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Q8N5H7

- SH2D3_HUMAN

UniProt

Q8N5H7 - SH2D3_HUMAN

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Protein

SH2 domain-containing protein 3C

Gene

SH2D3C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration By similarity.By similarity

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: InterPro
  2. SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

  1. JNK cascade Source: ProtInc
  2. positive regulation of signal transduction Source: GOC
  3. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8N5H7.

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 3C
Alternative name(s):
Novel SH2-containing protein 3
SH2 domain-containing Eph receptor-binding protein 1
Short name:
SHEP1
Gene namesi
Name:SH2D3C
Synonyms:NSP3
ORF Names:UNQ272/PRO309/PRO34088
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:16884. SH2D3C.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity
Note: Associated with the membrane when EGF-stimulated. Found at ruffling membranes By similarity.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38191.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860SH2 domain-containing protein 3CPRO_0000228833Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei278 – 2781PhosphotyrosineBy similarity
Modified residuei283 – 2831PhosphotyrosineBy similarity
Modified residuei440 – 4401PhosphoserineBy similarity
Modified residuei793 – 7931PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N5H7.
PaxDbiQ8N5H7.
PeptideAtlasiQ8N5H7.
PRIDEiQ8N5H7.

PTM databases

PhosphoSiteiQ8N5H7.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ8N5H7.
CleanExiHS_SH2D3C.
ExpressionAtlasiQ8N5H7. baseline and differential.
GenevestigatoriQ8N5H7.

Organism-specific databases

HPAiHPA047586.

Interactioni

Subunit structurei

Interacts with PTK2B. Interacts with NEDD9/HEF1 By similarity. Interacts (via C-terminus) with BCAR1/CAS.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KITP107214EBI-745980,EBI-1379503
METP085814EBI-745980,EBI-1039152

Protein-protein interaction databases

BioGridi115355. 5 interactions.
DIPiDIP-59443N.
IntActiQ8N5H7. 5 interactions.
MINTiMINT-1427552.
STRINGi9606.ENSP00000317817.

Structurei

Secondary structure

1
860
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi555 – 5573
Beta strandi561 – 5633
Helixi572 – 58312
Helixi587 – 60115
Beta strandi604 – 6063
Helixi609 – 6157
Beta strandi616 – 6183
Helixi620 – 6234
Helixi627 – 6293
Helixi630 – 65223
Helixi658 – 67720
Helixi682 – 69211
Helixi695 – 6984
Helixi701 – 71010
Helixi712 – 7209
Helixi722 – 7309
Helixi738 – 7403
Helixi747 – 7526
Helixi773 – 78715
Helixi790 – 80011
Turni801 – 8033
Helixi808 – 8136
Helixi816 – 8249
Helixi828 – 8303
Helixi833 – 85119

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T6GX-ray2.50A/C539-860[»]
ProteinModelPortaliQ8N5H7.
SMRiQ8N5H7. Positions 214-300, 543-855.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 319100SH2PROSITE-ProRule annotationAdd
BLAST
Domaini586 – 854269Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Domaini

The C-terminal Cdc25-homology/Ras-GEF domain adopts a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is required for interaction with BCAR1.

