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Protein

Arrestin domain-containing protein 1

Gene

ARRDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin domain-containing protein 1
Gene namesi
Name:ARRDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000197070.13.
HGNCiHGNC:28633. ARRDC1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197070.
PharmGKBiPA134938267.

Polymorphism and mutation databases

BioMutaiARRDC1.
DMDMi74751028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443451 – 433Arrestin domain-containing protein 1Add BLAST433

Proteomic databases

EPDiQ8N5I2.
MaxQBiQ8N5I2.
PaxDbiQ8N5I2.
PeptideAtlasiQ8N5I2.
PRIDEiQ8N5I2.

PTM databases

iPTMnetiQ8N5I2.
PhosphoSitePlusiQ8N5I2.

Expressioni

Gene expression databases

BgeeiENSG00000197070.
CleanExiHS_ARRDC1.
ExpressionAtlasiQ8N5I2. baseline and differential.
GenevisibleiQ8N5I2. HS.

Organism-specific databases

HPAiHPA022915.
HPA044345.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
WWP2O003083EBI-2339564,EBI-743923

Protein-protein interaction databases

BioGridi124970. 36 interactors.
IntActiQ8N5I2. 8 interactors.
STRINGi9606.ENSP00000360475.

Structurei

3D structure databases

ProteinModelPortaliQ8N5I2.
SMRiQ8N5I2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi290 – 416Pro-richAdd BLAST127

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiKOG3780. Eukaryota.
ENOG41102NY. LUCA.
GeneTreeiENSGT00550000074356.
HOGENOMiHOG000231531.
HOVERGENiHBG059908.
InParanoidiQ8N5I2.
OMAiRWIYDVR.
OrthoDBiEOG091G07XG.
PhylomeDBiQ8N5I2.
TreeFamiTF313650.

Family and domain databases

InterProiView protein in InterPro
IPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
IPR014756. Ig_E-set.
PfamiView protein in Pfam
PF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
SMARTiView protein in SMART
SM01017. Arrestin_C. 2 hits.
SUPFAMiSSF81296. SSF81296. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8N5I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRVQLFEIS LSHGRVVYSP GEPLAGTVRV RLGAPLPFRA IRVTCIGSCG
60 70 80 90 100
VSNKANDTAW VVEEGYFNSS LSLADKGSLP AGEHSFPFQF LLPATAPTSF
110 120 130 140 150
EGPFGKIVHQ VRAAIHTPRF SKDHKCSLVF YILSPLNLNS IPDIEQPNVA
160 170 180 190 200
SATKKFSYKL VKTGSVVLTA STDLRGYVVG QALQLHADVE NQSGKDTSPV
210 220 230 240 250
VASLLQKVSY KAKRWIHDVR TIAEVEGAGV KAWRRAQWHE QILVPALPQS
260 270 280 290 300
ALPGCSLIHI DYYLQVSLKA PEATVTLPVF IGNIAVNHAP VSPRPGLGLP
310 320 330 340 350
PGAPPLVVPS APPQEEAEAE AAAGGPHFLD PVFLSTKSHS QRQPLLATLS
360 370 380 390 400
SVPGAPEPCP QDGSPASHPL HPPLCISTGA TVPYFAEGSG GPVPTTSTLI
410 420 430
LPPEYSSWGY PYEAPPSYEQ SCGGVEPSLT PES
Length:433
Mass (Da):45,981
Last modified:October 1, 2002 - v1
Checksum:i5B52A79EE27B5DDB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048335363G → C. Corresponds to variant dbSNP:rs35018943Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032346 mRNA. Translation: AAH32346.1.
AL365502 Genomic DNA. No translation available.
CCDSiCCDS7049.1.
RefSeqiNP_689498.1. NM_152285.3.
UniGeneiHs.12999.

Genome annotation databases

EnsembliENST00000371421; ENSP00000360475; ENSG00000197070.
GeneIDi92714.
KEGGihsa:92714.
UCSCiuc004cns.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARRD1_HUMAN
AccessioniPrimary (citable) accession number: Q8N5I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families