Q8N5D0 (WDTC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD and tetratricopeptide repeats protein 1

Gene names

Name:	WDTC1
Synonyms:	KIAA1037

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	677 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 2 TPR repeats. Contains 7 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat TPR repeat WD repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular chemical homeostasis Inferred from electronic annotation. Source: Compara cellular response to insulin stimulus Inferred from electronic annotation. Source: Compara glucose metabolic process Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara multicellular organism growth Inferred from electronic annotation. Source: Compara negative regulation of fatty acid biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of cell size Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara intracellular membrane-bounded organelle Inferred from direct assay. Source: HPA nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	enzyme inhibitor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N5D0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q8N5D0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     548-677: SNAQYIVSGS...SEGQVQCRPS → RRPPTWSVCS...RVLHRPTSGA

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8N5D0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     548-677: SNAQYIVSGS...SEGQVQCRPS → RSEALKRRVQ...WANGFTFVSL

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8N5D0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     317-317: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q8N5D0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     317-317: Missing.
     548-677: SNAQYIVSGS...SEGQVQCRPS → RSEALKRRVQ...WANGFTFVSL

Note: No experimental confirmation available.

Isoform 6 (identifier: Q8N5D0-6)

The sequence of this isoform differs from the canonical sequence as follows:
     317-317: Missing.
     548-677: SNAQYIVSGS...SEGQVQCRPS → RRPPTWSVCS...RVLHRPTSGA

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 677

677

WD and tetratricopeptide repeats protein 1

PRO_0000051434

Regions

Repeat

45 – 84

40

WD 1

Repeat

88 – 129

42

WD 2

Repeat

132 – 172

41

WD 3

Repeat

182 – 222

41

WD 4

Repeat

265 – 305

41

WD 5

Repeat

362 – 395

34

TPR 1

Repeat

397 – 432

36

TPR 2

Repeat

535 – 575

41

WD 6

Repeat

578 – 617

40

WD 7

Amino acid modifications

Modified residue

511

1

Phosphoserine Ref.6 Ref.7

Natural variations

Alternative sequence

317

1

Missing in isoform 4, isoform 5 and isoform 6.

VSP_009290

Alternative sequence

548 – 677

130

SNAQY…QCRPS → RRPPTWSVCSKGMSPLSTAC SHTPATASWPPVASILLCGS GTPDQRVKTSQAESWKIWRV LHRPTSGA in isoform 2 and isoform 6.

VSP_009292

Alternative sequence

548 – 677

130

SNAQY…QCRPS → RSEALKRRVQPSWQREVEWG VLGHNGFREESQIPALPLYP WANGFTFVSL in isoform 3 and isoform 5.

VSP_009291

Experimental info

Sequence conflict

456

1

L → P in BAA91868. Ref.1

Secondary structure

1

.

.

.

677

Helix Strand Turn

Details...

