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Q8N5J4 (SPIC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor Spi-C
Gene names
Name:SPIC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression By similarity.

Subunit structure

Binds DNA as a monomer.

Subcellular location

Nucleus Probable.

Tissue specificity

Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver. Ref.1

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Transcription factor Spi-C
PRO_0000204140

Regions

DNA binding111 – 19484ETS

Sequences

Sequence LengthMass (Da)Tools
Q8N5J4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: D4DC97EA0FFEE71E

FASTA24829,180
        10         20         30         40         50         60 
MTCVEQDKLG QAFEDAFEVL RQHSTGDLQY SPDYRNYLAL INHRPHVKGN SSCYGVLPTE 

        70         80         90        100        110        120 
EPVYNWRTVI NSAADFYFEG NIHQSLQNIT ENQLVQPTLL QQKGGKGRKK LRLFEYLHES 

       130        140        150        160        170        180 
LYNPEMASCI QWVDKTKGIF QFVSKNKEKL AELWGKRKGN RKTMTYQKMA RALRNYGRSG 

       190        200        210        220        230        240 
EITKIRRKLT YQFSEAILQR LSPSYFLGKE IFYSQCVQPD QEYLSLNNWN ANYNYTYANY 


HELNHHDC 

« Hide

References

« Hide 'large scale' references
[1]"Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C."
Carlsson R., Hjalmarsson A., Liberg D., Persson C., Leanderson T.
Gene 299:271-278(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC032317 mRNA. Translation: AAH32317.1.
AF518404 mRNA. Translation: AAN84476.1.
CCDSCCDS9082.1.
RefSeqNP_689536.1. NM_152323.1.
XP_005268703.1. XM_005268646.1.
XP_006719301.1. XM_006719238.1.
XP_006719302.1. XM_006719239.1.
UniGeneHs.577097.

3D structure databases

ProteinModelPortalQ8N5J4.
SMRQ8N5J4. Positions 110-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125739. 1 interaction.
STRING9606.ENSP00000299272.

PTM databases

PhosphoSiteQ8N5J4.

Polymorphism databases

DMDM68566054.

Proteomic databases

PaxDbQ8N5J4.
PRIDEQ8N5J4.

Protocols and materials databases

DNASU121599.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299272; ENSP00000299272; ENSG00000166211.
ENST00000551346; ENSP00000448580; ENSG00000166211.
GeneID121599.
KEGGhsa:121599.
UCSCuc001tid.3. human.

Organism-specific databases

CTD121599.
GeneCardsGC12P101870.
HGNCHGNC:29549. SPIC.
HPAHPA042864.
MIM612568. gene.
neXtProtNX_Q8N5J4.
PharmGKBPA134897775.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG296613.
HOGENOMHOG000132995.
HOVERGENHBG060389.
InParanoidQ8N5J4.
KOK09440.
OMAQERAHIT.
OrthoDBEOG78M02J.
PhylomeDBQ8N5J4.
TreeFamTF318679.

Gene expression databases

BgeeQ8N5J4.
CleanExHS_SPIC.
GenevestigatorQ8N5J4.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00178. Ets. 1 hit.
[Graphical view]
PRINTSPR00454. ETSDOMAIN.
SMARTSM00413. ETS. 1 hit.
[Graphical view]
PROSITEPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi121599.
NextBio80782.
PROQ8N5J4.
SOURCESearch...

Entry information

Entry nameSPIC_HUMAN
AccessionPrimary (citable) accession number: Q8N5J4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM