##gff-version 3 Q8N5J2 UniProtKB Chain 1 469 . . . ID=PRO_0000344037;Note=Ubiquitin carboxyl-terminal hydrolase MINDY-1 Q8N5J2 UniProtKB Region 1 85 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8N5J2 UniProtKB Region 388 426 . . . Note=Ubiquitin-binding domain (UBD);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Region 441 469 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8N5J2 UniProtKB Compositional bias 27 53 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8N5J2 UniProtKB Compositional bias 452 469 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8N5J2 UniProtKB Active site 137 137 . . . Note=Nucleophile;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Active site 319 319 . . . Note=Proton acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Site 412 412 . . . Note=Ubiquitin-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Site 415 416 . . . Note=Ubiquitin-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Site 419 419 . . . Note=Ubiquitin-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Modified residue 103 103 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8N5J2 UniProtKB Modified residue 441 441 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569 Q8N5J2 UniProtKB Alternative sequence 1 142 . . . ID=VSP_034715;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8N5J2 UniProtKB Alternative sequence 1 95 . . . ID=VSP_037076;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8N5J2 UniProtKB Alternative sequence 1 1 . . . ID=VSP_037077;Note=In isoform 3. M->MLLGPPPFNESTKPSPSPCHSFASQAWLRQVPEVSKHLQCPSAKSLLTM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8N5J2 UniProtKB Natural variant 385 385 . . . ID=VAR_044541;Note=T->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10718198,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.4;Dbxref=dbSNP:rs2925741,PMID:10718198,PMID:14702039,PMID:15489334 Q8N5J2 UniProtKB Mutagenesis 131 131 . . . Note=Abolishes ubiquitin hydrolase activity. Q->A%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Mutagenesis 137 137 . . . Note=Abolishes ubiquitin hydrolase activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Mutagenesis 209 209 . . . Note=Abolishes ubiquitin hydrolase activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Mutagenesis 210 210 . . . Note=Greatly impairs ubiquitin hydrolase activity. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Mutagenesis 240 240 . . . Note=Abolishes ubiquitin hydrolase activity. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Mutagenesis 258 258 . . . Note=Abolishes ubiquitin hydrolase activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Mutagenesis 263 263 . . . Note=Greatly impairs ubiquitin hydrolase activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Mutagenesis 263 263 . . . Note=Abolishes ubiquitin hydrolase activity. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Mutagenesis 315 315 . . . Note=Abolishes ubiquitin hydrolase activity. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Mutagenesis 319 319 . . . Note=Abolishes ubiquitin hydrolase activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Mutagenesis 396 396 . . . Note=No effect on binding to 'Lys-48' tetraubiquitin chains. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 408 408 . . . Note=No effect on binding to 'Lys-48' tetraubiquitin chains. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 411 411 . . . Note=No effect on binding to 'Lys-48' tetraubiquitin chains. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 412 412 . . . Note=Loss of binding to 'Lys-48' tetraubiquitin chains. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 413 413 . . . Note=No effect on binding to 'Lys-48' tetraubiquitin chains. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 414 414 . . . Note=No effect on binding to 'Lys-48' tetraubiquitin chains. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 415 416 . . . Note=Decreased association with 'Lys-48'-linked conjugated ubiquitin. LA->AG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27292798;Dbxref=PMID:27292798 Q8N5J2 UniProtKB Mutagenesis 415 415 . . . Note=Loss of binding to 'Lys-48' tetraubiquitin chains. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 416 416 . . . Note=Loss of binding to 'Lys-48' tetraubiquitin chains. A->G%2CD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 416 416 . . . Note=No effect on binding to 'Lys-48' tetraubiquitin chains. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 418 418 . . . Note=No effect on binding to 'Lys-48' tetraubiquitin chains. Q->A%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 419 419 . . . Note=Loss of binding to 'Lys-48' tetraubiquitin chains. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 420 420 . . . Note=Loss of binding to 'Lys-48' tetraubiquitin chains. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 421 421 . . . Note=No effect on binding to 'Lys-48' tetraubiquitin chains. Q->E%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 422 422 . . . Note=No effect on binding to 'Lys-48' tetraubiquitin chains. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 423 423 . . . Note=Loss of binding to 'Lys-48' tetraubiquitin chains. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 423 423 . . . Note=Loss of binding to 'Lys-48' tetraubiquitin chains. E->EA%2CEAAA%2CEAAAAAA%2CEAAAAAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 423 423 . . . Note=Loss of binding to 'Lys-48' tetraubiquitin chains. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 424 424 . . . Note=Decreased binding to 'Lys-48' tetraubiquitin chains. Y->A%2CD%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Mutagenesis 424 424 . . . Note=No effect on binding to 'Lys-48' tetraubiquitin chains. Y->F%2CW;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28082312;Dbxref=PMID:28082312 Q8N5J2 UniProtKB Sequence conflict 287 287 . . . Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8N5J2 UniProtKB Sequence conflict 367 367 . . . Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8N5J2 UniProtKB Beta strand 113 121 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Beta strand 124 129 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Beta strand 131 135 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Helix 137 148 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Beta strand 160 162 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Helix 163 175 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Helix 188 200 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Helix 201 205 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Beta strand 208 210 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Beta strand 212 215 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YJG Q8N5J2 UniProtKB Helix 224 231 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Beta strand 236 239 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5JKN Q8N5J2 UniProtKB Helix 247 253 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Helix 258 269 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Helix 274 289 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Turn 290 292 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Helix 296 305 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Beta strand 311 315 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Beta strand 320 326 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Beta strand 329 333 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Helix 337 339 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Beta strand 347 350 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Beta strand 352 355 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6TUV Q8N5J2 UniProtKB Helix 411 425 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5MN9 Q8N5J2 UniProtKB Sequence conflict 44 44 . . . Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305