ID   Q8N5F4_HUMAN            Unreviewed;       233 AA.
AC   Q8N5F4;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 136.
DE   SubName: Full=IGL@ protein {ECO:0000313|EMBL:AAH32452.1};
GN   Name=IGL@ {ECO:0000313|EMBL:AAH32452.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH32452.1};
RN   [1] {ECO:0000313|EMBL:AAH32452.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAH32452.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0007829|PDB:4DAG}
RP   X-RAY CRYSTALLOGRAPHY (3.39 ANGSTROMS) OF 23-233, AND DISULFIDE BONDS.
RX   PubMed=22388735; DOI=10.1038/nsmb.2250;
RA   Wen X., Krause J.C., Leser G.P., Cox R.G., Lamb R.A., Williams J.V.,
RA   Crowe J.E., Jardetzky T.S.;
RT   "Structure of the human metapneumovirus fusion protein with neutralizing
RT   antibody identifies a pneumovirus antigenic site.";
RL   Nat. Struct. Mol. Biol. 19:461-463(2012).
RN   [3] {ECO:0007829|PDB:4HPY}
RP   X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 20-233, AND DISULFIDE BONDS.
RX   PubMed=23313589; DOI=10.1016/j.immuni.2012.11.011;
RA   Liao H.X., Bonsignori M., Alam S.M., McLellan J.S., Tomaras G.D.,
RA   Moody M.A., Kozink D.M., Hwang K.K., Chen X., Tsao C.Y., Liu P., Lu X.,
RA   Parks R.J., Montefiori D.C., Ferrari G., Pollara J., Rao M., Peachman K.K.,
RA   Santra S., Letvin N.L., Karasavvas N., Yang Z.Y., Dai K., Pancera M.,
RA   Gorman J., Wiehe K., Nicely N.I., Rerks-Ngarm S., Nitayaphan S.,
RA   Kaewkungwal J., Pitisuttithum P., Tartaglia J., Sinangil F., Kim J.H.,
RA   Michael N.L., Kepler T.B., Kwong P.D., Mascola J.R., Nabel G.J., Pinter A.,
RA   Zolla-Pazner S., Haynes B.F.;
RT   "Vaccine induction of antibodies against a structurally heterogeneous site
RT   of immune pressure within HIV-1 envelope protein variable regions 1 and
RT   2.";
RL   Immunity 38:176-186(2013).
RN   [4] {ECO:0007829|PDB:6OKP}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.28 ANGSTROMS) OF 29-233, AND DISULFIDE
RP   BONDS.
RX   PubMed=31126879; DOI=10.1016/j.immuni.2019.04.014;
RA   Schoofs T., Barnes C.O., Suh-Toma N., Golijanin J., Schommers P.,
RA   Gruell H., West A.P., Bach F., Lee Y.E., Nogueira L., Georgiev I.S.,
RA   Bailer R.T., Czartoski J., Mascola J.R., Seaman M.S., McElrath M.J.,
RA   Doria-Rose N.A., Klein F., Nussenzweig M.C., Bjorkman P.J.;
RT   "Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the
RT   HIV Envelope.";
RL   Immunity 50:1513-1529.e9(2019).
RN   [5] {ECO:0007829|PDB:6V8Z}
RP   STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) OF 29-232, AND DISULFIDE
RP   BONDS.
RX   PubMed=31980614; DOI=10.1038/s41467-019-14196-w;
RA   Henderson R., Lu M., Zhou Y., Mu Z., Parks R., Han Q., Hsu A.L., Carter E.,
RA   Blanchard S.C., Edwards R.J., Wiehe K., Saunders K.O., Borgnia M.J.,
RA   Bartesaghi A., Mothes W., Haynes B.F., Acharya P., Munir Alam S.;
RT   "Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced
RT   rearrangements.";
RL   Nat. Commun. 11:520-520(2020).
RN   [6] {ECO:0007829|PDB:7CZP, ECO:0007829|PDB:7CZT}
RP   STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 115-233, AND DISULFIDE
RP   BONDS.
RX   PubMed=33731853; DOI=10.1038/s41422-021-00487-9;
RA   Yan R., Wang R., Ju B., Yu J., Zhang Y., Liu N., Wang J., Zhang Q.,
RA   Chen P., Zhou B., Li Y., Shen Y., Zhang S., Tian L., Guo Y., Xia L.,
RA   Zhong X., Cheng L., Ge X., Zhao J., Wang H.W., Wang X., Zhang Z., Zhang L.,
RA   Zhou Q.;
RT   "Structural basis for bivalent binding and inhibition of SARS-CoV-2
RT   infection by human potent neutralizing antibodies.";
RL   Cell Res. 31:517-525(2021).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   EMBL; BC032452; AAH32452.1; -; mRNA.
DR   PIR; A39949; A39949.
DR   PIR; S12441; S12441.
DR   PIR; S12443; S12443.
DR   PDB; 4DAG; X-ray; 3.39 A; L=23-233.
DR   PDB; 4HPY; X-ray; 1.50 A; L=20-233.
DR   PDB; 6OKP; EM; 3.28 A; L=29-233.
DR   PDB; 6V8Z; EM; 2.90 A; E/K/Q=29-232.
DR   PDB; 7CZP; EM; 3.00 A; L/N=128-233.
DR   PDB; 7CZT; EM; 2.70 A; L/M=128-233.
DR   PDBsum; 4HPY; -.
DR   PDBsum; 6V8Z; -.
DR   AlphaFoldDB; Q8N5F4; -.
DR   SMR; Q8N5F4; -.
DR   MEROPS; I43.001; -.
DR   ChiTaRS; IGL; human.
DR   CDD; cd07699; IgC1_L; 1.
DR   CDD; cd04984; IgV_L_lambda; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR19944:SF98; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4DAG, ECO:0007829|PDB:4HPY};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..233
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004311182"
FT   DOMAIN          9..112
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          134..228
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DISULFID        41..106
FT                   /evidence="ECO:0007829|PDB:4DAG, ECO:0007829|PDB:4HPY"
FT   DISULFID        155..214
FT                   /evidence="ECO:0007829|PDB:4DAG, ECO:0007829|PDB:4HPY"
SQ   SEQUENCE   233 AA;  24961 MW;  F092CFB6AA6E3A9A CRC64;
     MAWTPLLLPL LTFCTVSEAS YELTQPPSVS VSPGQTARIT CSGDALPKKY AYWYQQKSGQ
     TPVLVIYDDT ERPSGIPERF SGSSSGTVAT LTLSGAQVED EADYYCYSSD SSGNHWVFGG
     GTKLTVLGQP KAAPSVTLFP PSSEELQANK ATLVCLISDF YPGAVTVAWK ADSSPVKAGV
     ETTTPSKQSN NKYAASSYLS LTPEQWKSHR SYSCQVTHEG STVEKTVAPT ECS
//