SH2D3C

Functionⁱ

Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity).By similarity

GO - Molecular functionⁱ

guanyl-nucleotide exchange factor activity Source: InterPro
SH3/SH2 adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 10187783

Complete GO annotation...

GO - Biological processⁱ

JNK cascade
Source: ProtInc
Traceable author statementⁱ
- 10187783
small GTPase mediated signal transduction Source: InterPro

Complete GO annotation...

Enzyme and pathway databases

SignaLinkⁱ	Q8N5H7.

SignaLinkⁱ

Q8N5H7.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SH2 domain-containing protein 3C Alternative name(s): Novel SH2-containing protein 3 SH2 domain-containing Eph receptor-binding protein 1 Short name: SHEP1
Gene namesⁱ	Name:SH2D3C Synonyms:NSP3 ORF Names:UNQ272/PRO309/PRO34088
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16884. SH2D3C.

HGNCⁱ

HGNC:16884. SH2D3C.

Subcellular locationⁱ

Cytoplasm By similarity
Membrane By similarity; Peripheral membrane protein By similarity

Note:

Associated with the membrane when EGF-stimulated. Found at ruffling membranes (By similarity).By similarity

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell
membrane Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10044.
Open Targets More...OpenTargetsⁱ	ENSG00000095370.
PharmGKBⁱ	PA38191.

Polymorphism and mutation databases

BioMutaⁱ	SH2D3C.
DMDMⁱ	74751027.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000228833	1 – 860	SH2 domain-containing protein 3CAdd BLAST		860

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	22	PhosphoserineBy similarity	1
Modified residueⁱ	278	PhosphotyrosineBy similarity	1
Modified residueⁱ	283	PhosphotyrosineBy similarity	1
Modified residueⁱ	359	PhosphoserineBy similarity	1
Modified residueⁱ	440	PhosphoserineCombined sources	1
Modified residueⁱ	793	PhosphotyrosineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8N5H7.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N5H7.
PaxDbⁱ	Q8N5H7.
PeptideAtlas More...PeptideAtlasⁱ	Q8N5H7.
PRIDEⁱ	Q8N5H7.

PTM databases

iPTMnetⁱ	Q8N5H7.
PhosphoSitePlusⁱ	Q8N5H7.

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000095370.
CleanExⁱ	HS_SH2D3C.
ExpressionAtlasⁱ	Q8N5H7. baseline and differential.
Genevisibleⁱ	Q8N5H7. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047586.

HPAⁱ

HPA047586.

Interactionⁱ

Subunit structureⁱ

Interacts with PTK2B. Interacts with NEDD9/HEF1 (By similarity). Interacts (via C-terminus) with BCAR1/CAS.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
KIT	P10721	4	EBI-745980,EBI-1379503
MET	P08581	4	EBI-745980,EBI-1039152

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GO - Molecular functionⁱ

SH3/SH2 adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 10187783

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	115355. 6 interactors.
Database of interacting proteins More...DIPⁱ	DIP-59443N.
IntActⁱ	Q8N5H7. 5 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1427552.
STRINGⁱ	9606.ENSP00000317817.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	555 – 557	Combined sources	3
Beta strandⁱ	561 – 563	Combined sources	3
Helixⁱ	572 – 583	Combined sources	12
Helixⁱ	587 – 601	Combined sources	15
Beta strandⁱ	604 – 606	Combined sources	3
Helixⁱ	609 – 615	Combined sources	7
Beta strandⁱ	616 – 618	Combined sources	3
Helixⁱ	620 – 623	Combined sources	4
Helixⁱ	627 – 629	Combined sources	3
Helixⁱ	630 – 652	Combined sources	23
Helixⁱ	658 – 677	Combined sources	20
Helixⁱ	682 – 692	Combined sources	11
Helixⁱ	695 – 698	Combined sources	4
Helixⁱ	701 – 710	Combined sources	10
Helixⁱ	712 – 720	Combined sources	9
Helixⁱ	722 – 730	Combined sources	9
Helixⁱ	738 – 740	Combined sources	3
Helixⁱ	747 – 752	Combined sources	6
Helixⁱ	773 – 787	Combined sources	15
Helixⁱ	790 – 800	Combined sources	11
Turnⁱ	801 – 803	Combined sources	3
Helixⁱ	808 – 813	Combined sources	6
Helixⁱ	816 – 824	Combined sources	9
Helixⁱ	828 – 830	Combined sources	3
Helixⁱ	833 – 851	Combined sources	19

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3T6G	X-ray	2.50	A/C	539-860	[»]
ProteinModelPortalⁱ	Q8N5H7.
SMRⁱ	Q8N5H7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	220 – 319	SH2PROSITE-ProRule annotationAdd BLAST		100
Domainⁱ	586 – 854	Ras-GEFPROSITE-ProRule annotationAdd BLAST		269

Domainⁱ

The C-terminal Cdc25-homology/Ras-GEF domain adopts a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is required for interaction with BCAR1.

