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Protein

Uncharacterized protein C12orf45

Gene

C12orf45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C12orf45
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000151131.9
HGNCiHGNC:28628 C12orf45
neXtProtiNX_Q8N5I9

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151131

Polymorphism and mutation databases

BioMutaiC12orf45
DMDMi313104091

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636231 – 185Uncharacterized protein C12orf45Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N5I9
MaxQBiQ8N5I9
PaxDbiQ8N5I9
PeptideAtlasiQ8N5I9
PRIDEiQ8N5I9

PTM databases

iPTMnetiQ8N5I9
PhosphoSitePlusiQ8N5I9

Expressioni

Gene expression databases

BgeeiENSG00000151131
CleanExiHS_C12orf45
ExpressionAtlasiQ8N5I9 baseline and differential
GenevisibleiQ8N5I9 HS

Organism-specific databases

HPAiHPA038722

Interactioni

Protein-protein interaction databases

BioGridi125706, 15 interactors
IntActiQ8N5I9, 7 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8N5I9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J22I Eukaryota
ENOG410YT0H LUCA
GeneTreeiENSGT00390000000376
HOGENOMiHOG000111760
HOVERGENiHBG081239
InParanoidiQ8N5I9
PhylomeDBiQ8N5I9
TreeFamiTF333191

Family and domain databases

InterProiView protein in InterPro
IPR027921 DUF4598
PfamiView protein in Pfam
PF15370 DUF4598, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N5I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVHGKPKAS PSCSSPTRDS SGVPVSKELL TAGSDGRGGI WDRLLINSQP
60 70 80 90 100
KSRKTSTLQT VRIERSPLLD QVQTFLPQMA RANEKLRKEM AAAPPGRFNI
110 120 130 140 150
ENIDGPHSKV IQMDVALFEM NQSDSKEVDS SEESSQDSSE NSSESEDEDD
160 170 180
SIPSEVTIDN IKLPNSEGGK GKIEVLDSPA SKKKK
Length:185
Mass (Da):20,123
Last modified:November 30, 2010 - v2
Checksum:i608CDD290D18B257
GO

Sequence cautioni

The sequence AAH32326 differs from that shown. Reason: Frameshift at position 185.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0568335G → S. Corresponds to variant dbSNP:rs12580271Ensembl.1
Natural variantiVAR_0604388K → Q. Corresponds to variant dbSNP:rs1129593Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090051 Genomic DNA No translation available.
BC032326 mRNA Translation: AAH32326.1 Frameshift.
CCDSiCCDS41825.1
RefSeqiNP_689531.2, NM_152318.2
UniGeneiHs.295563

Genome annotation databases

EnsembliENST00000552951; ENSP00000447057; ENSG00000151131
GeneIDi121053
KEGGihsa:121053
UCSCiuc001tlb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCL045_HUMAN
AccessioniPrimary (citable) accession number: Q8N5I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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