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Q8N5J4

- SPIC_HUMAN

UniProt

Q8N5J4 - SPIC_HUMAN

Protein

Transcription factor Spi-C

Gene

SPIC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi111 – 19484ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. blastocyst development Source: Ensembl
    2. cell differentiation Source: RefGenome
    3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    5. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor Spi-C
    Gene namesi
    Name:SPIC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:29549. SPIC.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134897775.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Transcription factor Spi-CPRO_0000204140Add
    BLAST

    Proteomic databases

    PaxDbiQ8N5J4.
    PRIDEiQ8N5J4.

    PTM databases

    PhosphoSiteiQ8N5J4.

    Expressioni

    Tissue specificityi

    Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver.1 Publication

    Gene expression databases

    BgeeiQ8N5J4.
    CleanExiHS_SPIC.
    GenevestigatoriQ8N5J4.

    Organism-specific databases

    HPAiHPA042864.

    Interactioni

    Subunit structurei

    Binds DNA as a monomer.

    Protein-protein interaction databases

    BioGridi125739. 1 interaction.
    STRINGi9606.ENSP00000299272.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N5J4.
    SMRiQ8N5J4. Positions 110-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG296613.
    HOGENOMiHOG000132995.
    HOVERGENiHBG060389.
    InParanoidiQ8N5J4.
    KOiK09440.
    OMAiQERAHIT.
    OrthoDBiEOG78M02J.
    PhylomeDBiQ8N5J4.
    TreeFamiTF318679.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N5J4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTCVEQDKLG QAFEDAFEVL RQHSTGDLQY SPDYRNYLAL INHRPHVKGN    50
    SSCYGVLPTE EPVYNWRTVI NSAADFYFEG NIHQSLQNIT ENQLVQPTLL 100
    QQKGGKGRKK LRLFEYLHES LYNPEMASCI QWVDKTKGIF QFVSKNKEKL 150
    AELWGKRKGN RKTMTYQKMA RALRNYGRSG EITKIRRKLT YQFSEAILQR 200
    LSPSYFLGKE IFYSQCVQPD QEYLSLNNWN ANYNYTYANY HELNHHDC 248
    Length:248
    Mass (Da):29,180
    Last modified:October 1, 2002 - v1
    Checksum:iD4DC97EA0FFEE71E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC032317 mRNA. Translation: AAH32317.1.
    AF518404 mRNA. Translation: AAN84476.1.
    CCDSiCCDS9082.1.
    RefSeqiNP_689536.1. NM_152323.1.
    XP_005268703.1. XM_005268646.1.
    XP_006719301.1. XM_006719238.1.
    XP_006719302.1. XM_006719239.1.
    UniGeneiHs.577097.

    Genome annotation databases

    EnsembliENST00000551346; ENSP00000448580; ENSG00000166211.
    GeneIDi121599.
    KEGGihsa:121599.
    UCSCiuc001tid.3. human.

    Polymorphism databases

    DMDMi68566054.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC032317 mRNA. Translation: AAH32317.1 .
    AF518404 mRNA. Translation: AAN84476.1 .
    CCDSi CCDS9082.1.
    RefSeqi NP_689536.1. NM_152323.1.
    XP_005268703.1. XM_005268646.1.
    XP_006719301.1. XM_006719238.1.
    XP_006719302.1. XM_006719239.1.
    UniGenei Hs.577097.

    3D structure databases

    ProteinModelPortali Q8N5J4.
    SMRi Q8N5J4. Positions 110-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125739. 1 interaction.
    STRINGi 9606.ENSP00000299272.

    PTM databases

    PhosphoSitei Q8N5J4.

    Polymorphism databases

    DMDMi 68566054.

    Proteomic databases

    PaxDbi Q8N5J4.
    PRIDEi Q8N5J4.

    Protocols and materials databases

    DNASUi 121599.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000551346 ; ENSP00000448580 ; ENSG00000166211 .
    GeneIDi 121599.
    KEGGi hsa:121599.
    UCSCi uc001tid.3. human.

    Organism-specific databases

    CTDi 121599.
    GeneCardsi GC12P101870.
    HGNCi HGNC:29549. SPIC.
    HPAi HPA042864.
    MIMi 612568. gene.
    neXtProti NX_Q8N5J4.
    PharmGKBi PA134897775.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG296613.
    HOGENOMi HOG000132995.
    HOVERGENi HBG060389.
    InParanoidi Q8N5J4.
    KOi K09440.
    OMAi QERAHIT.
    OrthoDBi EOG78M02J.
    PhylomeDBi Q8N5J4.
    TreeFami TF318679.

    Miscellaneous databases

    GenomeRNAii 121599.
    NextBioi 80782.
    PROi Q8N5J4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8N5J4.
    CleanExi HS_SPIC.
    Genevestigatori Q8N5J4.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C."
      Carlsson R., Hjalmarsson A., Liberg D., Persson C., Leanderson T.
      Gene 299:271-278(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiSPIC_HUMAN
    AccessioniPrimary (citable) accession number: Q8N5J4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3