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Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Gene

TAB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri682 – 712RanBP2-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-450302 activated TAK1 mediates p38 MAPK activation
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex
R-HSA-9020702 Interleukin-1 signaling
R-HSA-937042 IRAK2 mediated activation of TAK1 complex
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
SIGNORiQ8N5C8

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3
NF-kappa-B-activating protein 1
TAK1-binding protein 3
Short name:
TAB-3
TGF-beta-activated kinase 1-binding protein 3
Gene namesi
Name:TAB3
Synonyms:MAP3K7IP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000157625.15
HGNCiHGNC:30681 TAB3
MIMi300480 gene
neXtProtiNX_Q8N5C8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi257397
OpenTargetsiENSG00000157625
PharmGKBiPA165757406

Polymorphism and mutation databases

BioMutaiTAB3
DMDMi229462756

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002269722 – 712TGF-beta-activated kinase 1 and MAP3K7-binding protein 3Add BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei404PhosphothreonineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1
Modified residuei506Phosphoserine; by MAPKAPK2 and MAPKAPK31 Publication1

Post-translational modificationi

Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.1 Publication
Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment.3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8N5C8
PaxDbiQ8N5C8
PeptideAtlasiQ8N5C8
PRIDEiQ8N5C8

PTM databases

iPTMnetiQ8N5C8
PhosphoSitePlusiQ8N5C8

Expressioni

Tissue specificityi

Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.2 Publications

Gene expression databases

BgeeiENSG00000157625
CleanExiHS_MAP3K7IP3
ExpressionAtlasiQ8N5C8 baseline and differential
GenevisibleiQ8N5C8 HS

Organism-specific databases

HPAiHPA034980
HPA034981

Interactioni

Subunit structurei

Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Interacts with WDR34 (via the WD domains). Interacts with RBCK1. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with TRIM5.6 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi129216, 29 interactors
CORUMiQ8N5C8
DIPiDIP-32489N
IntActiQ8N5C8, 15 interactors
MINTiQ8N5C8
STRINGi9606.ENSP00000288422

Structurei

3D structure databases

ProteinModelPortaliQ8N5C8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 51CUEPROSITE-ProRule annotationAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili517 – 559Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi152 – 451Pro-richAdd BLAST300
Compositional biasi504 – 509Poly-Ser6
Compositional biasi659 – 662Poly-Ala4

Domaini

The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri682 – 712RanBP2-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IG4E Eukaryota
ENOG410XPAC LUCA
GeneTreeiENSGT00530000063642
HOGENOMiHOG000261646
HOVERGENiHBG056952
InParanoidiQ8N5C8
KOiK12793
OrthoDBiEOG091G0AYA
PhylomeDBiQ8N5C8
TreeFamiTF332021

Family and domain databases

InterProiView protein in InterPro
IPR003892 CUE
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PfamiView protein in Pfam
PF02845 CUE, 1 hit
SMARTiView protein in SMART
SM00546 CUE, 1 hit
SM00547 ZnF_RBZ, 1 hit
SUPFAMiSSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N5C8-1) [UniParc]FASTAAdd to basket
Also known as: Tab3a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQSSPQLDI QVLHDLRQRF PEIPEGVVSQ CMLQNNNNLE ACCRALSQES
60 70 80 90 100
SKYLYMEYHS PDDNRMNRNR LLHINLGIHS PSSYHPGDGA QLNGGRTLVH
110 120 130 140 150
SSSDGHIDPQ HAAGKQLICL VQEPHSAPAV VAATPNYNPF FMNEQNRSAA
160 170 180 190 200
TPPSQPPQQP SSMQTGMNPS AMQGPSPPPP PPSYMHIPRY STNPITVTVS
210 220 230 240 250
QNLPSGQTVP RALQILPQIP SNLYGSPGSI YIRQTSQSSS GRQTPQSTPW
260 270 280 290 300
QSSPQGPVPH YSQRPLPVYP HQQNYQPSQY SPKQQQIPQS AYHSPPPSQC
310 320 330 340 350
PSPFSSPQHQ VQPSQLGHIF MPPSPSTTPP HPYQQGPPSY QKQGSHSVAY
360 370 380 390 400
LPYTASSLSK GSMKKIEITV EPSQRPGTAI NRSPSPISNQ PSPRNQHSLY
410 420 430 440 450
TATTPPSSSP SRGISSQPKP PFSVNPVYIT YTQPTGPSCT PSPSPRVIPN
460 470 480 490 500
PTTVFKITVG RATTENLLNL VDQEERSAAP EPIQPISVIP GSGGEKGSHK
510 520 530 540 550
YQRSSSSGSD DYAYTQALLL HQRARMERLA KQLKLEKEEL ERLKSEVNGM
560 570 580 590 600
EHDLMQRRLR RVSCTTAIPT PEEMTRLRSM NRQLQINVDC TLKEVDLLQS
610 620 630 640 650
RGNFDPKAMN NFYDNIEPGP VVPPKPSKKD SSDPCTIERK ARRISVTSKV
660 670 680 690 700
QADIHDTQAA AADEHRTGST QSPRTQPRDE DYEGAPWNCD SCTFLNHPAL
710
NRCEQCEMPR YT
Length:712
Mass (Da):78,653
Last modified:March 28, 2018 - v3
Checksum:i2FAC686AE5CDB1E5
GO
Isoform 2 (identifier: Q8N5C8-2) [UniParc]FASTAAdd to basket
Also known as: Tab3b

The sequence of this isoform differs from the canonical sequence as follows:
     602-629: Missing.

Show »
Length:684
Mass (Da):75,569
Checksum:i6161E53E24A59A3B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055294394R → W. Corresponds to variant dbSNP:rs5927629Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017516602 – 629Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY437560 mRNA Translation: AAR06179.1
AY371491 mRNA Translation: AAQ88279.1
AY331591 mRNA Translation: AAQ92938.1
AY331592 mRNA Translation: AAQ92939.1
AC108359 Genomic DNA No translation available.
BC032526 mRNA Translation: AAH32526.1
CCDSiCCDS14226.1 [Q8N5C8-1]
RefSeqiNP_690000.3, NM_152787.4 [Q8N5C8-1]
XP_005274540.2, XM_005274483.3 [Q8N5C8-2]
UniGeneiHs.188256

Genome annotation databases

EnsembliENST00000378930; ENSP00000368212; ENSG00000157625 [Q8N5C8-1]
ENST00000378932; ENSP00000368214; ENSG00000157625 [Q8N5C8-2]
ENST00000378933; ENSP00000368215; ENSG00000157625 [Q8N5C8-1]
GeneIDi257397
KEGGihsa:257397
UCSCiuc004dck.3 human [Q8N5C8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTAB3_HUMAN
AccessioniPrimary (citable) accession number: Q8N5C8
Secondary accession number(s): A6NDD9, Q6VQR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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