Keywords - Domainⁱ

SH2 domain

Phylogenomic databases

eggNOGⁱ	ENOG410IFQG. Eukaryota. ENOG410XTJR. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008976.
HOGENOMⁱ	HOG000231595.
HOVERGENⁱ	HBG053174.
InParanoidⁱ	Q8N5H7.
OMAⁱ	QPDNYVL.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01KG.
PhylomeDBⁱ	Q8N5H7.
TreeFamⁱ	TF323756.

Family and domain databases

Gene3Dⁱ	1.10.840.10. 1 hit. 3.30.505.10. 1 hit.
InterProⁱ	View protein in InterPro IPR023578. Ras_GEF_dom. IPR001895. RASGEF_cat_dom. IPR000980. SH2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00617. RasGEF. 1 hit. PF00017. SH2. 1 hit.
SMARTⁱ	View protein in SMART SM00147. RasGEF. 1 hit. SM00252. SH2. 1 hit.
SUPFAMⁱ	SSF48366. SSF48366. 1 hit. SSF55550. SSF55550. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50009. RASGEF_CAT. 1 hit. PS50001. SH2. 1 hit.

Sequences (6)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8N5H7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MTEGTKKTSK KFKFFKFKGF GSLSNLPRSF TLRRSSASIS RQSHLEPDTF 
        60         70         80         90        100
EATQDDMVTV PKSPPAYARS SDMYSHMGTM PRPSIKKAQN SQAARQAQEA 
       110        120        130        140        150
GPKPNLVPGG VPDPPGLEAA KEVMVKATGP LEDTPAMEPN PSAVEVDPIR 
       160        170        180        190        200
KPEVPTGDVE EERPPRDVHS ERAAGEPEAG SDYVKFSKEK YILDSSPEKL 
       210        220        230        240        250
HKELEEELKL SSTDLRSHAW YHGRIPREVS ETLVQRNGDF LIRDSLTSLG 
       260        270        280        290        300
DYVLTCRWRN QALHFKINKV VVKAGESYTH IQYLFEQESF DHVPALVRYH 
       310        320        330        340        350
VGSRKAVSEQ SGAIIYCPVN RTFPLRYLEA SYGLGQGSSK PASPVSPSGP 
       360        370        380        390        400
KGSHMKRRSV TMTDGLTADK VTRSDGCPTS TSLPRPRDSI RSCALSMDQI 
       410        420        430        440        450
PDLHSPMSPI SESPSSPAYS TVTRVHAAPA APSATALPAS PVARRSSEPQ 
       460        470        480        490        500
LCPGSAPKTH GESDKGPHTS PSHTLGKASP SPSLSSYSDP DSGHYCQLQP 
       510        520        530        540        550
PVRGSREWAA TETSSQQARS YGERLKELSE NGAPEGDWGK TFTVPIVEVT 
       560        570        580        590        600
SSFNPATFQS LLIPRDNRPL EVGLLRKVKE LLAEVDARTL ARHVTKVDCL 
       610        620        630        640        650
VARILGVTKE MQTLMGVRWG MELLTLPHGR QLRLDLLERF HTMSIMLAVD 
       660        670        680        690        700
ILGCTGSAEE RAALLHKTIQ LAAELRGTMG NMFSFAAVMG ALDMAQISRL 
       710        720        730        740        750
EQTWVTLRQR HTEGAILYEK KLKPFLKSLN EGKEGPPLSN TTFPHVLPLI 
       760        770        780        790        800
TLLECDSAPP EGPEPWGSTE HGVEVVLAHL EAARTVAHHG GLYHTNAEVK 
       810        820        830        840        850
LQGFQARPEL LEVFSTEFQM RLLWGSQGAS SSQARRYEKF DKVLTALSHK 
       860
LEPAVRSSEL

Length:860

Mass (Da):94,411

Last modified:October 1, 2002 - v1

Checksum:ⁱ62598F2F643147C5

GO

Isoform 2 (identifier: Q8N5H7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-172: MTEGTKKTSK...RPPRDVHSER → MTAVGRRCPALGSRG

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        10         20         30         40         50
MTAVGRRCPA LGSRGAAGEP EAGSDYVKFS KEKYILDSSP EKLHKELEEE 
        60         70         80         90        100
LKLSSTDLRS HAWYHGRIPR EVSETLVQRN GDFLIRDSLT SLGDYVLTCR 
       110        120        130        140        150
WRNQALHFKI NKVVVKAGES YTHIQYLFEQ ESFDHVPALV RYHVGSRKAV 
       160        170        180        190        200
SEQSGAIIYC PVNRTFPLRY LEASYGLGQG SSKPASPVSP SGPKGSHMKR 
       210        220        230        240        250
RSVTMTDGLT ADKVTRSDGC PTSTSLPRPR DSIRSCALSM DQIPDLHSPM 
       260        270        280        290        300
SPISESPSSP AYSTVTRVHA APAAPSATAL PASPVARRSS EPQLCPGSAP 
       310        320        330        340        350
KTHGESDKGP HTSPSHTLGK ASPSPSLSSY SDPDSGHYCQ LQPPVRGSRE 
       360        370        380        390        400
WAATETSSQQ ARSYGERLKE LSENGAPEGD WGKTFTVPIV EVTSSFNPAT 
       410        420        430        440        450
FQSLLIPRDN RPLEVGLLRK VKELLAEVDA RTLARHVTKV DCLVARILGV 
       460        470        480        490        500
TKEMQTLMGV RWGMELLTLP HGRQLRLDLL ERFHTMSIML AVDILGCTGS 
       510        520        530        540        550
AEERAALLHK TIQLAAELRG TMGNMFSFAA VMGALDMAQI SRLEQTWVTL 
       560        570        580        590        600
RQRHTEGAIL YEKKLKPFLK SLNEGKEGPP LSNTTFPHVL PLITLLECDS 
       610        620        630        640        650
APPEGPEPWG STEHGVEVVL AHLEAARTVA HHGGLYHTNA EVKLQGFQAR 
       660        670        680        690        700
PELLEVFSTE FQMRLLWGSQ GASSSQARRY EKFDKVLTAL SHKLEPAVRS 

SEL

Show »

Length:703

Mass (Da):77,141

Checksum:ⁱ005B0EA32F7CA869

GO

Isoform 3 (identifier: Q8N5H7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-354: Missing.

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        10         20         30         40         50
MKRRSVTMTD GLTADKVTRS DGCPTSTSLP RPRDSIRSCA LSMDQIPDLH 
        60         70         80         90        100
SPMSPISESP SSPAYSTVTR VHAAPAAPSA TALPASPVAR RSSEPQLCPG 
       110        120        130        140        150
SAPKTHGESD KGPHTSPSHT LGKASPSPSL SSYSDPDSGH YCQLQPPVRG 
       160        170        180        190        200
SREWAATETS SQQARSYGER LKELSENGAP EGDWGKTFTV PIVEVTSSFN 
       210        220        230        240        250
PATFQSLLIP RDNRPLEVGL LRKVKELLAE VDARTLARHV TKVDCLVARI 
       260        270        280        290        300
LGVTKEMQTL MGVRWGMELL TLPHGRQLRL DLLERFHTMS IMLAVDILGC 
       310        320        330        340        350
TGSAEERAAL LHKTIQLAAE LRGTMGNMFS FAAVMGALDM AQISRLEQTW 
       360        370        380        390        400
VTLRQRHTEG AILYEKKLKP FLKSLNEGKE GPPLSNTTFP HVLPLITLLE 
       410        420        430        440        450
CDSAPPEGPE PWGSTEHGVE VVLAHLEAAR TVAHHGGLYH TNAEVKLQGF 
       460        470        480        490        500
QARPELLEVF STEFQMRLLW GSQGASSSQA RRYEKFDKVL TALSHKLEPA 

VRSSEL

Show »

Length:506

Mass (Da):55,191

Checksum:ⁱ6A525DAC855CF389

GO

Isoform 4 (identifier: Q8N5H7-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-172: MTEGTKKTSK...RPPRDVHSER → MAPALPSPHK...GRCPLLLCGG

