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Q8N5H7

- SH2D3_HUMAN

UniProt

Q8N5H7 - SH2D3_HUMAN

Protein

SH2 domain-containing protein 3C

Gene

SH2D3C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration By similarity.By similarity

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: InterPro
    2. protein binding Source: IntAct
    3. SH3/SH2 adaptor activity Source: ProtInc

    GO - Biological processi

    1. JNK cascade Source: ProtInc
    2. positive regulation of signal transduction Source: GOC
    3. small GTPase mediated signal transduction Source: InterPro

    Enzyme and pathway databases

    SignaLinkiQ8N5H7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH2 domain-containing protein 3C
    Alternative name(s):
    Novel SH2-containing protein 3
    SH2 domain-containing Eph receptor-binding protein 1
    Short name:
    SHEP1
    Gene namesi
    Name:SH2D3C
    Synonyms:NSP3
    ORF Names:UNQ272/PRO309/PRO34088
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:16884. SH2D3C.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity
    Note: Associated with the membrane when EGF-stimulated. Found at ruffling membranes By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38191.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 860860SH2 domain-containing protein 3CPRO_0000228833Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei278 – 2781PhosphotyrosineBy similarity
    Modified residuei283 – 2831PhosphotyrosineBy similarity
    Modified residuei440 – 4401PhosphoserineBy similarity
    Modified residuei793 – 7931PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8N5H7.
    PaxDbiQ8N5H7.
    PeptideAtlasiQ8N5H7.
    PRIDEiQ8N5H7.

    PTM databases

    PhosphoSiteiQ8N5H7.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ8N5H7.
    BgeeiQ8N5H7.
    CleanExiHS_SH2D3C.
    GenevestigatoriQ8N5H7.

    Organism-specific databases

    HPAiHPA047586.

    Interactioni

    Subunit structurei

    Interacts with PTK2B. Interacts with NEDD9/HEF1 By similarity. Interacts (via C-terminus) with BCAR1/CAS.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KITP107214EBI-745980,EBI-1379503
    METP085814EBI-745980,EBI-1039152

    Protein-protein interaction databases

    BioGridi115355. 5 interactions.
    DIPiDIP-59443N.
    IntActiQ8N5H7. 4 interactions.
    MINTiMINT-1427552.
    STRINGi9606.ENSP00000317817.

    Structurei

    Secondary structure

    1
    860
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi555 – 5573
    Beta strandi561 – 5633
    Helixi572 – 58312
    Helixi587 – 60115
    Beta strandi604 – 6063
    Helixi609 – 6157
    Beta strandi616 – 6183
    Helixi620 – 6234
    Helixi627 – 6293
    Helixi630 – 65223
    Helixi658 – 67720
    Helixi682 – 69211
    Helixi695 – 6984
    Helixi701 – 71010
    Helixi712 – 7209
    Helixi722 – 7309
    Helixi738 – 7403
    Helixi747 – 7526
    Helixi773 – 78715
    Helixi790 – 80011
    Turni801 – 8033
    Helixi808 – 8136
    Helixi816 – 8249
    Helixi828 – 8303
    Helixi833 – 85119

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3T6GX-ray2.50A/C539-860[»]
    ProteinModelPortaliQ8N5H7.
    SMRiQ8N5H7. Positions 219-300, 543-855.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini220 – 319100SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini586 – 854269Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The C-terminal Cdc25-homology/Ras-GEF domain adopts a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is required for interaction with BCAR1.

