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Protein

Uncharacterized protein C12orf45

Gene

C12orf45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C12orf45
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28628. C12orf45.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151131.

Polymorphism and mutation databases

BioMutaiC12orf45.
DMDMi313104091.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636231 – 185Uncharacterized protein C12orf45Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N5I9.
MaxQBiQ8N5I9.
PaxDbiQ8N5I9.
PeptideAtlasiQ8N5I9.
PRIDEiQ8N5I9.

PTM databases

iPTMnetiQ8N5I9.
PhosphoSitePlusiQ8N5I9.

Expressioni

Gene expression databases

BgeeiENSG00000151131.
CleanExiHS_C12orf45.
ExpressionAtlasiQ8N5I9. baseline and differential.
GenevisibleiQ8N5I9. HS.

Organism-specific databases

HPAiHPA038722.

Interactioni

Protein-protein interaction databases

BioGridi125706. 12 interactors.
IntActiQ8N5I9. 7 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8N5I9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J22I. Eukaryota.
ENOG410YT0H. LUCA.
GeneTreeiENSGT00390000000376.
HOGENOMiHOG000111760.
HOVERGENiHBG081239.
InParanoidiQ8N5I9.
PhylomeDBiQ8N5I9.
TreeFamiTF333191.

Family and domain databases

InterProiView protein in InterPro
IPR027921. DUF4598.
PfamiView protein in Pfam
PF15370. DUF4598. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N5I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVHGKPKAS PSCSSPTRDS SGVPVSKELL TAGSDGRGGI WDRLLINSQP
60 70 80 90 100
KSRKTSTLQT VRIERSPLLD QVQTFLPQMA RANEKLRKEM AAAPPGRFNI
110 120 130 140 150
ENIDGPHSKV IQMDVALFEM NQSDSKEVDS SEESSQDSSE NSSESEDEDD
160 170 180
SIPSEVTIDN IKLPNSEGGK GKIEVLDSPA SKKKK
Length:185
Mass (Da):20,123
Last modified:November 30, 2010 - v2
Checksum:i608CDD290D18B257
GO

Sequence cautioni

The sequence AAH32326 differs from that shown. Reason: Frameshift at position 185.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0568335G → S. Corresponds to variant dbSNP:rs12580271Ensembl.1
Natural variantiVAR_0604388K → Q. Corresponds to variant dbSNP:rs1129593Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090051 Genomic DNA. No translation available.
BC032326 mRNA. Translation: AAH32326.1. Frameshift.
CCDSiCCDS41825.1.
RefSeqiNP_689531.2. NM_152318.2.
UniGeneiHs.295563.

Genome annotation databases

EnsembliENST00000552951; ENSP00000447057; ENSG00000151131.
GeneIDi121053.
KEGGihsa:121053.
UCSCiuc001tlb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCL045_HUMAN
AccessioniPrimary (citable) accession number: Q8N5I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 30, 2010
Last modified: February 15, 2017
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations