439278;
CC       Q8N5M4; Q9BSH3: NICN1; NbExp=3; IntAct=EBI-2851213, EBI-13324229;
CC       Q8N5M4; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-2851213, EBI-742388;
CC       Q8N5M4; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-2851213, EBI-302345;
CC       Q8N5M4; P63208: SKP1; NbExp=10; IntAct=EBI-2851213, EBI-307486;
CC       Q8N5M4; O75478: TADA2A; NbExp=3; IntAct=EBI-2851213, EBI-742268;
CC       Q8N5M4; Q9H0E2: TOLLIP; NbExp=3; IntAct=EBI-2851213, EBI-74615;
CC       Q8N5M4; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-2851213, EBI-2130429;
CC       Q8N5M4; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-2851213, EBI-739895;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N5M4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N5M4-2; Sequence=VSP_056610, VSP_056611;
CC   -!- SIMILARITY: Belongs to the TTC9 family. {ECO:0000305}.
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DR   EMBL; AF289605; AAL55789.1; -; mRNA.
DR   EMBL; AF451992; AAP97691.1; -; mRNA.
DR   EMBL; AF451993; AAP97692.1; -; mRNA.
DR   EMBL; AP001160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC032123; AAH32123.1; -; mRNA.
DR   EMBL; BC053665; AAH53665.1; -; mRNA.
DR   CCDS; CCDS8033.1; -. [Q8N5M4-1]
DR   RefSeq; NP_001305741.1; NM_001318812.1. [Q8N5M4-1]
DR   RefSeq; NP_001305742.1; NM_001318813.1. [Q8N5M4-1]
DR   RefSeq; NP_001305743.1; NM_001318814.1.
DR   RefSeq; NP_001305744.1; NM_001318815.1.
DR   RefSeq; NP_001305745.1; NM_001318816.1.
DR   RefSeq; NP_776171.1; NM_173810.3. [Q8N5M4-1]
DR   AlphaFoldDB; Q8N5M4; -.
DR   SMR; Q8N5M4; -.
DR   BioGRID; 129507; 147.
DR   IntAct; Q8N5M4; 46.
DR   STRING; 9606.ENSP00000325266; -.
DR   GlyGen; Q8N5M4; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8N5M4; -.
DR   PhosphoSitePlus; Q8N5M4; -.
DR   BioMuta; TTC9C; -.
DR   DMDM; 74759911; -.
DR   EPD; Q8N5M4; -.
DR   jPOST; Q8N5M4; -.
DR   MassIVE; Q8N5M4; -.
DR   MaxQB; Q8N5M4; -.
DR   PaxDb; 9606-ENSP00000325266; -.
DR   PeptideAtlas; Q8N5M4; -.
DR   ProteomicsDB; 72075; -. [Q8N5M4-1]
DR   ProteomicsDB; 75201; -.
DR   Pumba; Q8N5M4; -.
DR   Antibodypedia; 43795; 108 antibodies from 17 providers.
DR   DNASU; 283237; -.
DR   Ensembl; ENST00000316461.9; ENSP00000325266.3; ENSG00000162222.14. [Q8N5M4-1]
DR   Ensembl; ENST00000532583.1; ENSP00000434340.1; ENSG00000162222.14. [Q8N5M4-1]
DR   GeneID; 283237; -.
DR   KEGG; hsa:283237; -.
DR   MANE-Select; ENST00000316461.9; ENSP00000325266.3; NM_173810.4; NP_776171.1.
DR   UCSC; uc001nuy.4; human. [Q8N5M4-1]
DR   AGR; HGNC:28432; -.
DR   CTD; 283237; -.
DR   DisGeNET; 283237; -.
DR   GeneCards; TTC9C; -.
DR   HGNC; HGNC:28432; TTC9C.
DR   HPA; ENSG00000162222; Low tissue specificity.
DR   neXtProt; NX_Q8N5M4; -.
DR   OpenTargets; ENSG00000162222; -.
DR   PharmGKB; PA142670685; -.
DR   VEuPathDB; HostDB:ENSG00000162222; -.
DR   eggNOG; ENOG502RXZG; Eukaryota.
DR   GeneTree; ENSGT00940000161805; -.
DR   InParanoid; Q8N5M4; -.
DR   OMA; KIYANMS; -.
DR   OrthoDB; 1083789at2759; -.
DR   PhylomeDB; Q8N5M4; -.
DR   TreeFam; TF331917; -.
DR   PathwayCommons; Q8N5M4; -.
DR   SignaLink; Q8N5M4; -.
DR   BioGRID-ORCS; 283237; 19 hits in 1164 CRISPR screens.
DR   ChiTaRS; TTC9C; human.
DR   GenomeRNAi; 283237; -.
DR   Pharos; Q8N5M4; Tdark.
DR   PRO; PR:Q8N5M4; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8N5M4; Protein.
DR   Bgee; ENSG00000162222; Expressed in primordial germ cell in gonad and 165 other cell types or tissues.
DR   ExpressionAtlas; Q8N5M4; baseline and differential.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR46512; PEPTIDYLPROLYL ISOMERASE; 1.
DR   PANTHER; PTHR46512:SF9; TETRATRICOPEPTIDE REPEAT DOMAIN 9; 1.
DR   Pfam; PF14559; TPR_19; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 2.
DR   Genevisible; Q8N5M4; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..171
FT                   /note="Tetratricopeptide repeat protein 9C"
FT                   /id="PRO_0000294465"
FT   REPEAT          8..41
FT                   /note="TPR 1"
FT   REPEAT          72..107
FT                   /note="TPR 2"
FT   REPEAT          108..141
FT                   /note="TPR 3"
FT   VAR_SEQ         1
FT                   /note="M -> MLNKEEELELLEALWSFSTSPAHSLLLPGRGGAGPIERRKPVSQAFS
FT                   RPQQFLSRALLEFFGKSHPPPHRLFRKSLNVGLHYSHIPFLTTCLHFLRKRLQKGEVGL
FT                   SVETSKPQVPVGGLSRKKVPQEPWATVM (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_056610"
FT   VAR_SEQ         80..171
FT                   /note="ACLLQMEPVNYERVREYSQKVLERQPDNAKALYRAGVAFFHLQDYDQARHYL
FT                   LAAVNRQPKDANVRRYLQLTQSELSSYHRKEKQLYLGMFG -> VVK (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_056611"
SQ   SEQUENCE   171 AA;  20013 MW;  A583DFC56CD3346E CRC64;
     MEKRLQEAQL YKEEGNQRYR EGKYRDAVSR YHRALLQLRG LDPSLPSPLP NLGPQGPALT
     PEQENILHTT QTDCYNNLAA CLLQMEPVNY ERVREYSQKV LERQPDNAKA LYRAGVAFFH
     LQDYDQARHY LLAAVNRQPK DANVRRYLQL TQSELSSYHR KEKQLYLGMF G
//