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Q8N587 (ZN561_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 561
Gene names
Name:ZNF561
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 12 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence AAH12144.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH32668.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Zinc finger protein 561
PRO_0000047650

Regions

Domain41 – 11272KRAB
Zinc finger118 – 14023C2H2-type 1; degenerate
Zinc finger169 – 19123C2H2-type 2; degenerate
Zinc finger197 – 21923C2H2-type 3
Zinc finger223 – 24725C2H2-type 4; degenerate
Zinc finger253 – 27523C2H2-type 5; degenerate
Zinc finger281 – 30323C2H2-type 6
Zinc finger309 – 33123C2H2-type 7
Zinc finger337 – 35923C2H2-type 8
Zinc finger365 – 38723C2H2-type 9
Zinc finger393 – 41523C2H2-type 10
Zinc finger421 – 44323C2H2-type 11
Zinc finger449 – 47123C2H2-type 12

Sequences

Sequence LengthMass (Da)Tools
Q8N587 [UniParc].

Last modified November 22, 2005. Version 2.
Checksum: 108E8C7BBAEC764C

FASTA48655,197
        10         20         30         40         50         60 
MAAIYLSRGF FSREPICPFE EKTKVERMVE DYLASGYQDS VTFDDVAVDF TPEEWALLDT 

        70         80         90        100        110        120 
TEKYLYRDVM LENYMNLASV EWEIQPRTKR SSLQQGFLKN QIFSGIQMTR GYSGWKLCDC 

       130        140        150        160        170        180 
KNCGEVFREQ FCLKTHMRVQ NGGNTSEGNC YGKDTLSVHK EASTGQELSK FNPCGKVFTL 

       190        200        210        220        230        240 
TPGLAVHLEV LNARQPYKCK ECGKGFKYFA SLDNHMGIHT DEKLCEFQEY GRAVTASSHL 

       250        260        270        280        290        300 
KQCVAVHTGK KSKKTKKCGK SFTNFSQLYA PVKTHKGEKS FECKECGRSF RNSSCLNDHI 

       310        320        330        340        350        360 
QIHTGIKPHK CTYCGKAFTR STQLTEHVRT HTGIKPYECK ECGQAFAQYS GLSIHIRSHS 

       370        380        390        400        410        420 
GKKPYQCKEC GKAFTTSTSL IQHTRIHTGE KPYECVECGK TFITSSRRSK HLKTHSGEKP 

       430        440        450        460        470        480 
FVCKICGKAF LYSSRLNVHL RTHTGEKPFV CKECGKAFAV SSRLSRHERI HTGEKPYECK 


DMSVTI 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC012144 mRNA. Translation: AAH12144.1. Sequence problems.
BC032668 mRNA. Translation: AAH32668.1. Different initiation.
CCDSCCDS12216.2.
RefSeqNP_689502.2. NM_152289.2.
XP_005260207.1. XM_005260150.1.
UniGeneHs.720081.

3D structure databases

ProteinModelPortalQ8N587.
SMRQ8N587. Positions 34-85, 110-481.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125005. 1 interaction.
STRING9606.ENSP00000303915.

Polymorphism databases

DMDM82582592.

Proteomic databases

MaxQBQ8N587.
PaxDbQ8N587.
PRIDEQ8N587.

Protocols and materials databases

DNASU93134.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302851; ENSP00000303915; ENSG00000171469.
GeneID93134.
KEGGhsa:93134.
UCSCuc002mlu.3. human.

Organism-specific databases

CTD93134.
GeneCardsGC19M009715.
HGNCHGNC:28684. ZNF561.
neXtProtNX_Q8N587.
PharmGKBPA134935834.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ8N587.
KOK09228.
OMADEKLCEF.
PhylomeDBQ8N587.
TreeFamTF341966.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ8N587.
BgeeQ8N587.
GenevestigatorQ8N587.

Family and domain databases

Gene3D3.30.160.60. 9 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi93134.
NextBio78000.
PROQ8N587.

Entry information

Entry nameZN561_HUMAN
AccessionPrimary (citable) accession number: Q8N587
Secondary accession number(s): Q6PJS0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM