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Protein

Dehydrogenase/reductase SDR family member on chromosome X

Gene

DHRSX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the positive regulation of starvation-induced autophagy (PubMed:25076851).1 Publication

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei183SubstrateBy similarity1
Active sitei208Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi47 – 71NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • positive regulation of autophagy Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member on chromosome X (EC:1.1.-.-)
Alternative name(s):
DHRSXY
Short chain dehydrogenase/reductase family 46C member 1
Short chain dehydrogenase/reductase family 7C member 6
Gene namesi
Name:DHRSX
Synonyms:CXorf11, DHRS5X, SDR46C1, SDR7C6
ORF Names:UNQ6508/PRO21433
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18399. DHRSX.

Subcellular locationi

  • Secreted 1 Publication

  • Note: Secreted in a non-classical form. A signal peptide sequence at position 1-31 is predicted.

GO - Cellular componenti

  • extracellular region Source: UniProtKB

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi207063.
OpenTargetsiENSG00000169084.
PharmGKBiPA27330.

Polymorphism and mutation databases

BioMutaiDHRSX.
DMDMi229462837.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000319742 – 330Dehydrogenase/reductase SDR family member on chromosome XAdd BLAST329

Proteomic databases

EPDiQ8N5I4.
MaxQBiQ8N5I4.
PaxDbiQ8N5I4.
PeptideAtlasiQ8N5I4.
PRIDEiQ8N5I4.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in the pancreas.2 Publications

Gene expression databases

BgeeiENSG00000169084.
CleanExiHS_DHRSX.
ExpressionAtlasiQ8N5I4. baseline and differential.
GenevisibleiQ8N5I4. HS.

Organism-specific databases

HPAiHPA003035.

Interactioni

Protein-protein interaction databases

BioGridi128508. 4 interactors.
IntActiQ8N5I4. 2 interactors.
MINTiMINT-5003345.
STRINGi9606.ENSP00000334113.

Structurei

3D structure databases

ProteinModelPortaliQ8N5I4.
SMRiQ8N5I4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000119068.
HOVERGENiHBG078800.
InParanoidiQ8N5I4.
KOiK11170.
OMAiPAKCEQL.
OrthoDBiEOG091G0FGA.
PhylomeDBiQ8N5I4.
TreeFamiTF105429.

Family and domain databases

InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N5I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPLSAARAA LRVYAVGAAV ILAQLLRRCR GGFLEPVFPP RPDRVAIVTG
60 70 80 90 100
GTDGIGYSTA KHLARLGMHV IIAGNNDSKA KQVVSKIKEE TLNDKVEFLY
110 120 130 140 150
CDLASMTSIR QFVQKFKMKK IPLHVLINNA GVMMVPQRKT RDGFEEHFGL
160 170 180 190 200
NYLGHFLLTN LLLDTLKESG SPGHSARVVT VSSATHYVAE LNMDDLQSSA
210 220 230 240 250
CYSPHAAYAQ SKLALVLFTY HLQRLLAAEG SHVTANVVDP GVVNTDVYKH
260 270 280 290 300
VFWATRLAKK LLGWLLFKTP DEGAWTSIYA AVTPELEGVG GHYLYNEKET
310 320 330
KSLHVTYNQK LQQQLWSKSC EMTGVLDVTL
Length:330
Mass (Da):36,443
Last modified:May 5, 2009 - v2
Checksum:i0191EC6B0B98F56F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055354247V → L3 PublicationsCorresponds to variant dbSNP:rs1127915Ensembl.1
Natural variantiVAR_055355292H → R4 PublicationsCorresponds to variant dbSNP:rs3210910Ensembl.1
Natural variantiVAR_016100297E → K2 PublicationsCorresponds to variant dbSNP:rs12010Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293620 mRNA. Translation: CAC82170.1.
AY358849 mRNA. Translation: AAQ89208.1.
AC079176 Genomic DNA. No translation available.
BX119919 Genomic DNA. No translation available.
BX649443 Genomic DNA. No translation available.
CR381696 Genomic DNA. No translation available.
CR856018 Genomic DNA. No translation available.
BC019696 mRNA. Translation: AAH19696.2. Sequence problems.
BC032340 mRNA. Translation: AAH32340.1.
AL137300 mRNA. Translation: CAB70685.1.
CCDSiCCDS35195.1.
PIRiT46363.
RefSeqiNP_660160.2. NM_145177.2.
UniGeneiHs.131452.

Genome annotation databases

EnsembliENST00000334651; ENSP00000334113; ENSG00000169084.
GeneIDi207063.
KEGGihsa:207063.
UCSCiuc004cqf.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDHRSX_HUMAN
AccessioniPrimary (citable) accession number: Q8N5I4
Secondary accession number(s): Q6UWC7
, Q8WUS4, Q96GR8, Q9NTF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: May 5, 2009
Last modified: June 7, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families