Helix

6 – 14

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 16, 2004. Version 2. Checksum: 2BDFA8061B2C266C	FASTA	677	75,920
	10 20 30 40 50 60 MAKVNITRDL IRRQIKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV NCLEWNEKGD 70 80 90 100 110 120 LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP HAGDRILITG AADSKVHVHD 130 140 150 160 170 180 LTVKETIHMF GDHTNRVKRI ATAPMWPNTF WSAAEDGLIR QYDLRENSKH SEVLIDLTEY 190 200 210 220 230 240 CGQLVEAKCL TVNPQDNNCL AVGASGPFVR LYDIRMIHNH RKSMKQSPSA GVHTFCDRQK 250 260 270 280 290 300 PLPDGAAQYY VAGHLPVKLP DYNNRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK 310 320 330 340 350 360 QRPYTFLLPR KCHSSGEVQN GKMSTNGVSN GVSNGLHLHS NGFRLPESRG HVSPQVELPP 370 380 390 400 410 420 YLERVKQQAN EAFACQQWTQ AIQLYSKAVQ RAPHNAMLYG NRAAAYMKRK WDGDHYDALR 430 440 450 460 470 480 DCLKAISLNP CHLKAHFRLA RCLFELKYVA EALECLDDFK GKFPEQAHSS ACDALGRDIT 490 500 510 520 530 540 AALFSKNDGE EKKGPGGGAP VRLRSTSRKD SISEDEMVLR ERSYDYQFRY CGHCNTTTDI 550 560 570 580 590 600 KEANFFGSNA QYIVSGSDDG SFFIWEKETT NLVRVLQGDE SIVNCLQPHP SYCFLATSGI 610 620 630 640 650 660 DPVVRLWNPR PESEDLTGRV VEDMEGASQA NQRRMNADPL EVMLLNMGYR ITGLSSGGAG 670 ASDDEDSSEG QVQCRPS
	Isoform 2 [UniParc]. Checksum: 67FBA050EB7AD4E7	FASTA	615	69,065
	10 20 30 40 50 60 MAKVNITRDL IRRQIKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV NCLEWNEKGD 70 80 90 100 110 120 LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP HAGDRILITG AADSKVHVHD 130 140 150 160 170 180 LTVKETIHMF GDHTNRVKRI ATAPMWPNTF WSAAEDGLIR QYDLRENSKH SEVLIDLTEY 190 200 210 220 230 240 CGQLVEAKCL TVNPQDNNCL AVGASGPFVR LYDIRMIHNH RKSMKQSPSA GVHTFCDRQK 250 260 270 280 290 300 PLPDGAAQYY VAGHLPVKLP DYNNRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK 310 320 330 340 350 360 QRPYTFLLPR KCHSSGEVQN GKMSTNGVSN GVSNGLHLHS NGFRLPESRG HVSPQVELPP 370 380 390 400 410 420 YLERVKQQAN EAFACQQWTQ AIQLYSKAVQ RAPHNAMLYG NRAAAYMKRK WDGDHYDALR 430 440 450 460 470 480 DCLKAISLNP CHLKAHFRLA RCLFELKYVA EALECLDDFK GKFPEQAHSS ACDALGRDIT 490 500 510 520 530 540 AALFSKNDGE EKKGPGGGAP VRLRSTSRKD SISEDEMVLR ERSYDYQFRY CGHCNTTTDI 550 560 570 580 590 600 KEANFFGRRP PTWSVCSKGM SPLSTACSHT PATASWPPVA SILLCGSGTP DQRVKTSQAE 610 SWKIWRVLHR PTSGA
	Isoform 3 [UniParc]. Checksum: 330E6A5A2BB525B6	FASTA	597	67,590
	10 20 30 40 50 60 MAKVNITRDL IRRQIKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV NCLEWNEKGD 70 80 90 100 110 120 LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP HAGDRILITG AADSKVHVHD 130 140 150 160 170 180 LTVKETIHMF GDHTNRVKRI ATAPMWPNTF WSAAEDGLIR QYDLRENSKH SEVLIDLTEY 190 200 210 220 230 240 CGQLVEAKCL TVNPQDNNCL AVGASGPFVR LYDIRMIHNH RKSMKQSPSA GVHTFCDRQK 250 260 270 280 290 300 PLPDGAAQYY VAGHLPVKLP DYNNRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK 310 320 330 340 350 360 QRPYTFLLPR KCHSSGEVQN GKMSTNGVSN GVSNGLHLHS NGFRLPESRG HVSPQVELPP 370 380 390 400 410 420 YLERVKQQAN EAFACQQWTQ AIQLYSKAVQ RAPHNAMLYG NRAAAYMKRK WDGDHYDALR 430 440 450 460 470 480 DCLKAISLNP CHLKAHFRLA RCLFELKYVA EALECLDDFK GKFPEQAHSS ACDALGRDIT 490 500 510 520 530 540 AALFSKNDGE EKKGPGGGAP VRLRSTSRKD SISEDEMVLR ERSYDYQFRY CGHCNTTTDI 550 560 570 580 590 KEANFFGRSE ALKRRVQPSW QREVEWGVLG HNGFREESQI PALPLYPWAN GFTFVSL