Sequence similaritiesi

Contains 1 Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG149796.
GeneTreeiENSGT00390000008976.
HOGENOMiHOG000231595.
HOVERGENiHBG053174.
InParanoidiQ8N5H7.
OrthoDBiEOG77126R.
PhylomeDBiQ8N5H7.
TreeFamiTF323756.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR000980. SH2.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50009. RASGEF_CAT. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N5H7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEGTKKTSK KFKFFKFKGF GSLSNLPRSF TLRRSSASIS RQSHLEPDTF
60 70 80 90 100
EATQDDMVTV PKSPPAYARS SDMYSHMGTM PRPSIKKAQN SQAARQAQEA
110 120 130 140 150
GPKPNLVPGG VPDPPGLEAA KEVMVKATGP LEDTPAMEPN PSAVEVDPIR
160 170 180 190 200
KPEVPTGDVE EERPPRDVHS ERAAGEPEAG SDYVKFSKEK YILDSSPEKL
210 220 230 240 250
HKELEEELKL SSTDLRSHAW YHGRIPREVS ETLVQRNGDF LIRDSLTSLG
260 270 280 290 300
DYVLTCRWRN QALHFKINKV VVKAGESYTH IQYLFEQESF DHVPALVRYH
310 320 330 340 350
VGSRKAVSEQ SGAIIYCPVN RTFPLRYLEA SYGLGQGSSK PASPVSPSGP
360 370 380 390 400
KGSHMKRRSV TMTDGLTADK VTRSDGCPTS TSLPRPRDSI RSCALSMDQI
410 420 430 440 450
PDLHSPMSPI SESPSSPAYS TVTRVHAAPA APSATALPAS PVARRSSEPQ
460 470 480 490 500
LCPGSAPKTH GESDKGPHTS PSHTLGKASP SPSLSSYSDP DSGHYCQLQP
510 520 530 540 550
PVRGSREWAA TETSSQQARS YGERLKELSE NGAPEGDWGK TFTVPIVEVT
560 570 580 590 600
SSFNPATFQS LLIPRDNRPL EVGLLRKVKE LLAEVDARTL ARHVTKVDCL
610 620 630 640 650
VARILGVTKE MQTLMGVRWG MELLTLPHGR QLRLDLLERF HTMSIMLAVD
660 670 680 690 700
ILGCTGSAEE RAALLHKTIQ LAAELRGTMG NMFSFAAVMG ALDMAQISRL
710 720 730 740 750
EQTWVTLRQR HTEGAILYEK KLKPFLKSLN EGKEGPPLSN TTFPHVLPLI
760 770 780 790 800
TLLECDSAPP EGPEPWGSTE HGVEVVLAHL EAARTVAHHG GLYHTNAEVK
810 820 830 840 850
LQGFQARPEL LEVFSTEFQM RLLWGSQGAS SSQARRYEKF DKVLTALSHK
860
LEPAVRSSEL
Length:860
Mass (Da):94,411
Last modified:October 1, 2002 - v1
Checksum:i62598F2F643147C5
GO
Isoform 2 (identifier: Q8N5H7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: MTEGTKKTSK...RPPRDVHSER → MTAVGRRCPALGSRG

Show »
Length:703
Mass (Da):77,141
Checksum:i005B0EA32F7CA869
GO
Isoform 3 (identifier: Q8N5H7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-354: Missing.

Show »
Length:506
Mass (Da):55,191
Checksum:i6A525DAC855CF389
GO
Isoform 4 (identifier: Q8N5H7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: MTEGTKKTSK...RPPRDVHSER → MAPALPSPHK...GRCPLLLCGG

Note: No experimental confirmation available.

Show »
Length:792
Mass (Da):86,436
Checksum:iCF76362417FEC80E
GO
Isoform 5 (identifier: Q8N5H7-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-185: MTEGTKKTSK...EPEAGSDYVK → MTERCSLWSALSAAACCFYRGSFVQ
     186-186: F → VQF

Note: No experimental confirmation available.

Show »
Length:702
Mass (Da):77,349
Checksum:iF1B0521F92431081
GO
Isoform 6 (identifier: Q8N5H7-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-185: MTEGTKKTSK...EPEAGSDYVK → MTERCSLWSALSAAACCFYRGSFVQ

Note: No experimental confirmation available.

Show »
Length:700
Mass (Da):77,122
Checksum:i26650B429A943FF8
GO

Sequence cautioni

The sequence AAQ88456.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti445 – 4451R → C in AAD28246. (PubMed:10187783)Curated
Sequence conflicti445 – 4451R → C in AAQ89948. (PubMed:12975309)Curated
Sequence conflicti723 – 7231K → E in BAF84082. (PubMed:14702039)Curated
Isoform 3 (identifier: Q8N5H7-3)
Sequence conflicti29 – 291L → T in CAI46101. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231L → F.
Corresponds to variant rs10760500 [ dbSNP | Ensembl ].
VAR_051352