    Sequence similaritiesi

    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG149796.
    HOGENOMiHOG000231595.
    HOVERGENiHBG053174.
    InParanoidiQ8N5H7.
    OrthoDBiEOG77126R.
    PhylomeDBiQ8N5H7.
    TreeFamiTF323756.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR000980. SH2.
    [Graphical view]
    PfamiPF00617. RasGEF. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    SMARTiSM00147. RasGEF. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50009. RASGEF_CAT. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N5H7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTEGTKKTSK KFKFFKFKGF GSLSNLPRSF TLRRSSASIS RQSHLEPDTF    50
    EATQDDMVTV PKSPPAYARS SDMYSHMGTM PRPSIKKAQN SQAARQAQEA 100
    GPKPNLVPGG VPDPPGLEAA KEVMVKATGP LEDTPAMEPN PSAVEVDPIR 150
    KPEVPTGDVE EERPPRDVHS ERAAGEPEAG SDYVKFSKEK YILDSSPEKL 200
    HKELEEELKL SSTDLRSHAW YHGRIPREVS ETLVQRNGDF LIRDSLTSLG 250
    DYVLTCRWRN QALHFKINKV VVKAGESYTH IQYLFEQESF DHVPALVRYH 300
    VGSRKAVSEQ SGAIIYCPVN RTFPLRYLEA SYGLGQGSSK PASPVSPSGP 350
    KGSHMKRRSV TMTDGLTADK VTRSDGCPTS TSLPRPRDSI RSCALSMDQI 400
    PDLHSPMSPI SESPSSPAYS TVTRVHAAPA APSATALPAS PVARRSSEPQ 450
    LCPGSAPKTH GESDKGPHTS PSHTLGKASP SPSLSSYSDP DSGHYCQLQP 500
    PVRGSREWAA TETSSQQARS YGERLKELSE NGAPEGDWGK TFTVPIVEVT 550
    SSFNPATFQS LLIPRDNRPL EVGLLRKVKE LLAEVDARTL ARHVTKVDCL 600
    VARILGVTKE MQTLMGVRWG MELLTLPHGR QLRLDLLERF HTMSIMLAVD 650
    ILGCTGSAEE RAALLHKTIQ LAAELRGTMG NMFSFAAVMG ALDMAQISRL 700
    EQTWVTLRQR HTEGAILYEK KLKPFLKSLN EGKEGPPLSN TTFPHVLPLI 750
    TLLECDSAPP EGPEPWGSTE HGVEVVLAHL EAARTVAHHG GLYHTNAEVK 800
    LQGFQARPEL LEVFSTEFQM RLLWGSQGAS SSQARRYEKF DKVLTALSHK 850
    LEPAVRSSEL 860
    Length:860
    Mass (Da):94,411
    Last modified:October 1, 2002 - v1
    Checksum:i62598F2F643147C5
    GO
    Isoform 2 (identifier: Q8N5H7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-172: MTEGTKKTSK...RPPRDVHSER → MTAVGRRCPALGSRG

    Show »
    Length:703
    Mass (Da):77,141
    Checksum:i005B0EA32F7CA869
    GO
    Isoform 3 (identifier: Q8N5H7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-354: Missing.

    Show »
    Length:506
    Mass (Da):55,191
    Checksum:i6A525DAC855CF389
    GO
    Isoform 4 (identifier: Q8N5H7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-172: MTEGTKKTSK...RPPRDVHSER → MAPALPSPHK...GRCPLLLCGG

    Note: No experimental confirmation available.

    Show »
    Length:792
    Mass (Da):86,436
    Checksum:iCF76362417FEC80E
    GO
    Isoform 5 (identifier: Q8N5H7-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-185: MTEGTKKTSK...EPEAGSDYVK → MTERCSLWSALSAAACCFYRGSFVQ
         186-186: F → VQF

    Note: No experimental confirmation available.

    Show »
    Length:702
    Mass (Da):77,349
    Checksum:iF1B0521F92431081
    GO
    Isoform 6 (identifier: Q8N5H7-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-185: MTEGTKKTSK...EPEAGSDYVK → MTERCSLWSALSAAACCFYRGSFVQ

    Note: No experimental confirmation available.

    Show »
    Length:700
    Mass (Da):77,122
    Checksum:i26650B429A943FF8
    GO

    Sequence cautioni

    The sequence AAQ88456.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti445 – 4451R → C in AAD28246. (PubMed:10187783)Curated
    Sequence conflicti445 – 4451R → C in AAQ89948. (PubMed:12975309)Curated
    Sequence conflicti723 – 7231K → E in BAF84082. (PubMed:14702039)Curated
    Isoform 3 (identifier: Q8N5H7-3)
    Sequence conflicti29 – 291L → T in CAI46101. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231L → F.
    Corresponds to variant rs10760500 [ dbSNP | Ensembl ].
    VAR_051352

