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Protein

Ribonuclease P protein subunit p25-like protein

Gene

RPP25L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a component of ribonuclease P or MRP.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p25-like protein
Short name:
RNase P protein subunit-like p25
Alternative name(s):
Rpp25-like protein
Gene namesi
Name:RPP25L
Synonyms:C9orf23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:19909. RPP25L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134989644.

Polymorphism and mutation databases

BioMutaiRPP25L.
DMDMi74751030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Ribonuclease P protein subunit p25-like proteinPRO_0000271032Add
BLAST

Proteomic databases

EPDiQ8N5L8.
MaxQBiQ8N5L8.
PaxDbiQ8N5L8.
PeptideAtlasiQ8N5L8.
PRIDEiQ8N5L8.

PTM databases

iPTMnetiQ8N5L8.
PhosphoSiteiQ8N5L8.

Expressioni

Gene expression databases

BgeeiENSG00000164967.
CleanExiHS_C9orf23.
GenevisibleiQ8N5L8. HS.

Organism-specific databases

HPAiHPA052187.
HPA059698.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ARHGEF2Q929743EBI-10189722,EBI-302405
KLHL12Q53G593EBI-10189722,EBI-740929
MID2Q9UJV3-23EBI-10189722,EBI-10172526
PNMA1Q8ND903EBI-10189722,EBI-302345
POP7O758175EBI-10189722,EBI-366574
RPGRIP1Q96KN73EBI-10189722,EBI-1050213

Protein-protein interaction databases

BioGridi126519. 23 interactions.
IntActiQ8N5L8. 13 interactions.
STRINGi9606.ENSP00000297613.

Structurei

3D structure databases

ProteinModelPortaliQ8N5L8.
SMRiQ8N5L8. Positions 25-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

eggNOGiKOG2567. Eukaryota.
ENOG4111WGZ. LUCA.
GeneTreeiENSGT00390000002564.
HOGENOMiHOG000231665.
HOVERGENiHBG056729.
InParanoidiQ8N5L8.
KOiK14525.
OMAiDFWEGGG.
OrthoDBiEOG091G0OAF.
PhylomeDBiQ8N5L8.
TreeFamiTF325688.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
InterProiIPR002775. DNA/RNA-bd_Alba-like.
[Graphical view]
PfamiPF01918. Alba. 1 hit.
[Graphical view]
SUPFAMiSSF82704. SSF82704. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N5L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHYRKAGSV ELPAPSPMPQ LPPDTLEMRV RDGSKIRNLL GLALGRLEGG
60 70 80 90 100
SARHVVFSGS GRAAGKAVSC AEIVKRRVPG LHQLTKLRFL QTEDSWVPAS
110 120 130 140 150
PDTGLDPLTV RRHVPAVWVL LSRDPLDPNE CGYQPPGAPP GLGSMPSSSC
160
GPRSRRRARD TRS
Length:163
Mass (Da):17,631
Last modified:October 1, 2002 - v1
Checksum:i442C8727191A0BCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160270 Genomic DNA. Translation: CAI13161.1.
CH471071 Genomic DNA. Translation: EAW58443.1.
CH471071 Genomic DNA. Translation: EAW58444.1.
BC032136 mRNA. Translation: AAH32136.1.
CCDSiCCDS6559.1.
RefSeqiNP_680544.1. NM_148178.2.
NP_680545.1. NM_148179.2.
UniGeneiHs.15961.

Genome annotation databases

EnsembliENST00000297613; ENSP00000297613; ENSG00000164967.
ENST00000378959; ENSP00000368242; ENSG00000164967.
GeneIDi138716.
KEGGihsa:138716.
UCSCiuc003zuu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160270 Genomic DNA. Translation: CAI13161.1.
CH471071 Genomic DNA. Translation: EAW58443.1.
CH471071 Genomic DNA. Translation: EAW58444.1.
BC032136 mRNA. Translation: AAH32136.1.
CCDSiCCDS6559.1.
RefSeqiNP_680544.1. NM_148178.2.
NP_680545.1. NM_148179.2.
UniGeneiHs.15961.

3D structure databases

ProteinModelPortaliQ8N5L8.
SMRiQ8N5L8. Positions 25-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126519. 23 interactions.
IntActiQ8N5L8. 13 interactions.
STRINGi9606.ENSP00000297613.

PTM databases

iPTMnetiQ8N5L8.
PhosphoSiteiQ8N5L8.

Polymorphism and mutation databases

BioMutaiRPP25L.
DMDMi74751030.

Proteomic databases

EPDiQ8N5L8.
MaxQBiQ8N5L8.
PaxDbiQ8N5L8.
PeptideAtlasiQ8N5L8.
PRIDEiQ8N5L8.

Protocols and materials databases

DNASUi138716.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297613; ENSP00000297613; ENSG00000164967.
ENST00000378959; ENSP00000368242; ENSG00000164967.
GeneIDi138716.
KEGGihsa:138716.
UCSCiuc003zuu.4. human.

Organism-specific databases

CTDi138716.
GeneCardsiRPP25L.
H-InvDBHIX0007998.
HGNCiHGNC:19909. RPP25L.
HPAiHPA052187.
HPA059698.
neXtProtiNX_Q8N5L8.
PharmGKBiPA134989644.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2567. Eukaryota.
ENOG4111WGZ. LUCA.
GeneTreeiENSGT00390000002564.
HOGENOMiHOG000231665.
HOVERGENiHBG056729.
InParanoidiQ8N5L8.
KOiK14525.
OMAiDFWEGGG.
OrthoDBiEOG091G0OAF.
PhylomeDBiQ8N5L8.
TreeFamiTF325688.

Miscellaneous databases

GenomeRNAii138716.
PROiQ8N5L8.

Gene expression databases

BgeeiENSG00000164967.
CleanExiHS_C9orf23.
GenevisibleiQ8N5L8. HS.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
InterProiIPR002775. DNA/RNA-bd_Alba-like.
[Graphical view]
PfamiPF01918. Alba. 1 hit.
[Graphical view]
SUPFAMiSSF82704. SSF82704. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRP25L_HUMAN
AccessioniPrimary (citable) accession number: Q8N5L8
Secondary accession number(s): D3DRM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.