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        10         20         30         40         50
MAPALPSPHK AVARPELLLD TAAHSGKLRA PDGGEGAECA GHNGGPSWGV 
        60         70         80         90        100
GQGQSQEPSR QGIPQAPWLV SWQRRGFPPS SFCPGPLRTE KLRAGRCPLL 
       110        120        130        140        150
LCGGAAGEPE AGSDYVKFSK EKYILDSSPE KLHKELEEEL KLSSTDLRSH 
       160        170        180        190        200
AWYHGRIPRE VSETLVQRNG DFLIRDSLTS LGDYVLTCRW RNQALHFKIN 
       210        220        230        240        250
KVVVKAGESY THIQYLFEQE SFDHVPALVR YHVGSRKAVS EQSGAIIYCP 
       260        270        280        290        300
VNRTFPLRYL EASYGLGQGS SKPASPVSPS GPKGSHMKRR SVTMTDGLTA 
       310        320        330        340        350
DKVTRSDGCP TSTSLPRPRD SIRSCALSMD QIPDLHSPMS PISESPSSPA 
       360        370        380        390        400
YSTVTRVHAA PAAPSATALP ASPVARRSSE PQLCPGSAPK THGESDKGPH 
       410        420        430        440        450
TSPSHTLGKA SPSPSLSSYS DPDSGHYCQL QPPVRGSREW AATETSSQQA 
       460        470        480        490        500
RSYGERLKEL SENGAPEGDW GKTFTVPIVE VTSSFNPATF QSLLIPRDNR 
       510        520        530        540        550
PLEVGLLRKV KELLAEVDAR TLARHVTKVD CLVARILGVT KEMQTLMGVR 
       560        570        580        590        600
WGMELLTLPH GRQLRLDLLE RFHTMSIMLA VDILGCTGSA EERAALLHKT 
       610        620        630        640        650
IQLAAELRGT MGNMFSFAAV MGALDMAQIS RLEQTWVTLR QRHTEGAILY 
       660        670        680        690        700
EKKLKPFLKS LNEGKEGPPL SNTTFPHVLP LITLLECDSA PPEGPEPWGS 
       710        720        730        740        750
TEHGVEVVLA HLEAARTVAH HGGLYHTNAE VKLQGFQARP ELLEVFSTEF 
       760        770        780        790 
QMRLLWGSQG ASSSQARRYE KFDKVLTALS HKLEPAVRSS EL

Note: No experimental confirmation available.

Show »

Length:792

Mass (Da):86,436

Checksum:ⁱCF76362417FEC80E

GO

Isoform 5 (identifier: Q8N5H7-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-185: MTEGTKKTSK...EPEAGSDYVK → MTERCSLWSALSAAACCFYRGSFVQ
186-186: F → VQF

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        10         20         30         40         50
MTERCSLWSA LSAAACCFYR GSFVQVQFSK EKYILDSSPE KLHKELEEEL 
        60         70         80         90        100
KLSSTDLRSH AWYHGRIPRE VSETLVQRNG DFLIRDSLTS LGDYVLTCRW 
       110        120        130        140        150
RNQALHFKIN KVVVKAGESY THIQYLFEQE SFDHVPALVR YHVGSRKAVS 
       160        170        180        190        200
EQSGAIIYCP VNRTFPLRYL EASYGLGQGS SKPASPVSPS GPKGSHMKRR 
       210        220        230        240        250
SVTMTDGLTA DKVTRSDGCP TSTSLPRPRD SIRSCALSMD QIPDLHSPMS 
       260        270        280        290        300
PISESPSSPA YSTVTRVHAA PAAPSATALP ASPVARRSSE PQLCPGSAPK 
       310        320        330        340        350
THGESDKGPH TSPSHTLGKA SPSPSLSSYS DPDSGHYCQL QPPVRGSREW 
       360        370        380        390        400
AATETSSQQA RSYGERLKEL SENGAPEGDW GKTFTVPIVE VTSSFNPATF 
       410        420        430        440        450
QSLLIPRDNR PLEVGLLRKV KELLAEVDAR TLARHVTKVD CLVARILGVT 
       460        470        480        490        500
KEMQTLMGVR WGMELLTLPH GRQLRLDLLE RFHTMSIMLA VDILGCTGSA 
       510        520        530        540        550
EERAALLHKT IQLAAELRGT MGNMFSFAAV MGALDMAQIS RLEQTWVTLR 
       560        570        580        590        600
QRHTEGAILY EKKLKPFLKS LNEGKEGPPL SNTTFPHVLP LITLLECDSA 
       610        620        630        640        650
PPEGPEPWGS TEHGVEVVLA HLEAARTVAH HGGLYHTNAE VKLQGFQARP 
       660        670        680        690        700
ELLEVFSTEF QMRLLWGSQG ASSSQARRYE KFDKVLTALS HKLEPAVRSS 

EL

Note: No experimental confirmation available.

