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Q8N587

- ZN561_HUMAN

UniProt

Q8N587 - ZN561_HUMAN

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Protein
Zinc finger protein 561
Gene
ZNF561
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri118 – 14023C2H2-type 1; degenerate
Add
BLAST
Zinc fingeri169 – 19123C2H2-type 2; degenerate
Add
BLAST
Zinc fingeri197 – 21923C2H2-type 3
Add
BLAST
Zinc fingeri223 – 24725C2H2-type 4; degenerate
Add
BLAST
Zinc fingeri253 – 27523C2H2-type 5; degenerate
Add
BLAST
Zinc fingeri281 – 30323C2H2-type 6
Add
BLAST
Zinc fingeri309 – 33123C2H2-type 7
Add
BLAST
Zinc fingeri337 – 35923C2H2-type 8
Add
BLAST
Zinc fingeri365 – 38723C2H2-type 9
Add
BLAST
Zinc fingeri393 – 41523C2H2-type 10
Add
BLAST
Zinc fingeri421 – 44323C2H2-type 11
Add
BLAST
Zinc fingeri449 – 47123C2H2-type 12
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 561
Gene namesi
Name:ZNF561
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:28684. ZNF561.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134935834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Zinc finger protein 561
PRO_0000047650Add
BLAST

Proteomic databases

MaxQBiQ8N587.
PaxDbiQ8N587.
PRIDEiQ8N587.

Expressioni

Gene expression databases

ArrayExpressiQ8N587.
BgeeiQ8N587.
GenevestigatoriQ8N587.

Interactioni

Protein-protein interaction databases

BioGridi125005. 1 interaction.
STRINGi9606.ENSP00000303915.

Structurei

3D structure databases

ProteinModelPortaliQ8N587.
SMRiQ8N587. Positions 34-85, 110-481.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 11272KRAB
Add
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N587.
KOiK09228.
OMAiDEKLCEF.
PhylomeDBiQ8N587.
TreeFamiTF341966.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N587-1 [UniParc]FASTAAdd to Basket

« Hide

MAAIYLSRGF FSREPICPFE EKTKVERMVE DYLASGYQDS VTFDDVAVDF    50
TPEEWALLDT TEKYLYRDVM LENYMNLASV EWEIQPRTKR SSLQQGFLKN 100
QIFSGIQMTR GYSGWKLCDC KNCGEVFREQ FCLKTHMRVQ NGGNTSEGNC 150
YGKDTLSVHK EASTGQELSK FNPCGKVFTL TPGLAVHLEV LNARQPYKCK 200
ECGKGFKYFA SLDNHMGIHT DEKLCEFQEY GRAVTASSHL KQCVAVHTGK 250
KSKKTKKCGK SFTNFSQLYA PVKTHKGEKS FECKECGRSF RNSSCLNDHI 300
QIHTGIKPHK CTYCGKAFTR STQLTEHVRT HTGIKPYECK ECGQAFAQYS 350
GLSIHIRSHS GKKPYQCKEC GKAFTTSTSL IQHTRIHTGE KPYECVECGK 400
TFITSSRRSK HLKTHSGEKP FVCKICGKAF LYSSRLNVHL RTHTGEKPFV 450
CKECGKAFAV SSRLSRHERI HTGEKPYECK DMSVTI 486
Length:486
Mass (Da):55,197
Last modified:November 22, 2005 - v2
Checksum:i108E8C7BBAEC764C
GO

Sequence cautioni

The sequence AAH12144.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAH32668.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC012144 mRNA. Translation: AAH12144.1. Sequence problems.
BC032668 mRNA. Translation: AAH32668.1. Different initiation.
CCDSiCCDS12216.2.
RefSeqiNP_689502.2. NM_152289.2.
XP_005260207.1. XM_005260150.1.
UniGeneiHs.720081.

Genome annotation databases

EnsembliENST00000302851; ENSP00000303915; ENSG00000171469.
GeneIDi93134.
KEGGihsa:93134.
UCSCiuc002mlu.3. human.

Polymorphism databases

DMDMi82582592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC012144 mRNA. Translation: AAH12144.1 . Sequence problems.
BC032668 mRNA. Translation: AAH32668.1 . Different initiation.
CCDSi CCDS12216.2.
RefSeqi NP_689502.2. NM_152289.2.
XP_005260207.1. XM_005260150.1.
UniGenei Hs.720081.

3D structure databases

ProteinModelPortali Q8N587.
SMRi Q8N587. Positions 34-85, 110-481.
ModBasei Search...

Protein-protein interaction databases

BioGridi 125005. 1 interaction.
STRINGi 9606.ENSP00000303915.

Polymorphism databases

DMDMi 82582592.

Proteomic databases

MaxQBi Q8N587.
PaxDbi Q8N587.
PRIDEi Q8N587.

Protocols and materials databases

DNASUi 93134.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302851 ; ENSP00000303915 ; ENSG00000171469 .
GeneIDi 93134.
KEGGi hsa:93134.
UCSCi uc002mlu.3. human.

Organism-specific databases

CTDi 93134.
GeneCardsi GC19M009715.
HGNCi HGNC:28684. ZNF561.
neXtProti NX_Q8N587.
PharmGKBi PA134935834.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q8N587.
KOi K09228.
OMAi DEKLCEF.
PhylomeDBi Q8N587.
TreeFami TF341966.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 93134.
NextBioi 78000.
PROi Q8N587.

Gene expression databases

ArrayExpressi Q8N587.
Bgeei Q8N587.
Genevestigatori Q8N587.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Skin.

Entry informationi

Entry nameiZN561_HUMAN
AccessioniPrimary (citable) accession number: Q8N587
Secondary accession number(s): Q6PJS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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