Reviewed, UniProtKB/Swiss-Prot Q8N5J2 (FA63A_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein FAM63A

Gene names

Name:	FAM63A
Synonyms:	KIAA1390

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the FAM63 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSM8	O95777	1	EBI-372322,EBI-347779

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N5J2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N5J2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Isoform 3 (identifier: Q8N5J2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLLGPPPFNESTKPSPSPCHSFASQAWLRQVPEVSKHLQCPSAESLLTM

Isoform 4 (identifier: Q8N5J2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Protein FAM63A		PRO_0000344037
Regions
	Compositional bias	386 – 431	46	Gln-rich
Amino acid modifications
	Modified residue	103	1	Phosphoserine By similarity
	Modified residue	441	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1 – 142	142	Missing in isoform 2.		VSP_034715
	Alternative sequence	1 – 95	95	Missing in isoform 4.		VSP_037076
	Alternative sequence	1	1	M → MLLGPPPFNESTKPSPSPCH SFASQAWLRQVPEVSKHLQC PSAESLLTM in isoform 3.		VSP_037077
	Natural variant	385	1	K → T: dbSNP rs2925741. Ref.3		VAR_044541
Experimental info
	Sequence conflict	287	1	L → P in BAA92104. Ref.2
	Sequence conflict	367	1	S → R in BAA92104. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: B1A8B7BAEED2C400	FASTA	469	51,805
	10 20 30 40 50 60 MEYHQPEDPA PGKAGTAEAV IPENHEVLAG PDEHPQDTDA RDADGEARER EPADQALLPS 70 80 90 100 110 120 QCGDNLESPL PEASSAPPGP TLGTLPEVET IRACSMPQEL PQSPRTRQPE PDFYCVKWIP 130 140 150 160 170 180 WKGEQTPIIT QSTNGPCPLL AIMNILFLQW KVKLPPQKEV ITSDELMAHL GNCLLSIKPQ 190 200 210 220 230 240 EKSEGLQLNF QQNVDDAMTV LPKLATGLDV NVRFTGVSDF EYTPECSVFD LLGIPLYHGW 250 260 270 280 290 300 LVDPQSPEAV RAVGKLSYNQ LVERIITCKH SSDTNLVTEG LIAEQFLETT AAQLTYHGLC 310 320 330 340 350 360 ELTAAAKEGE LSVFFRNNHF STMTKHKSHL YLLVTDQGFL QEEQVVWESL HNVDGDSCFC 370 380 390 400 410 420 DSDFHLSHSL GKGPGAEGGS GSPEKQLQVD QDYLIALSLQ QQQPRGPLGL TDLELAQQLQ 430 440 450 460 QEEYQQQQAA QPVRMRTRVL SLQGRGATSG RPAGERRQRP KHESDCILL
	Isoform 2. Checksum: EFAFBCB6A45BC7BC	FASTA	327	36,485
	10 20 30 40 50 60 MNILFLQWKV KLPPQKEVIT SDELMAHLGN CLLSIKPQEK SEGLQLNFQQ NVDDAMTVLP 70 80 90 100 110 120 KLATGLDVNV RFTGVSDFEY TPECSVFDLL GIPLYHGWLV DPQSPEAVRA VGKLSYNQLV 130 140 150 160 170 180 ERIITCKHSS DTNLVTEGLI AEQFLETTAA QLTYHGLCEL TAAAKEGELS VFFRNNHFST 190 200 210 220 230 240 MTKHKSHLYL LVTDQGFLQE EQVVWESLHN VDGDSCFCDS DFHLSHSLGK GPGAEGGSGS 250 260 270 280 290 300 PEKQLQVDQD YLIALSLQQQ QPRGPLGLTD LELAQQLQQE EYQQQQAAQP VRMRTRVLSL 310 320 QGRGATSGRP AGERRQRPKH ESDCILL
	Isoform 3. Checksum: 03309D374EF8E701	FASTA	517	57,019
	10 20 30 40 50 60 MLLGPPPFNE STKPSPSPCH SFASQAWLRQ VPEVSKHLQC PSAESLLTME YHQPEDPAPG 70 80 90 100 110 120 KAGTAEAVIP ENHEVLAGPD EHPQDTDARD ADGEAREREP ADQALLPSQC GDNLESPLPE 130 140 150 160 170 180 ASSAPPGPTL GTLPEVETIR ACSMPQELPQ SPRTRQPEPD FYCVKWIPWK GEQTPIITQS 190 200 210 220 230 240 TNGPCPLLAI MNILFLQWKV KLPPQKEVIT SDELMAHLGN CLLSIKPQEK SEGLQLNFQQ 250 260 270 280 290 300 NVDDAMTVLP KLATGLDVNV RFTGVSDFEY TPECSVFDLL GIPLYHGWLV DPQSPEAVRA 310 320 330 340 350 360 VGKLSYNQLV ERIITCKHSS DTNLVTEGLI AEQFLETTAA QLTYHGLCEL TAAAKEGELS 370 380 390 400 410 420 VFFRNNHFST MTKHKSHLYL LVTDQGFLQE EQVVWESLHN VDGDSCFCDS DFHLSHSLGK 430 440 450 460 470 480 GPGAEGGSGS PEKQLQVDQD YLIALSLQQQ QPRGPLGLTD LELAQQLQQE EYQQQQAAQP 490 500 510 VRMRTRVLSL QGRGATSGRP AGERRQRPKH ESDCILL
	Isoform 4. Checksum: 06DD3592E333A7DC	FASTA	374	41,860
	10 20 30 40 50 60 MPQELPQSPR TRQPEPDFYC VKWIPWKGEQ TPIITQSTNG PCPLLAIMNI LFLQWKVKLP 70 80 90 100 110 120 PQKEVITSDE LMAHLGNCLL SIKPQEKSEG LQLNFQQNVD DAMTVLPKLA TGLDVNVRFT 130 140 150 160 170 180 GVSDFEYTPE CSVFDLLGIP LYHGWLVDPQ SPEAVRAVGK LSYNQLVERI ITCKHSSDTN 190 200 210 220 230 240 LVTEGLIAEQ FLETTAAQLT YHGLCELTAA AKEGELSVFF RNNHFSTMTK HKSHLYLLVT 250 260 270 280 290 300 DQGFLQEEQV VWESLHNVDG DSCFCDSDFH LSHSLGKGPG AEGGSGSPEK QLQVDQDYLI 310 320 330 340 350 360 ALSLQQQQPR GPLGLTDLEL AQQLQQEEYQ QQQAAQPVRM RTRVLSLQGR GATSGRPAGE 370 RRQRPKHESD CILL

