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Q8N584 (TT39C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetratricopeptide repeat protein 39C

Short name=TPR repeat protein 39C
Gene names
Name:TTC39C
Synonyms:C18orf17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length583 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TTC39 family.

Contains 3 TPR repeats.

Sequence caution

The sequence AAH32684.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainRepeat
TPR repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N584-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N584-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
Isoform 3 (identifier: Q8N584-3)

The sequence of this isoform differs from the canonical sequence as follows:
     57-76: NHSPLMSFGASFVSFLNAMM → KSFLTSEKTSALPGETQRRL
     77-583: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 583583Tetratricopeptide repeat protein 39C
PRO_0000274352

Regions

Repeat315 – 34834TPR 1
Repeat353 – 38634TPR 2
Repeat485 – 51834TPR 3
Compositional bias19 – 257Poly-Ala

Natural variations

Alternative sequence1 – 6161Missing in isoform 2.
VSP_022720
Alternative sequence57 – 7620NHSPL…LNAMM → KSFLTSEKTSALPGETQRRL in isoform 3.
VSP_046039
Alternative sequence77 – 583507Missing in isoform 3.
VSP_046040

Experimental info

Sequence conflict2101E → G in BAC03578. Ref.1
Sequence conflict2621E → V in BAC03578. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 6, 2007. Version 2.
Checksum: 438BF2F476F533AD

FASTA58365,870
        10         20         30         40         50         60 
MAGSEQQRPR RRDDGDSDAA AAAAAPLQDA ELALAGINML LNNGFRESDQ LFKQYRNHSP 

        70         80         90        100        110        120 
LMSFGASFVS FLNAMMTFEE EKMQLACDDL KTTEKLCESE EAGVIETIKN KIKKNVDVRK 

       130        140        150        160        170        180 
SAPSMVDRLQ RQIIIADCQV YLAVLSFVKQ ELSAYIKGGW ILRKAWKIYN KCYLDINALQ 

       190        200        210        220        230        240 
ELYQKKLTEE SLTSDAANDN HIVAEGVSEE SLNRLKGAVS FGYGLFHLCI SMVPPNLLKI 

       250        260        270        280        290        300 
INLLGFPGDR LQGLSSLMYA SESKDMKAPL ATLALLWYHT VVRPFFALDG SDNKAGLDEA 

       310        320        330        340        350        360 
KEILLKKEAA YPNSSLFMFF KGRIQRLECQ INSALTSFHT ALELAVDQRE IQHVCLYEIG 

       370        380        390        400        410        420 
WCSMIELNFK DAFDSFERLK NESRWSQCYY AYLTAVCQGA TGDVDGAQIV FKEVQKLFKR 

       430        440        450        460        470        480 
KNNQIEQFSV KKAERFRKQT PTKALCVLAS IEVLYLWKAL PNCSFPNLQR MSQACHEVDD 

       490        500        510        520        530        540 
SSVVGLKYLL LGAIHKCLGN SEDAVQYFQR AVKDELCRQN NLYVQPYACY ELGCLLLDKP 

       550        560        570        580 
ETVGRGRALL LQAKEDFSGY DFENRLHVRI HAALASLREL VPQ 

« Hide

Isoform 2 [UniParc].

Checksum: 24344A674155D963
Show »

FASTA52259,217
Isoform 3 [UniParc].

Checksum: 063CA2A2C5167C08
Show »

FASTA768,353

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Corpus callosum.
[2]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-583 (ISOFORM 1).
Tissue: Ovarian adenocarcinoma and Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK091080 mRNA. Translation: BAC03578.1.
AC010754 Genomic DNA. No translation available.
AC090772 Genomic DNA. No translation available.
BC016833 mRNA. No translation available.
BC032684 mRNA. Translation: AAH32684.1. Different initiation.
BC121034 mRNA. Translation: AAI21035.1.
BC121035 mRNA. Translation: AAI21036.1.
CCDSCCDS32804.1. [Q8N584-2]
CCDS45839.1. [Q8N584-1]
CCDS58616.1. [Q8N584-3]
RefSeqNP_001129465.1. NM_001135993.1. [Q8N584-1]
NP_001230354.1. NM_001243425.1. [Q8N584-3]
NP_694943.2. NM_153211.3. [Q8N584-2]
XP_005258255.1. XM_005258198.2. [Q8N584-2]
UniGeneHs.128576.
Hs.732771.

3D structure databases

ProteinModelPortalQ8N584.
SMRQ8N584. Positions 486-555.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125929. 2 interactions.
STRING9606.ENSP00000323645.

PTM databases

PhosphoSiteQ8N584.

Polymorphism databases

DMDM125863935.

Proteomic databases

MaxQBQ8N584.
PaxDbQ8N584.
PRIDEQ8N584.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304621; ENSP00000306598; ENSG00000168234. [Q8N584-2]
ENST00000317571; ENSP00000323645; ENSG00000168234. [Q8N584-1]
ENST00000584250; ENSP00000464344; ENSG00000168234. [Q8N584-3]
GeneID125488.
KEGGhsa:125488.
UCSCuc002kuu.3. human. [Q8N584-1]

Organism-specific databases

CTD125488.
GeneCardsGC18P021572.
H-InvDBHIX0202665.
HGNCHGNC:26595. TTC39C.
neXtProtNX_Q8N584.
PharmGKBPA162407262.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG240873.
HOGENOMHOG000007788.
HOVERGENHBG081333.
InParanoidQ8N584.
OMANKCYLDI.
OrthoDBEOG73RBB2.
PhylomeDBQ8N584.
TreeFamTF313761.

Gene expression databases

ArrayExpressQ8N584.
BgeeQ8N584.
CleanExHS_TTC39C.
GenevestigatorQ8N584.

Family and domain databases

Gene3D1.25.40.10. 2 hits.
InterProIPR019412. OMP_IML2_mit/TPR_39.
IPR011990. TPR-like_helical.
[Graphical view]
PfamPF10300. DUF3808. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTTC39C. human.
GenomeRNAi125488.
NextBio35537133.
PROQ8N584.

Entry information

Entry nameTT39C_HUMAN
AccessionPrimary (citable) accession number: Q8N584
Secondary accession number(s): B7WP63 expand/collapse secondary AC list , J3QRR1, Q0VAJ2, Q8N284
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM