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Q8N5J4

- SPIC_HUMAN

UniProt

Q8N5J4 - SPIC_HUMAN

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Protein

Transcription factor Spi-C

Gene

SPIC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi111 – 19484ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. blastocyst development Source: Ensembl
  2. cell differentiation Source: RefGenome
  3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  5. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Spi-C
Gene namesi
Name:SPIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:29549. SPIC.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134897775.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Transcription factor Spi-CPRO_0000204140Add
BLAST

Proteomic databases

PaxDbiQ8N5J4.
PRIDEiQ8N5J4.

PTM databases

PhosphoSiteiQ8N5J4.

Expressioni

Tissue specificityi

Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver.1 Publication

Gene expression databases

BgeeiQ8N5J4.
CleanExiHS_SPIC.
GenevestigatoriQ8N5J4.

Organism-specific databases

HPAiHPA042864.

Interactioni

Subunit structurei

Binds DNA as a monomer.

Protein-protein interaction databases

BioGridi125739. 1 interaction.
STRINGi9606.ENSP00000299272.

Structurei

3D structure databases

ProteinModelPortaliQ8N5J4.
SMRiQ8N5J4. Positions 110-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG296613.
GeneTreeiENSGT00390000015212.
HOGENOMiHOG000132995.
HOVERGENiHBG060389.
InParanoidiQ8N5J4.
KOiK09440.
OMAiQERAHIT.
OrthoDBiEOG78M02J.
PhylomeDBiQ8N5J4.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N5J4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTCVEQDKLG QAFEDAFEVL RQHSTGDLQY SPDYRNYLAL INHRPHVKGN
60 70 80 90 100
SSCYGVLPTE EPVYNWRTVI NSAADFYFEG NIHQSLQNIT ENQLVQPTLL
110 120 130 140 150
QQKGGKGRKK LRLFEYLHES LYNPEMASCI QWVDKTKGIF QFVSKNKEKL
160 170 180 190 200
AELWGKRKGN RKTMTYQKMA RALRNYGRSG EITKIRRKLT YQFSEAILQR
210 220 230 240
LSPSYFLGKE IFYSQCVQPD QEYLSLNNWN ANYNYTYANY HELNHHDC
Length:248
Mass (Da):29,180
Last modified:October 1, 2002 - v1
Checksum:iD4DC97EA0FFEE71E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032317 mRNA. Translation: AAH32317.1.
AF518404 mRNA. Translation: AAN84476.1.
CCDSiCCDS9082.1.
RefSeqiNP_689536.1. NM_152323.1.
XP_005268703.1. XM_005268646.1.
XP_006719301.1. XM_006719238.1.
XP_006719302.1. XM_006719239.1.
UniGeneiHs.577097.

Genome annotation databases

EnsembliENST00000551346; ENSP00000448580; ENSG00000166211.
GeneIDi121599.
KEGGihsa:121599.
UCSCiuc001tid.3. human.

Polymorphism databases

DMDMi68566054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032317 mRNA. Translation: AAH32317.1 .
AF518404 mRNA. Translation: AAN84476.1 .
CCDSi CCDS9082.1.
RefSeqi NP_689536.1. NM_152323.1.
XP_005268703.1. XM_005268646.1.
XP_006719301.1. XM_006719238.1.
XP_006719302.1. XM_006719239.1.
UniGenei Hs.577097.

3D structure databases

ProteinModelPortali Q8N5J4.
SMRi Q8N5J4. Positions 110-194.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125739. 1 interaction.
STRINGi 9606.ENSP00000299272.

PTM databases

PhosphoSitei Q8N5J4.

Polymorphism databases

DMDMi 68566054.

Proteomic databases

PaxDbi Q8N5J4.
PRIDEi Q8N5J4.

Protocols and materials databases

DNASUi 121599.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000551346 ; ENSP00000448580 ; ENSG00000166211 .
GeneIDi 121599.
KEGGi hsa:121599.
UCSCi uc001tid.3. human.

Organism-specific databases

CTDi 121599.
GeneCardsi GC12P101870.
HGNCi HGNC:29549. SPIC.
HPAi HPA042864.
MIMi 612568. gene.
neXtProti NX_Q8N5J4.
PharmGKBi PA134897775.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG296613.
GeneTreei ENSGT00390000015212.
HOGENOMi HOG000132995.
HOVERGENi HBG060389.
InParanoidi Q8N5J4.
KOi K09440.
OMAi QERAHIT.
OrthoDBi EOG78M02J.
PhylomeDBi Q8N5J4.
TreeFami TF318679.

Miscellaneous databases

GenomeRNAii 121599.
NextBioi 80782.
PROi Q8N5J4.
SOURCEi Search...

Gene expression databases

Bgeei Q8N5J4.
CleanExi HS_SPIC.
Genevestigatori Q8N5J4.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
[Graphical view ]
PROSITEi PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C."
    Carlsson R., Hjalmarsson A., Liberg D., Persson C., Leanderson T.
    Gene 299:271-278(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiSPIC_HUMAN
AccessioniPrimary (citable) accession number: Q8N5J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3