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Protein

Dehydrogenase/reductase SDR family member on chromosome X

Gene

DHRSX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei183 – 1831SubstrateBy similarity
Active sitei208 – 2081Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi47 – 7125NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member on chromosome X (EC:1.1.-.-)
Alternative name(s):
DHRSXY
Gene namesi
Name:DHRSX
Synonyms:CXorf11, DHRS5X
ORF Names:UNQ6508/PRO21433
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:18399. DHRSX.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 330299Dehydrogenase/reductase SDR family member on chromosome XPRO_0000031974Add
BLAST

Proteomic databases

MaxQBiQ8N5I4.
PaxDbiQ8N5I4.
PRIDEiQ8N5I4.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiQ8N5I4.
CleanExiHS_DHRSX.
ExpressionAtlasiQ8N5I4. baseline and differential.
GenevestigatoriQ8N5I4.

Organism-specific databases

HPAiHPA003035.

Interactioni

Protein-protein interaction databases

BioGridi128508. 4 interactions.
IntActiQ8N5I4. 2 interactions.
MINTiMINT-5003345.
STRINGi9606.ENSP00000334113.

Structurei

3D structure databases

ProteinModelPortaliQ8N5I4.
SMRiQ8N5I4. Positions 32-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00760000119068.
HOVERGENiHBG078800.
InParanoidiQ8N5I4.
KOiK11170.
OMAiICYSSHA.
OrthoDBiEOG73Z2TK.
PhylomeDBiQ8N5I4.
TreeFamiTF105429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N5I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPLSAARAA LRVYAVGAAV ILAQLLRRCR GGFLEPVFPP RPDRVAIVTG
60 70 80 90 100
GTDGIGYSTA KHLARLGMHV IIAGNNDSKA KQVVSKIKEE TLNDKVEFLY
110 120 130 140 150
CDLASMTSIR QFVQKFKMKK IPLHVLINNA GVMMVPQRKT RDGFEEHFGL
160 170 180 190 200
NYLGHFLLTN LLLDTLKESG SPGHSARVVT VSSATHYVAE LNMDDLQSSA
210 220 230 240 250
CYSPHAAYAQ SKLALVLFTY HLQRLLAAEG SHVTANVVDP GVVNTDVYKH
260 270 280 290 300
VFWATRLAKK LLGWLLFKTP DEGAWTSIYA AVTPELEGVG GHYLYNEKET
310 320 330
KSLHVTYNQK LQQQLWSKSC EMTGVLDVTL
Length:330
Mass (Da):36,443
Last modified:May 5, 2009 - v2
Checksum:i0191EC6B0B98F56F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti247 – 2471V → L.3 Publications
Corresponds to variant rs1127915 [ dbSNP | Ensembl ].
VAR_055354
Natural varianti292 – 2921H → R.4 Publications
Corresponds to variant rs3210910 [ dbSNP | Ensembl ].
VAR_055355
Natural varianti297 – 2971E → K.2 Publications
Corresponds to variant rs12010 [ dbSNP | Ensembl ].
VAR_016100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293620 mRNA. Translation: CAC82170.1.
AY358849 mRNA. Translation: AAQ89208.1.
AC079176 Genomic DNA. No translation available.
BX119919 Genomic DNA. No translation available.
BX649443 Genomic DNA. No translation available.
CR381696 Genomic DNA. No translation available.
CR856018 Genomic DNA. No translation available.
BC019696 mRNA. Translation: AAH19696.2. Sequence problems.
BC032340 mRNA. Translation: AAH32340.1.
AL137300 mRNA. Translation: CAB70685.1.
CCDSiCCDS35195.1.
PIRiT46363.
RefSeqiNP_660160.2. NM_145177.2.
UniGeneiHs.131452.

Genome annotation databases

EnsembliENST00000334651; ENSP00000334113; ENSG00000169084.
GeneIDi207063.
KEGGihsa:207063.
UCSCiuc004cqf.4. human.

Polymorphism databases

DMDMi229462837.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293620 mRNA. Translation: CAC82170.1.
AY358849 mRNA. Translation: AAQ89208.1.
AC079176 Genomic DNA. No translation available.
BX119919 Genomic DNA. No translation available.
BX649443 Genomic DNA. No translation available.
CR381696 Genomic DNA. No translation available.
CR856018 Genomic DNA. No translation available.
BC019696 mRNA. Translation: AAH19696.2. Sequence problems.
BC032340 mRNA. Translation: AAH32340.1.
AL137300 mRNA. Translation: CAB70685.1.
CCDSiCCDS35195.1.
PIRiT46363.
RefSeqiNP_660160.2. NM_145177.2.
UniGeneiHs.131452.

3D structure databases

ProteinModelPortaliQ8N5I4.
SMRiQ8N5I4. Positions 32-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128508. 4 interactions.
IntActiQ8N5I4. 2 interactions.
MINTiMINT-5003345.
STRINGi9606.ENSP00000334113.

Polymorphism databases

DMDMi229462837.

Proteomic databases

MaxQBiQ8N5I4.
PaxDbiQ8N5I4.
PRIDEiQ8N5I4.

Protocols and materials databases

DNASUi207063.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334651; ENSP00000334113; ENSG00000169084.
GeneIDi207063.
KEGGihsa:207063.
UCSCiuc004cqf.4. human.

Organism-specific databases

CTDi207063.
GeneCardsiGC0XM002147.
H-InvDBHIX0016629.
HIX0177589.
HGNCiHGNC:18399. DHRSX.
HPAiHPA003035.
neXtProtiNX_Q8N5I4.
PharmGKBiPA27330.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00760000119068.
HOVERGENiHBG078800.
InParanoidiQ8N5I4.
KOiK11170.
OMAiICYSSHA.
OrthoDBiEOG73Z2TK.
PhylomeDBiQ8N5I4.
TreeFamiTF105429.

Miscellaneous databases

GeneWikiiDHRSX.
GenomeRNAii207063.
NextBioi90543.
PROiQ8N5I4.

Gene expression databases

BgeeiQ8N5I4.
CleanExiHS_DHRSX.
ExpressionAtlasiQ8N5I4. baseline and differential.
GenevestigatoriQ8N5I4.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution."
    Gianfrancesco F., Sanges R., Esposito T., Tempesta S., Rao E., Rappold G., Archidiacono N., Graves J.A.M., Forabosco A., D'Urso M.
    Genome Res. 11:2095-2100(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-247 AND ARG-292.
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-292 AND LYS-297.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-247; ARG-292 AND LYS-297.
    Tissue: Brain, Duodenum and Ovary.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-330, VARIANTS LEU-247 AND ARG-292.
    Tissue: Testis.

Entry informationi

Entry nameiDHRSX_HUMAN
AccessioniPrimary (citable) accession number: Q8N5I4
Secondary accession number(s): Q6UWC7
, Q8WUS4, Q96GR8, Q9NTF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: May 5, 2009
Last modified: January 7, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.