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Q8N584

- TT39C_HUMAN

UniProt

Q8N584 - TT39C_HUMAN

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Protein

Tetratricopeptide repeat protein 39C

Gene

TTC39C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 39C
Short name:
TPR repeat protein 39C
Gene namesi
Name:TTC39C
Synonyms:C18orf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:26595. TTC39C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407262.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 583583Tetratricopeptide repeat protein 39CPRO_0000274352Add
BLAST

Proteomic databases

MaxQBiQ8N584.
PaxDbiQ8N584.
PRIDEiQ8N584.

PTM databases

PhosphoSiteiQ8N584.

Expressioni

Gene expression databases

BgeeiQ8N584.
CleanExiHS_TTC39C.
ExpressionAtlasiQ8N584. baseline and differential.
GenevestigatoriQ8N584.

Interactioni

Protein-protein interaction databases

BioGridi125929. 2 interactions.
IntActiQ8N584. 1 interaction.
STRINGi9606.ENSP00000323645.

Structurei

3D structure databases

ProteinModelPortaliQ8N584.
SMRiQ8N584. Positions 34-96, 486-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati315 – 34834TPR 1Add
BLAST
Repeati353 – 38634TPR 2Add
BLAST
Repeati485 – 51834TPR 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi19 – 257Poly-Ala

Sequence similaritiesi

Belongs to the TTC39 family.Curated
Contains 3 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG240873.
GeneTreeiENSGT00390000009763.
HOGENOMiHOG000007788.
HOVERGENiHBG081333.
InParanoidiQ8N584.
OMAiNKCYLDI.
OrthoDBiEOG73RBB2.
PhylomeDBiQ8N584.
TreeFamiTF313761.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR019412. OMP_IML2_mit/TPR_39.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF10300. DUF3808. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N584-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSEQQRPR RRDDGDSDAA AAAAAPLQDA ELALAGINML LNNGFRESDQ
60 70 80 90 100
LFKQYRNHSP LMSFGASFVS FLNAMMTFEE EKMQLACDDL KTTEKLCESE
110 120 130 140 150
EAGVIETIKN KIKKNVDVRK SAPSMVDRLQ RQIIIADCQV YLAVLSFVKQ
160 170 180 190 200
ELSAYIKGGW ILRKAWKIYN KCYLDINALQ ELYQKKLTEE SLTSDAANDN
210 220 230 240 250
HIVAEGVSEE SLNRLKGAVS FGYGLFHLCI SMVPPNLLKI INLLGFPGDR
260 270 280 290 300
LQGLSSLMYA SESKDMKAPL ATLALLWYHT VVRPFFALDG SDNKAGLDEA
310 320 330 340 350
KEILLKKEAA YPNSSLFMFF KGRIQRLECQ INSALTSFHT ALELAVDQRE
360 370 380 390 400
IQHVCLYEIG WCSMIELNFK DAFDSFERLK NESRWSQCYY AYLTAVCQGA
410 420 430 440 450
TGDVDGAQIV FKEVQKLFKR KNNQIEQFSV KKAERFRKQT PTKALCVLAS
460 470 480 490 500
IEVLYLWKAL PNCSFPNLQR MSQACHEVDD SSVVGLKYLL LGAIHKCLGN
510 520 530 540 550
SEDAVQYFQR AVKDELCRQN NLYVQPYACY ELGCLLLDKP ETVGRGRALL
560 570 580
LQAKEDFSGY DFENRLHVRI HAALASLREL VPQ
Length:583
Mass (Da):65,870
Last modified:February 6, 2007 - v2
Checksum:i438BF2F476F533AD
GO
Isoform 2 (identifier: Q8N584-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Show »
Length:522
Mass (Da):59,217
Checksum:i24344A674155D963
GO
Isoform 3 (identifier: Q8N584-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-76: NHSPLMSFGASFVSFLNAMM → KSFLTSEKTSALPGETQRRL
     77-583: Missing.

Note: No experimental confirmation available.