References

[1]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed: 10718198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4). Tissue: Placenta, Testis and Trachea.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-385.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB037811 mRNA. Translation: BAA92628.1. Different initiation. AK002142 mRNA. Translation: BAA92104.1. AK125493 mRNA. Translation: BAG54206.1. AK125959 mRNA. Translation: BAG54270.1. AK301946 mRNA. Translation: BAG63364.1. AK303962 mRNA. Translation: BAG64886.1. AL590133 Genomic DNA. Translation: CAI13336.1. CH471121 Genomic DNA. Translation: EAW53491.1. CH471121 Genomic DNA. Translation: EAW53492.1. BC032321 mRNA. Translation: AAH32321.1.
IPI	IPI00292905. IPI00413164. IPI00646860. IPI00929269.
RefSeq	NP_060849.2.
UniGene	Hs.714698
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N5J2. 1 interaction.
PTM databases
PhosphoSite	Q8N5J2.
Genome annotation databases
Ensembl	ENSG00000143409. Homo sapiens. [Contig view]
GeneID	55793.
Organism-specific databases
GeneCards	GC01M149232.
HGNC	HGNC:25648. FAM63A.
PharmGKB	PA142671872.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8N5J2.
Gene expression databases
ArrayExpress	Q8N5J2.
Bgee	Q8N5J2.
CleanEx	HS_FAM63A.
Family and domain databases
InterPro	IPR007518. DUF544. [Graphical view]
PANTHER	PTHR18063. DUF544. 1 hit.
Pfam	PF04424. DUF544. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	60909.

Entry information

Entry name

FA63A_HUMAN

Accession

Primary (citable) accession number: Q8N5J2
Secondary accession number(s): B3KWP4 , B3KWV8, B4DXF2, B4E1S4, Q5SZF0, Q9NUL9, Q9P2F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	October 1, 2002
Last modified:	July 7, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)