ID SRBD1_HUMAN Reviewed; 995 AA. AC Q8N5C6; Q53T56; Q96TA4; Q9NW11; DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot. DT 17-APR-2007, sequence version 2. DT 27-MAR-2024, entry version 160. DE RecName: Full=S1 RNA-binding domain-containing protein 1; GN Name=SRBD1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Teratocarcinoma; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-964, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-861 AND SER-964, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [8] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-134; LYS-185 AND LYS-955, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25218447; DOI=10.1038/nsmb.2890; RA Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., RA Vertegaal A.C.; RT "Uncovering global SUMOylation signaling networks in a site-specific RT manner."; RL Nat. Struct. Mol. Biol. 21:927-936(2014). RN [9] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-185, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25114211; DOI=10.1073/pnas.1413825111; RA Impens F., Radoshevich L., Cossart P., Ribet D.; RT "Mapping of SUMO sites and analysis of SUMOylation changes induced by RT external stimuli."; RL Proc. Natl. Acad. Sci. U.S.A. 111:12432-12437(2014). RN [10] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-134 AND LYS-185, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25772364; DOI=10.1016/j.celrep.2015.02.033; RA Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V., RA Vertegaal A.C.; RT "SUMO-2 orchestrates chromatin modifiers in response to DNA damage."; RL Cell Rep. 10:1778-1791(2015). RN [11] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-84; LYS-134; LYS-166; LYS-167; RP LYS-183 AND LYS-185, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RX PubMed=28112733; DOI=10.1038/nsmb.3366; RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C., RA Nielsen M.L.; RT "Site-specific mapping of the human SUMO proteome reveals co-modification RT with phosphorylation."; RL Nat. Struct. Mol. Biol. 24:325-336(2017). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q8N5C6-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8N5C6-2; Sequence=VSP_024461; CC -!- SEQUENCE CAUTION: CC Sequence=AAY14821.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK001241; BAA91577.1; -; mRNA. DR EMBL; AK056536; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AC012072; AAY14821.1; ALT_SEQ; Genomic_DNA. DR EMBL; AC008179; AAK52078.1; -; Genomic_DNA. DR EMBL; BC032538; AAH32538.1; -; mRNA. DR CCDS; CCDS1823.1; -. [Q8N5C6-1] DR RefSeq; NP_060549.4; NM_018079.4. [Q8N5C6-1] DR AlphaFoldDB; Q8N5C6; -. DR SMR; Q8N5C6; -. DR BioGRID; 120439; 126. DR IntAct; Q8N5C6; 34. DR MINT; Q8N5C6; -. DR STRING; 9606.ENSP00000263736; -. DR GlyGen; Q8N5C6; 2 sites, 1 O-linked glycan (2 sites). DR iPTMnet; Q8N5C6; -. DR PhosphoSitePlus; Q8N5C6; -. DR SwissPalm; Q8N5C6; -. DR BioMuta; SRBD1; -. DR DMDM; 145566960; -. DR EPD; Q8N5C6; -. DR jPOST; Q8N5C6; -. DR MassIVE; Q8N5C6; -. DR MaxQB; Q8N5C6; -. DR PaxDb; 9606-ENSP00000263736; -. DR PeptideAtlas; Q8N5C6; -. DR ProteomicsDB; 72030; -. [Q8N5C6-1] DR ProteomicsDB; 72031; -. [Q8N5C6-2] DR Pumba; Q8N5C6; -. DR Antibodypedia; 29937; 135 antibodies from 24 providers. DR DNASU; 55133; -. DR Ensembl; ENST00000263736.5; ENSP00000263736.4; ENSG00000068784.13. [Q8N5C6-1] DR GeneID; 55133; -. DR KEGG; hsa:55133; -. DR MANE-Select; ENST00000263736.5; ENSP00000263736.4; NM_018079.5; NP_060549.4. DR UCSC; uc002rus.4; human. [Q8N5C6-1] DR AGR; HGNC:25521; -. DR CTD; 55133; -. DR DisGeNET; 55133; -. DR GeneCards; SRBD1; -. DR HGNC; HGNC:25521; SRBD1. DR HPA; ENSG00000068784; Low tissue specificity. DR neXtProt; NX_Q8N5C6; -. DR OpenTargets; ENSG00000068784; -. DR PharmGKB; PA144596269; -. DR VEuPathDB; HostDB:ENSG00000068784; -. DR eggNOG; KOG1857; Eukaryota. DR GeneTree; ENSGT00510000047850; -. DR HOGENOM; CLU_009833_1_0_1; -. DR InParanoid; Q8N5C6; -. DR OMA; RWAWRTR; -. DR OrthoDB; 170310at2759; -. DR PhylomeDB; Q8N5C6; -. DR TreeFam; TF313600; -. DR PathwayCommons; Q8N5C6; -. DR SignaLink; Q8N5C6; -. DR BioGRID-ORCS; 55133; 776 hits in 1167 CRISPR screens. DR ChiTaRS; SRBD1; human. DR GenomeRNAi; 55133; -. DR Pharos; Q8N5C6; Tbio. DR PRO; PR:Q8N5C6; -. DR Proteomes; UP000005640; Chromosome 2. DR RNAct; Q8N5C6; Protein. DR Bgee; ENSG00000068784; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 135 other cell types or tissues. DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central. DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central. DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro. DR GO; GO:0006412; P:translation; IBA:GO_Central. DR CDD; cd05685; S1_Tex; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR Gene3D; 1.10.10.650; RuvA domain 2-like; 1. DR Gene3D; 1.10.3500.10; Tex N-terminal region-like; 1. DR Gene3D; 1.10.150.310; Tex RuvX-like domain-like; 1. DR Gene3D; 3.30.420.140; YqgF/RNase H-like domain; 1. DR InterPro; IPR041692; HHH_9. