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Protein

WD and tetratricopeptide repeats protein 1

Gene

WDTC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ8N5D0.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
WD and tetratricopeptide repeats protein 1
Gene namesi
Name:WDTC1
Synonyms:KIAA1037
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29175. WDTC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981539.

Polymorphism and mutation databases

DMDMi41018470.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677WD and tetratricopeptide repeats protein 1PRO_0000051434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei353 – 3531PhosphoserineCombined sources
Modified residuei511 – 5111PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N5D0.
MaxQBiQ8N5D0.
PaxDbiQ8N5D0.
PeptideAtlasiQ8N5D0.
PRIDEiQ8N5D0.

PTM databases

iPTMnetiQ8N5D0.
PhosphoSiteiQ8N5D0.

Expressioni

Gene expression databases

BgeeiENSG00000142784.
CleanExiHS_WDTC1.
ExpressionAtlasiQ8N5D0. baseline and differential.
GenevisibleiQ8N5D0. HS.

Organism-specific databases

HPAiHPA028177.
HPA028180.
HPA028182.

Interactioni

Protein-protein interaction databases

BioGridi116677. 29 interactions.
DIPiDIP-31627N.
IntActiQ8N5D0. 6 interactions.
STRINGi9606.ENSP00000355317.

Structurei

Secondary structure

1
677
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 149Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I7NX-ray2.80B5-17[»]
ProteinModelPortaliQ8N5D0.
SMRiQ8N5D0. Positions 26-299, 363-471, 511-671.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N5D0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati45 – 8440WD 1Add
BLAST
Repeati88 – 12942WD 2Add
BLAST
Repeati132 – 17241WD 3Add
BLAST
Repeati182 – 22241WD 4Add
BLAST
Repeati265 – 30541WD 5Add
BLAST
Repeati362 – 39534TPR 1Add
BLAST
Repeati397 – 43236TPR 2Add
BLAST
Repeati535 – 57541WD 6Add
BLAST
Repeati578 – 61740WD 7Add
BLAST

Sequence similaritiesi

Contains 2 TPR repeats.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1310. Eukaryota.
KOG1334. Eukaryota.
ENOG410XWAR. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000231334.
HOVERGENiHBG059105.
InParanoidiQ8N5D0.
KOiK11807.
OMAiIWDPFRK.
OrthoDBiEOG091G08IE.
PhylomeDBiQ8N5D0.
TreeFamiTF320710.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.130.10.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50978. SSF50978. 3 hits.
PROSITEiPS50293. TPR_REGION. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N5D0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKVNITRDL IRRQIKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV
60 70 80 90 100
NCLEWNEKGD LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP
110 120 130 140 150
HAGDRILITG AADSKVHVHD LTVKETIHMF GDHTNRVKRI ATAPMWPNTF
160 170 180 190 200
WSAAEDGLIR QYDLRENSKH SEVLIDLTEY CGQLVEAKCL TVNPQDNNCL
210 220 230 240 250
AVGASGPFVR LYDIRMIHNH RKSMKQSPSA GVHTFCDRQK PLPDGAAQYY
260 270 280 290 300
VAGHLPVKLP DYNNRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK
310 320 330 340 350
QRPYTFLLPR KCHSSGEVQN GKMSTNGVSN GVSNGLHLHS NGFRLPESRG
360 370 380 390 400
HVSPQVELPP YLERVKQQAN EAFACQQWTQ AIQLYSKAVQ RAPHNAMLYG
410 420 430 440 450
NRAAAYMKRK WDGDHYDALR DCLKAISLNP CHLKAHFRLA RCLFELKYVA
460 470 480 490 500
EALECLDDFK GKFPEQAHSS ACDALGRDIT AALFSKNDGE EKKGPGGGAP
510 520 530 540 550
VRLRSTSRKD SISEDEMVLR ERSYDYQFRY CGHCNTTTDI KEANFFGSNA
560 570 580 590 600
QYIVSGSDDG SFFIWEKETT NLVRVLQGDE SIVNCLQPHP SYCFLATSGI
610 620 630 640 650
DPVVRLWNPR PESEDLTGRV VEDMEGASQA NQRRMNADPL EVMLLNMGYR
660 670
ITGLSSGGAG ASDDEDSSEG QVQCRPS
Note: No experimental confirmation available.
Length:677
Mass (Da):75,920
Last modified:January 16, 2004 - v2
Checksum:i2BDFA8061B2C266C
GO
Isoform 2 (identifier: Q8N5D0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     548-677: SNAQYIVSGS...SEGQVQCRPS → RRPPTWSVCS...RVLHRPTSGA

Note: No experimental confirmation available.
Show »
Length:615
Mass (Da):69,065
Checksum:i67FBA050EB7AD4E7
GO
Isoform 3 (identifier: Q8N5D0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     548-677: SNAQYIVSGS...SEGQVQCRPS → RSEALKRRVQ...WANGFTFVSL

Note: No experimental confirmation available.
Show »
Length:597
Mass (Da):67,590
Checksum:i330E6A5A2BB525B6
GO
Isoform 4 (identifier: Q8N5D0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-317: Missing.