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 354354Missing in isoform 3. 1 PublicationVSP_017706Add
BLAST
Alternative sequencei1 – 185185MTEGT…SDYVK → MTERCSLWSALSAAACCFYR GSFVQ in isoform 5 and isoform 6. 1 PublicationVSP_044581Add
BLAST
Alternative sequencei1 – 172172MTEGT…VHSER → MTAVGRRCPALGSRG in isoform 2. 3 PublicationsVSP_017707Add
BLAST
Alternative sequencei1 – 172172MTEGT…VHSER → MAPALPSPHKAVARPELLLD TAAHSGKLRAPDGGEGAECA GHNGGPSWGVGQGQSQEPSR QGIPQAPWLVSWQRRGFPPS SFCPGPLRTEKLRAGRCPLL LCGG in isoform 4. 1 PublicationVSP_017708Add
BLAST
Alternative sequencei186 – 1861F → VQF in isoform 5. 1 PublicationVSP_044582

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF124251 mRNA. Translation: AAD28246.1.
AY358089 Transcribed RNA. Translation: AAQ88456.1. Different initiation.
AY358440 mRNA. Translation: AAQ89948.1.
AK056068 mRNA. Translation: BAG51614.1.
AK291393 mRNA. Translation: BAF84082.1.
BX647905 mRNA. Translation: CAI46101.1.
AL162586, AL162426 Genomic DNA. Translation: CAI39761.1.
AL162586, AL162426 Genomic DNA. Translation: CAI39763.1.
AL162586, AL162426 Genomic DNA. Translation: CAI39766.1.
AL162426, AL162586 Genomic DNA. Translation: CAI41177.1.
AL162426, AL162586 Genomic DNA. Translation: CAI41179.1.
AL162426, AL162586 Genomic DNA. Translation: CAI41182.1.
BC027962 mRNA. Translation: AAH27962.1.
BC032365 mRNA. Translation: AAH32365.1.
CCDSiCCDS48026.1. [Q8N5H7-5]
CCDS48028.1. [Q8N5H7-3]
CCDS59145.1. [Q8N5H7-4]
CCDS6877.1. [Q8N5H7-1]
CCDS6878.1. [Q8N5H7-2]
RefSeqiNP_001136004.1. NM_001142532.1. [Q8N5H7-3]
NP_001136005.1. NM_001142533.1. [Q8N5H7-5]
NP_001136006.1. NM_001142534.1. [Q8N5H7-6]
NP_001239263.1. NM_001252334.1. [Q8N5H7-4]
NP_005480.2. NM_005489.3. [Q8N5H7-2]
NP_733745.1. NM_170600.2. [Q8N5H7-1]
XP_005251696.1. XM_005251639.1. [Q8N5H7-3]
UniGeneiHs.306412.

Genome annotation databases

EnsembliENST00000314830; ENSP00000317817; ENSG00000095370. [Q8N5H7-1]
ENST00000373276; ENSP00000362373; ENSG00000095370. [Q8N5H7-4]
ENST00000373277; ENSP00000362374; ENSG00000095370. [Q8N5H7-2]
ENST00000420366; ENSP00000388536; ENSG00000095370. [Q8N5H7-5]
ENST00000429553; ENSP00000394632; ENSG00000095370. [Q8N5H7-3]
GeneIDi10044.
KEGGihsa:10044.
UCSCiuc004bry.3. human. [Q8N5H7-5]
uc004brz.4. human. [Q8N5H7-1]
uc004bsa.3. human. [Q8N5H7-2]