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 354354Missing in isoform 3. 1 PublicationVSP_017706Add
    BLAST
    Alternative sequencei1 – 185185MTEGT…SDYVK → MTERCSLWSALSAAACCFYR GSFVQ in isoform 5 and isoform 6. 1 PublicationVSP_044581Add
    BLAST
    Alternative sequencei1 – 172172MTEGT…VHSER → MTAVGRRCPALGSRG in isoform 2. 3 PublicationsVSP_017707Add
    BLAST
    Alternative sequencei1 – 172172MTEGT…VHSER → MAPALPSPHKAVARPELLLD TAAHSGKLRAPDGGEGAECA GHNGGPSWGVGQGQSQEPSR QGIPQAPWLVSWQRRGFPPS SFCPGPLRTEKLRAGRCPLL LCGG in isoform 4. 1 PublicationVSP_017708Add
    BLAST
    Alternative sequencei186 – 1861F → VQF in isoform 5. 1 PublicationVSP_044582

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124251 mRNA. Translation: AAD28246.1.
    AY358089 Transcribed RNA. Translation: AAQ88456.1. Different initiation.
    AY358440 mRNA. Translation: AAQ89948.1.
    AK056068 mRNA. Translation: BAG51614.1.
    AK291393 mRNA. Translation: BAF84082.1.
    BX647905 mRNA. Translation: CAI46101.1.
    AL162586, AL162426 Genomic DNA. Translation: CAI39761.1.
    AL162586, AL162426 Genomic DNA. Translation: CAI39763.1.
    AL162586, AL162426 Genomic DNA. Translation: CAI39766.1.
    AL162426, AL162586 Genomic DNA. Translation: CAI41177.1.
    AL162426, AL162586 Genomic DNA. Translation: CAI41179.1.
    AL162426, AL162586 Genomic DNA. Translation: CAI41182.1.
    BC027962 mRNA. Translation: AAH27962.1.
    BC032365 mRNA. Translation: AAH32365.1.
    CCDSiCCDS48026.1. [Q8N5H7-5]
    CCDS48027.1. [Q8N5H7-6]
    CCDS48028.1. [Q8N5H7-3]
    CCDS59145.1. [Q8N5H7-4]
    CCDS6877.1. [Q8N5H7-1]
    CCDS6878.1. [Q8N5H7-2]
    RefSeqiNP_001136004.1. NM_001142532.1. [Q8N5H7-3]
    NP_001136005.1. NM_001142533.1. [Q8N5H7-5]
    NP_001136006.1. NM_001142534.1. [Q8N5H7-6]
    NP_001239263.1. NM_001252334.1. [Q8N5H7-4]
    NP_005480.2. NM_005489.3. [Q8N5H7-2]
    NP_733745.1. NM_170600.2. [Q8N5H7-1]
    XP_005251696.1. XM_005251639.1. [Q8N5H7-3]
    UniGeneiHs.306412.

    Genome annotation databases

    EnsembliENST00000314830; ENSP00000317817; ENSG00000095370. [Q8N5H7-1]
    ENST00000373276; ENSP00000362373; ENSG00000095370. [Q8N5H7-4]
    ENST00000373277; ENSP00000362374; ENSG00000095370. [Q8N5H7-2]
    ENST00000420366; ENSP00000388536; ENSG00000095370. [Q8N5H7-5]
    ENST00000429553; ENSP00000394632; ENSG00000095370. [Q8N5H7-3]
    GeneIDi10044.
    KEGGihsa:10044.
    UCSCiuc004bry.3. human. [Q8N5H7-5]
    uc004brz.4. human. [Q8N5H7-1]
    uc004bsa.3. human. [Q8N5H7-2]

