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Protein

S1 RNA-binding domain-containing protein 1

Gene

SRBD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000068784-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
S1 RNA-binding domain-containing protein 1
Gene namesi
Name:SRBD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25521. SRBD1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi55133.
OpenTargetsiENSG00000068784.
PharmGKBiPA144596269.

Polymorphism and mutation databases

BioMutaiSRBD1.
DMDMi145566960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002843571 – 995S1 RNA-binding domain-containing protein 1Add BLAST995

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei861PhosphoserineCombined sources1
Cross-linki955Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei964PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8N5C6.
MaxQBiQ8N5C6.
PaxDbiQ8N5C6.
PeptideAtlasiQ8N5C6.
PRIDEiQ8N5C6.

PTM databases

iPTMnetiQ8N5C6.
PhosphoSitePlusiQ8N5C6.

Expressioni

Gene expression databases

BgeeiENSG00000068784.
CleanExiHS_SRBD1.
GenevisibleiQ8N5C6. HS.

Organism-specific databases

HPAiHPA030567.
HPA030568.

Interactioni

Protein-protein interaction databases

BioGridi120439. 36 interactors.
IntActiQ8N5C6. 10 interactors.
STRINGi9606.ENSP00000263736.

Structurei

3D structure databases

ProteinModelPortaliQ8N5C6.
SMRiQ8N5C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini919 – 992S1 motifPROSITE-ProRule annotationAdd BLAST74

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili258 – 288Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi80 – 83Poly-Val4

Sequence similaritiesi

Contains 1 S1 motif domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1857. Eukaryota.
COG2183. LUCA.
GeneTreeiENSGT00510000047850.
HOGENOMiHOG000270498.
HOVERGENiHBG101592.
InParanoidiQ8N5C6.
OMAiENIYEPF.
OrthoDBiEOG091G06F1.
PhylomeDBiQ8N5C6.
TreeFamiTF313600.

Family and domain databases

Gene3Di1.10.10.650. 1 hit.
1.10.150.310. 2 hits.
1.10.3500.10. 2 hits.
3.30.420.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR012337. RNaseH-like_dom.
IPR010994. RuvA_2-like.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR023323. Tex-like_dom.
IPR023319. Tex-like_HTH_dom.
IPR018974. Tex-like_N.
IPR023097. Tex_RuvX-like_dom.
IPR032639. Tex_YqgF.
IPR006641. YqgF/RNaseH-like_dom.
[Graphical view]
PfamiPF00575. S1. 1 hit.
PF09371. Tex_N. 1 hit.
PF16921. Tex_YqgF. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
SM00732. YqgFc. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 2 hits.
SSF50249. SSF50249. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N5C6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLPRRAKV QVQDVVLKDE FSSFSELSSA SEEDDKEDSA WEPQKKVPRS
60 70 80 90 100
RKQPPPKESK PKRMPRVKKN APQISDGSEV VVVKEELNSS VAIADTALED
110 120 130 140 150
RKNKLDTVQT LKTAKTKQKC AAQPHTVRRT KKLKVEEETS KASNLEGESN
160 170 180 190 200
SSETPSTSTV WGGTCKKEEN DDDFTFGQSA LKKIKTETYP QGQPVKFPAN
210 220 230 240 250
ANSTKEEVEM NWDMVQVLSE RTNIEPWVCA NIIRLFNDDN TIPFIIRYRK
260 270 280 290 300
ELINNLDADS LREVQQTLEE LRAVAKKVHS TIQKIKKEGK MSECLLKAML
310 320 330 340 350
NCKTFEELEH VSAPYKTGSK GTKAQRARQL GLEGAARALL EKPGELSLLS
360 370 380 390 400
YIRPDVKGLS TLQDIEIGVQ HILADMIAKD KDTLDFIRNL CQKRHVCIQS
410 420 430 440 450
SLAKVSSKKV NEKDVDKFLL YQHFSCNIRN IHHHQILAIN RGENLKVLTV
460 470 480 490 500
KVNISDGVKD EFCRWCIQNR WRPRSFARPE LMKILYNSLN DSFKRLIYPL
510 520 530 540 550
LCREFRAKLT SDAEKESVMM FGRNLRQLLL TSPVPGRTLM GVDPGYKHGC
560 570 580 590 600
KLAIISPTSQ ILHTDVVYLH CGQGFREAEK IKTLLLNFNC STVVIGNGTA
610 620 630 640 650
CRETEAYFAD LIMKNYFAPL DVVYCIVSEA GASIYSVSPE ANKEMPGLDP
660 670 680 690 700
NLRSAVSIAR RVQDPLAELV KIEPKHIGVG MYQHDVSQTL LKATLDSVVE
710 720 730 740 750
ECVSFVGVDI NICSEVLLRH IAGLNANRAK NIIEWREKNG PFINREQLKK
760 770 780 790 800
VKGLGPKSFQ QCAGFIRINQ DYIRTFCSQQ TETSGQIQGV AVTSSADVEV
810 820 830 840 850
TNEKQGKKKS KTAVNVLLKP NPLDQTCIHP ESYDIAMRFL SSIGGTLYEV
860 870 880 890 900
GKPEMQQKIN SFLEKEGMEK IAERLQTTVH TLQVIIDGLS QPESFDFRTD
910 920 930 940 950
FDKPDFKRSI VCLEDLQIGT VLTGKVENAT LFGIFVDIGV GKSGLIPIRN
960 970 980 990
VTEAKLSKTK KRRSLGLGPG ERVEVQVLNI DIPRSRITLD LIRVL
Length:995
Mass (Da):111,776
Last modified:April 17, 2007 - v2
Checksum:iBB286FB734708C55
GO
Isoform 2 (identifier: Q8N5C6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-375: Missing.

