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Protein

Arrestin domain-containing protein 1

Gene

ARRDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin domain-containing protein 1
Gene namesi
Name:ARRDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28633. ARRDC1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic vesicle Source: MGI
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134938267.

Polymorphism and mutation databases

BioMutaiARRDC1.
DMDMi74751028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Arrestin domain-containing protein 1PRO_0000244345Add
BLAST

Proteomic databases

EPDiQ8N5I2.
MaxQBiQ8N5I2.
PaxDbiQ8N5I2.
PRIDEiQ8N5I2.

PTM databases

iPTMnetiQ8N5I2.
PhosphoSiteiQ8N5I2.

Expressioni

Gene expression databases

BgeeiQ8N5I2.
CleanExiHS_ARRDC1.
ExpressionAtlasiQ8N5I2. baseline and differential.
GenevisibleiQ8N5I2. HS.

Organism-specific databases

HPAiHPA044345.

Interactioni

Protein-protein interaction databases

BioGridi124970. 34 interactions.
IntActiQ8N5I2. 5 interactions.
STRINGi9606.ENSP00000360475.

Structurei

3D structure databases

ProteinModelPortaliQ8N5I2.
SMRiQ8N5I2. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi290 – 416127Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiKOG3780. Eukaryota.
ENOG41102NY. LUCA.
GeneTreeiENSGT00550000074356.
HOGENOMiHOG000231531.
HOVERGENiHBG059908.
InParanoidiQ8N5I2.
OMAiIHTPRFS.
OrthoDBiEOG7Z0JWG.
PhylomeDBiQ8N5I2.
TreeFamiTF313650.

Family and domain databases

InterProiIPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 2 hits.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8N5I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRVQLFEIS LSHGRVVYSP GEPLAGTVRV RLGAPLPFRA IRVTCIGSCG
60 70 80 90 100
VSNKANDTAW VVEEGYFNSS LSLADKGSLP AGEHSFPFQF LLPATAPTSF
110 120 130 140 150
EGPFGKIVHQ VRAAIHTPRF SKDHKCSLVF YILSPLNLNS IPDIEQPNVA
160 170 180 190 200
SATKKFSYKL VKTGSVVLTA STDLRGYVVG QALQLHADVE NQSGKDTSPV
210 220 230 240 250
VASLLQKVSY KAKRWIHDVR TIAEVEGAGV KAWRRAQWHE QILVPALPQS
260 270 280 290 300
ALPGCSLIHI DYYLQVSLKA PEATVTLPVF IGNIAVNHAP VSPRPGLGLP
310 320 330 340 350
PGAPPLVVPS APPQEEAEAE AAAGGPHFLD PVFLSTKSHS QRQPLLATLS
360 370 380 390 400
SVPGAPEPCP QDGSPASHPL HPPLCISTGA TVPYFAEGSG GPVPTTSTLI
410 420 430
LPPEYSSWGY PYEAPPSYEQ SCGGVEPSLT PES
Length:433
Mass (Da):45,981
Last modified:October 1, 2002 - v1
Checksum:i5B52A79EE27B5DDB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti363 – 3631G → C.
Corresponds to variant rs35018943 [ dbSNP | Ensembl ].
VAR_048335

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032346 mRNA. Translation: AAH32346.1.
AL365502 Genomic DNA. Translation: CAI14589.1.
CCDSiCCDS7049.1.
RefSeqiNP_689498.1. NM_152285.3.
UniGeneiHs.12999.

Genome annotation databases

EnsembliENST00000371421; ENSP00000360475; ENSG00000197070.
GeneIDi92714.
KEGGihsa:92714.
UCSCiuc004cns.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032346 mRNA. Translation: AAH32346.1.
AL365502 Genomic DNA. Translation: CAI14589.1.
CCDSiCCDS7049.1.
RefSeqiNP_689498.1. NM_152285.3.
UniGeneiHs.12999.

3D structure databases

ProteinModelPortaliQ8N5I2.
SMRiQ8N5I2. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124970. 34 interactions.
IntActiQ8N5I2. 5 interactions.
STRINGi9606.ENSP00000360475.

PTM databases

iPTMnetiQ8N5I2.
PhosphoSiteiQ8N5I2.

Polymorphism and mutation databases

BioMutaiARRDC1.
DMDMi74751028.

Proteomic databases

EPDiQ8N5I2.
MaxQBiQ8N5I2.
PaxDbiQ8N5I2.
PRIDEiQ8N5I2.

Protocols and materials databases

DNASUi92714.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371421; ENSP00000360475; ENSG00000197070.
GeneIDi92714.
KEGGihsa:92714.
UCSCiuc004cns.4. human.

Organism-specific databases

CTDi92714.
GeneCardsiARRDC1.
HGNCiHGNC:28633. ARRDC1.
HPAiHPA044345.
neXtProtiNX_Q8N5I2.
PharmGKBiPA134938267.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3780. Eukaryota.
ENOG41102NY. LUCA.
GeneTreeiENSGT00550000074356.
HOGENOMiHOG000231531.
HOVERGENiHBG059908.
InParanoidiQ8N5I2.
OMAiIHTPRFS.
OrthoDBiEOG7Z0JWG.
PhylomeDBiQ8N5I2.
TreeFamiTF313650.

Miscellaneous databases

ChiTaRSiARRDC1. human.
GenomeRNAii92714.
PROiQ8N5I2.

Gene expression databases

BgeeiQ8N5I2.
CleanExiHS_ARRDC1.
ExpressionAtlasiQ8N5I2. baseline and differential.
GenevisibleiQ8N5I2. HS.

Family and domain databases

InterProiIPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 2 hits.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  3. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiARRD1_HUMAN
AccessioniPrimary (citable) accession number: Q8N5I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.