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Q8N5A5

- ZGPAT_HUMAN

UniProt

Q8N5A5 - ZGPAT_HUMAN

Protein

Zinc finger CCCH-type with G patch domain-containing protein

Gene

ZGPAT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 3 (15 May 2007)
      Previous versions | rss
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    Functioni

    Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.1 Publication
    Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri175 – 20127C3H1-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
    2. negative regulation of transcription, DNA-templated Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger CCCH-type with G patch domain-containing protein
    Alternative name(s):
    G patch domain-containing protein 6
    Zinc finger CCCH domain-containing protein 9
    Zinc finger and G patch domain-containing protein
    Gene namesi
    Name:ZGPAT
    Synonyms:GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC9, ZIP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15948. ZGPAT.

    Subcellular locationi

    Nucleus 1 Publication
    Isoform 4 : Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134881248.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 531531Zinc finger CCCH-type with G patch domain-containing proteinPRO_0000213894Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Post-translational modificationi

    Ubiquitinated in case of infection by HIV-1, leading to its degradation. Ubiquitination is mediated by the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP.1 Publication

    Keywords - PTMi

    Acetylation, Ubl conjugation

    Proteomic databases

    MaxQBiQ8N5A5.
    PaxDbiQ8N5A5.
    PRIDEiQ8N5A5.

    PTM databases

    PhosphoSiteiQ8N5A5.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Inductioni

    Down-regulated in breast carcinomas.

    Gene expression databases

    BgeeiQ8N5A5.
    CleanExiHS_ZGPAT.
    GenevestigatoriQ8N5A5.

    Organism-specific databases

    HPAiHPA043248.

    Interactioni

    Subunit structurei

    Interacts with CHD4/Mi-2; the interaction is direct.2 Publications

    Protein-protein interaction databases

    BioGridi124150. 9 interactions.
    IntActiQ8N5A5. 19 interactions.
    MINTiMINT-2810381.

    Structurei

    Secondary structure

    1
    531
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi133 – 1386
    Beta strandi146 – 15712
    Beta strandi163 – 1719
    Helixi175 – 1773
    Helixi183 – 1853
    Beta strandi195 – 1973
    Beta strandi200 – 2034
    Helixi204 – 2063
    Beta strandi223 – 2275
    Beta strandi233 – 24412
    Beta strandi246 – 2527
    Beta strandi258 – 2603
    Helixi262 – 2643

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4II1X-ray2.65A/B/C/D120-268[»]
    ProteinModelPortaliQ8N5A5.
    SMRiQ8N5A5. Positions 127-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini333 – 37947G-patchPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi119 – 12810Poly-Glu

    Sequence similaritiesi

    Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
    Contains 1 G-patch domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri175 – 20127C3H1-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG241375.
    HOVERGENiHBG056371.
    InParanoidiQ8N5A5.
    OMAiKEIYHAS.
    OrthoDBiEOG71RXK5.
    PhylomeDBiQ8N5A5.
    TreeFamiTF105970.

    Family and domain databases

    Gene3Di4.10.1000.10. 1 hit.
    InterProiIPR000467. G_patch_dom.
    IPR000571. Znf_CCCH.
    [Graphical view]
    PfamiPF01585. G-patch. 1 hit.
    [Graphical view]
    SMARTiSM00443. G_patch. 1 hit.
    SM00356. ZnF_C3H1. 1 hit.
    [Graphical view]
    PROSITEiPS50174. G_PATCH. 1 hit.
    PS50103. ZF_C3H1. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N5A5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDEESLESAL QTYRAQLQQV ELALGAGLDS SEQADLRQLQ GDLKELIELT    50
    EASLVSVRKS SLLAALDEER PGRQEDAEYQ AFREAITEAV EAPAAARGSG 100
    SETVPKAEAG PESAAGGQEE EEGEDEEELS GTKVSAPYYS SWGTLEYHNA 150
    MVVGTEEAED GSAGVRVLYL YPTHKSLKPC PFFLEGKCRF KENCRFSHGQ 200
    VVSLDELRPF QDPDLSSLQA GSACLAKHQD GLWHAARITD VDNGYYTVKF 250
    DSLLLREAVV EGDGILPPLR TEATESDSDS DGTGDSSYAR VVGSDAVDSA 300
    QSSALCPSLA VVGSDAVDSG TCSSAFAGWE VHTRGIGSRL LTKMGYEFGK 350
    GLGRHAEGRV EPIHAVVLPR GKSLDQCVET LQKQTRVGKA GTNKPPRCRG 400
    RGARPGGRPA PRNVFDFLNE KLQGQAPGAL EAGAAPAGRR SKDMYHASKS 450
    AKRALSLRLF QTEEKIERTQ RDIRSIQEAL ARNAGRHSVA SAQLQEKLAG 500
    AQRQLGQLRA QEAGLQQEQR KADTHKKMTE F 531

    Note: No experimental confirmation available.

    Length:531
    Mass (Da):57,359
    Last modified:May 15, 2007 - v3
    Checksum:i36572156BABDA876
    GO
    Isoform 2 (identifier: Q8N5A5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         291-310: Missing.

