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Q8N5A5

- ZGPAT_HUMAN

UniProt

Q8N5A5 - ZGPAT_HUMAN

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Protein

Zinc finger CCCH-type with G patch domain-containing protein

Gene

ZGPAT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.1 Publication
Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 20127C3H1-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
  2. negative regulation of transcription, DNA-templated Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH-type with G patch domain-containing protein
Alternative name(s):
G patch domain-containing protein 6
Zinc finger CCCH domain-containing protein 9
Zinc finger and G patch domain-containing protein
Gene namesi
Name:ZGPAT
Synonyms:GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC9, ZIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15948. ZGPAT.

Subcellular locationi

Nucleus 1 Publication
Isoform 4 : Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134881248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Zinc finger CCCH-type with G patch domain-containing proteinPRO_0000213894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Post-translational modificationi

Ubiquitinated in case of infection by HIV-1, leading to its degradation. Ubiquitination is mediated by the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP.1 Publication

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

MaxQBiQ8N5A5.
PaxDbiQ8N5A5.
PRIDEiQ8N5A5.

PTM databases

PhosphoSiteiQ8N5A5.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

Down-regulated in breast carcinomas.

Gene expression databases

BgeeiQ8N5A5.
CleanExiHS_ZGPAT.
ExpressionAtlasiQ8N5A5. baseline.
GenevestigatoriQ8N5A5.

Organism-specific databases

HPAiHPA043248.

Interactioni

Subunit structurei

Interacts with CHD4/Mi-2; the interaction is direct.2 Publications

Protein-protein interaction databases

BioGridi124150. 10 interactions.
IntActiQ8N5A5. 19 interactions.
MINTiMINT-2810381.

Structurei

Secondary structure

1
531
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi133 – 1386Combined sources
Beta strandi146 – 15712Combined sources
Beta strandi163 – 1719Combined sources
Helixi175 – 1773Combined sources
Helixi183 – 1853Combined sources
Beta strandi195 – 1973Combined sources
Beta strandi200 – 2034Combined sources
Helixi204 – 2063Combined sources
Beta strandi223 – 2275Combined sources
Beta strandi233 – 24412Combined sources
Beta strandi246 – 2527Combined sources
Beta strandi258 – 2603Combined sources
Helixi262 – 2643Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4II1X-ray2.65A/B/C/D120-268[»]
ProteinModelPortaliQ8N5A5.
SMRiQ8N5A5. Positions 127-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini333 – 37947G-patchPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi119 – 12810Poly-Glu

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 1 G-patch domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 20127C3H1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG241375.
GeneTreeiENSGT00390000000732.
HOVERGENiHBG056371.
InParanoidiQ8N5A5.
OMAiKEIYHAS.
OrthoDBiEOG71RXK5.
PhylomeDBiQ8N5A5.
TreeFamiTF105970.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR000467. G_patch_dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N5A5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEESLESAL QTYRAQLQQV ELALGAGLDS SEQADLRQLQ GDLKELIELT
60 70 80 90 100
EASLVSVRKS SLLAALDEER PGRQEDAEYQ AFREAITEAV EAPAAARGSG
110 120 130 140 150
SETVPKAEAG PESAAGGQEE EEGEDEEELS GTKVSAPYYS SWGTLEYHNA
160 170 180 190 200
MVVGTEEAED GSAGVRVLYL YPTHKSLKPC PFFLEGKCRF KENCRFSHGQ
210 220 230 240 250
VVSLDELRPF QDPDLSSLQA GSACLAKHQD GLWHAARITD VDNGYYTVKF
260 270 280 290 300
DSLLLREAVV EGDGILPPLR TEATESDSDS DGTGDSSYAR VVGSDAVDSA
310 320 330 340 350
QSSALCPSLA VVGSDAVDSG TCSSAFAGWE VHTRGIGSRL LTKMGYEFGK
360 370 380 390 400
GLGRHAEGRV EPIHAVVLPR GKSLDQCVET LQKQTRVGKA GTNKPPRCRG
410 420 430 440 450
RGARPGGRPA PRNVFDFLNE KLQGQAPGAL EAGAAPAGRR SKDMYHASKS
460 470 480 490 500
AKRALSLRLF QTEEKIERTQ RDIRSIQEAL ARNAGRHSVA SAQLQEKLAG
510 520 530
AQRQLGQLRA QEAGLQQEQR KADTHKKMTE F

Note: No experimental confirmation available.

Length:531
Mass (Da):57,359
Last modified:May 15, 2007 - v3
Checksum:i36572156BABDA876
GO
Isoform 2 (identifier: Q8N5A5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     291-310: Missing.

Show »
Length:511
Mass (Da):55,500
Checksum:i5007C362ECC2CD79
GO
Isoform 3 (identifier: Q8N5A5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     282-310: Missing.

