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Q8N5M4

- TTC9C_HUMAN

UniProt

Q8N5M4 - TTC9C_HUMAN

Protein

Tetratricopeptide repeat protein 9C

Gene

TTC9C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetratricopeptide repeat protein 9C
    Short name:
    TPR repeat protein 9C
    Gene namesi
    Name:TTC9C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:28432. TTC9C.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670685.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 171171Tetratricopeptide repeat protein 9CPRO_0000294465Add
    BLAST

    Proteomic databases

    MaxQBiQ8N5M4.
    PaxDbiQ8N5M4.
    PRIDEiQ8N5M4.

    PTM databases

    PhosphoSiteiQ8N5M4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N5M4.
    BgeeiQ8N5M4.
    CleanExiHS_TTC9C.
    GenevestigatoriQ8N5M4.

    Organism-specific databases

    HPAiHPA055169.

    Interactioni

    Protein-protein interaction databases

    BioGridi129507. 24 interactions.
    IntActiQ8N5M4. 5 interactions.
    STRINGi9606.ENSP00000325266.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N5M4.
    SMRiQ8N5M4. Positions 12-141.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati8 – 4134TPR 1Add
    BLAST
    Repeati72 – 10736TPR 2Add
    BLAST
    Repeati108 – 14134TPR 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the TTC9 family.Curated
    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiNOG74457.
    HOGENOMiHOG000012996.
    HOVERGENiHBG062451.
    OMAiENMLHTT.
    PhylomeDBiQ8N5M4.
    TreeFamiTF331917.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR023566. PPIase_FKBP.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF07719. TPR_2. 1 hit.
    [Graphical view]
    SMARTiSM00028. TPR. 3 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N5M4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEKRLQEAQL YKEEGNQRYR EGKYRDAVSR YHRALLQLRG LDPSLPSPLP    50
    NLGPQGPALT PEQENILHTT QTDCYNNLAA CLLQMEPVNY ERVREYSQKV 100
    LERQPDNAKA LYRAGVAFFH LQDYDQARHY LLAAVNRQPK DANVRRYLQL 150
    TQSELSSYHR KEKQLYLGMF G 171
    Length:171
    Mass (Da):20,013
    Last modified:October 1, 2002 - v1
    Checksum:iA583DFC56CD3346E
    GO
    Isoform 2 (identifier: Q8N5M4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLNKEEELEL...VPQEPWATVM
         80-171: ACLLQMEPVN...EKQLYLGMFG → VVK

    Note: No experimental confirmation available.

    Show »
    Length:215
    Mass (Da):24,373
    Checksum:i9DF9DB9E64F3E106
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MLNKEEELELLEALWSFSTS PAHSLLLPGRGGAGPIERRK PVSQAFSRPQQFLSRALLEF FGKSHPPPHRLFRKSLNVGL HYSHIPFLTTCLHFLRKRLQ KGEVGLSVETSKPQVPVGGL SRKKVPQEPWATVM in isoform 2. 1 PublicationVSP_056610
    Alternative sequencei80 – 17192ACLLQ…LGMFG → VVK in isoform 2. 1 PublicationVSP_056611Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF289605 mRNA. Translation: AAL55789.1.
    AF451992 mRNA. Translation: AAP97691.1.
    AF451993 mRNA. Translation: AAP97692.1.
    AP001160 Genomic DNA. No translation available.
    BC032123 mRNA. Translation: AAH32123.1.
    BC053665 mRNA. Translation: AAH53665.1.
    CCDSiCCDS8033.1.
    RefSeqiNP_776171.1. NM_173810.3.
    XP_005273987.1. XM_005273930.1.
    XP_005273988.1. XM_005273931.1.
    UniGeneiHs.31704.

    Genome annotation databases

    EnsembliENST00000316461; ENSP00000325266; ENSG00000162222.
    ENST00000513247; ENSP00000444031; ENSG00000162222.
    ENST00000532583; ENSP00000434340; ENSG00000162222.
    GeneIDi283237.
    KEGGihsa:283237.
    UCSCiuc001nuy.3. human.

    Polymorphism databases

    DMDMi74759911.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF289605 mRNA. Translation: AAL55789.1 .
    AF451992 mRNA. Translation: AAP97691.1 .
    AF451993 mRNA. Translation: AAP97692.1 .
    AP001160 Genomic DNA. No translation available.
    BC032123 mRNA. Translation: AAH32123.1 .
    BC053665 mRNA. Translation: AAH53665.1 .
    CCDSi CCDS8033.1.
    RefSeqi NP_776171.1. NM_173810.3.
    XP_005273987.1. XM_005273930.1.
    XP_005273988.1. XM_005273931.1.
    UniGenei Hs.31704.

    3D structure databases

    ProteinModelPortali Q8N5M4.
    SMRi Q8N5M4. Positions 12-141.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129507. 24 interactions.
    IntActi Q8N5M4. 5 interactions.
    STRINGi 9606.ENSP00000325266.

    PTM databases

    PhosphoSitei Q8N5M4.

    Polymorphism databases

    DMDMi 74759911.

    Proteomic databases

    MaxQBi Q8N5M4.
    PaxDbi Q8N5M4.
    PRIDEi Q8N5M4.

    Protocols and materials databases

    DNASUi 283237.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316461 ; ENSP00000325266 ; ENSG00000162222 .
    ENST00000513247 ; ENSP00000444031 ; ENSG00000162222 .
    ENST00000532583 ; ENSP00000434340 ; ENSG00000162222 .
    GeneIDi 283237.
    KEGGi hsa:283237.
    UCSCi uc001nuy.3. human.

    Organism-specific databases

    CTDi 283237.
    GeneCardsi GC11P062495.
    HGNCi HGNC:28432. TTC9C.
    HPAi HPA055169.
    neXtProti NX_Q8N5M4.
    PharmGKBi PA142670685.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74457.
    HOGENOMi HOG000012996.
    HOVERGENi HBG062451.
    OMAi ENMLHTT.
    PhylomeDBi Q8N5M4.
    TreeFami TF331917.

    Miscellaneous databases

    ChiTaRSi TTC9C. human.
    GenomeRNAii 283237.
    NextBioi 93756.
    PROi Q8N5M4.

    Gene expression databases

    ArrayExpressi Q8N5M4.
    Bgeei Q8N5M4.
    CleanExi HS_TTC9C.
    Genevestigatori Q8N5M4.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR023566. PPIase_FKBP.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF07719. TPR_2. 1 hit.
    [Graphical view ]
    SMARTi SM00028. TPR. 3 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel human cDNA clones with function of inhibiting cancer cell growth."
      Zhou X.M., Zhang P.P., Jiang H.Q., Huang Y., Qin W.X., Zhao X.T., Wan D.F., Gu J.R.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. Zan Q., Guo J.H., Yu L.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: B-cell and Eye.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTTC9C_HUMAN
    AccessioniPrimary (citable) accession number: Q8N5M4
    Secondary accession number(s): Q8WYY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3