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Protein

DTW domain-containing protein 1

Gene

DTWD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
DTW domain-containing protein 1
Gene namesi
Name:DTWD1
ORF Names:MDS009
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:30926. DTWD1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104047.
PharmGKBiPA142671942.

Polymorphism and mutation databases

BioMutaiDTWD1.
DMDMi74728976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003082122 – 304DTW domain-containing protein 1Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8N5C7.
MaxQBiQ8N5C7.
PaxDbiQ8N5C7.
PeptideAtlasiQ8N5C7.
PRIDEiQ8N5C7.
TopDownProteomicsiQ8N5C7-2. [Q8N5C7-2]

PTM databases

iPTMnetiQ8N5C7.
PhosphoSitePlusiQ8N5C7.

Expressioni

Gene expression databases

BgeeiENSG00000104047.
CleanExiHS_DTWD1.
ExpressionAtlasiQ8N5C7. baseline and differential.
GenevisibleiQ8N5C7. HS.

Organism-specific databases

HPAiHPA042214.

Interactioni

Protein-protein interaction databases

BioGridi121303. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8N5C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi206 – 209DXTW4

Domaini

Contains 1 DXTW motif.

Sequence similaritiesi

Belongs to the DTW family.Curated

Phylogenomic databases

eggNOGiKOG3795. Eukaryota.
ENOG4111F3J. LUCA.
GeneTreeiENSGT00510000047544.
HOGENOMiHOG000045368.
HOVERGENiHBG099835.
InParanoidiQ8N5C7.
OMAiKFFCYSC.
OrthoDBiEOG091G07PH.
PhylomeDBiQ8N5C7.
TreeFamiTF324733.

Family and domain databases

InterProiIPR005636. DTW.
[Graphical view]
PfamiPF03942. DTW. 1 hit.
[Graphical view]
SMARTiSM01144. DTW. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N5C7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLNPPIFLK RSEENSSKFV ETKQSQTTSI ASEDPLQNLC LASQEVLQKA
60 70 80 90 100
QQSGRSKCLK CGGSRMFYCY TCYVPVENVP IEQIPLVKLP LKIDIIKHPN
110 120 130 140 150
ETDGKSTAIH AKLLAPEFVN IYTYPCIPEY EEKDHEVALI FPGPQSISIK
160 170 180 190 200
DISFHLQKRI QNNVRGKNDD PDKPSFKRKR TEEQEFCDLN DSKCKGTTLK
210 220 230 240 250
KIIFIDSTWN QTNKIFTDER LQGLLQVELK TRKTCFWRHQ KGKPDTFLST
260 270 280 290 300
IEAIYYFLVD YHTDILKEKY RGQYDNLLFF YSFMYQLIKN AKCSGDKETG

KLTH
Length:304
Mass (Da):35,248
Last modified:October 1, 2002 - v1
Checksum:i8756C5CE34BA0C28
GO
Isoform 2 (identifier: Q8N5C7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MSLNPPIFLK...VPIEQIPLVK → M

Note: No experimental confirmation available.
Show »
Length:217
Mass (Da):25,522
Checksum:i141BE335CAFE0BF9
GO
Isoform 3 (identifier: Q8N5C7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-304: LPLKIDIIKH...GDKETGKLTH → FSLYHLGQSMVSSASKITCIG

Note: No experimental confirmation available.
Show »
Length:109
Mass (Da):12,087
Checksum:i070ECED227DE2E92
GO

Sequence cautioni

The sequence AAF87319 differs from that shown. Reason: Frameshift at positions 132, 182, 187, 188, 192, 194, 196, 199, 204, 207 and 209.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0367579L → P.Corresponds to variant rs11539522dbSNPEnsembl.1
Natural variantiVAR_03675813E → K.Corresponds to variant rs11539519dbSNPEnsembl.1
Natural variantiVAR_03675925S → P.Corresponds to variant rs11539521dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0289221 – 88MSLNP…IPLVK → M in isoform 2. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_02892389 – 304LPLKI…GKLTH → FSLYHLGQSMVSSASKITCI G in isoform 3. 1 PublicationAdd BLAST216

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168717 mRNA. Translation: AAF87319.1. Frameshift.
AC018927 Genomic DNA. No translation available.
BC018028 mRNA. Translation: AAH18028.1.
BC032535 mRNA. Translation: AAH32535.1.
BC093073 mRNA. Translation: AAH93073.1.
CCDSiCCDS10132.1. [Q8N5C7-1]
RefSeqiNP_001138427.1. NM_001144955.1. [Q8N5C7-1]
NP_064619.2. NM_020234.5. [Q8N5C7-1]
XP_016877908.1. XM_017022419.1. [Q8N5C7-1]
XP_016877909.1. XM_017022420.1. [Q8N5C7-1]
XP_016877910.1. XM_017022421.1. [Q8N5C7-1]
XP_016877911.1. XM_017022422.1. [Q8N5C7-1]
XP_016877916.1. XM_017022427.1. [Q8N5C7-2]
XP_016877917.1. XM_017022428.1. [Q8N5C7-2]
XP_016877918.1. XM_017022429.1. [Q8N5C7-2]
XP_016877919.1. XM_017022430.1. [Q8N5C7-2]
XP_016877920.1. XM_017022431.1. [Q8N5C7-2]
UniGeneiHs.127432.
Hs.594784.