Note: No experimental confirmation available.

Show »
Length:502
Mass (Da):54,605
Checksum:i8DD60FEEDB37D2F9
GO
Isoform 4 (identifier: Q8N5A5-4) [UniParc]FASTAAdd to Basket

Also known as: sZIP

The sequence of this isoform differs from the canonical sequence as follows:
     1-343: Missing.

Show »
Length:188
Mass (Da):20,697
Checksum:i00ABC2D9BC65E7C9
GO

Sequence cautioni

The sequence BAB47476.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11317.1 differs from that shown. Reason: Frameshift at position 290. Curated
The sequence CAI95713.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841L → Q in BAB55426. (PubMed:14702039)Curated
Sequence conflicti188 – 1881C → R in BAC11317. (PubMed:14702039)Curated
Sequence conflicti344 – 3441M → V in BAB55426. (PubMed:14702039)Curated
Sequence conflicti433 – 4331G → R in AAH19338. (PubMed:15489334)Curated
Sequence conflicti519 – 5191Q → R in BAB55426. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611S → R.4 Publications
Corresponds to variant rs1291212 [ dbSNP | Ensembl ].
VAR_025539

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 343343Missing in isoform 4. CuratedVSP_053599Add
BLAST
Alternative sequencei282 – 31029Missing in isoform 3. 1 PublicationVSP_038121Add
BLAST
Alternative sequencei291 – 31020Missing in isoform 2. 2 PublicationsVSP_007754Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058750 mRNA. Translation: BAB47476.3. Different initiation.
AK027878 mRNA. Translation: BAB55426.1.
AK074961 mRNA. Translation: BAC11317.1. Frameshift.
AL121845 Genomic DNA. Translation: CAC03670.1.
AL121845 Genomic DNA. Translation: CAI21879.1.
AL121845 Genomic DNA. Translation: CAI21880.1.
AL121845 Genomic DNA. Translation: CAI95713.1. Sequence problems.
CH471077 Genomic DNA. Translation: EAW75223.1.
CH471077 Genomic DNA. Translation: EAW75226.1.
BC019338 mRNA. Translation: AAH19338.1.
BC032612 mRNA. Translation: AAH32612.1.
CCDSiCCDS13534.1. [Q8N5A5-1]
CCDS13535.1. [Q8N5A5-2]
CCDS56203.1. [Q8N5A5-3]
RefSeqiNP_001076582.1. NM_001083113.1. [Q8N5A5-2]
NP_001182582.1. NM_001195653.1. [Q8N5A5-2]
NP_001182583.1. NM_001195654.1. [Q8N5A5-3]
NP_115916.3. NM_032527.4. [Q8N5A5-1]
NP_852150.2. NM_181485.2. [Q8N5A5-2]
UniGeneiHs.590868.

Genome annotation databases

EnsembliENST00000328969; ENSP00000332013; ENSG00000197114. [Q8N5A5-1]
ENST00000355969; ENSP00000348242; ENSG00000197114. [Q8N5A5-2]
ENST00000357119; ENSP00000349634; ENSG00000197114. [Q8N5A5-3]
ENST00000369967; ENSP00000358984; ENSG00000197114. [Q8N5A5-2]
ENST00000448100; ENSP00000391176; ENSG00000197114. [Q8N5A5-2]
GeneIDi84619.
KEGGihsa:84619.
UCSCiuc002ygi.2. human. [Q8N5A5-2]
uc002ygk.3. human. [Q8N5A5-1]
uc002ygm.3. human. [Q8N5A5-3]

Polymorphism databases

DMDMi147744602.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058750 mRNA. Translation: BAB47476.3 . Different initiation.
AK027878 mRNA. Translation: BAB55426.1 .
AK074961 mRNA. Translation: BAC11317.1 . Frameshift.
AL121845 Genomic DNA. Translation: CAC03670.1 .
AL121845 Genomic DNA. Translation: CAI21879.1 .
AL121845 Genomic DNA. Translation: CAI21880.1 .
AL121845 Genomic DNA. Translation: CAI95713.1 . Sequence problems.
CH471077 Genomic DNA. Translation: EAW75223.1 .
CH471077 Genomic DNA. Translation: EAW75226.1 .
BC019338 mRNA. Translation: AAH19338.1 .
BC032612 mRNA. Translation: AAH32612.1 .
CCDSi CCDS13534.1. [Q8N5A5-1 ]
CCDS13535.1. [Q8N5A5-2 ]
CCDS56203.1. [Q8N5A5-3 ]
RefSeqi NP_001076582.1. NM_001083113.1. [Q8N5A5-2 ]
NP_001182582.1. NM_001195653.1. [Q8N5A5-2 ]
NP_001182583.1. NM_001195654.1. [Q8N5A5-3 ]
NP_115916.3. NM_032527.4. [Q8N5A5-1 ]
NP_852150.2. NM_181485.2. [Q8N5A5-2 ]
UniGenei Hs.590868.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4II1 X-ray 2.65 A/B/C/D 120-268 [» ]
ProteinModelPortali Q8N5A5.
SMRi Q8N5A5. Positions 127-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124150. 10 interactions.
IntActi Q8N5A5. 19 interactions.
MINTi MINT-2810381.

