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Q8N584

- TT39C_HUMAN

UniProt

Q8N584 - TT39C_HUMAN

Protein

Tetratricopeptide repeat protein 39C

Gene

TTC39C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (06 Feb 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetratricopeptide repeat protein 39C
    Short name:
    TPR repeat protein 39C
    Gene namesi
    Name:TTC39C
    Synonyms:C18orf17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:26595. TTC39C.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162407262.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 583583Tetratricopeptide repeat protein 39CPRO_0000274352Add
    BLAST

    Proteomic databases

    MaxQBiQ8N584.
    PaxDbiQ8N584.
    PRIDEiQ8N584.

    PTM databases

    PhosphoSiteiQ8N584.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N584.
    BgeeiQ8N584.
    CleanExiHS_TTC39C.
    GenevestigatoriQ8N584.

    Interactioni

    Protein-protein interaction databases

    BioGridi125929. 2 interactions.
    STRINGi9606.ENSP00000323645.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N584.
    SMRiQ8N584. Positions 486-555.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati315 – 34834TPR 1Add
    BLAST
    Repeati353 – 38634TPR 2Add
    BLAST
    Repeati485 – 51834TPR 3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi19 – 257Poly-Ala

    Sequence similaritiesi

    Belongs to the TTC39 family.Curated
    Contains 3 TPR repeats.Curated

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiNOG240873.
    HOGENOMiHOG000007788.
    HOVERGENiHBG081333.
    InParanoidiQ8N584.
    OMAiNKCYLDI.
    OrthoDBiEOG73RBB2.
    PhylomeDBiQ8N584.
    TreeFamiTF313761.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR019412. OMP_IML2_mit/TPR_39.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PfamiPF10300. DUF3808. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N584-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGSEQQRPR RRDDGDSDAA AAAAAPLQDA ELALAGINML LNNGFRESDQ    50
    LFKQYRNHSP LMSFGASFVS FLNAMMTFEE EKMQLACDDL KTTEKLCESE 100
    EAGVIETIKN KIKKNVDVRK SAPSMVDRLQ RQIIIADCQV YLAVLSFVKQ 150
    ELSAYIKGGW ILRKAWKIYN KCYLDINALQ ELYQKKLTEE SLTSDAANDN 200
    HIVAEGVSEE SLNRLKGAVS FGYGLFHLCI SMVPPNLLKI INLLGFPGDR 250
    LQGLSSLMYA SESKDMKAPL ATLALLWYHT VVRPFFALDG SDNKAGLDEA 300
    KEILLKKEAA YPNSSLFMFF KGRIQRLECQ INSALTSFHT ALELAVDQRE 350
    IQHVCLYEIG WCSMIELNFK DAFDSFERLK NESRWSQCYY AYLTAVCQGA 400
    TGDVDGAQIV FKEVQKLFKR KNNQIEQFSV KKAERFRKQT PTKALCVLAS 450
    IEVLYLWKAL PNCSFPNLQR MSQACHEVDD SSVVGLKYLL LGAIHKCLGN 500
    SEDAVQYFQR AVKDELCRQN NLYVQPYACY ELGCLLLDKP ETVGRGRALL 550
    LQAKEDFSGY DFENRLHVRI HAALASLREL VPQ 583
    Length:583
    Mass (Da):65,870
    Last modified:February 6, 2007 - v2
    Checksum:i438BF2F476F533AD
    GO
    Isoform 2 (identifier: Q8N584-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-61: Missing.

    Show »
    Length:522
    Mass (Da):59,217
    Checksum:i24344A674155D963
    GO
    Isoform 3 (identifier: Q8N584-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         57-76: NHSPLMSFGASFVSFLNAMM → KSFLTSEKTSALPGETQRRL
         77-583: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:76
    Mass (Da):8,353
    Checksum:i063CA2A2C5167C08
    GO