    Show »
    Length:511
    Mass (Da):55,500
    Checksum:i5007C362ECC2CD79
    GO
    Isoform 3 (identifier: Q8N5A5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         282-310: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:502
    Mass (Da):54,605
    Checksum:i8DD60FEEDB37D2F9
    GO
    Isoform 4 (identifier: Q8N5A5-4) [UniParc]FASTAAdd to Basket

    Also known as: sZIP

    The sequence of this isoform differs from the canonical sequence as follows:
         1-343: Missing.

    Show »
    Length:188
    Mass (Da):20,697
    Checksum:i00ABC2D9BC65E7C9
    GO

    Sequence cautioni

    The sequence BAC11317.1 differs from that shown. Reason: Frameshift at position 290.
    The sequence BAB47476.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAI95713.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti184 – 1841L → Q in BAB55426. (PubMed:14702039)Curated
    Sequence conflicti188 – 1881C → R in BAC11317. (PubMed:14702039)Curated
    Sequence conflicti344 – 3441M → V in BAB55426. (PubMed:14702039)Curated
    Sequence conflicti433 – 4331G → R in AAH19338. (PubMed:15489334)Curated
    Sequence conflicti519 – 5191Q → R in BAB55426. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611S → R.4 Publications
    Corresponds to variant rs1291212 [ dbSNP | Ensembl ].
    VAR_025539

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 343343Missing in isoform 4. CuratedVSP_053599Add
    BLAST
    Alternative sequencei282 – 31029Missing in isoform 3. 1 PublicationVSP_038121Add
    BLAST
    Alternative sequencei291 – 31020Missing in isoform 2. 2 PublicationsVSP_007754Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB058750 mRNA. Translation: BAB47476.3. Different initiation.
    AK027878 mRNA. Translation: BAB55426.1.
    AK074961 mRNA. Translation: BAC11317.1. Frameshift.
    AL121845 Genomic DNA. Translation: CAC03670.1.
    AL121845 Genomic DNA. Translation: CAI21879.1.
    AL121845 Genomic DNA. Translation: CAI21880.1.
    AL121845 Genomic DNA. Translation: CAI95713.1. Sequence problems.
    CH471077 Genomic DNA. Translation: EAW75223.1.
    CH471077 Genomic DNA. Translation: EAW75226.1.
    BC019338 mRNA. Translation: AAH19338.1.
    BC032612 mRNA. Translation: AAH32612.1.
    CCDSiCCDS13534.1. [Q8N5A5-1]
    CCDS13535.1. [Q8N5A5-2]
    CCDS56203.1. [Q8N5A5-3]
    RefSeqiNP_001076582.1. NM_001083113.1. [Q8N5A5-2]
    NP_001182582.1. NM_001195653.1. [Q8N5A5-2]
    NP_001182583.1. NM_001195654.1. [Q8N5A5-3]
    NP_115916.3. NM_032527.4. [Q8N5A5-1]
    NP_852150.2. NM_181485.2. [Q8N5A5-2]
    UniGeneiHs.590868.

    Genome annotation databases

    EnsembliENST00000328969; ENSP00000332013; ENSG00000197114. [Q8N5A5-1]
    ENST00000355969; ENSP00000348242; ENSG00000197114. [Q8N5A5-2]
    ENST00000357119; ENSP00000349634; ENSG00000197114. [Q8N5A5-3]
    ENST00000369967; ENSP00000358984; ENSG00000197114. [Q8N5A5-2]
    ENST00000448100; ENSP00000391176; ENSG00000197114. [Q8N5A5-2]
    GeneIDi84619.
    KEGGihsa:84619.
    UCSCiuc002ygi.2. human. [Q8N5A5-2]
    uc002ygk.3. human. [Q8N5A5-1]
    uc002ygm.3. human. [Q8N5A5-3]

    Polymorphism databases

    DMDMi147744602.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB058750 mRNA. Translation: BAB47476.3 . Different initiation.
    AK027878 mRNA. Translation: BAB55426.1 .
    AK074961 mRNA. Translation: BAC11317.1 . Frameshift.
    AL121845 Genomic DNA. Translation: CAC03670.1 .
    AL121845 Genomic DNA. Translation: CAI21879.1 .
    AL121845 Genomic DNA. Translation: CAI21880.1 .
    AL121845 Genomic DNA. Translation: CAI95713.1 . Sequence problems.
    CH471077 Genomic DNA. Translation: EAW75223.1 .
    CH471077 Genomic DNA. Translation: EAW75226.1 .
    BC019338 mRNA. Translation: AAH19338.1 .
    BC032612 mRNA. Translation: AAH32612.1 .
    CCDSi CCDS13534.1. [Q8N5A5-1 ]
    CCDS13535.1. [Q8N5A5-2 ]
    CCDS56203.1. [Q8N5A5-3 ]
    RefSeqi NP_001076582.1. NM_001083113.1. [Q8N5A5-2 ]
    NP_001182582.1. NM_001195653.1. [Q8N5A5-2 ]
    NP_001182583.1. NM_001195654.1. [Q8N5A5-3 ]
    NP_115916.3. NM_032527.4. [Q8N5A5-1 ]
    NP_852150.2. NM_181485.2. [Q8N5A5-2 ]
    UniGenei Hs.590868.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4II1 X-ray 2.65 A/B/C/D 120-268 [» ]
    ProteinModelPortali Q8N5A5.
    SMRi Q8N5A5. Positions 127-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124150. 9 interactions.
    IntActi Q8N5A5. 19 interactions.
    MINTi MINT-2810381.

