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Q8N5I4 (DHRSX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dehydrogenase/reductase SDR family member on chromosome X

EC=1.1.-.-
Alternative name(s):
DHRSXY
Gene names
Name:DHRSX
Synonyms:CXorf11, DHRS5X
ORF Names:UNQ6508/PRO21433
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Widely expressed.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionoxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 330299Dehydrogenase/reductase SDR family member on chromosome X
PRO_0000031974

Regions

Nucleotide binding47 – 7125NAD or NADP By similarity

Sites

Active site2081Proton acceptor By similarity
Binding site1831Substrate By similarity

Natural variations

Natural variant2471V → L. Ref.1 Ref.4 Ref.5
Corresponds to variant rs1127915 [ dbSNP | Ensembl ].
VAR_055354
Natural variant2921H → R. Ref.1 Ref.2 Ref.4 Ref.5
Corresponds to variant rs3210910 [ dbSNP | Ensembl ].
VAR_055355
Natural variant2971E → K. Ref.2 Ref.4
Corresponds to variant rs12010 [ dbSNP | Ensembl ].
VAR_016100

Sequences

Sequence LengthMass (Da)Tools
Q8N5I4 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 0191EC6B0B98F56F

FASTA33036,443
        10         20         30         40         50         60 
MSPLSAARAA LRVYAVGAAV ILAQLLRRCR GGFLEPVFPP RPDRVAIVTG GTDGIGYSTA 

        70         80         90        100        110        120 
KHLARLGMHV IIAGNNDSKA KQVVSKIKEE TLNDKVEFLY CDLASMTSIR QFVQKFKMKK 

       130        140        150        160        170        180 
IPLHVLINNA GVMMVPQRKT RDGFEEHFGL NYLGHFLLTN LLLDTLKESG SPGHSARVVT 

       190        200        210        220        230        240 
VSSATHYVAE LNMDDLQSSA CYSPHAAYAQ SKLALVLFTY HLQRLLAAEG SHVTANVVDP 

       250        260        270        280        290        300 
GVVNTDVYKH VFWATRLAKK LLGWLLFKTP DEGAWTSIYA AVTPELEGVG GHYLYNEKET 

       310        320        330 
KSLHVTYNQK LQQQLWSKSC EMTGVLDVTL 

« Hide

References

« Hide 'large scale' references
[1]"Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution."
Gianfrancesco F., Sanges R., Esposito T., Tempesta S., Rao E., Rappold G., Archidiacono N., Graves J.A.M., Forabosco A., D'Urso M.
Genome Res. 11:2095-2100(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-247 AND ARG-292.
Tissue: Teratocarcinoma.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-292 AND LYS-297.
[3]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-247; ARG-292 AND LYS-297.
Tissue: Brain, Duodenum and Ovary.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-330, VARIANTS LEU-247 AND ARG-292.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ293620 mRNA. Translation: CAC82170.1.
AY358849 mRNA. Translation: AAQ89208.1.
AC079176 Genomic DNA. No translation available.
BX119919 Genomic DNA. No translation available.
BX649443 Genomic DNA. No translation available.
CR381696 Genomic DNA. No translation available.
CR856018 Genomic DNA. No translation available.
BC019696 mRNA. Translation: AAH19696.2. Sequence problems.
BC032340 mRNA. Translation: AAH32340.1.
AL137300 mRNA. Translation: CAB70685.1.
PIRT46363.
RefSeqNP_660160.2. NM_145177.2.
UniGeneHs.131452.

3D structure databases

ProteinModelPortalQ8N5I4.
SMRQ8N5I4. Positions 31-326.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128508. 3 interactions.
IntActQ8N5I4. 2 interactions.
MINTMINT-5003345.
STRING9606.ENSP00000334113.

Polymorphism databases

DMDM229462837.

Proteomic databases

PaxDbQ8N5I4.
PRIDEQ8N5I4.

Protocols and materials databases

DNASU207063.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334651; ENSP00000334113; ENSG00000169084.
GeneID207063.
KEGGhsa:207063.
UCSCuc004cqf.4. human.

Organism-specific databases

CTD207063.
GeneCardsGC0XM002147.
H-InvDBHIX0016629.
HIX0177589.
HGNCHGNC:18399. DHRSX.
HPAHPA003035.
neXtProtNX_Q8N5I4.
PharmGKBPA27330.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1028.
HOVERGENHBG078800.
InParanoidQ8N5I4.
KOK11170.
OMALWARSCQ.
OrthoDBEOG73Z2TK.
TreeFamTF105429.

Gene expression databases

ArrayExpressQ8N5I4.
BgeeQ8N5I4.
CleanExHS_DHRSX.
GenevestigatorQ8N5I4.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiDHRSX.
GenomeRNAi207063.
NextBio90543.
PROQ8N5I4.

Entry information

Entry nameDHRSX_HUMAN
AccessionPrimary (citable) accession number: Q8N5I4
Secondary accession number(s): Q6UWC7 expand/collapse secondary AC list , Q8WUS4, Q96GR8, Q9NTF6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: May 5, 2009
Last modified: March 19, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM