Reviewed, UniProtKB/Swiss-Prot Q8N5I2 (ARRD1_HUMAN)

Names and origin

Protein names

Recommended name:
    Arrestin domain-containing protein 1

Gene names

Name:

ARRDC1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the arrestin family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Arrestin domain-containing protein 1		PRO_0000244345
Regions
	Compositional bias	290 – 416	127	Pro-rich
Natural variations
	Natural variant	363	1	G → C: dbSNP rs35018943.		VAR_048335

Sequences

	Sequence		Length	Mass (Da)
	Q8N5I2-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 5B52A79EE27B5DDB	FASTA	433	45,981
	10 20 30 40 50 60 MGRVQLFEIS LSHGRVVYSP GEPLAGTVRV RLGAPLPFRA IRVTCIGSCG VSNKANDTAW 70 80 90 100 110 120 VVEEGYFNSS LSLADKGSLP AGEHSFPFQF LLPATAPTSF EGPFGKIVHQ VRAAIHTPRF 130 140 150 160 170 180 SKDHKCSLVF YILSPLNLNS IPDIEQPNVA SATKKFSYKL VKTGSVVLTA STDLRGYVVG 190 200 210 220 230 240 QALQLHADVE NQSGKDTSPV VASLLQKVSY KAKRWIHDVR TIAEVEGAGV KAWRRAQWHE 250 260 270 280 290 300 QILVPALPQS ALPGCSLIHI DYYLQVSLKA PEATVTLPVF IGNIAVNHAP VSPRPGLGLP 310 320 330 340 350 360 PGAPPLVVPS APPQEEAEAE AAAGGPHFLD PVFLSTKSHS QRQPLLATLS SVPGAPEPCP 370 380 390 400 410 420 QDGSPASHPL HPPLCISTGA TVPYFAEGSG GPVPTTSTLI LPPEYSSWGY PYEAPPSYEQ 430 SCGGVEPSLT PES

References

[1]

"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC032346 mRNA. Translation: AAH32346.1. AL365502 Genomic DNA. Translation: CAI14589.1.
IPI	IPI00166858.
RefSeq	NP_689498.1.
UniGene	Hs.12999
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N5I2. 2 interactions.
Proteomic databases
PRIDE	Q8N5I2.
Genome annotation databases
Ensembl	ENST00000371421; ENSP00000360475; ENSG00000197070; Homo sapiens. [Genome view]
GeneID	92714.
KEGG	hsa:92714.
UCSC	uc004cns.1. human.
Organism-specific databases
CTD	92714.
GeneCards	GC09P139619.
HGNC	HGNC:28633. ARRDC1.
PharmGKB	PA134938267.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8N5I2.
HOVERGEN	Q8N5I2.
OMA	QADIENQ
OrthoDB	EOG9D55J1
Gene expression databases
ArrayExpress	Q8N5I2.
Bgee	Q8N5I2.
CleanEx	HS_ARRDC1.
Genevestigator	Q8N5I2.
GermOnline	ENSG00000197070. Homo sapiens.
Family and domain databases
InterPro	IPR011022. Arrestin-like_C. IPR011021. Arrestin-like_N. IPR014756. Ig_E-set. [Graphical view]
Pfam	PF02752. Arrestin_C. 1 hit. PF00339. Arrestin_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	77849.

Entry information

Entry name

ARRD1_HUMAN

Accession

Primary (citable) accession number: Q8N5I2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 1, 2002
Last modified:	November 24, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.