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Protein

Transcription factor Spi-C

Gene

SPIC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi111 – 194ETSPROSITE-ProRule annotationAdd BLAST84

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Spi-C
Gene namesi
Name:SPIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166211.7.
HGNCiHGNC:29549. SPIC.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi121599.
OpenTargetsiENSG00000166211.
PharmGKBiPA134897775.

Polymorphism and mutation databases

BioMutaiSPIC.
DMDMi68566054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041401 – 248Transcription factor Spi-CAdd BLAST248

Proteomic databases

PaxDbiQ8N5J4.
PRIDEiQ8N5J4.

PTM databases

PhosphoSitePlusiQ8N5J4.

Expressioni

Tissue specificityi

Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000166211.
CleanExiHS_SPIC.
GenevisibleiQ8N5J4. HS.

Interactioni

Subunit structurei

Binds DNA as a monomer.

Protein-protein interaction databases

BioGridi125739. 1 interactor.
IntActiQ8N5J4. 3 interactors.
STRINGi9606.ENSP00000299272.

Structurei

3D structure databases

ProteinModelPortaliQ8N5J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3805. Eukaryota.
ENOG410XSXU. LUCA.
GeneTreeiENSGT00390000015212.
HOGENOMiHOG000132995.
HOVERGENiHBG060389.
InParanoidiQ8N5J4.
KOiK09440.
OMAiYLHESLY.
OrthoDBiEOG091G0DTY.
PhylomeDBiQ8N5J4.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000418. Ets_dom.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF00178. Ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiView protein in SMART
SM00413. ETS. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N5J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCVEQDKLG QAFEDAFEVL RQHSTGDLQY SPDYRNYLAL INHRPHVKGN
60 70 80 90 100
SSCYGVLPTE EPVYNWRTVI NSAADFYFEG NIHQSLQNIT ENQLVQPTLL
110 120 130 140 150
QQKGGKGRKK LRLFEYLHES LYNPEMASCI QWVDKTKGIF QFVSKNKEKL
160 170 180 190 200
AELWGKRKGN RKTMTYQKMA RALRNYGRSG EITKIRRKLT YQFSEAILQR
210 220 230 240
LSPSYFLGKE IFYSQCVQPD QEYLSLNNWN ANYNYTYANY HELNHHDC
Length:248
Mass (Da):29,180
Last modified:October 1, 2002 - v1
Checksum:iD4DC97EA0FFEE71E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032317 mRNA. Translation: AAH32317.1.
AF518404 mRNA. Translation: AAN84476.1.
CCDSiCCDS9082.1.
RefSeqiNP_689536.1. NM_152323.2.
XP_005268703.1. XM_005268646.3.
XP_006719302.1. XM_006719239.3.
UniGeneiHs.577097.

Genome annotation databases

EnsembliENST00000551346; ENSP00000448580; ENSG00000166211.
GeneIDi121599.
KEGGihsa:121599.
UCSCiuc001tid.3. human.

Similar proteinsi

Entry informationi

Entry nameiSPIC_HUMAN
AccessioniPrimary (citable) accession number: Q8N5J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2002
Last modified: October 25, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families