    PTM databases

    PhosphoSitei Q8N5A5.

    Polymorphism databases

    DMDMi 147744602.

    Proteomic databases

    MaxQBi Q8N5A5.
    PaxDbi Q8N5A5.
    PRIDEi Q8N5A5.

    Protocols and materials databases

    DNASUi 84619.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328969 ; ENSP00000332013 ; ENSG00000197114 . [Q8N5A5-1 ]
    ENST00000355969 ; ENSP00000348242 ; ENSG00000197114 . [Q8N5A5-2 ]
    ENST00000357119 ; ENSP00000349634 ; ENSG00000197114 . [Q8N5A5-3 ]
    ENST00000369967 ; ENSP00000358984 ; ENSG00000197114 . [Q8N5A5-2 ]
    ENST00000448100 ; ENSP00000391176 ; ENSG00000197114 . [Q8N5A5-2 ]
    GeneIDi 84619.
    KEGGi hsa:84619.
    UCSCi uc002ygi.2. human. [Q8N5A5-2 ]
    uc002ygk.3. human. [Q8N5A5-1 ]
    uc002ygm.3. human. [Q8N5A5-3 ]

    Organism-specific databases

    CTDi 84619.
    GeneCardsi GC20P062338.
    H-InvDB HIX0138076.
    HGNCi HGNC:15948. ZGPAT.
    HPAi HPA043248.
    neXtProti NX_Q8N5A5.
    PharmGKBi PA134881248.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241375.
    HOVERGENi HBG056371.
    InParanoidi Q8N5A5.
    OMAi KEIYHAS.
    OrthoDBi EOG71RXK5.
    PhylomeDBi Q8N5A5.
    TreeFami TF105970.

    Miscellaneous databases

    ChiTaRSi ZGPAT. human.
    GeneWikii ZGPAT.
    GenomeRNAii 84619.
    NextBioi 74496.
    PROi Q8N5A5.

    Gene expression databases

    Bgeei Q8N5A5.
    CleanExi HS_ZGPAT.
    Genevestigatori Q8N5A5.

    Family and domain databases

    Gene3Di 4.10.1000.10. 1 hit.
    InterProi IPR000467. G_patch_dom.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    Pfami PF01585. G-patch. 1 hit.
    [Graphical view ]
    SMARTi SM00443. G_patch. 1 hit.
    SM00356. ZnF_C3H1. 1 hit.
    [Graphical view ]
    PROSITEi PS50174. G_PATCH. 1 hit.
    PS50103. ZF_C3H1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-61.
      Tissue: Brain.
    2. Ohara O., Nagase T., Kikuno R.
      Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-61.
      Tissue: Thyroid.
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-61.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-61.
      Tissue: Placenta and Uterus.
    7. "ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis."
      Li R., Zhang H., Yu W., Chen Y., Gui B., Liang J., Wang Y., Sun L., Yang X., Zhang Y., Shi L., Li Y., Shang Y.
      EMBO J. 28:2763-2776(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DNA-BINDING, TISSUE SPECIFICITY, INTERACTION WITH CHD4.
    8. "sZIP, an alternative splice variant of ZIP, antagonizes transcription repression and growth inhibition by ZIP."
      Yu W., Li R., Gui B., Shang Y.
      J. Biol. Chem. 285:14301-14307(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORM 4), FUNCTION (ISOFORM 4), SUBCELLULAR LOCATION (ISOFORM 4).
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "HIV-1 Vpr Induces the Degradation of ZIP and sZIP, Adaptors of the NuRD Chromatin Remodeling Complex, by Hijacking DCAF1/VprBP."
      Maudet C., Sourisce A., Dragin L., Lahouassa H., Rain J.C., Bouaziz S., Ramirez B.C., Margottin-Goguet F.
      PLoS ONE 8:E77320-E77320(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION.
    12. "Crystal structure of the zinc finger of ZGPAT."
      Structural genomics consortium (SGC)
      Submitted (FEB-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 120-268 IN COMPLEX WITH ZINC IONS.

    Entry informationi

    Entry nameiZGPAT_HUMAN
    AccessioniPrimary (citable) accession number: Q8N5A5
    Secondary accession number(s): E1P5K1
    , Q4VXN9, Q5JWI9, Q5JWJ0, Q8NC55, Q8WUV4, Q96JI0, Q96JU4, Q9H401
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2003
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 108 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3