Show »

Length:702

Mass (Da):77,349

Checksum:ⁱF1B0521F92431081

GO

Isoform 6 (identifier: Q8N5H7-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-185: MTEGTKKTSK...EPEAGSDYVK → MTERCSLWSALSAAACCFYRGSFVQ

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        10         20         30         40         50
MTERCSLWSA LSAAACCFYR GSFVQFSKEK YILDSSPEKL HKELEEELKL 
        60         70         80         90        100
SSTDLRSHAW YHGRIPREVS ETLVQRNGDF LIRDSLTSLG DYVLTCRWRN 
       110        120        130        140        150
QALHFKINKV VVKAGESYTH IQYLFEQESF DHVPALVRYH VGSRKAVSEQ 
       160        170        180        190        200
SGAIIYCPVN RTFPLRYLEA SYGLGQGSSK PASPVSPSGP KGSHMKRRSV 
       210        220        230        240        250
TMTDGLTADK VTRSDGCPTS TSLPRPRDSI RSCALSMDQI PDLHSPMSPI 
       260        270        280        290        300
SESPSSPAYS TVTRVHAAPA APSATALPAS PVARRSSEPQ LCPGSAPKTH 
       310        320        330        340        350
GESDKGPHTS PSHTLGKASP SPSLSSYSDP DSGHYCQLQP PVRGSREWAA 
       360        370        380        390        400
TETSSQQARS YGERLKELSE NGAPEGDWGK TFTVPIVEVT SSFNPATFQS 
       410        420        430        440        450
LLIPRDNRPL EVGLLRKVKE LLAEVDARTL ARHVTKVDCL VARILGVTKE 
       460        470        480        490        500
MQTLMGVRWG MELLTLPHGR QLRLDLLERF HTMSIMLAVD ILGCTGSAEE 
       510        520        530        540        550
RAALLHKTIQ LAAELRGTMG NMFSFAAVMG ALDMAQISRL EQTWVTLRQR 
       560        570        580        590        600
HTEGAILYEK KLKPFLKSLN EGKEGPPLSN TTFPHVLPLI TLLECDSAPP 
       610        620        630        640        650
EGPEPWGSTE HGVEVVLAHL EAARTVAHHG GLYHTNAEVK LQGFQARPEL 
       660        670        680        690        700
LEVFSTEFQM RLLWGSQGAS SSQARRYEKF DKVLTALSHK LEPAVRSSEL

Note: No experimental confirmation available.

Show »

