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Q8N5C6

- SRBD1_HUMAN

UniProt

Q8N5C6 - SRBD1_HUMAN

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Protein
S1 RNA-binding domain-containing protein 1
Gene
SRBD1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. hydrolase activity, acting on ester bonds Source: InterPro

GO - Biological processi

  1. nucleobase-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
S1 RNA-binding domain-containing protein 1
Gene namesi
Name:SRBD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:25521. SRBD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596269.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 995995S1 RNA-binding domain-containing protein 1
PRO_0000284357Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei964 – 9641Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N5C6.
PaxDbiQ8N5C6.
PRIDEiQ8N5C6.

PTM databases

PhosphoSiteiQ8N5C6.

Expressioni

Gene expression databases

ArrayExpressiQ8N5C6.
BgeeiQ8N5C6.
CleanExiHS_SRBD1.
GenevestigatoriQ8N5C6.

Organism-specific databases

HPAiHPA030567.
HPA030568.

Interactioni

Protein-protein interaction databases

BioGridi120439. 13 interactions.
IntActiQ8N5C6. 3 interactions.
STRINGi9606.ENSP00000263736.

Structurei

3D structure databases

ProteinModelPortaliQ8N5C6.
SMRiQ8N5C6. Positions 224-991.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini919 – 99274S1 motif
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili258 – 28831 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi80 – 834Poly-Val

Sequence similaritiesi

Contains 1 S1 motif domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG2183.
HOGENOMiHOG000270498.
HOVERGENiHBG101592.
InParanoidiQ8N5C6.
OMAiFVEDPHQ.
OrthoDBiEOG7SR4M1.
PhylomeDBiQ8N5C6.
TreeFamiTF313600.

Family and domain databases

Gene3Di1.10.10.650. 1 hit.
1.10.150.310. 2 hits.
1.10.3500.10. 2 hits.
2.40.50.140. 1 hit.
3.30.420.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. RNA-binding_domain_S1.
IPR012337. RNaseH-like_dom.
IPR010994. RuvA_2-like.
IPR023323. Tex-like_dom.
IPR023319. Tex-like_HTH_dom.
IPR018974. Tex-like_N.
IPR023097. Tex_RuvX-like_dom.
IPR006641. YqgF/RNaseH-like_dom.
[Graphical view]
PfamiPF00575. S1. 1 hit.
PF09371. Tex_N. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
SM00732. YqgFc. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 2 hits.
SSF50249. SSF50249. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N5C6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSLPRRAKV QVQDVVLKDE FSSFSELSSA SEEDDKEDSA WEPQKKVPRS    50
RKQPPPKESK PKRMPRVKKN APQISDGSEV VVVKEELNSS VAIADTALED 100
RKNKLDTVQT LKTAKTKQKC AAQPHTVRRT KKLKVEEETS KASNLEGESN 150
SSETPSTSTV WGGTCKKEEN DDDFTFGQSA LKKIKTETYP QGQPVKFPAN 200
ANSTKEEVEM NWDMVQVLSE RTNIEPWVCA NIIRLFNDDN TIPFIIRYRK 250
ELINNLDADS LREVQQTLEE LRAVAKKVHS TIQKIKKEGK MSECLLKAML 300
NCKTFEELEH VSAPYKTGSK GTKAQRARQL GLEGAARALL EKPGELSLLS 350
YIRPDVKGLS TLQDIEIGVQ HILADMIAKD KDTLDFIRNL CQKRHVCIQS 400
SLAKVSSKKV NEKDVDKFLL YQHFSCNIRN IHHHQILAIN RGENLKVLTV 450
KVNISDGVKD EFCRWCIQNR WRPRSFARPE LMKILYNSLN DSFKRLIYPL 500
LCREFRAKLT SDAEKESVMM FGRNLRQLLL TSPVPGRTLM GVDPGYKHGC 550
KLAIISPTSQ ILHTDVVYLH CGQGFREAEK IKTLLLNFNC STVVIGNGTA 600
CRETEAYFAD LIMKNYFAPL DVVYCIVSEA GASIYSVSPE ANKEMPGLDP 650
NLRSAVSIAR RVQDPLAELV KIEPKHIGVG MYQHDVSQTL LKATLDSVVE 700
ECVSFVGVDI NICSEVLLRH IAGLNANRAK NIIEWREKNG PFINREQLKK 750
VKGLGPKSFQ QCAGFIRINQ DYIRTFCSQQ TETSGQIQGV AVTSSADVEV 800
TNEKQGKKKS KTAVNVLLKP NPLDQTCIHP ESYDIAMRFL SSIGGTLYEV 850
GKPEMQQKIN SFLEKEGMEK IAERLQTTVH TLQVIIDGLS QPESFDFRTD 900
FDKPDFKRSI VCLEDLQIGT VLTGKVENAT LFGIFVDIGV GKSGLIPIRN 950
VTEAKLSKTK KRRSLGLGPG ERVEVQVLNI DIPRSRITLD LIRVL 995
Length:995
Mass (Da):111,776
Last modified:April 17, 2007 - v2
Checksum:iBB286FB734708C55
GO
Isoform 2 (identifier: Q8N5C6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-375: Missing.