PTM databases

PhosphoSitei Q8N5A5.

Polymorphism databases

DMDMi 147744602.

Proteomic databases

MaxQBi Q8N5A5.
PaxDbi Q8N5A5.
PRIDEi Q8N5A5.

Protocols and materials databases

DNASUi 84619.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328969 ; ENSP00000332013 ; ENSG00000197114 . [Q8N5A5-1 ]
ENST00000355969 ; ENSP00000348242 ; ENSG00000197114 . [Q8N5A5-2 ]
ENST00000357119 ; ENSP00000349634 ; ENSG00000197114 . [Q8N5A5-3 ]
ENST00000369967 ; ENSP00000358984 ; ENSG00000197114 . [Q8N5A5-2 ]
ENST00000448100 ; ENSP00000391176 ; ENSG00000197114 . [Q8N5A5-2 ]
GeneIDi 84619.
KEGGi hsa:84619.
UCSCi uc002ygi.2. human. [Q8N5A5-2 ]
uc002ygk.3. human. [Q8N5A5-1 ]
uc002ygm.3. human. [Q8N5A5-3 ]

Organism-specific databases

CTDi 84619.
GeneCardsi GC20P062338.
H-InvDB HIX0138076.
HGNCi HGNC:15948. ZGPAT.
HPAi HPA043248.
neXtProti NX_Q8N5A5.
PharmGKBi PA134881248.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241375.
GeneTreei ENSGT00390000000732.
HOVERGENi HBG056371.
InParanoidi Q8N5A5.
OMAi KEIYHAS.
OrthoDBi EOG71RXK5.
PhylomeDBi Q8N5A5.
TreeFami TF105970.

Miscellaneous databases

ChiTaRSi ZGPAT. human.
GeneWikii ZGPAT.
GenomeRNAii 84619.
NextBioi 74496.
PROi Q8N5A5.

Gene expression databases

Bgeei Q8N5A5.
CleanExi HS_ZGPAT.
ExpressionAtlasi Q8N5A5. baseline.
Genevestigatori Q8N5A5.

Family and domain databases

Gene3Di 4.10.1000.10. 1 hit.
InterProi IPR000467. G_patch_dom.
IPR000571. Znf_CCCH.
[Graphical view ]
Pfami PF01585. G-patch. 1 hit.
[Graphical view ]
SMARTi SM00443. G_patch. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view ]
PROSITEi PS50174. G_PATCH. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-61.
    Tissue: Brain.
  2. Ohara O., Nagase T., Kikuno R.
    Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-61.
    Tissue: Thyroid.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-61.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-61.
    Tissue: Placenta and Uterus.
  7. "ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis."
    Li R., Zhang H., Yu W., Chen Y., Gui B., Liang J., Wang Y., Sun L., Yang X., Zhang Y., Shi L., Li Y., Shang Y.
    EMBO J. 28:2763-2776(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DNA-BINDING, TISSUE SPECIFICITY, INTERACTION WITH CHD4.
  8. "sZIP, an alternative splice variant of ZIP, antagonizes transcription repression and growth inhibition by ZIP."
    Yu W., Li R., Gui B., Shang Y.
    J. Biol. Chem. 285:14301-14307(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORM 4), FUNCTION (ISOFORM 4), SUBCELLULAR LOCATION (ISOFORM 4).
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "HIV-1 Vpr Induces the Degradation of ZIP and sZIP, Adaptors of the NuRD Chromatin Remodeling Complex, by Hijacking DCAF1/VprBP."
    Maudet C., Sourisce A., Dragin L., Lahouassa H., Rain J.C., Bouaziz S., Ramirez B.C., Margottin-Goguet F.
    PLoS ONE 8:E77320-E77320(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.
  12. "Crystal structure of the zinc finger of ZGPAT."
    Structural genomics consortium (SGC)
    Submitted (FEB-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 120-268 IN COMPLEX WITH ZINC IONS.

Entry informationi

Entry nameiZGPAT_HUMAN
AccessioniPrimary (citable) accession number: Q8N5A5
Secondary accession number(s): E1P5K1
, Q4VXN9, Q5JWI9, Q5JWJ0, Q8NC55, Q8WUV4, Q96JI0, Q96JU4, Q9H401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: May 15, 2007
Last modified: November 26, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3