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Q8N5C6

- SRBD1_HUMAN

UniProt

Q8N5C6 - SRBD1_HUMAN

Protein

S1 RNA-binding domain-containing protein 1

Gene

SRBD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. hydrolase activity, acting on ester bonds Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleobase-containing compound metabolic process Source: InterPro

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S1 RNA-binding domain-containing protein 1
    Gene namesi
    Name:SRBD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:25521. SRBD1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596269.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 995995S1 RNA-binding domain-containing protein 1PRO_0000284357Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei964 – 9641Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8N5C6.
    PaxDbiQ8N5C6.
    PRIDEiQ8N5C6.

    PTM databases

    PhosphoSiteiQ8N5C6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N5C6.
    BgeeiQ8N5C6.
    CleanExiHS_SRBD1.
    GenevestigatoriQ8N5C6.

    Organism-specific databases

    HPAiHPA030567.
    HPA030568.

    Interactioni

    Protein-protein interaction databases

    BioGridi120439. 13 interactions.
    IntActiQ8N5C6. 3 interactions.
    STRINGi9606.ENSP00000263736.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N5C6.
    SMRiQ8N5C6. Positions 224-991.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini919 – 99274S1 motifPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili258 – 28831Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi80 – 834Poly-Val

    Sequence similaritiesi

    Contains 1 S1 motif domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG2183.
    HOGENOMiHOG000270498.
    HOVERGENiHBG101592.
    InParanoidiQ8N5C6.
    OMAiFVEDPHQ.
    OrthoDBiEOG7SR4M1.
    PhylomeDBiQ8N5C6.
    TreeFamiTF313600.

    Family and domain databases

    Gene3Di1.10.10.650. 1 hit.
    1.10.150.310. 2 hits.
    1.10.3500.10. 2 hits.
    2.40.50.140. 1 hit.
    3.30.420.140. 1 hit.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR022967. RNA-binding_domain_S1.
    IPR012337. RNaseH-like_dom.
    IPR010994. RuvA_2-like.
    IPR023323. Tex-like_dom.
    IPR023319. Tex-like_HTH_dom.
    IPR018974. Tex-like_N.
    IPR023097. Tex_RuvX-like_dom.
    IPR006641. YqgF/RNaseH-like_dom.
    [Graphical view]
    PfamiPF00575. S1. 1 hit.
    PF09371. Tex_N. 1 hit.
    [Graphical view]
    SMARTiSM00316. S1. 1 hit.
    SM00732. YqgFc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47781. SSF47781. 2 hits.
    SSF50249. SSF50249. 1 hit.
    SSF53098. SSF53098. 1 hit.
    PROSITEiPS50126. S1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N5C6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSLPRRAKV QVQDVVLKDE FSSFSELSSA SEEDDKEDSA WEPQKKVPRS    50
    RKQPPPKESK PKRMPRVKKN APQISDGSEV VVVKEELNSS VAIADTALED 100
    RKNKLDTVQT LKTAKTKQKC AAQPHTVRRT KKLKVEEETS KASNLEGESN 150
    SSETPSTSTV WGGTCKKEEN DDDFTFGQSA LKKIKTETYP QGQPVKFPAN 200
    ANSTKEEVEM NWDMVQVLSE RTNIEPWVCA NIIRLFNDDN TIPFIIRYRK 250
    ELINNLDADS LREVQQTLEE LRAVAKKVHS TIQKIKKEGK MSECLLKAML 300
    NCKTFEELEH VSAPYKTGSK GTKAQRARQL GLEGAARALL EKPGELSLLS 350
    YIRPDVKGLS TLQDIEIGVQ HILADMIAKD KDTLDFIRNL CQKRHVCIQS 400
    SLAKVSSKKV NEKDVDKFLL YQHFSCNIRN IHHHQILAIN RGENLKVLTV 450
    KVNISDGVKD EFCRWCIQNR WRPRSFARPE LMKILYNSLN DSFKRLIYPL 500
    LCREFRAKLT SDAEKESVMM FGRNLRQLLL TSPVPGRTLM GVDPGYKHGC 550
    KLAIISPTSQ ILHTDVVYLH CGQGFREAEK IKTLLLNFNC STVVIGNGTA 600
    CRETEAYFAD LIMKNYFAPL DVVYCIVSEA GASIYSVSPE ANKEMPGLDP 650
    NLRSAVSIAR RVQDPLAELV KIEPKHIGVG MYQHDVSQTL LKATLDSVVE 700
    ECVSFVGVDI NICSEVLLRH IAGLNANRAK NIIEWREKNG PFINREQLKK 750
    VKGLGPKSFQ QCAGFIRINQ DYIRTFCSQQ TETSGQIQGV AVTSSADVEV 800
    TNEKQGKKKS KTAVNVLLKP NPLDQTCIHP ESYDIAMRFL SSIGGTLYEV 850
    GKPEMQQKIN SFLEKEGMEK IAERLQTTVH TLQVIIDGLS QPESFDFRTD 900
    FDKPDFKRSI VCLEDLQIGT VLTGKVENAT LFGIFVDIGV GKSGLIPIRN 950
    VTEAKLSKTK KRRSLGLGPG ERVEVQVLNI DIPRSRITLD LIRVL 995
    Length:995
    Mass (Da):111,776
    Last modified:April 17, 2007 - v2
    Checksum:iBB286FB734708C55
    GO
    Isoform 2 (identifier: Q8N5C6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-375: Missing.