Note: No experimental confirmation available.
Show »
Length:676
Mass (Da):75,791
Checksum:i25FFD27AD1E90F3E
GO
Isoform 5 (identifier: Q8N5D0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-317: Missing.
     548-677: SNAQYIVSGS...SEGQVQCRPS → RSEALKRRVQ...WANGFTFVSL

Note: No experimental confirmation available.
Show »
Length:596
Mass (Da):67,461
Checksum:i58DB84890ECED479
GO
Isoform 6 (identifier: Q8N5D0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-317: Missing.
     548-677: SNAQYIVSGS...SEGQVQCRPS → RRPPTWSVCS...RVLHRPTSGA

Note: No experimental confirmation available.
Show »
Length:614
Mass (Da):68,936
Checksum:iA81D1F64FC48A772
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti456 – 4561L → P in BAA91868 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei317 – 3171Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_009290
Alternative sequencei548 – 677130SNAQY…QCRPS → RRPPTWSVCSKGMSPLSTAC SHTPATASWPPVASILLCGS GTPDQRVKTSQAESWKIWRV LHRPTSGA in isoform 2 and isoform 6. 1 PublicationVSP_009292Add
BLAST
Alternative sequencei548 – 677130SNAQY…QCRPS → RSEALKRRVQPSWQREVEWG VLGHNGFREESQIPALPLYP WANGFTFVSL in isoform 3 and isoform 5. 1 PublicationVSP_009291Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001734 mRNA. Translation: BAA91868.1.
AL590640 Genomic DNA. No translation available.
FO393419 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07770.1.
CH471059 Genomic DNA. Translation: EAX07771.1.
BC032523 mRNA. Translation: AAH32523.1.
AB028960 mRNA. Translation: BAA82989.1.
CCDSiCCDS296.1. [Q8N5D0-4]
CCDS60044.1. [Q8N5D0-1]
RefSeqiNP_001263181.1. NM_001276252.1. [Q8N5D0-1]
NP_055838.2. NM_015023.4. [Q8N5D0-4]
XP_011539359.1. XM_011541057.1. [Q8N5D0-1]
UniGeneiHs.469154.

Genome annotation databases

EnsembliENST00000319394; ENSP00000317971; ENSG00000142784. [Q8N5D0-1]
ENST00000361771; ENSP00000355317; ENSG00000142784. [Q8N5D0-4]
ENST00000447062; ENSP00000434578; ENSG00000142784. [Q8N5D0-2]
GeneIDi23038.
KEGGihsa:23038.
UCSCiuc001bno.5. human. [Q8N5D0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001734 mRNA. Translation: BAA91868.1.
AL590640 Genomic DNA. No translation available.
FO393419 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07770.1.
CH471059 Genomic DNA. Translation: EAX07771.1.
BC032523 mRNA. Translation: AAH32523.1.
AB028960 mRNA. Translation: BAA82989.1.
CCDSiCCDS296.1. [Q8N5D0-4]
CCDS60044.1. [Q8N5D0-1]
RefSeqiNP_001263181.1. NM_001276252.1. [Q8N5D0-1]
NP_055838.2. NM_015023.4. [Q8N5D0-4]
XP_011539359.1. XM_011541057.1. [Q8N5D0-1]
UniGeneiHs.469154.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I7NX-ray2.80B5-17[»]
ProteinModelPortaliQ8N5D0.
SMRiQ8N5D0. Positions 26-299, 363-471, 511-671.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116677. 29 interactions.
DIPiDIP-31627N.
IntActiQ8N5D0. 6 interactions.
STRINGi9606.ENSP00000355317.

PTM databases

iPTMnetiQ8N5D0.
PhosphoSiteiQ8N5D0.

Polymorphism and mutation databases

DMDMi41018470.

Proteomic databases

EPDiQ8N5D0.
MaxQBiQ8N5D0.
PaxDbiQ8N5D0.
PeptideAtlasiQ8N5D0.
PRIDEiQ8N5D0.

Protocols and materials databases

DNASUi23038.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319394; ENSP00000317971; ENSG00000142784. [Q8N5D0-1]
ENST00000361771; ENSP00000355317; ENSG00000142784. [Q8N5D0-4]
ENST00000447062; ENSP00000434578; ENSG00000142784. [Q8N5D0-2]
GeneIDi23038.
KEGGihsa:23038.
UCSCiuc001bno.5. human. [Q8N5D0-1]

Organism-specific databases

CTDi23038.
GeneCardsiWDTC1.
HGNCiHGNC:29175. WDTC1.
HPAiHPA028177.
HPA028180.
HPA028182.
neXtProtiNX_Q8N5D0.
PharmGKBiPA134981539.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1310. Eukaryota.
KOG1334. Eukaryota.
ENOG410XWAR. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000231334.
HOVERGENiHBG059105.
InParanoidiQ8N5D0.
KOiK11807.
OMAiIWDPFRK.
OrthoDBiEOG091G08IE.
PhylomeDBiQ8N5D0.
TreeFamiTF320710.

Enzyme and pathway databases

UniPathwayiUPA00143.
SignaLinkiQ8N5D0.

Miscellaneous databases

ChiTaRSiWDTC1. human.
EvolutionaryTraceiQ8N5D0.
GenomeRNAii23038.
PROiQ8N5D0.

Gene expression databases

BgeeiENSG00000142784.
CleanExiHS_WDTC1.
ExpressionAtlasiQ8N5D0. baseline and differential.
GenevisibleiQ8N5D0. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.130.10.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50978. SSF50978. 3 hits.
PROSITEiPS50293. TPR_REGION. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDTC1_HUMAN
AccessioniPrimary (citable) accession number: Q8N5D0
Secondary accession number(s): D3DPL5
, Q5SSC5, Q9NV87, Q9UPW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: September 7, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.