Q8N5J4 (SPIC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor Spi-C

Gene names

Name:

SPIC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression By similarity.
Subunit structure	Binds DNA as a monomer.
Subcellular location	Nucleus Probable.
Tissue specificity	Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver. Ref.1
Sequence similarities	Belongs to the ETS family. Contains 1 ETS DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blastocyst development Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	Transcription factor Spi-C		PRO_0000204140
Regions
	DNA binding	111 – 194	84	ETS

Sequences

	Sequence		Length	Mass (Da)
	Q8N5J4 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: D4DC97EA0FFEE71E	FASTA	248	29,180
	10 20 30 40 50 60 MTCVEQDKLG QAFEDAFEVL RQHSTGDLQY SPDYRNYLAL INHRPHVKGN SSCYGVLPTE 70 80 90 100 110 120 EPVYNWRTVI NSAADFYFEG NIHQSLQNIT ENQLVQPTLL QQKGGKGRKK LRLFEYLHES 130 140 150 160 170 180 LYNPEMASCI QWVDKTKGIF QFVSKNKEKL AELWGKRKGN RKTMTYQKMA RALRNYGRSG 190 200 210 220 230 240 EITKIRRKLT YQFSEAILQR LSPSYFLGKE IFYSQCVQPD QEYLSLNNWN ANYNYTYANY HELNHHDC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C." Carlsson R., Hjalmarsson A., Liberg D., Persson C., Leanderson T. Gene 299:271-278(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC032317 mRNA. Translation: AAH32317.1. AF518404 mRNA. Translation: AAN84476.1.
IPI	IPI00166862.
RefSeq	NP_689536.1. NM_152323.1.
UniGene	Hs.577097.
3D structure databases
ProteinModelPortal	Q8N5J4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000299272.
PTM databases
PhosphoSite	Q8N5J4.
Polymorphism databases
DMDM	68566054.
Proteomic databases
PaxDb	Q8N5J4.
PRIDE	Q8N5J4.
Protocols and materials databases
DNASU	121599.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299272; ENSP00000299272; ENSG00000166211. ENST00000551346; ENSP00000448580; ENSG00000166211.
GeneID	121599.
KEGG	hsa:121599.
UCSC	uc001tid.3. human.
Organism-specific databases
CTD	121599.
GeneCards	GC12P101870.
HGNC	HGNC:29549. SPIC.
HPA	HPA042864.
MIM	612568. gene.
neXtProt	NX_Q8N5J4.
PharmGKB	PA134897775.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG296613.
HOGENOM	HOG000132995.
HOVERGEN	HBG060389.
InParanoid	Q8N5J4.
KO	K09440.
OMA	LRNYGRS.
OrthoDB	EOG4C87TF.
PhylomeDB	Q8N5J4.
Gene expression databases
Bgee	Q8N5J4.
CleanEx	HS_SPIC.
Genevestigator	Q8N5J4.
GermOnline	ENSG00000166211. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR000418. Ets_dom. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00178. Ets. 1 hit. [Graphical view]
PRINTS	PR00454. ETSDOMAIN.
SMART	SM00413. ETS. 1 hit. [Graphical view]
PROSITE	PS00345. ETS_DOMAIN_1. False negative. PS00346. ETS_DOMAIN_2. 1 hit. PS50061. ETS_DOMAIN_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	121599.
NextBio	80782.
SOURCE	Search...

Entry information

Entry name

SPIC_HUMAN

Accession

Primary (citable) accession number: Q8N5J4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.