Genome annotation databases

EnsembliENST00000251250; ENSP00000251250; ENSG00000104047. [Q8N5C7-1]
ENST00000403028; ENSP00000385399; ENSG00000104047. [Q8N5C7-1]
ENST00000557968; ENSP00000452628; ENSG00000104047. [Q8N5C7-3]
ENST00000558653; ENSP00000453529; ENSG00000104047. [Q8N5C7-1]
GeneIDi56986.
KEGGihsa:56986.
UCSCiuc001zxq.4. human. [Q8N5C7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168717 mRNA. Translation: AAF87319.1. Frameshift.
AC018927 Genomic DNA. No translation available.
BC018028 mRNA. Translation: AAH18028.1.
BC032535 mRNA. Translation: AAH32535.1.
BC093073 mRNA. Translation: AAH93073.1.
CCDSiCCDS10132.1. [Q8N5C7-1]
RefSeqiNP_001138427.1. NM_001144955.1. [Q8N5C7-1]
NP_064619.2. NM_020234.5. [Q8N5C7-1]
XP_016877908.1. XM_017022419.1. [Q8N5C7-1]
XP_016877909.1. XM_017022420.1. [Q8N5C7-1]
XP_016877910.1. XM_017022421.1. [Q8N5C7-1]
XP_016877911.1. XM_017022422.1. [Q8N5C7-1]
XP_016877916.1. XM_017022427.1. [Q8N5C7-2]
XP_016877917.1. XM_017022428.1. [Q8N5C7-2]
XP_016877918.1. XM_017022429.1. [Q8N5C7-2]
XP_016877919.1. XM_017022430.1. [Q8N5C7-2]
XP_016877920.1. XM_017022431.1. [Q8N5C7-2]
UniGeneiHs.127432.
Hs.594784.

3D structure databases

ProteinModelPortaliQ8N5C7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121303. 2 interactors.

PTM databases

iPTMnetiQ8N5C7.
PhosphoSitePlusiQ8N5C7.

Polymorphism and mutation databases

BioMutaiDTWD1.
DMDMi74728976.

Proteomic databases

EPDiQ8N5C7.
MaxQBiQ8N5C7.
PaxDbiQ8N5C7.
PeptideAtlasiQ8N5C7.
PRIDEiQ8N5C7.
TopDownProteomicsiQ8N5C7-2. [Q8N5C7-2]

Protocols and materials databases

DNASUi56986.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251250; ENSP00000251250; ENSG00000104047. [Q8N5C7-1]
ENST00000403028; ENSP00000385399; ENSG00000104047. [Q8N5C7-1]
ENST00000557968; ENSP00000452628; ENSG00000104047. [Q8N5C7-3]
ENST00000558653; ENSP00000453529; ENSG00000104047. [Q8N5C7-1]
GeneIDi56986.
KEGGihsa:56986.
UCSCiuc001zxq.4. human. [Q8N5C7-1]

Organism-specific databases

CTDi56986.
GeneCardsiDTWD1.
HGNCiHGNC:30926. DTWD1.
HPAiHPA042214.
neXtProtiNX_Q8N5C7.
OpenTargetsiENSG00000104047.
PharmGKBiPA142671942.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3795. Eukaryota.
ENOG4111F3J. LUCA.
GeneTreeiENSGT00510000047544.
HOGENOMiHOG000045368.
HOVERGENiHBG099835.
InParanoidiQ8N5C7.
OMAiKFFCYSC.
OrthoDBiEOG091G07PH.
PhylomeDBiQ8N5C7.
TreeFamiTF324733.

Miscellaneous databases

ChiTaRSiDTWD1. human.
GeneWikiiDTWD1.
GenomeRNAii56986.
PROiQ8N5C7.

Gene expression databases

BgeeiENSG00000104047.
CleanExiHS_DTWD1.
ExpressionAtlasiQ8N5C7. baseline and differential.
GenevisibleiQ8N5C7. HS.

Family and domain databases

InterProiIPR005636. DTW.
[Graphical view]
PfamiPF03942. DTW. 1 hit.
[Graphical view]
SMARTiSM01144. DTW. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDTWD1_HUMAN
AccessioniPrimary (citable) accession number: Q8N5C7
Secondary accession number(s): Q567Q3, Q8WVG9, Q9NRU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.