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Protein

Tetratricopeptide repeat protein 39C

Gene

TTC39C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 39C
Short name:
TPR repeat protein 39C
Gene namesi
Name:TTC39C
Synonyms:C18orf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000168234.12
HGNCiHGNC:26595 TTC39C
neXtProtiNX_Q8N584

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168234
PharmGKBiPA162407262

Polymorphism and mutation databases

BioMutaiTTC39C
DMDMi125863935

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743521 – 583Tetratricopeptide repeat protein 39CAdd BLAST583

Proteomic databases

EPDiQ8N584
MaxQBiQ8N584
PaxDbiQ8N584
PeptideAtlasiQ8N584
PRIDEiQ8N584

PTM databases

iPTMnetiQ8N584
PhosphoSitePlusiQ8N584

Expressioni

Gene expression databases

BgeeiENSG00000168234
CleanExiHS_TTC39C
ExpressionAtlasiQ8N584 baseline and differential
GenevisibleiQ8N584 HS

Organism-specific databases

HPAiHPA065705
HPA065713

Interactioni

Protein-protein interaction databases

BioGridi125929, 7 interactors
IntActiQ8N584, 1 interactor
STRINGi9606.ENSP00000323645

Structurei

3D structure databases

ProteinModelPortaliQ8N584
SMRiQ8N584
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati315 – 348TPR 1Add BLAST34
Repeati353 – 386TPR 2Add BLAST34
Repeati485 – 518TPR 3Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi19 – 25Poly-Ala7

Sequence similaritiesi

Belongs to the TTC39 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG3783 Eukaryota
ENOG410XTBZ LUCA
GeneTreeiENSGT00390000009763
HOGENOMiHOG000007788
HOVERGENiHBG081333
InParanoidiQ8N584
OMAiKCYLDIN
OrthoDBiEOG091G0BPM
PhylomeDBiQ8N584
TreeFamiTF313761

Family and domain databases

InterProiView protein in InterPro
IPR019412 Iml2/TPR_39
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR31859 PTHR31859, 1 hit
PfamiView protein in Pfam
PF10300 DUF3808, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N584-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSEQQRPR RRDDGDSDAA AAAAAPLQDA ELALAGINML LNNGFRESDQ
60 70 80 90 100
LFKQYRNHSP LMSFGASFVS FLNAMMTFEE EKMQLACDDL KTTEKLCESE
110 120 130 140 150
EAGVIETIKN KIKKNVDVRK SAPSMVDRLQ RQIIIADCQV YLAVLSFVKQ
160 170 180 190 200
ELSAYIKGGW ILRKAWKIYN KCYLDINALQ ELYQKKLTEE SLTSDAANDN
210 220 230 240 250
HIVAEGVSEE SLNRLKGAVS FGYGLFHLCI SMVPPNLLKI INLLGFPGDR
260 270 280 290 300
LQGLSSLMYA SESKDMKAPL ATLALLWYHT VVRPFFALDG SDNKAGLDEA
310 320 330 340 350
KEILLKKEAA YPNSSLFMFF KGRIQRLECQ INSALTSFHT ALELAVDQRE
360 370 380 390 400
IQHVCLYEIG WCSMIELNFK DAFDSFERLK NESRWSQCYY AYLTAVCQGA
410 420 430 440 450
TGDVDGAQIV FKEVQKLFKR KNNQIEQFSV KKAERFRKQT PTKALCVLAS
460 470 480 490 500
IEVLYLWKAL PNCSFPNLQR MSQACHEVDD SSVVGLKYLL LGAIHKCLGN
510 520 530 540 550
SEDAVQYFQR AVKDELCRQN NLYVQPYACY ELGCLLLDKP ETVGRGRALL
560 570 580
LQAKEDFSGY DFENRLHVRI HAALASLREL VPQ
Length:583
Mass (Da):65,870
Last modified:February 6, 2007 - v2
Checksum:i438BF2F476F533AD
GO
Isoform 2 (identifier: Q8N584-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Show »
Length:522
Mass (Da):59,217
Checksum:i24344A674155D963
GO
Isoform 3 (identifier: Q8N584-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-76: NHSPLMSFGASFVSFLNAMM → KSFLTSEKTSALPGETQRRL
     77-583: Missing.

Note: No experimental confirmation available.
Show »
Length:76
Mass (Da):8,353
Checksum:i063CA2A2C5167C08
GO

Sequence cautioni

The sequence AAH32684 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210E → G in BAC03578 (PubMed:14702039).Curated1
Sequence conflicti262E → V in BAC03578 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0227201 – 61Missing in isoform 2. 2 PublicationsAdd BLAST61
Alternative sequenceiVSP_04603957 – 76NHSPL…LNAMM → KSFLTSEKTSALPGETQRRL in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_04604077 – 583Missing in isoform 3. 1 PublicationAdd BLAST507

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091080 mRNA Translation: BAC03578.1
AC010754 Genomic DNA No translation available.
AC090772 Genomic DNA No translation available.
BC016833 mRNA No translation available.
BC032684 mRNA Translation: AAH32684.1 Different initiation.
BC121034 mRNA Translation: AAI21035.1
BC121035 mRNA Translation: AAI21036.1
CCDSiCCDS32804.1 [Q8N584-2]
CCDS45839.1 [Q8N584-1]
CCDS58616.1 [Q8N584-3]
RefSeqiNP_001129465.1, NM_001135993.1 [Q8N584-1]
NP_001230354.1, NM_001243425.1 [Q8N584-3]
NP_001278959.1, NM_001292030.1
NP_694943.2, NM_153211.3 [Q8N584-2]
XP_005258255.1, XM_005258198.4 [Q8N584-2]
XP_016881039.1, XM_017025550.1 [Q8N584-2]
UniGeneiHs.128576
Hs.732771

Genome annotation databases

EnsembliENST00000304621; ENSP00000306598; ENSG00000168234 [Q8N584-2]
ENST00000317571; ENSP00000323645; ENSG00000168234 [Q8N584-1]
ENST00000584250; ENSP00000464344; ENSG00000168234 [Q8N584-3]
GeneIDi125488
KEGGihsa:125488
UCSCiuc002kuu.4 human [Q8N584-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTT39C_HUMAN
AccessioniPrimary (citable) accession number: Q8N584
Secondary accession number(s): B7WP63
, J3QRR1, Q0VAJ2, Q8N284
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: April 25, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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