Q8N5C6 (SRBD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
S1 RNA-binding domain-containing protein 1

Gene names

Name:

SRBD1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	995 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Contains 1 S1 motif domain.
Sequence caution	The sequence AAY14821.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleobase-containing compound metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N5C6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N5C6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-375: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 995	995	S1 RNA-binding domain-containing protein 1		PRO_0000284357
Regions
	Domain	919 – 992	74	S1 motif
	Coiled coil	258 – 288	31	Potential
	Compositional bias	80 – 83	4	Poly-Val
Amino acid modifications
	Modified residue	89	1	Phosphoserine By similarity
	Modified residue	964	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	1 – 375	375	Missing in isoform 2.		VSP_024461
	Natural variant	361	1	T → M. Corresponds to variant rs6544834 [ dbSNP | Ensembl ].		VAR_056995
	Natural variant	798	1	V → F. Corresponds to variant rs3755073 [ dbSNP | Ensembl ].		VAR_056996
	Natural variant	811	1	K → R. Corresponds to variant rs3755072 [ dbSNP | Ensembl ].		VAR_056997
Experimental info
	Sequence conflict	597	1	N → S in BAA91577. Ref.1
	Sequence conflict	638	1	S → G in AK056536. Ref.1
	Sequence conflict	795	1	S → P in BAA91577. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 17, 2007. Version 2. Checksum: BB286FB734708C55	FASTA	995	111,776
	10 20 30 40 50 60 MSSLPRRAKV QVQDVVLKDE FSSFSELSSA SEEDDKEDSA WEPQKKVPRS RKQPPPKESK 70 80 90 100 110 120 PKRMPRVKKN APQISDGSEV VVVKEELNSS VAIADTALED RKNKLDTVQT LKTAKTKQKC 130 140 150 160 170 180 AAQPHTVRRT KKLKVEEETS KASNLEGESN SSETPSTSTV WGGTCKKEEN DDDFTFGQSA 190 200 210 220 230 240 LKKIKTETYP QGQPVKFPAN ANSTKEEVEM NWDMVQVLSE RTNIEPWVCA NIIRLFNDDN 250 260 270 280 290 300 TIPFIIRYRK ELINNLDADS LREVQQTLEE LRAVAKKVHS TIQKIKKEGK MSECLLKAML 310 320 330 340 350 360 NCKTFEELEH VSAPYKTGSK GTKAQRARQL GLEGAARALL EKPGELSLLS YIRPDVKGLS 370 380 390 400 410 420 TLQDIEIGVQ HILADMIAKD KDTLDFIRNL CQKRHVCIQS SLAKVSSKKV NEKDVDKFLL 430 440 450 460 470 480 YQHFSCNIRN IHHHQILAIN RGENLKVLTV KVNISDGVKD EFCRWCIQNR WRPRSFARPE 490 500 510 520 530 540 LMKILYNSLN DSFKRLIYPL LCREFRAKLT SDAEKESVMM FGRNLRQLLL TSPVPGRTLM 550 560 570 580 590 600 GVDPGYKHGC KLAIISPTSQ ILHTDVVYLH CGQGFREAEK IKTLLLNFNC STVVIGNGTA 610 620 630 640 650 660 CRETEAYFAD LIMKNYFAPL DVVYCIVSEA GASIYSVSPE ANKEMPGLDP NLRSAVSIAR 670 680 690 700 710 720 RVQDPLAELV KIEPKHIGVG MYQHDVSQTL LKATLDSVVE ECVSFVGVDI NICSEVLLRH 730 740 750 760 770 780 IAGLNANRAK NIIEWREKNG PFINREQLKK VKGLGPKSFQ QCAGFIRINQ DYIRTFCSQQ 790 800 810 820 830 840 TETSGQIQGV AVTSSADVEV TNEKQGKKKS KTAVNVLLKP NPLDQTCIHP ESYDIAMRFL 850 860 870 880 890 900 SSIGGTLYEV GKPEMQQKIN SFLEKEGMEK IAERLQTTVH TLQVIIDGLS QPESFDFRTD 910 920 930 940 950 960 FDKPDFKRSI VCLEDLQIGT VLTGKVENAT LFGIFVDIGV GKSGLIPIRN VTEAKLSKTK 970 980 990 KRRSLGLGPG ERVEVQVLNI DIPRSRITLD LIRVL
	Isoform 2 [UniParc]. Checksum: FB472BF51F89E75F	FASTA	620	69,714