Show »
Length:620
Mass (Da):69,714
Checksum:iFB472BF51F89E75F
GO

Sequence cautioni

The sequence AAY14821 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti597N → S in BAA91577 (PubMed:14702039).Curated1
Sequence conflicti638S → G in AK056536 (PubMed:14702039).Curated1
Sequence conflicti795S → P in BAA91577 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056995361T → M.Corresponds to variant rs6544834dbSNPEnsembl.1
Natural variantiVAR_056996798V → F.Corresponds to variant rs3755073dbSNPEnsembl.1
Natural variantiVAR_056997811K → R.Corresponds to variant rs3755072dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0244611 – 375Missing in isoform 2. 2 PublicationsAdd BLAST375

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001241 mRNA. Translation: BAA91577.1.
AK056536 mRNA. No translation available.
AC012072 Genomic DNA. Translation: AAY14821.1. Sequence problems.
AC008179 Genomic DNA. Translation: AAK52078.1.
BC032538 mRNA. Translation: AAH32538.1.
CCDSiCCDS1823.1. [Q8N5C6-1]
RefSeqiNP_060549.4. NM_018079.4. [Q8N5C6-1]
UniGeneiHs.14229.

Genome annotation databases

EnsembliENST00000263736; ENSP00000263736; ENSG00000068784. [Q8N5C6-1]
GeneIDi55133.
KEGGihsa:55133.
UCSCiuc002rus.4. human. [Q8N5C6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001241 mRNA. Translation: BAA91577.1.
AK056536 mRNA. No translation available.
AC012072 Genomic DNA. Translation: AAY14821.1. Sequence problems.
AC008179 Genomic DNA. Translation: AAK52078.1.
BC032538 mRNA. Translation: AAH32538.1.
CCDSiCCDS1823.1. [Q8N5C6-1]
RefSeqiNP_060549.4. NM_018079.4. [Q8N5C6-1]
UniGeneiHs.14229.

3D structure databases

ProteinModelPortaliQ8N5C6.
SMRiQ8N5C6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120439. 36 interactors.
IntActiQ8N5C6. 10 interactors.
STRINGi9606.ENSP00000263736.

PTM databases

iPTMnetiQ8N5C6.
PhosphoSitePlusiQ8N5C6.

Polymorphism and mutation databases

BioMutaiSRBD1.
DMDMi145566960.

Proteomic databases

EPDiQ8N5C6.
MaxQBiQ8N5C6.
PaxDbiQ8N5C6.
PeptideAtlasiQ8N5C6.
PRIDEiQ8N5C6.

Protocols and materials databases

DNASUi55133.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263736; ENSP00000263736; ENSG00000068784. [Q8N5C6-1]
GeneIDi55133.
KEGGihsa:55133.
UCSCiuc002rus.4. human. [Q8N5C6-1]

Organism-specific databases

CTDi55133.
DisGeNETi55133.
GeneCardsiSRBD1.
H-InvDBHIX0002022.
HGNCiHGNC:25521. SRBD1.
HPAiHPA030567.
HPA030568.
neXtProtiNX_Q8N5C6.
OpenTargetsiENSG00000068784.
PharmGKBiPA144596269.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1857. Eukaryota.
COG2183. LUCA.
GeneTreeiENSGT00510000047850.
HOGENOMiHOG000270498.
HOVERGENiHBG101592.
InParanoidiQ8N5C6.
OMAiENIYEPF.
OrthoDBiEOG091G06F1.
PhylomeDBiQ8N5C6.
TreeFamiTF313600.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000068784-MONOMER.

Miscellaneous databases

ChiTaRSiSRBD1. human.
GenomeRNAii55133.
PROiQ8N5C6.

Gene expression databases

BgeeiENSG00000068784.
CleanExiHS_SRBD1.
GenevisibleiQ8N5C6. HS.

Family and domain databases

Gene3Di1.10.10.650. 1 hit.
1.10.150.310. 2 hits.
1.10.3500.10. 2 hits.
3.30.420.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR012337. RNaseH-like_dom.
IPR010994. RuvA_2-like.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR023323. Tex-like_dom.
IPR023319. Tex-like_HTH_dom.
IPR018974. Tex-like_N.
IPR023097. Tex_RuvX-like_dom.
IPR032639. Tex_YqgF.
IPR006641. YqgF/RNaseH-like_dom.
[Graphical view]
PfamiPF00575. S1. 1 hit.
PF09371. Tex_N. 1 hit.
PF16921. Tex_YqgF. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
SM00732. YqgFc. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 2 hits.
SSF50249. SSF50249. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRBD1_HUMAN
AccessioniPrimary (citable) accession number: Q8N5C6
Secondary accession number(s): Q53T56, Q96TA4, Q9NW11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.