Show »
Length:620
Mass (Da):69,714
Checksum:iFB472BF51F89E75F
GO

Sequence cautioni

The sequence AAY14821.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti361 – 3611T → M.
Corresponds to variant rs6544834 [ dbSNP | Ensembl ].
VAR_056995
Natural varianti798 – 7981V → F.
Corresponds to variant rs3755073 [ dbSNP | Ensembl ].
VAR_056996
Natural varianti811 – 8111K → R.
Corresponds to variant rs3755072 [ dbSNP | Ensembl ].
VAR_056997

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 375375Missing in isoform 2.
VSP_024461Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti597 – 5971N → S in BAA91577. 1 Publication
Sequence conflicti638 – 6381S → G in AK056536. 1 Publication
Sequence conflicti795 – 7951S → P in BAA91577. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001241 mRNA. Translation: BAA91577.1.
AK056536 mRNA. No translation available.
AC012072 Genomic DNA. Translation: AAY14821.1. Sequence problems.
AC008179 Genomic DNA. Translation: AAK52078.1.
BC032538 mRNA. Translation: AAH32538.1.
CCDSiCCDS1823.1. [Q8N5C6-1]
RefSeqiNP_060549.4. NM_018079.4. [Q8N5C6-1]
UniGeneiHs.14229.

Genome annotation databases

EnsembliENST00000263736; ENSP00000263736; ENSG00000068784. [Q8N5C6-1]
GeneIDi55133.
KEGGihsa:55133.
UCSCiuc002rus.3. human. [Q8N5C6-1]

Polymorphism databases

DMDMi145566960.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001241 mRNA. Translation: BAA91577.1 .
AK056536 mRNA. No translation available.
AC012072 Genomic DNA. Translation: AAY14821.1 . Sequence problems.
AC008179 Genomic DNA. Translation: AAK52078.1 .
BC032538 mRNA. Translation: AAH32538.1 .
CCDSi CCDS1823.1. [Q8N5C6-1 ]
RefSeqi NP_060549.4. NM_018079.4. [Q8N5C6-1 ]
UniGenei Hs.14229.

3D structure databases

ProteinModelPortali Q8N5C6.
SMRi Q8N5C6. Positions 224-991.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120439. 13 interactions.
IntActi Q8N5C6. 3 interactions.
STRINGi 9606.ENSP00000263736.

PTM databases

PhosphoSitei Q8N5C6.

Polymorphism databases

DMDMi 145566960.

Proteomic databases

MaxQBi Q8N5C6.
PaxDbi Q8N5C6.
PRIDEi Q8N5C6.

Protocols and materials databases

DNASUi 55133.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263736 ; ENSP00000263736 ; ENSG00000068784 . [Q8N5C6-1 ]
GeneIDi 55133.
KEGGi hsa:55133.
UCSCi uc002rus.3. human. [Q8N5C6-1 ]

Organism-specific databases

CTDi 55133.
GeneCardsi GC02M045615.
H-InvDB HIX0002022.
HGNCi HGNC:25521. SRBD1.
HPAi HPA030567.
HPA030568.
neXtProti NX_Q8N5C6.
PharmGKBi PA144596269.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2183.
HOGENOMi HOG000270498.
HOVERGENi HBG101592.
InParanoidi Q8N5C6.
OMAi FVEDPHQ.
OrthoDBi EOG7SR4M1.
PhylomeDBi Q8N5C6.
TreeFami TF313600.

Miscellaneous databases

GenomeRNAii 55133.
NextBioi 58814.
PROi Q8N5C6.

Gene expression databases

ArrayExpressi Q8N5C6.
Bgeei Q8N5C6.
CleanExi HS_SRBD1.
Genevestigatori Q8N5C6.

Family and domain databases

Gene3Di 1.10.10.650. 1 hit.
1.10.150.310. 2 hits.
1.10.3500.10. 2 hits.
2.40.50.140. 1 hit.
3.30.420.140. 1 hit.
InterProi IPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. RNA-binding_domain_S1.
IPR012337. RNaseH-like_dom.
IPR010994. RuvA_2-like.
IPR023323. Tex-like_dom.
IPR023319. Tex-like_HTH_dom.
IPR018974. Tex-like_N.
IPR023097. Tex_RuvX-like_dom.
IPR006641. YqgF/RNaseH-like_dom.
[Graphical view ]
Pfami PF00575. S1. 1 hit.
PF09371. Tex_N. 1 hit.
[Graphical view ]
SMARTi SM00316. S1. 1 hit.
SM00732. YqgFc. 1 hit.
[Graphical view ]
SUPFAMi SSF47781. SSF47781. 2 hits.
SSF50249. SSF50249. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEi PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Teratocarcinoma.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-964, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSRBD1_HUMAN
AccessioniPrimary (citable) accession number: Q8N5C6
Secondary accession number(s): Q53T56, Q96TA4, Q9NW11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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