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Protein

Zinc finger protein 561

Gene

ZNF561

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri118 – 14023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24725C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 561
Gene namesi
Name:ZNF561
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28684. ZNF561.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134935834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Zinc finger protein 561PRO_0000047650Add
BLAST

Proteomic databases

MaxQBiQ8N587.
PaxDbiQ8N587.
PRIDEiQ8N587.

Expressioni

Gene expression databases

BgeeiQ8N587.
ExpressionAtlasiQ8N587. baseline and differential.
GenevestigatoriQ8N587.

Organism-specific databases

HPAiHPA055332.

Interactioni

Protein-protein interaction databases

BioGridi125005. 3 interactions.
STRINGi9606.ENSP00000303915.

Structurei

3D structure databases

ProteinModelPortaliQ8N587.
SMRiQ8N587. Positions 34-85, 110-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 11272KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri118 – 14023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24725C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N587.
KOiK09228.
OMAiDEKLCEF.
PhylomeDBiQ8N587.
TreeFamiTF341966.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAIYLSRGF FSREPICPFE EKTKVERMVE DYLASGYQDS VTFDDVAVDF
60 70 80 90 100
TPEEWALLDT TEKYLYRDVM LENYMNLASV EWEIQPRTKR SSLQQGFLKN
110 120 130 140 150
QIFSGIQMTR GYSGWKLCDC KNCGEVFREQ FCLKTHMRVQ NGGNTSEGNC
160 170 180 190 200
YGKDTLSVHK EASTGQELSK FNPCGKVFTL TPGLAVHLEV LNARQPYKCK
210 220 230 240 250
ECGKGFKYFA SLDNHMGIHT DEKLCEFQEY GRAVTASSHL KQCVAVHTGK
260 270 280 290 300
KSKKTKKCGK SFTNFSQLYA PVKTHKGEKS FECKECGRSF RNSSCLNDHI
310 320 330 340 350
QIHTGIKPHK CTYCGKAFTR STQLTEHVRT HTGIKPYECK ECGQAFAQYS
360 370 380 390 400
GLSIHIRSHS GKKPYQCKEC GKAFTTSTSL IQHTRIHTGE KPYECVECGK
410 420 430 440 450
TFITSSRRSK HLKTHSGEKP FVCKICGKAF LYSSRLNVHL RTHTGEKPFV
460 470 480
CKECGKAFAV SSRLSRHERI HTGEKPYECK DMSVTI
Length:486
Mass (Da):55,197
Last modified:November 22, 2005 - v2
Checksum:i108E8C7BBAEC764C
GO
Isoform 2 (identifier: Q8N587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Note: No experimental confirmation available.

Show »
Length:350
Mass (Da):39,225
Checksum:i9183026F3331593F
GO

Sequence cautioni

The sequence AAH12144.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH32668.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 136136Missing in isoform 2. 1 PublicationVSP_055964Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304383 mRNA. Translation: BAG65220.1.
AC008759 Genomic DNA. No translation available.
BC012144 mRNA. Translation: AAH12144.1. Sequence problems.
BC032668 mRNA. Translation: AAH32668.1. Different initiation.
CCDSiCCDS12216.2. [Q8N587-1]
RefSeqiNP_689502.2. NM_152289.2. [Q8N587-1]
XP_005260207.1. XM_005260150.1. [Q8N587-1]
UniGeneiHs.720081.

Genome annotation databases

EnsembliENST00000302851; ENSP00000303915; ENSG00000171469. [Q8N587-1]
GeneIDi93134.
KEGGihsa:93134.
UCSCiuc002mlu.3. human. [Q8N587-1]

Polymorphism databases

DMDMi82582592.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304383 mRNA. Translation: BAG65220.1.
AC008759 Genomic DNA. No translation available.
BC012144 mRNA. Translation: AAH12144.1. Sequence problems.
BC032668 mRNA. Translation: AAH32668.1. Different initiation.
CCDSiCCDS12216.2. [Q8N587-1]
RefSeqiNP_689502.2. NM_152289.2. [Q8N587-1]
XP_005260207.1. XM_005260150.1. [Q8N587-1]
UniGeneiHs.720081.

3D structure databases

ProteinModelPortaliQ8N587.
SMRiQ8N587. Positions 34-85, 110-481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125005. 3 interactions.
STRINGi9606.ENSP00000303915.

Polymorphism databases

DMDMi82582592.

Proteomic databases

MaxQBiQ8N587.
PaxDbiQ8N587.
PRIDEiQ8N587.

Protocols and materials databases

DNASUi93134.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302851; ENSP00000303915; ENSG00000171469. [Q8N587-1]
GeneIDi93134.
KEGGihsa:93134.
UCSCiuc002mlu.3. human. [Q8N587-1]

Organism-specific databases

CTDi93134.
GeneCardsiGC19M009715.
HGNCiHGNC:28684. ZNF561.
HPAiHPA055332.
neXtProtiNX_Q8N587.
PharmGKBiPA134935834.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N587.
KOiK09228.
OMAiDEKLCEF.
PhylomeDBiQ8N587.
TreeFamiTF341966.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii93134.
NextBioi35477343.
PROiQ8N587.

Gene expression databases

BgeeiQ8N587.
ExpressionAtlasiQ8N587. baseline and differential.
GenevestigatoriQ8N587.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Trachea.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon and Skin.

Entry informationi

Entry nameiZN561_HUMAN
AccessioniPrimary (citable) accession number: Q8N587
Secondary accession number(s): B4E2Q8, Q6PJS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 4, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.