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Protein

Uncharacterized protein C12orf45

Gene

C12orf45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C12orf45
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28628. C12orf45.

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiC12orf45.
DMDMi313104091.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Uncharacterized protein C12orf45PRO_0000263623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341PhosphoserineCombined sources
Modified residuei66 – 661PhosphoserineCombined sources
Modified residuei178 – 1781PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N5I9.
MaxQBiQ8N5I9.
PaxDbiQ8N5I9.
PRIDEiQ8N5I9.

PTM databases

iPTMnetiQ8N5I9.
PhosphoSiteiQ8N5I9.

Expressioni

Gene expression databases

BgeeiQ8N5I9.
CleanExiHS_C12orf45.
ExpressionAtlasiQ8N5I9. baseline and differential.
GenevisibleiQ8N5I9. HS.

Organism-specific databases

HPAiHPA038722.

Interactioni

Protein-protein interaction databases

BioGridi125706. 12 interactions.
IntActiQ8N5I9. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8N5I9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J22I. Eukaryota.
ENOG410YT0H. LUCA.
GeneTreeiENSGT00390000000376.
HOGENOMiHOG000111760.
HOVERGENiHBG081239.
InParanoidiQ8N5I9.
OrthoDBiEOG7VDXR8.
PhylomeDBiQ8N5I9.
TreeFamiTF333191.

Family and domain databases

InterProiIPR027921. DUF4598.
[Graphical view]
PfamiPF15370. DUF4598. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N5I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVHGKPKAS PSCSSPTRDS SGVPVSKELL TAGSDGRGGI WDRLLINSQP
60 70 80 90 100
KSRKTSTLQT VRIERSPLLD QVQTFLPQMA RANEKLRKEM AAAPPGRFNI
110 120 130 140 150
ENIDGPHSKV IQMDVALFEM NQSDSKEVDS SEESSQDSSE NSSESEDEDD
160 170 180
SIPSEVTIDN IKLPNSEGGK GKIEVLDSPA SKKKK
Length:185
Mass (Da):20,123
Last modified:November 30, 2010 - v2
Checksum:i608CDD290D18B257
GO

Sequence cautioni

The sequence AAH32326.1 differs from that shown. Reason: Frameshift at position 185. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51G → S.
Corresponds to variant rs12580271 [ dbSNP | Ensembl ].
VAR_056833
Natural varianti8 – 81K → Q.
Corresponds to variant rs1129593 [ dbSNP | Ensembl ].
VAR_060438

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090051 Genomic DNA. No translation available.
BC032326 mRNA. Translation: AAH32326.1. Frameshift.
CCDSiCCDS41825.1.
RefSeqiNP_689531.2. NM_152318.2.
UniGeneiHs.295563.

Genome annotation databases

EnsembliENST00000552951; ENSP00000447057; ENSG00000151131.
GeneIDi121053.
KEGGihsa:121053.
UCSCiuc001tlb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090051 Genomic DNA. No translation available.
BC032326 mRNA. Translation: AAH32326.1. Frameshift.
CCDSiCCDS41825.1.
RefSeqiNP_689531.2. NM_152318.2.
UniGeneiHs.295563.

3D structure databases

ProteinModelPortaliQ8N5I9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125706. 12 interactions.
IntActiQ8N5I9. 7 interactions.

PTM databases

iPTMnetiQ8N5I9.
PhosphoSiteiQ8N5I9.

Polymorphism and mutation databases

BioMutaiC12orf45.
DMDMi313104091.

Proteomic databases

EPDiQ8N5I9.
MaxQBiQ8N5I9.
PaxDbiQ8N5I9.
PRIDEiQ8N5I9.

Protocols and materials databases

DNASUi121053.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000552951; ENSP00000447057; ENSG00000151131.
GeneIDi121053.
KEGGihsa:121053.
UCSCiuc001tlb.4. human.

Organism-specific databases

CTDi121053.
GeneCardsiC12orf45.
H-InvDBHIX0020628.
HGNCiHGNC:28628. C12orf45.
HPAiHPA038722.
neXtProtiNX_Q8N5I9.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J22I. Eukaryota.
ENOG410YT0H. LUCA.
GeneTreeiENSGT00390000000376.
HOGENOMiHOG000111760.
HOVERGENiHBG081239.
InParanoidiQ8N5I9.
OrthoDBiEOG7VDXR8.
PhylomeDBiQ8N5I9.
TreeFamiTF333191.

Miscellaneous databases

ChiTaRSiC12orf45. human.
GenomeRNAii121053.
PROiQ8N5I9.

Gene expression databases

BgeeiQ8N5I9.
CleanExiHS_C12orf45.
ExpressionAtlasiQ8N5I9. baseline and differential.
GenevisibleiQ8N5I9. HS.

Family and domain databases

InterProiIPR027921. DUF4598.
[Graphical view]
PfamiPF15370. DUF4598. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  3. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-66 AND SER-178, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCL045_HUMAN
AccessioniPrimary (citable) accession number: Q8N5I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 30, 2010
Last modified: June 8, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.