Length:700

Mass (Da):77,122

Checksum:ⁱ26650B429A943FF8

GO

Sequence cautionⁱ

The sequence AAQ88456 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	445	R → C in AAD28246 (PubMed:10187783).Curated	1
Sequence conflictⁱ	445	R → C in AAQ89948 (PubMed:12975309).Curated	1
Sequence conflictⁱ	723	K → E in BAF84082 (PubMed:14702039).Curated	1
Isoform 3 (identifier: Q8N5H7-3)
Sequence conflictⁱ	29	L → T in CAI46101 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051352	23	L → F. Corresponds to variant dbSNP:rs10760500Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_017706	1 – 354	Missing in isoform 3. 1 PublicationAdd BLAST	354
Alternative sequenceⁱVSP_044581	1 – 185	MTEGT…SDYVK → MTERCSLWSALSAAACCFYR GSFVQ in isoform 5 and isoform 6. 1 PublicationAdd BLAST	185
Alternative sequenceⁱVSP_017707	1 – 172	MTEGT…VHSER → MTAVGRRCPALGSRG in isoform 2. 3 PublicationsAdd BLAST	172
Alternative sequenceⁱVSP_017708	1 – 172	MTEGT…VHSER → MAPALPSPHKAVARPELLLD TAAHSGKLRAPDGGEGAECA GHNGGPSWGVGQGQSQEPSR QGIPQAPWLVSWQRRGFPPS SFCPGPLRTEKLRAGRCPLL LCGG in isoform 4. 1 PublicationAdd BLAST	172
Alternative sequenceⁱVSP_044582	186	F → VQF in isoform 5. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF124251 mRNA. Translation: AAD28246.1. AY358089 Transcribed RNA. Translation: AAQ88456.1. Different initiation. AY358440 mRNA. Translation: AAQ89948.1. AK056068 mRNA. Translation: BAG51614.1. AK291393 mRNA. Translation: BAF84082.1. BX647905 mRNA. Translation: CAI46101.1. AL162586, AL162426 Genomic DNA. Translation: CAI39761.1. AL162586, AL162426 Genomic DNA. Translation: CAI39763.1. AL162586, AL162426 Genomic DNA. Translation: CAI39766.1. AL162426, AL162586 Genomic DNA. Translation: CAI41177.1. AL162426, AL162586 Genomic DNA. Translation: CAI41179.1. AL162426, AL162586 Genomic DNA. Translation: CAI41182.1. BC027962 mRNA. Translation: AAH27962.1. BC032365 mRNA. Translation: AAH32365.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS48026.1. [Q8N5H7-5] CCDS48027.1. [Q8N5H7-6] CCDS48028.1. [Q8N5H7-3] CCDS59145.1. [Q8N5H7-4] CCDS6877.1. [Q8N5H7-1] CCDS6878.1. [Q8N5H7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001136004.1. NM_001142532.1. [Q8N5H7-3] NP_001136005.1. NM_001142533.1. [Q8N5H7-5] NP_001136006.1. NM_001142534.1. [Q8N5H7-6] NP_001239263.1. NM_001252334.1. [Q8N5H7-4] NP_005480.2. NM_005489.3. [Q8N5H7-2] NP_733745.1. NM_170600.2. [Q8N5H7-1] XP_005251696.1. XM_005251639.1. [Q8N5H7-3] XP_011516419.1. XM_011518117.2. [Q8N5H7-3] XP_016869663.1. XM_017014174.1. [Q8N5H7-3]
UniGeneⁱ	Hs.306412.

Genome annotation databases

Ensemblⁱ	ENST00000314830; ENSP00000317817; ENSG00000095370. [Q8N5H7-1] ENST00000373276; ENSP00000362373; ENSG00000095370. [Q8N5H7-4] ENST00000373277; ENSP00000362374; ENSG00000095370. [Q8N5H7-2] ENST00000420366; ENSP00000388536; ENSG00000095370. [Q8N5H7-5] ENST00000429553; ENSP00000394632; ENSG00000095370. [Q8N5H7-3] ENST00000629203; ENSP00000485866; ENSG00000095370. [Q8N5H7-6]
GeneIDⁱ	10044.
KEGGⁱ	hsa:10044.
UCSC genome browser More...UCSCⁱ	uc004bry.4. human. [Q8N5H7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF124251 mRNA. Translation: AAD28246.1. AY358089 Transcribed RNA. Translation: AAQ88456.1. Different initiation. AY358440 mRNA. Translation: AAQ89948.1. AK056068 mRNA. Translation: BAG51614.1. AK291393 mRNA. Translation: BAF84082.1. BX647905 mRNA. Translation: CAI46101.1. AL162586, AL162426 Genomic DNA. Translation: CAI39761.1. AL162586, AL162426 Genomic DNA. Translation: CAI39763.1. AL162586, AL162426 Genomic DNA. Translation: CAI39766.1. AL162426, AL162586 Genomic DNA. Translation: CAI41177.1. AL162426, AL162586 Genomic DNA. Translation: CAI41179.1. AL162426, AL162586 Genomic DNA. Translation: CAI41182.1. BC027962 mRNA. Translation: AAH27962.1. BC032365 mRNA. Translation: AAH32365.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS48026.1. [Q8N5H7-5] CCDS48027.1. [Q8N5H7-6] CCDS48028.1. [Q8N5H7-3] CCDS59145.1. [Q8N5H7-4] CCDS6877.1. [Q8N5H7-1] CCDS6878.1. [Q8N5H7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001136004.1. NM_001142532.1. [Q8N5H7-3] NP_001136005.1. NM_001142533.1. [Q8N5H7-5] NP_001136006.1. NM_001142534.1. [Q8N5H7-6] NP_001239263.1. NM_001252334.1. [Q8N5H7-4] NP_005480.2. NM_005489.3. [Q8N5H7-2] NP_733745.1. NM_170600.2. [Q8N5H7-1] XP_005251696.1. XM_005251639.1. [Q8N5H7-3] XP_011516419.1. XM_011518117.2. [Q8N5H7-3] XP_016869663.1. XM_017014174.1. [Q8N5H7-3]
UniGeneⁱ	Hs.306412.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3T6G	X-ray	2.50	A/C	539-860	[»]
ProteinModelPortalⁱ	Q8N5H7.
SMRⁱ	Q8N5H7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115355. 6 interactors.
Database of interacting proteins More...DIPⁱ	DIP-59443N.
IntActⁱ	Q8N5H7. 5 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1427552.
STRINGⁱ	9606.ENSP00000317817.

