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Q8N5I4

- DHRSX_HUMAN

UniProt

Q8N5I4 - DHRSX_HUMAN

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Protein

Dehydrogenase/reductase SDR family member on chromosome X

Gene
DHRSX, CXorf11, DHRS5X, UNQ6508/PRO21433
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei183 – 1831Substrate By similarity
Active sitei208 – 2081Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi47 – 7125NAD or NADP By similarityAdd
BLAST

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member on chromosome X (EC:1.1.-.-)
Alternative name(s):
DHRSXY
Gene namesi
Name:DHRSX
Synonyms:CXorf11, DHRS5X
ORF Names:UNQ6508/PRO21433
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:18399. DHRSX.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 Reviewed predictionAdd
BLAST
Chaini32 – 330299Dehydrogenase/reductase SDR family member on chromosome XPRO_0000031974Add
BLAST

Proteomic databases

MaxQBiQ8N5I4.
PaxDbiQ8N5I4.
PRIDEiQ8N5I4.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

ArrayExpressiQ8N5I4.
BgeeiQ8N5I4.
CleanExiHS_DHRSX.
GenevestigatoriQ8N5I4.

Organism-specific databases

HPAiHPA003035.

Interactioni

Protein-protein interaction databases

BioGridi128508. 3 interactions.
IntActiQ8N5I4. 2 interactions.
MINTiMINT-5003345.
STRINGi9606.ENSP00000334113.

Structurei

3D structure databases

ProteinModelPortaliQ8N5I4.
SMRiQ8N5I4. Positions 32-294.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG078800.
InParanoidiQ8N5I4.
KOiK11170.
OMAiGSATHYV.
OrthoDBiEOG73Z2TK.
PhylomeDBiQ8N5I4.
TreeFamiTF105429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N5I4-1 [UniParc]FASTAAdd to Basket

« Hide

MSPLSAARAA LRVYAVGAAV ILAQLLRRCR GGFLEPVFPP RPDRVAIVTG    50
GTDGIGYSTA KHLARLGMHV IIAGNNDSKA KQVVSKIKEE TLNDKVEFLY 100
CDLASMTSIR QFVQKFKMKK IPLHVLINNA GVMMVPQRKT RDGFEEHFGL 150
NYLGHFLLTN LLLDTLKESG SPGHSARVVT VSSATHYVAE LNMDDLQSSA 200
CYSPHAAYAQ SKLALVLFTY HLQRLLAAEG SHVTANVVDP GVVNTDVYKH 250
VFWATRLAKK LLGWLLFKTP DEGAWTSIYA AVTPELEGVG GHYLYNEKET 300
KSLHVTYNQK LQQQLWSKSC EMTGVLDVTL 330
Length:330
Mass (Da):36,443
Last modified:May 5, 2009 - v2
Checksum:i0191EC6B0B98F56F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti247 – 2471V → L.3 Publications
Corresponds to variant rs1127915 [ dbSNP | Ensembl ].
VAR_055354
Natural varianti292 – 2921H → R.4 Publications
Corresponds to variant rs3210910 [ dbSNP | Ensembl ].
VAR_055355
Natural varianti297 – 2971E → K.2 Publications
Corresponds to variant rs12010 [ dbSNP | Ensembl ].
VAR_016100

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293620 mRNA. Translation: CAC82170.1.
AY358849 mRNA. Translation: AAQ89208.1.
AC079176 Genomic DNA. No translation available.
BX119919 Genomic DNA. No translation available.
BX649443 Genomic DNA. No translation available.
CR381696 Genomic DNA. No translation available.
CR856018 Genomic DNA. No translation available.
BC019696 mRNA. Translation: AAH19696.2. Sequence problems.
BC032340 mRNA. Translation: AAH32340.1.
AL137300 mRNA. Translation: CAB70685.1.
CCDSiCCDS35195.1.
PIRiT46363.
RefSeqiNP_660160.2. NM_145177.2.
UniGeneiHs.131452.

Genome annotation databases

EnsembliENST00000334651; ENSP00000334113; ENSG00000169084.
GeneIDi207063.
KEGGihsa:207063.
UCSCiuc004cqf.4. human.

Polymorphism databases

DMDMi229462837.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293620 mRNA. Translation: CAC82170.1 .
AY358849 mRNA. Translation: AAQ89208.1 .
AC079176 Genomic DNA. No translation available.
BX119919 Genomic DNA. No translation available.
BX649443 Genomic DNA. No translation available.
CR381696 Genomic DNA. No translation available.
CR856018 Genomic DNA. No translation available.
BC019696 mRNA. Translation: AAH19696.2 . Sequence problems.
BC032340 mRNA. Translation: AAH32340.1 .
AL137300 mRNA. Translation: CAB70685.1 .
CCDSi CCDS35195.1.
PIRi T46363.
RefSeqi NP_660160.2. NM_145177.2.
UniGenei Hs.131452.

3D structure databases

ProteinModelPortali Q8N5I4.
SMRi Q8N5I4. Positions 32-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128508. 3 interactions.
IntActi Q8N5I4. 2 interactions.
MINTi MINT-5003345.
STRINGi 9606.ENSP00000334113.

Polymorphism databases

DMDMi 229462837.

Proteomic databases

MaxQBi Q8N5I4.
PaxDbi Q8N5I4.
PRIDEi Q8N5I4.

Protocols and materials databases

DNASUi 207063.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334651 ; ENSP00000334113 ; ENSG00000169084 .
GeneIDi 207063.
KEGGi hsa:207063.
UCSCi uc004cqf.4. human.

Organism-specific databases

CTDi 207063.
GeneCardsi GC0XM002147.
H-InvDB HIX0016629.
HIX0177589.
HGNCi HGNC:18399. DHRSX.
HPAi HPA003035.
neXtProti NX_Q8N5I4.
PharmGKBi PA27330.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1028.
HOVERGENi HBG078800.
InParanoidi Q8N5I4.
KOi K11170.
OMAi GSATHYV.
OrthoDBi EOG73Z2TK.
PhylomeDBi Q8N5I4.
TreeFami TF105429.

Miscellaneous databases

GeneWikii DHRSX.
GenomeRNAii 207063.
NextBioi 90543.
PROi Q8N5I4.

Gene expression databases

ArrayExpressi Q8N5I4.
Bgeei Q8N5I4.
CleanExi HS_DHRSX.
Genevestigatori Q8N5I4.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution."
    Gianfrancesco F., Sanges R., Esposito T., Tempesta S., Rao E., Rappold G., Archidiacono N., Graves J.A.M., Forabosco A., D'Urso M.
    Genome Res. 11:2095-2100(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-247 AND ARG-292.
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-292 AND LYS-297.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-247; ARG-292 AND LYS-297.
    Tissue: Brain, Duodenum and Ovary.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-330, VARIANTS LEU-247 AND ARG-292.
    Tissue: Testis.

Entry informationi

Entry nameiDHRSX_HUMAN
AccessioniPrimary (citable) accession number: Q8N5I4
Secondary accession number(s): Q6UWC7
, Q8WUS4, Q96GR8, Q9NTF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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