    Show »
    Length:620
    Mass (Da):69,714
    Checksum:iFB472BF51F89E75F
    GO

    Sequence cautioni

    The sequence AAY14821.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti597 – 5971N → S in BAA91577. (PubMed:14702039)Curated
    Sequence conflicti638 – 6381S → G in AK056536. (PubMed:14702039)Curated
    Sequence conflicti795 – 7951S → P in BAA91577. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti361 – 3611T → M.
    Corresponds to variant rs6544834 [ dbSNP | Ensembl ].
    VAR_056995
    Natural varianti798 – 7981V → F.
    Corresponds to variant rs3755073 [ dbSNP | Ensembl ].
    VAR_056996
    Natural varianti811 – 8111K → R.
    Corresponds to variant rs3755072 [ dbSNP | Ensembl ].
    VAR_056997

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 375375Missing in isoform 2. 2 PublicationsVSP_024461Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001241 mRNA. Translation: BAA91577.1.
    AK056536 mRNA. No translation available.
    AC012072 Genomic DNA. Translation: AAY14821.1. Sequence problems.
    AC008179 Genomic DNA. Translation: AAK52078.1.
    BC032538 mRNA. Translation: AAH32538.1.
    CCDSiCCDS1823.1. [Q8N5C6-1]
    RefSeqiNP_060549.4. NM_018079.4. [Q8N5C6-1]
    UniGeneiHs.14229.

    Genome annotation databases

    EnsembliENST00000263736; ENSP00000263736; ENSG00000068784. [Q8N5C6-1]
    GeneIDi55133.
    KEGGihsa:55133.
    UCSCiuc002rus.3. human. [Q8N5C6-1]

    Polymorphism databases

    DMDMi145566960.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001241 mRNA. Translation: BAA91577.1 .
    AK056536 mRNA. No translation available.
    AC012072 Genomic DNA. Translation: AAY14821.1 . Sequence problems.
    AC008179 Genomic DNA. Translation: AAK52078.1 .
    BC032538 mRNA. Translation: AAH32538.1 .
    CCDSi CCDS1823.1. [Q8N5C6-1 ]
    RefSeqi NP_060549.4. NM_018079.4. [Q8N5C6-1 ]
    UniGenei Hs.14229.

    3D structure databases

    ProteinModelPortali Q8N5C6.
    SMRi Q8N5C6. Positions 224-991.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120439. 13 interactions.
    IntActi Q8N5C6. 3 interactions.
    STRINGi 9606.ENSP00000263736.

    PTM databases

    PhosphoSitei Q8N5C6.

    Polymorphism databases

    DMDMi 145566960.

    Proteomic databases

    MaxQBi Q8N5C6.
    PaxDbi Q8N5C6.
    PRIDEi Q8N5C6.

    Protocols and materials databases

    DNASUi 55133.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263736 ; ENSP00000263736 ; ENSG00000068784 . [Q8N5C6-1 ]
    GeneIDi 55133.
    KEGGi hsa:55133.
    UCSCi uc002rus.3. human. [Q8N5C6-1 ]

    Organism-specific databases

    CTDi 55133.
    GeneCardsi GC02M045615.
    H-InvDB HIX0002022.
    HGNCi HGNC:25521. SRBD1.
    HPAi HPA030567.
    HPA030568.
    neXtProti NX_Q8N5C6.
    PharmGKBi PA144596269.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2183.
    HOGENOMi HOG000270498.
    HOVERGENi HBG101592.
    InParanoidi Q8N5C6.
    OMAi FVEDPHQ.
    OrthoDBi EOG7SR4M1.
    PhylomeDBi Q8N5C6.
    TreeFami TF313600.

    Miscellaneous databases

    GenomeRNAii 55133.
    NextBioi 58814.
    PROi Q8N5C6.

    Gene expression databases

    ArrayExpressi Q8N5C6.
    Bgeei Q8N5C6.
    CleanExi HS_SRBD1.
    Genevestigatori Q8N5C6.

    Family and domain databases

    Gene3Di 1.10.10.650. 1 hit.
    1.10.150.310. 2 hits.
    1.10.3500.10. 2 hits.
    2.40.50.140. 1 hit.
    3.30.420.140. 1 hit.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR022967. RNA-binding_domain_S1.
    IPR012337. RNaseH-like_dom.
    IPR010994. RuvA_2-like.
    IPR023323. Tex-like_dom.
    IPR023319. Tex-like_HTH_dom.
    IPR018974. Tex-like_N.
    IPR023097. Tex_RuvX-like_dom.
    IPR006641. YqgF/RNaseH-like_dom.
    [Graphical view ]
    Pfami PF00575. S1. 1 hit.
    PF09371. Tex_N. 1 hit.
    [Graphical view ]
    SMARTi SM00316. S1. 1 hit.
    SM00732. YqgFc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47781. SSF47781. 2 hits.
    SSF50249. SSF50249. 1 hit.
    SSF53098. SSF53098. 1 hit.
    PROSITEi PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Teratocarcinoma.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Skin.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-964, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSRBD1_HUMAN
    AccessioniPrimary (citable) accession number: Q8N5C6
    Secondary accession number(s): Q53T56, Q96TA4, Q9NW11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3