PTM databases

iPTMnetⁱ	Q8N5H7.
PhosphoSitePlusⁱ	Q8N5H7.

Polymorphism and mutation databases

BioMutaⁱ	SH2D3C.
DMDMⁱ	74751027.

Proteomic databases

EPDⁱ	Q8N5H7.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N5H7.
PaxDbⁱ	Q8N5H7.
PeptideAtlas More...PeptideAtlasⁱ	Q8N5H7.
PRIDEⁱ	Q8N5H7.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10044.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000314830; ENSP00000317817; ENSG00000095370. [Q8N5H7-1] ENST00000373276; ENSP00000362373; ENSG00000095370. [Q8N5H7-4] ENST00000373277; ENSP00000362374; ENSG00000095370. [Q8N5H7-2] ENST00000420366; ENSP00000388536; ENSG00000095370. [Q8N5H7-5] ENST00000429553; ENSP00000394632; ENSG00000095370. [Q8N5H7-3] ENST00000629203; ENSP00000485866; ENSG00000095370. [Q8N5H7-6]
GeneIDⁱ	10044.
KEGGⁱ	hsa:10044.
UCSC genome browser More...UCSCⁱ	uc004bry.4. human. [Q8N5H7-1]

Organism-specific databases

CTDⁱ	10044.
DisGeNET More...DisGeNETⁱ	10044.
GeneCardsⁱ	SH2D3C.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16884. SH2D3C.
Human Protein Atlas More...HPAⁱ	HPA047586.
MIMⁱ	604722. gene.
neXtProtⁱ	NX_Q8N5H7.
Open Targets More...OpenTargetsⁱ	ENSG00000095370.
PharmGKBⁱ	PA38191.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFQG. Eukaryota. ENOG410XTJR. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008976.
HOGENOMⁱ	HOG000231595.
HOVERGENⁱ	HBG053174.
InParanoidⁱ	Q8N5H7.
OMAⁱ	QPDNYVL.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01KG.
PhylomeDBⁱ	Q8N5H7.
TreeFamⁱ	TF323756.

Enzyme and pathway databases

SignaLinkⁱ	Q8N5H7.

SignaLinkⁱ

Q8N5H7.

Miscellaneous databases

ChiTaRSⁱ	SH2D3C. human.
GeneWikiⁱ	SH2D3C.
GenomeRNAiⁱ	10044.
Protein Ontology More...PROⁱ	PR:Q8N5H7.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000095370.
CleanExⁱ	HS_SH2D3C.
ExpressionAtlasⁱ	Q8N5H7. baseline and differential.
Genevisibleⁱ	Q8N5H7. HS.

Family and domain databases

Gene3Dⁱ	1.10.840.10. 1 hit. 3.30.505.10. 1 hit.
InterProⁱ	View protein in InterPro IPR023578. Ras_GEF_dom. IPR001895. RASGEF_cat_dom. IPR000980. SH2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00617. RasGEF. 1 hit. PF00017. SH2. 1 hit.
SMARTⁱ	View protein in SMART SM00147. RasGEF. 1 hit. SM00252. SH2. 1 hit.
SUPFAMⁱ	SSF48366. SSF48366. 1 hit. SSF55550. SSF55550. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50009. RASGEF_CAT. 1 hit. PS50001. SH2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SH2D3_HUMAN
Accessionⁱ	Q8N5H7Primary (citable) accession number: Q8N5H7 Secondary accession number(s): A8K5S8 Q9Y2X5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
	Last sequence update:	October 1, 2002
	Last modified:	June 7, 2017
	This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q8N5H7 (SH2D3_HUMAN)

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SH2 domain-containing protein 3C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequences (6)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