	10 20 30 40 50 60 MIAKDKDTLD FIRNLCQKRH VCIQSSLAKV SSKKVNEKDV DKFLLYQHFS CNIRNIHHHQ 70 80 90 100 110 120 ILAINRGENL KVLTVKVNIS DGVKDEFCRW CIQNRWRPRS FARPELMKIL YNSLNDSFKR 130 140 150 160 170 180 LIYPLLCREF RAKLTSDAEK ESVMMFGRNL RQLLLTSPVP GRTLMGVDPG YKHGCKLAII 190 200 210 220 230 240 SPTSQILHTD VVYLHCGQGF REAEKIKTLL LNFNCSTVVI GNGTACRETE AYFADLIMKN 250 260 270 280 290 300 YFAPLDVVYC IVSEAGASIY SVSPEANKEM PGLDPNLRSA VSIARRVQDP LAELVKIEPK 310 320 330 340 350 360 HIGVGMYQHD VSQTLLKATL DSVVEECVSF VGVDINICSE VLLRHIAGLN ANRAKNIIEW 370 380 390 400 410 420 REKNGPFINR EQLKKVKGLG PKSFQQCAGF IRINQDYIRT FCSQQTETSG QIQGVAVTSS 430 440 450 460 470 480 ADVEVTNEKQ GKKKSKTAVN VLLKPNPLDQ TCIHPESYDI AMRFLSSIGG TLYEVGKPEM 490 500 510 520 530 540 QQKINSFLEK EGMEKIAERL QTTVHTLQVI IDGLSQPESF DFRTDFDKPD FKRSIVCLED 550 560 570 580 590 600 LQIGTVLTGK VENATLFGIF VDIGVGKSGL IPIRNVTEAK LSKTKKRRSL GLGPGERVEV 610 620 QVLNIDIPRS RITLDLIRVL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Teratocarcinoma.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Skin.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[5]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-964, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001241 mRNA. Translation: BAA91577.1. AK056536 mRNA. No translation available. AC012072 Genomic DNA. Translation: AAY14821.1. Sequence problems. AC008179 Genomic DNA. Translation: AAK52078.1. BC032538 mRNA. Translation: AAH32538.1.
IPI	IPI00171087. IPI00843788.
RefSeq	NP_060549.4. NM_018079.4.
UniGene	Hs.14229.
3D structure databases
HSSP	HSSP built from PDB template 1SRO based on UniProtKB P05055.
ProteinModelPortal	Q8N5C6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N5C6. 3 interactions.
STRING	9606.ENSP00000263736.
PTM databases
PhosphoSite	Q8N5C6.
Polymorphism databases
DMDM	145566960.
Proteomic databases
PaxDb	Q8N5C6.
PRIDE	Q8N5C6.
Protocols and materials databases
DNASU	55133.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263736; ENSP00000263736; ENSG00000068784.
GeneID	55133.
KEGG	hsa:55133.
UCSC	uc002rus.3. human.
Organism-specific databases
CTD	55133.
GeneCards	GC02M045615.
H-InvDB	HIX0002022.
HGNC	HGNC:25521. SRBD1.
HPA	HPA030567. HPA030568.
neXtProt	NX_Q8N5C6.
PharmGKB	PA144596269.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2183.
HOGENOM	HOG000270498.
HOVERGEN	HBG101592.
InParanoid	Q8N5C6.
OMA	YKQKRRT.
OrthoDB	EOG44BB1H.
PhylomeDB	Q8N5C6.
Gene expression databases
ArrayExpress	Q8N5C6.
Bgee	Q8N5C6.
CleanEx	HS_SRBD1.
Genevestigator	Q8N5C6.
Family and domain databases
Gene3D	1.10.10.650. 1 hit. 1.10.150.310. 2 hits. 1.10.3500.10. 2 hits. 2.40.50.140. 1 hit. 3.30.420.140. 1 hit.
InterPro	IPR012340. NA-bd_OB-fold. IPR003029. Rbsml_prot_S1_RNA-bd_dom. IPR022967. RNA-binding_domain_S1. IPR023323. Tex-like_dom. IPR023319. Tex-like_HTH_dom. IPR018974. Tex-like_N. IPR023097. Tex_RuvX-like_dom. IPR006641. YqgF/RNaseH-like_dom. [Graphical view]
Pfam	PF00575. S1. 1 hit. PF09371. Tex_N. 1 hit. [Graphical view]
SMART	SM00316. S1. 1 hit. SM00732. YqgFc. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
PROSITE	PS50126. S1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55133.
NextBio	58814.

Entry information

Entry name

SRBD1_HUMAN

Accession

Primary (citable) accession number: Q8N5C6
Secondary accession number(s): Q53T56, Q96TA4, Q9NW11

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.