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Protein

Transcription factor Spi-C

Gene

SPIC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi111 – 194ETSPROSITE-ProRule annotationAdd BLAST84

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Spi-C
Gene namesi
Name:SPIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166211.7
HGNCiHGNC:29549 SPIC
MIMi612568 gene
neXtProtiNX_Q8N5J4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi121599
OpenTargetsiENSG00000166211
PharmGKBiPA134897775

Polymorphism and mutation databases

BioMutaiSPIC
DMDMi68566054

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041401 – 248Transcription factor Spi-CAdd BLAST248

Proteomic databases

PaxDbiQ8N5J4
PRIDEiQ8N5J4

PTM databases

PhosphoSitePlusiQ8N5J4

Expressioni

Tissue specificityi

Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000166211
CleanExiHS_SPIC
GenevisibleiQ8N5J4 HS

Interactioni

Subunit structurei

Binds DNA as a monomer.

Protein-protein interaction databases

BioGridi125739, 1 interactor
IntActiQ8N5J4, 3 interactors
STRINGi9606.ENSP00000299272

Structurei

3D structure databases

ProteinModelPortaliQ8N5J4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3805 Eukaryota
ENOG410XSXU LUCA
GeneTreeiENSGT00390000015212
HOGENOMiHOG000132995
HOVERGENiHBG060389
InParanoidiQ8N5J4
KOiK09440
OMAiYLHESLY
OrthoDBiEOG091G0DTY
PhylomeDBiQ8N5J4
TreeFamiTF318679

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N5J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCVEQDKLG QAFEDAFEVL RQHSTGDLQY SPDYRNYLAL INHRPHVKGN
60 70 80 90 100
SSCYGVLPTE EPVYNWRTVI NSAADFYFEG NIHQSLQNIT ENQLVQPTLL
110 120 130 140 150
QQKGGKGRKK LRLFEYLHES LYNPEMASCI QWVDKTKGIF QFVSKNKEKL
160 170 180 190 200
AELWGKRKGN RKTMTYQKMA RALRNYGRSG EITKIRRKLT YQFSEAILQR
210 220 230 240
LSPSYFLGKE IFYSQCVQPD QEYLSLNNWN ANYNYTYANY HELNHHDC
Length:248
Mass (Da):29,180
Last modified:October 1, 2002 - v1
Checksum:iD4DC97EA0FFEE71E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032317 mRNA Translation: AAH32317.1
AF518404 mRNA Translation: AAN84476.1
CCDSiCCDS9082.1
RefSeqiNP_689536.1, NM_152323.2
XP_005268703.1, XM_005268646.3
XP_006719302.1, XM_006719239.3
UniGeneiHs.577097

Genome annotation databases

EnsembliENST00000551346; ENSP00000448580; ENSG00000166211
GeneIDi121599
KEGGihsa:121599
UCSCiuc001tid.3 human

Similar proteinsi

Entry informationi

Entry nameiSPIC_HUMAN
AccessioniPrimary (citable) accession number: Q8N5J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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