    Polymorphism databases

    DMDMi74751027.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124251 mRNA. Translation: AAD28246.1 .
    AY358089 Transcribed RNA. Translation: AAQ88456.1 . Different initiation.
    AY358440 mRNA. Translation: AAQ89948.1 .
    AK056068 mRNA. Translation: BAG51614.1 .
    AK291393 mRNA. Translation: BAF84082.1 .
    BX647905 mRNA. Translation: CAI46101.1 .
    AL162586 , AL162426 Genomic DNA. Translation: CAI39761.1 .
    AL162586 , AL162426 Genomic DNA. Translation: CAI39763.1 .
    AL162586 , AL162426 Genomic DNA. Translation: CAI39766.1 .
    AL162426 , AL162586 Genomic DNA. Translation: CAI41177.1 .
    AL162426 , AL162586 Genomic DNA. Translation: CAI41179.1 .
    AL162426 , AL162586 Genomic DNA. Translation: CAI41182.1 .
    BC027962 mRNA. Translation: AAH27962.1 .
    BC032365 mRNA. Translation: AAH32365.1 .
    CCDSi CCDS48026.1. [Q8N5H7-5 ]
    CCDS48027.1. [Q8N5H7-6 ]
    CCDS48028.1. [Q8N5H7-3 ]
    CCDS59145.1. [Q8N5H7-4 ]
    CCDS6877.1. [Q8N5H7-1 ]
    CCDS6878.1. [Q8N5H7-2 ]
    RefSeqi NP_001136004.1. NM_001142532.1. [Q8N5H7-3 ]
    NP_001136005.1. NM_001142533.1. [Q8N5H7-5 ]
    NP_001136006.1. NM_001142534.1. [Q8N5H7-6 ]
    NP_001239263.1. NM_001252334.1. [Q8N5H7-4 ]
    NP_005480.2. NM_005489.3. [Q8N5H7-2 ]
    NP_733745.1. NM_170600.2. [Q8N5H7-1 ]
    XP_005251696.1. XM_005251639.1. [Q8N5H7-3 ]
    UniGenei Hs.306412.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3T6G X-ray 2.50 A/C 539-860 [» ]
    ProteinModelPortali Q8N5H7.
    SMRi Q8N5H7. Positions 219-300, 543-855.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115355. 5 interactions.
    DIPi DIP-59443N.
    IntActi Q8N5H7. 4 interactions.
    MINTi MINT-1427552.
    STRINGi 9606.ENSP00000317817.

    PTM databases

    PhosphoSitei Q8N5H7.

    Polymorphism databases

    DMDMi 74751027.

    Proteomic databases

    MaxQBi Q8N5H7.
    PaxDbi Q8N5H7.
    PeptideAtlasi Q8N5H7.
    PRIDEi Q8N5H7.

    Protocols and materials databases

    DNASUi 10044.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314830 ; ENSP00000317817 ; ENSG00000095370 . [Q8N5H7-1 ]
    ENST00000373276 ; ENSP00000362373 ; ENSG00000095370 . [Q8N5H7-4 ]
    ENST00000373277 ; ENSP00000362374 ; ENSG00000095370 . [Q8N5H7-2 ]
    ENST00000420366 ; ENSP00000388536 ; ENSG00000095370 . [Q8N5H7-5 ]
    ENST00000429553 ; ENSP00000394632 ; ENSG00000095370 . [Q8N5H7-3 ]
    GeneIDi 10044.
    KEGGi hsa:10044.
    UCSCi uc004bry.3. human. [Q8N5H7-5 ]
    uc004brz.4. human. [Q8N5H7-1 ]
    uc004bsa.3. human. [Q8N5H7-2 ]

    Organism-specific databases

    CTDi 10044.
    GeneCardsi GC09M130501.
    HGNCi HGNC:16884. SH2D3C.
    HPAi HPA047586.
    MIMi 604722. gene.
    neXtProti NX_Q8N5H7.
    PharmGKBi PA38191.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149796.
    HOGENOMi HOG000231595.
    HOVERGENi HBG053174.
    InParanoidi Q8N5H7.
    OrthoDBi EOG77126R.
    PhylomeDBi Q8N5H7.
    TreeFami TF323756.

    Enzyme and pathway databases

    SignaLinki Q8N5H7.

    Miscellaneous databases

    GeneWikii SH2D3C.
    GenomeRNAii 10044.
    NextBioi 37937.
    PROi Q8N5H7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N5H7.
    Bgeei Q8N5H7.
    CleanExi HS_SH2D3C.
    Genevestigatori Q8N5H7.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR000980. SH2.
    [Graphical view ]
    Pfami PF00617. RasGEF. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    SMARTi SM00147. RasGEF. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50009. RASGEF_CAT. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway."
      Lu Y., Brush J., Stewart T.A.
      J. Biol. Chem. 274:10047-10052(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Cervix.
    5. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Pancreas and Testis.
    7. "NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling."
      Mace P.D., Wallez Y., Dobaczewska M.K., Lee J.J., Robinson H., Pasquale E.B., Riedl S.J.
      Nat. Struct. Mol. Biol. 18:1381-1387(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 539-860 IN COMPLEX WITH BCAR1.

    Entry informationi

    Entry nameiSH2D3_HUMAN
    AccessioniPrimary (citable) accession number: Q8N5H7
    Secondary accession number(s): A8K5S8
    , E9PG48, Q5HYE5, Q5JU31, Q6UY42, Q8N6X3, Q9Y2X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3