    Sequence cautioni

    The sequence AAH32684.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti210 – 2101E → G in BAC03578. (PubMed:14702039)Curated
    Sequence conflicti262 – 2621E → V in BAC03578. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6161Missing in isoform 2. 2 PublicationsVSP_022720Add
    BLAST
    Alternative sequencei57 – 7620NHSPL…LNAMM → KSFLTSEKTSALPGETQRRL in isoform 3. 1 PublicationVSP_046039Add
    BLAST
    Alternative sequencei77 – 583507Missing in isoform 3. 1 PublicationVSP_046040Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091080 mRNA. Translation: BAC03578.1.
    AC010754 Genomic DNA. No translation available.
    AC090772 Genomic DNA. No translation available.
    BC016833 mRNA. No translation available.
    BC032684 mRNA. Translation: AAH32684.1. Different initiation.
    BC121034 mRNA. Translation: AAI21035.1.
    BC121035 mRNA. Translation: AAI21036.1.
    CCDSiCCDS32804.1. [Q8N584-2]
    CCDS45839.1. [Q8N584-1]
    CCDS58616.1. [Q8N584-3]
    RefSeqiNP_001129465.1. NM_001135993.1. [Q8N584-1]
    NP_001230354.1. NM_001243425.1. [Q8N584-3]
    NP_694943.2. NM_153211.3. [Q8N584-2]
    XP_005258255.1. XM_005258198.2. [Q8N584-2]
    UniGeneiHs.128576.
    Hs.732771.

    Genome annotation databases

    EnsembliENST00000304621; ENSP00000306598; ENSG00000168234. [Q8N584-2]
    ENST00000317571; ENSP00000323645; ENSG00000168234. [Q8N584-1]
    ENST00000584250; ENSP00000464344; ENSG00000168234. [Q8N584-3]
    GeneIDi125488.
    KEGGihsa:125488.
    UCSCiuc002kuu.3. human. [Q8N584-1]

    Polymorphism databases

    DMDMi125863935.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091080 mRNA. Translation: BAC03578.1 .
    AC010754 Genomic DNA. No translation available.
    AC090772 Genomic DNA. No translation available.
    BC016833 mRNA. No translation available.
    BC032684 mRNA. Translation: AAH32684.1 . Different initiation.
    BC121034 mRNA. Translation: AAI21035.1 .
    BC121035 mRNA. Translation: AAI21036.1 .
    CCDSi CCDS32804.1. [Q8N584-2 ]
    CCDS45839.1. [Q8N584-1 ]
    CCDS58616.1. [Q8N584-3 ]
    RefSeqi NP_001129465.1. NM_001135993.1. [Q8N584-1 ]
    NP_001230354.1. NM_001243425.1. [Q8N584-3 ]
    NP_694943.2. NM_153211.3. [Q8N584-2 ]
    XP_005258255.1. XM_005258198.2. [Q8N584-2 ]
    UniGenei Hs.128576.
    Hs.732771.

    3D structure databases

    ProteinModelPortali Q8N584.
    SMRi Q8N584. Positions 486-555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125929. 2 interactions.
    STRINGi 9606.ENSP00000323645.

    PTM databases

    PhosphoSitei Q8N584.

    Polymorphism databases

    DMDMi 125863935.

    Proteomic databases

    MaxQBi Q8N584.
    PaxDbi Q8N584.
    PRIDEi Q8N584.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304621 ; ENSP00000306598 ; ENSG00000168234 . [Q8N584-2 ]
    ENST00000317571 ; ENSP00000323645 ; ENSG00000168234 . [Q8N584-1 ]
    ENST00000584250 ; ENSP00000464344 ; ENSG00000168234 . [Q8N584-3 ]
    GeneIDi 125488.
    KEGGi hsa:125488.
    UCSCi uc002kuu.3. human. [Q8N584-1 ]

    Organism-specific databases

    CTDi 125488.
    GeneCardsi GC18P021572.
    H-InvDB HIX0202665.
    HGNCi HGNC:26595. TTC39C.
    neXtProti NX_Q8N584.
    PharmGKBi PA162407262.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240873.
    HOGENOMi HOG000007788.
    HOVERGENi HBG081333.
    InParanoidi Q8N584.
    OMAi NKCYLDI.
    OrthoDBi EOG73RBB2.
    PhylomeDBi Q8N584.
    TreeFami TF313761.

    Miscellaneous databases

    ChiTaRSi TTC39C. human.
    GenomeRNAii 125488.
    NextBioi 35537133.
    PROi Q8N584.

    Gene expression databases

    ArrayExpressi Q8N584.
    Bgeei Q8N584.
    CleanExi HS_TTC39C.
    Genevestigatori Q8N584.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR019412. OMP_IML2_mit/TPR_39.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    Pfami PF10300. DUF3808. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Corpus callosum.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-583 (ISOFORM 1).
      Tissue: Ovarian adenocarcinoma and Testis.

    Entry informationi

    Entry nameiTT39C_HUMAN
    AccessioniPrimary (citable) accession number: Q8N584
    Secondary accession number(s): B7WP63
    , J3QRR1, Q0VAJ2, Q8N284
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3