Reviewed,
UniProtKB/Swiss-Prot Q8N5C8 (TAB3_HUMAN)
Last modified
December 15, 2009.
Version 60.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 Alternative name(s): TAK1-binding protein 3 NF-kappa-B-activating protein 1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 712 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. Ref.1 Ref.3 |
| Subunit structure | Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Ref.1 Ref.3 Ref.2 |
| Tissue specificity | Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript. Ref.3 Ref.2 |
| Post-translational modification | Phosphorylated. Ref.1 Ref.2 Ref.6 Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ref.1 |
| Sequence similarities | Contains 1 CUE domain. Contains 1 RanBP2-type zinc finger. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Coiled coil Zinc-finger |
| Ligand | Metal-binding Zinc |
| PTM | Phosphoprotein Ubl conjugation |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | intracellular Inferred from electronic annotation. Source: InterPro |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| Map3k7 | Q62073 | 1 | EBI-359964,EBI-1775345 | From a different organism. |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8N5C8-1) Also known as: Tab3a; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8N5C8-2) Also known as: Tab3b; The sequence of this isoform differs from the canonical sequence as follows: 602-629: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 712 | 712 | Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 | PRO_0000226972 | |||||
Regions | |||||||||
| Domain | 8 – 51 | 44 | CUE | ||||||
| Zinc finger | 682 – 712 | 31 | RanBP2-type | ||||||
| Coiled coil | 517 – 559 | 43 | Potential | ||||||
| Compositional bias | 152 – 451 | 300 | Pro-rich | ||||||
| Compositional bias | 504 – 509 | 6 | Poly-Ser | ||||||
| Compositional bias | 659 – 662 | 4 | Poly-Ala | ||||||
Amino acid modifications | |||||||||
| Modified residue | 60 | 1 | Phosphoserine Ref.6 | ||||||
| Modified residue | 404 | 1 | Phosphothreonine Ref.6 | ||||||
| Modified residue | 408 | 1 | Phosphoserine Ref.6 | ||||||
| Modified residue | 492 | 1 | Phosphoserine Ref.6 | ||||||
Natural variations | |||||||||
| Alternative sequence | 602 – 629 | 28 | Missing in isoform 2. | VSP_017516 | |||||
| Natural variant | 394 | 1 | W → R: dbSNP rs5927629. Ref.1 Ref.3 Ref.2 Ref.5 | VAR_055294 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling." Ishitani T., Takaesu G., Ninomiya-Tsuji J., Shibuya H., Gaynor R.B., Matsumoto K. EMBO J. 22:6277-6288(2003) [PubMed: 14633987] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH MAP3K7; TRAF2 AND TRAF6, UBIQUITINATION, PHOSPHORYLATION, FUNCTION, VARIANT ARG-394. Tissue: Kidney. |
| [2] | "TAB3, a new binding partner of the protein kinase TAK1." Cheung P.C., Nebreda A.R., Cohen P. Biochem. J. 378:27-34(2004) [PubMed: 14670075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, PHOSPHORYLATION, INTERACTION WITH TAB1; TAB2 AND MAP3K7, VARIANT ARG-394. |
| [3] | "Identification of a human NF-kappaB-activating protein, TAB3." Jin G., Klika A., Callahan M., Faga B., Danzig J., Jiang Z., Li X., Stark G.R., Harrington J., Sherf B. Proc. Natl. Acad. Sci. U.S.A. 101:2028-2033(2004) [PubMed: 14766965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), INTERACTION WITH MAP3K7 AND TRAF6, TISSUE SPECIFICITY, FUNCTION, VARIANT ARG-394. |
| [4] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-394. Tissue: Eye. |
| [6] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; THR-404; SER-408 AND SER-492, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AY437560 mRNA. Translation: AAR06179.1. AY371491 mRNA. Translation: AAQ88279.1. AY331591 mRNA. Translation: AAQ92938.1. AY331592 mRNA. Translation: AAQ92939.1. AC108359 Genomic DNA. No translation available. BC032526 mRNA. Translation: AAH32526.1. | |
| IPI | IPI00166840. IPI00397561. |
| RefSeq | NP_690000.2. |
| UniGene | Hs.188256 |
3D structure databases | |
| SMR | Q8N5C8. Positions 4-57. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q8N5C8. 4 interactions. |
| STRING | Q8N5C8. |
PTM databases | |
| PhosphoSite | Q8N5C8. |
Proteomic databases | |
| PRIDE | Q8N5C8. |
Genome annotation databases | |
| Ensembl | ENST00000288422; ENSP00000288422; ENSG00000157625; Homo sapiens. [Genome view] ENST00000378930; ENSP00000368212; ENSG00000157625; Homo sapiens. [Genome view] ENST00000378933; ENSP00000368215; ENSG00000157625; Homo sapiens. [Genome view] |
| GeneID | 257397. |
| KEGG | hsa:257397. |
| UCSC | uc010ngl.1. human. |
Organism-specific databases | |
| CTD | 257397. |
| GeneCards | GC0XM030755. |
| H-InvDB | HIX0016717. |
| HGNC | HGNC:30681. MAP3K7IP3. |
| MIM | 300480. gene. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG714653. |
| HOVERGEN | Q8N5C8. |
| InParanoid | Q8N5C8. |
| OMA | LSKGSMK. |
| OrthoDB | EOG9HX7KQ. |
Gene expression databases | |
| ArrayExpress | Q8N5C8. |
| Bgee | Q8N5C8. |
| CleanEx | HS_MAP3K7IP3. |
| Genevestigator | Q8N5C8. |
| GermOnline | ENSG00000157625. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR003892. CUE. IPR001876. Znf_RanBP2. [Graphical view] |
| Pfam | PF02845. CUE. 1 hit. PF00641. zf-RanBP. 1 hit. [Graphical view] |
| SMART | SM00546. CUE. 1 hit. SM00547. ZnF_RBZ. 1 hit. [Graphical view] |
| PROSITE | PS51140. CUE. 1 hit. PS01358. ZF_RANBP2_1. 1 hit. PS50199. ZF_RANBP2_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 93003. |
| SOURCE | Search... |
Entry information
| Entry name | TAB3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8N5C8 Secondary accession number(s): A6NDD9, Q6VQR0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


