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Protein

Transcription factor Spi-C

Gene

SPIC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi111 – 19484ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. blastocyst development Source: Ensembl
  2. cell differentiation Source: GO_Central
  3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  5. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Spi-C
Gene namesi
Name:SPIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29549. SPIC.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134897775.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Transcription factor Spi-CPRO_0000204140Add
BLAST

Proteomic databases

PaxDbiQ8N5J4.
PRIDEiQ8N5J4.

PTM databases

PhosphoSiteiQ8N5J4.

Expressioni

Tissue specificityi

Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver.1 Publication

Gene expression databases

BgeeiQ8N5J4.
CleanExiHS_SPIC.
GenevestigatoriQ8N5J4.

Organism-specific databases

HPAiHPA042864.

Interactioni

Subunit structurei

Binds DNA as a monomer.

Protein-protein interaction databases

BioGridi125739. 1 interaction.
STRINGi9606.ENSP00000299272.

Structurei

3D structure databases

ProteinModelPortaliQ8N5J4.
SMRiQ8N5J4. Positions 110-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG296613.
GeneTreeiENSGT00390000015212.
HOGENOMiHOG000132995.
HOVERGENiHBG060389.
InParanoidiQ8N5J4.
KOiK09440.
OMAiYLHESLY.
OrthoDBiEOG78M02J.
PhylomeDBiQ8N5J4.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N5J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCVEQDKLG QAFEDAFEVL RQHSTGDLQY SPDYRNYLAL INHRPHVKGN
60 70 80 90 100
SSCYGVLPTE EPVYNWRTVI NSAADFYFEG NIHQSLQNIT ENQLVQPTLL
110 120 130 140 150
QQKGGKGRKK LRLFEYLHES LYNPEMASCI QWVDKTKGIF QFVSKNKEKL
160 170 180 190 200
AELWGKRKGN RKTMTYQKMA RALRNYGRSG EITKIRRKLT YQFSEAILQR
210 220 230 240
LSPSYFLGKE IFYSQCVQPD QEYLSLNNWN ANYNYTYANY HELNHHDC
Length:248
Mass (Da):29,180
Last modified:September 30, 2002 - v1
Checksum:iD4DC97EA0FFEE71E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032317 mRNA. Translation: AAH32317.1.
AF518404 mRNA. Translation: AAN84476.1.
CCDSiCCDS9082.1.
RefSeqiNP_689536.1. NM_152323.1.
XP_005268703.1. XM_005268646.1.
XP_006719301.1. XM_006719238.1.
XP_006719302.1. XM_006719239.1.
UniGeneiHs.577097.

Genome annotation databases

EnsembliENST00000551346; ENSP00000448580; ENSG00000166211.
GeneIDi121599.
KEGGihsa:121599.
UCSCiuc001tid.3. human.

Polymorphism databases

DMDMi68566054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032317 mRNA. Translation: AAH32317.1.
AF518404 mRNA. Translation: AAN84476.1.
CCDSiCCDS9082.1.
RefSeqiNP_689536.1. NM_152323.1.
XP_005268703.1. XM_005268646.1.
XP_006719301.1. XM_006719238.1.
XP_006719302.1. XM_006719239.1.
UniGeneiHs.577097.

3D structure databases

ProteinModelPortaliQ8N5J4.
SMRiQ8N5J4. Positions 110-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125739. 1 interaction.
STRINGi9606.ENSP00000299272.

PTM databases

PhosphoSiteiQ8N5J4.

Polymorphism databases

DMDMi68566054.

Proteomic databases

PaxDbiQ8N5J4.
PRIDEiQ8N5J4.

Protocols and materials databases

DNASUi121599.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000551346; ENSP00000448580; ENSG00000166211.
GeneIDi121599.
KEGGihsa:121599.
UCSCiuc001tid.3. human.

Organism-specific databases

CTDi121599.
GeneCardsiGC12P101870.
HGNCiHGNC:29549. SPIC.
HPAiHPA042864.
MIMi612568. gene.
neXtProtiNX_Q8N5J4.
PharmGKBiPA134897775.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG296613.
GeneTreeiENSGT00390000015212.
HOGENOMiHOG000132995.
HOVERGENiHBG060389.
InParanoidiQ8N5J4.
KOiK09440.
OMAiYLHESLY.
OrthoDBiEOG78M02J.
PhylomeDBiQ8N5J4.
TreeFamiTF318679.

Miscellaneous databases

GenomeRNAii121599.
NextBioi80782.
PROiQ8N5J4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N5J4.
CleanExiHS_SPIC.
GenevestigatoriQ8N5J4.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C."
    Carlsson R., Hjalmarsson A., Liberg D., Persson C., Leanderson T.
    Gene 299:271-278(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiSPIC_HUMAN
AccessioniPrimary (citable) accession number: Q8N5J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 4, 2005
Last sequence update: September 30, 2002
Last modified: February 3, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.