Polymorphism databases

DMDMi74751027.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF124251 mRNA. Translation: AAD28246.1 .
AY358089 Transcribed RNA. Translation: AAQ88456.1 . Different initiation.
AY358440 mRNA. Translation: AAQ89948.1 .
AK056068 mRNA. Translation: BAG51614.1 .
AK291393 mRNA. Translation: BAF84082.1 .
BX647905 mRNA. Translation: CAI46101.1 .
AL162586 , AL162426 Genomic DNA. Translation: CAI39761.1 .
AL162586 , AL162426 Genomic DNA. Translation: CAI39763.1 .
AL162586 , AL162426 Genomic DNA. Translation: CAI39766.1 .
AL162426 , AL162586 Genomic DNA. Translation: CAI41177.1 .
AL162426 , AL162586 Genomic DNA. Translation: CAI41179.1 .
AL162426 , AL162586 Genomic DNA. Translation: CAI41182.1 .
BC027962 mRNA. Translation: AAH27962.1 .
BC032365 mRNA. Translation: AAH32365.1 .
CCDSi CCDS48026.1. [Q8N5H7-5 ]
CCDS48028.1. [Q8N5H7-3 ]
CCDS59145.1. [Q8N5H7-4 ]
CCDS6877.1. [Q8N5H7-1 ]
CCDS6878.1. [Q8N5H7-2 ]
RefSeqi NP_001136004.1. NM_001142532.1. [Q8N5H7-3 ]
NP_001136005.1. NM_001142533.1. [Q8N5H7-5 ]
NP_001136006.1. NM_001142534.1. [Q8N5H7-6 ]
NP_001239263.1. NM_001252334.1. [Q8N5H7-4 ]
NP_005480.2. NM_005489.3. [Q8N5H7-2 ]
NP_733745.1. NM_170600.2. [Q8N5H7-1 ]
XP_005251696.1. XM_005251639.1. [Q8N5H7-3 ]
UniGenei Hs.306412.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3T6G X-ray 2.50 A/C 539-860 [» ]
ProteinModelPortali Q8N5H7.
SMRi Q8N5H7. Positions 214-300, 543-855.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115355. 5 interactions.
DIPi DIP-59443N.
IntActi Q8N5H7. 5 interactions.
MINTi MINT-1427552.
STRINGi 9606.ENSP00000317817.

PTM databases

PhosphoSitei Q8N5H7.

Polymorphism databases

DMDMi 74751027.

Proteomic databases

MaxQBi Q8N5H7.
PaxDbi Q8N5H7.
PeptideAtlasi Q8N5H7.
PRIDEi Q8N5H7.

Protocols and materials databases

DNASUi 10044.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314830 ; ENSP00000317817 ; ENSG00000095370 . [Q8N5H7-1 ]
ENST00000373276 ; ENSP00000362373 ; ENSG00000095370 . [Q8N5H7-4 ]
ENST00000373277 ; ENSP00000362374 ; ENSG00000095370 . [Q8N5H7-2 ]
ENST00000420366 ; ENSP00000388536 ; ENSG00000095370 . [Q8N5H7-5 ]
ENST00000429553 ; ENSP00000394632 ; ENSG00000095370 . [Q8N5H7-3 ]
GeneIDi 10044.
KEGGi hsa:10044.
UCSCi uc004bry.3. human. [Q8N5H7-5 ]
uc004brz.4. human. [Q8N5H7-1 ]
uc004bsa.3. human. [Q8N5H7-2 ]

Organism-specific databases

CTDi 10044.
GeneCardsi GC09M130501.
HGNCi HGNC:16884. SH2D3C.
HPAi HPA047586.
MIMi 604722. gene.
neXtProti NX_Q8N5H7.
PharmGKBi PA38191.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149796.
GeneTreei ENSGT00390000008976.
HOGENOMi HOG000231595.
HOVERGENi HBG053174.
InParanoidi Q8N5H7.
OrthoDBi EOG77126R.
PhylomeDBi Q8N5H7.
TreeFami TF323756.

Enzyme and pathway databases

SignaLinki Q8N5H7.

Miscellaneous databases

GeneWikii SH2D3C.
GenomeRNAii 10044.
NextBioi 37937.
PROi Q8N5H7.
SOURCEi Search...

Gene expression databases

Bgeei Q8N5H7.
CleanExi HS_SH2D3C.
ExpressionAtlasi Q8N5H7. baseline and differential.
Genevestigatori Q8N5H7.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR000980. SH2.
[Graphical view ]
Pfami PF00617. RasGEF. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
SMARTi SM00147. RasGEF. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50009. RASGEF_CAT. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway."
    Lu Y., Brush J., Stewart T.A.
    J. Biol. Chem. 274:10047-10052(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Cervix.
  5. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pancreas and Testis.
  7. "NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling."
    Mace P.D., Wallez Y., Dobaczewska M.K., Lee J.J., Robinson H., Pasquale E.B., Riedl S.J.
    Nat. Struct. Mol. Biol. 18:1381-1387(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 539-860 IN COMPLEX WITH BCAR1.

Entry informationi

Entry nameiSH2D3_HUMAN
AccessioniPrimary (citable) accession number: Q8N5H7
Secondary accession number(s): A8K5S8
, E9PG48, Q5HYE5, Q5JU31, Q6UY42, Q8N6X3, Q9Y2X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3