	Isoform 4 [UniParc]. Checksum: 25FFD27AD1E90F3E	FASTA	676	75,791
	10 20 30 40 50 60 MAKVNITRDL IRRQIKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV NCLEWNEKGD 70 80 90 100 110 120 LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP HAGDRILITG AADSKVHVHD 130 140 150 160 170 180 LTVKETIHMF GDHTNRVKRI ATAPMWPNTF WSAAEDGLIR QYDLRENSKH SEVLIDLTEY 190 200 210 220 230 240 CGQLVEAKCL TVNPQDNNCL AVGASGPFVR LYDIRMIHNH RKSMKQSPSA GVHTFCDRQK 250 260 270 280 290 300 PLPDGAAQYY VAGHLPVKLP DYNNRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK 310 320 330 340 350 360 QRPYTFLLPR KCHSSGVQNG KMSTNGVSNG VSNGLHLHSN GFRLPESRGH VSPQVELPPY 370 380 390 400 410 420 LERVKQQANE AFACQQWTQA IQLYSKAVQR APHNAMLYGN RAAAYMKRKW DGDHYDALRD 430 440 450 460 470 480 CLKAISLNPC HLKAHFRLAR CLFELKYVAE ALECLDDFKG KFPEQAHSSA CDALGRDITA 490 500 510 520 530 540 ALFSKNDGEE KKGPGGGAPV RLRSTSRKDS ISEDEMVLRE RSYDYQFRYC GHCNTTTDIK 550 560 570 580 590 600 EANFFGSNAQ YIVSGSDDGS FFIWEKETTN LVRVLQGDES IVNCLQPHPS YCFLATSGID 610 620 630 640 650 660 PVVRLWNPRP ESEDLTGRVV EDMEGASQAN QRRMNADPLE VMLLNMGYRI TGLSSGGAGA 670 SDDEDSSEGQ VQCRPS
	Isoform 5 [UniParc]. Checksum: 58DB84890ECED479	FASTA	596	67,461
	10 20 30 40 50 60 MAKVNITRDL IRRQIKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV NCLEWNEKGD 70 80 90 100 110 120 LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP HAGDRILITG AADSKVHVHD 130 140 150 160 170 180 LTVKETIHMF GDHTNRVKRI ATAPMWPNTF WSAAEDGLIR QYDLRENSKH SEVLIDLTEY 190 200 210 220 230 240 CGQLVEAKCL TVNPQDNNCL AVGASGPFVR LYDIRMIHNH RKSMKQSPSA GVHTFCDRQK 250 260 270 280 290 300 PLPDGAAQYY VAGHLPVKLP DYNNRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK 310 320 330 340 350 360 QRPYTFLLPR KCHSSGVQNG KMSTNGVSNG VSNGLHLHSN GFRLPESRGH VSPQVELPPY 370 380 390 400 410 420 LERVKQQANE AFACQQWTQA IQLYSKAVQR APHNAMLYGN RAAAYMKRKW DGDHYDALRD 430 440 450 460 470 480 CLKAISLNPC HLKAHFRLAR CLFELKYVAE ALECLDDFKG KFPEQAHSSA CDALGRDITA 490 500 510 520 530 540 ALFSKNDGEE KKGPGGGAPV RLRSTSRKDS ISEDEMVLRE RSYDYQFRYC GHCNTTTDIK 550 560 570 580 590 EANFFGRSEA LKRRVQPSWQ REVEWGVLGH NGFREESQIP ALPLYPWANG FTFVSL
	Isoform 6 [UniParc]. Checksum: A81D1F64FC48A772	FASTA	614	68,936
	10 20 30 40 50 60 MAKVNITRDL IRRQIKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV NCLEWNEKGD 70 80 90 100 110 120 LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP HAGDRILITG AADSKVHVHD 130 140 150 160 170 180 LTVKETIHMF GDHTNRVKRI ATAPMWPNTF WSAAEDGLIR QYDLRENSKH SEVLIDLTEY 190 200 210 220 230 240 CGQLVEAKCL TVNPQDNNCL AVGASGPFVR LYDIRMIHNH RKSMKQSPSA GVHTFCDRQK 250 260 270 280 290 300 PLPDGAAQYY VAGHLPVKLP DYNNRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK 310 320 330 340 350 360 QRPYTFLLPR KCHSSGVQNG KMSTNGVSNG VSNGLHLHSN GFRLPESRGH VSPQVELPPY 370 380 390 400 410 420 LERVKQQANE AFACQQWTQA IQLYSKAVQR APHNAMLYGN RAAAYMKRKW DGDHYDALRD 430 440 450 460 470 480 CLKAISLNPC HLKAHFRLAR CLFELKYVAE ALECLDDFKG KFPEQAHSSA CDALGRDITA 490 500 510 520 530 540 ALFSKNDGEE KKGPGGGAPV RLRSTSRKDS ISEDEMVLRE RSYDYQFRYC GHCNTTTDIK 550 560 570 580 590 600 EANFFGRRPP TWSVCSKGMS PLSTACSHTP ATASWPPVAS ILLCGSGTPD QRVKTSQAES 610 WKIWRVLHRP TSGA