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR012337; RNaseH-like_sf. DR InterPro; IPR010994; RuvA_2-like. DR InterPro; IPR003029; S1_domain. DR InterPro; IPR044146; S1_Tex. DR InterPro; IPR023323; Tex-like_dom_sf. DR InterPro; IPR023319; Tex-like_HTH_dom_sf. DR InterPro; IPR018974; Tex-like_N. DR InterPro; IPR032639; Tex_YqgF. DR InterPro; IPR006641; YqgF/RNaseH-like_dom. DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf. DR PANTHER; PTHR10724; 30S RIBOSOMAL PROTEIN S1; 1. DR PANTHER; PTHR10724:SF10; S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1; 1. DR Pfam; PF12836; HHH_3; 1. DR Pfam; PF17674; HHH_9; 1. DR Pfam; PF00575; S1; 1. DR Pfam; PF09371; Tex_N; 1. DR Pfam; PF16921; Tex_YqgF; 1. DR SMART; SM00316; S1; 1. DR SMART; SM00732; YqgFc; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR SUPFAM; SSF53098; Ribonuclease H-like; 1. DR SUPFAM; SSF47781; RuvA domain 2-like; 2. DR SUPFAM; SSF158832; Tex N-terminal region-like; 1. DR PROSITE; PS50126; S1; 1. DR Genevisible; Q8N5C6; HS. PE 1: Evidence at protein level; KW Alternative splicing; Coiled coil; Isopeptide bond; Phosphoprotein; KW Reference proteome; RNA-binding; Ubl conjugation. FT CHAIN 1..995 FT /note="S1 RNA-binding domain-containing protein 1" FT /id="PRO_0000284357" FT DOMAIN 919..992 FT /note="S1 motif" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180" FT REGION 23..81 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 120..165 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 258..288 FT /evidence="ECO:0000255" FT COMPBIAS 38..61 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 129..143 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 144..164 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 861 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 964 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:20068231, FT ECO:0007744|PubMed:23186163" FT CROSSLNK 84 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT CROSSLNK 134 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:25218447, FT ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733" FT CROSSLNK 166 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT CROSSLNK 167 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT CROSSLNK 183 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT CROSSLNK 185 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO1); alternate" FT /evidence="ECO:0007744|PubMed:25114211" FT CROSSLNK 185 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2); alternate" FT /evidence="ECO:0007744|PubMed:25218447, FT ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733" FT CROSSLNK 955 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:25218447" FT VAR_SEQ 1..375 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334" FT /id="VSP_024461" FT VARIANT 361 FT /note="T -> M (in dbSNP:rs6544834)" FT /id="VAR_056995" FT VARIANT 798 FT /note="V -> F (in dbSNP:rs3755073)" FT /id="VAR_056996" FT VARIANT 811 FT /note="K -> R (in dbSNP:rs3755072)" FT /id="VAR_056997" FT CONFLICT 597 FT /note="N -> S (in Ref. 1; BAA91577)" FT /evidence="ECO:0000305" FT CONFLICT 638 FT /note="S -> G (in Ref. 1; AK056536)" FT /evidence="ECO:0000305" FT CONFLICT 795 FT /note="S -> P (in Ref. 1; BAA91577)" FT /evidence="ECO:0000305" SQ SEQUENCE 995 AA; 111776 MW; BB286FB734708C55 CRC64; MSSLPRRAKV QVQDVVLKDE FSSFSELSSA SEEDDKEDSA WEPQKKVPRS RKQPPPKESK PKRMPRVKKN APQISDGSEV VVVKEELNSS VAIADTALED RKNKLDTVQT LKTAKTKQKC AAQPHTVRRT KKLKVEEETS KASNLEGESN SSETPSTSTV WGGTCKKEEN DDDFTFGQSA LKKIKTETYP QGQPVKFPAN ANSTKEEVEM NWDMVQVLSE RTNIEPWVCA NIIRLFNDDN TIPFIIRYRK ELINNLDADS LREVQQTLEE LRAVAKKVHS TIQKIKKEGK MSECLLKAML NCKTFEELEH VSAPYKTGSK GTKAQRARQL GLEGAARALL EKPGELSLLS YIRPDVKGLS TLQDIEIGVQ HILADMIAKD KDTLDFIRNL CQKRHVCIQS SLAKVSSKKV NEKDVDKFLL YQHFSCNIRN IHHHQILAIN RGENLKVLTV KVNISDGVKD EFCRWCIQNR WRPRSFARPE LMKILYNSLN DSFKRLIYPL LCREFRAKLT SDAEKESVMM FGRNLRQLLL TSPVPGRTLM GVDPGYKHGC KLAIISPTSQ ILHTDVVYLH CGQGFREAEK IKTLLLNFNC STVVIGNGTA CRETEAYFAD LIMKNYFAPL DVVYCIVSEA GASIYSVSPE ANKEMPGLDP NLRSAVSIAR RVQDPLAELV KIEPKHIGVG MYQHDVSQTL LKATLDSVVE ECVSFVGVDI NICSEVLLRH IAGLNANRAK NIIEWREKNG PFINREQLKK VKGLGPKSFQ QCAGFIRINQ DYIRTFCSQQ TETSGQIQGV AVTSSADVEV TNEKQGKKKS KTAVNVLLKP NPLDQTCIHP ESYDIAMRFL SSIGGTLYEV GKPEMQQKIN SFLEKEGMEK IAERLQTTVH TLQVIIDGLS QPESFDFRTD FDKPDFKRSI VCLEDLQIGT VLTGKVENAT LFGIFVDIGV GKSGLIPIRN VTEAKLSKTK KRRSLGLGPG ERVEVQVLNI DIPRSRITLD LIRVL //