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Lymph.
[5]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-677 (ISOFORM 3). Tissue: Brain.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK001734 mRNA. Translation: BAA91868.1.
AL590640, AL663123 Genomic DNA. Translation: CAH73549.1.
AL663123, AL590640 Genomic DNA. Translation: CAI14787.1.
CH471059 Genomic DNA. Translation: EAX07770.1.
CH471059 Genomic DNA. Translation: EAX07771.1.
BC032523 mRNA. Translation: AAH32523.1.
AB028960 mRNA. Translation: BAA82989.1.

IPI

IPI00186384.
IPI00398202.
IPI00398203.
IPI00398204.
IPI00398205.
IPI00398206.

RefSeq

NP_001263181.1. NM_001276252.1.
NP_055838.2. NM_015023.4.

UniGene

Hs.469154.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3I7N	X-ray	2.80	B	5-17	[»]

ProteinModelPortal

Q8N5D0.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-31627N.

IntAct

Q8N5D0. 4 interactions.

STRING

9606.ENSP00000355317.

PTM databases

PhosphoSite

Q8N5D0.

Polymorphism databases

DMDM

41018470.

Proteomic databases

PaxDb

Q8N5D0.

PRIDE

Q8N5D0.

Protocols and materials databases

DNASU

23038.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000319394; ENSP00000317971; ENSG00000142784.
ENST00000361771; ENSP00000355317; ENSG00000142784.
ENST00000447062; ENSP00000434578; ENSG00000142784.

GeneID

23038.

KEGG

hsa:23038.

UCSC

uc001bno.3. human.
uc001bnq.3. human.

Organism-specific databases

CTD

23038.

GeneCards

GC01P027561.

HGNC

HGNC:29175. WDTC1.

HPA

HPA028177.
HPA028180.
HPA028182.

neXtProt

NX_Q8N5D0.

PharmGKB

PA134981539.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG2319.

HOGENOM

HOG000231334.

HOVERGEN

HBG059105.

InParanoid

Q8N5D0.

KO

K11807.

OMA

HRYCGHC.

OrthoDB

EOG4CRKZJ.

PhylomeDB

Q8N5D0.

Gene expression databases

ArrayExpress

Q8N5D0.

Bgee

Q8N5D0.

CleanEx

HS_WDTC1.

Genevestigator

Q8N5D0.

GermOnline

ENSG00000142784. Homo sapiens.

Family and domain databases

Gene3D

1.25.40.10. 1 hit.
2.130.10.10. 3 hits.

InterPro

IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]

Pfam

PF07719. TPR_2. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]

SMART

SM00320. WD40. 6 hits.
[Graphical view]

SUPFAM

SSF50978. WD40_like. 1 hit.

PROSITE

PS50005. TPR. False negative.
PS50293. TPR_REGION. 1 hit.
PS00678. WD_REPEATS_1. False negative.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

WDTC1. human.

EvolutionaryTrace

Q8N5D0.

GenomeRNAi

23038.

NextBio

44050.

Entry information

Entry name

WDTC1_HUMAN

Accession

Primary (citable) accession number: Q8N5D0
Secondary accession number(s): D3DPL5 , Q5SSC5, Q9NV87, Q9UPW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	January 16, 2004
Last modified:	May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.