Show »
Length:76
Mass (Da):8,353
Checksum:i063CA2A2C5167C08
GO

Sequence cautioni

The sequence AAH32684.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 2101E → G in BAC03578. (PubMed:14702039)Curated
Sequence conflicti262 – 2621E → V in BAC03578. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6161Missing in isoform 2. 2 PublicationsVSP_022720Add
BLAST
Alternative sequencei57 – 7620NHSPL…LNAMM → KSFLTSEKTSALPGETQRRL in isoform 3. 1 PublicationVSP_046039Add
BLAST
Alternative sequencei77 – 583507Missing in isoform 3. 1 PublicationVSP_046040Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091080 mRNA. Translation: BAC03578.1.
AC010754 Genomic DNA. No translation available.
AC090772 Genomic DNA. No translation available.
BC016833 mRNA. No translation available.
BC032684 mRNA. Translation: AAH32684.1. Different initiation.
BC121034 mRNA. Translation: AAI21035.1.
BC121035 mRNA. Translation: AAI21036.1.
CCDSiCCDS32804.1. [Q8N584-2]
CCDS45839.1. [Q8N584-1]
CCDS58616.1. [Q8N584-3]
RefSeqiNP_001129465.1. NM_001135993.1. [Q8N584-1]
NP_001230354.1. NM_001243425.1. [Q8N584-3]
NP_001278959.1. NM_001292030.1.
NP_694943.2. NM_153211.3. [Q8N584-2]
XP_005258255.1. XM_005258198.2. [Q8N584-2]
UniGeneiHs.128576.
Hs.732771.

Genome annotation databases

EnsembliENST00000304621; ENSP00000306598; ENSG00000168234. [Q8N584-2]
ENST00000317571; ENSP00000323645; ENSG00000168234. [Q8N584-1]
ENST00000584250; ENSP00000464344; ENSG00000168234. [Q8N584-3]
GeneIDi125488.
KEGGihsa:125488.
UCSCiuc002kuu.3. human. [Q8N584-1]

Polymorphism databases

DMDMi125863935.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091080 mRNA. Translation: BAC03578.1 .
AC010754 Genomic DNA. No translation available.
AC090772 Genomic DNA. No translation available.
BC016833 mRNA. No translation available.
BC032684 mRNA. Translation: AAH32684.1 . Different initiation.
BC121034 mRNA. Translation: AAI21035.1 .
BC121035 mRNA. Translation: AAI21036.1 .
CCDSi CCDS32804.1. [Q8N584-2 ]
CCDS45839.1. [Q8N584-1 ]
CCDS58616.1. [Q8N584-3 ]
RefSeqi NP_001129465.1. NM_001135993.1. [Q8N584-1 ]
NP_001230354.1. NM_001243425.1. [Q8N584-3 ]
NP_001278959.1. NM_001292030.1.
NP_694943.2. NM_153211.3. [Q8N584-2 ]
XP_005258255.1. XM_005258198.2. [Q8N584-2 ]
UniGenei Hs.128576.
Hs.732771.

3D structure databases

ProteinModelPortali Q8N584.
SMRi Q8N584. Positions 34-96, 486-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125929. 2 interactions.
IntActi Q8N584. 1 interaction.
STRINGi 9606.ENSP00000323645.

PTM databases

PhosphoSitei Q8N584.

Polymorphism databases

DMDMi 125863935.

Proteomic databases

MaxQBi Q8N584.
PaxDbi Q8N584.
PRIDEi Q8N584.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304621 ; ENSP00000306598 ; ENSG00000168234 . [Q8N584-2 ]
ENST00000317571 ; ENSP00000323645 ; ENSG00000168234 . [Q8N584-1 ]
ENST00000584250 ; ENSP00000464344 ; ENSG00000168234 . [Q8N584-3 ]
GeneIDi 125488.
KEGGi hsa:125488.
UCSCi uc002kuu.3. human. [Q8N584-1 ]

Organism-specific databases

CTDi 125488.
GeneCardsi GC18P021572.
H-InvDB HIX0202665.
HGNCi HGNC:26595. TTC39C.
neXtProti NX_Q8N584.
PharmGKBi PA162407262.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240873.
GeneTreei ENSGT00390000009763.
HOGENOMi HOG000007788.
HOVERGENi HBG081333.
InParanoidi Q8N584.
OMAi NKCYLDI.
OrthoDBi EOG73RBB2.
PhylomeDBi Q8N584.
TreeFami TF313761.

Miscellaneous databases

ChiTaRSi TTC39C. human.
GenomeRNAii 125488.
NextBioi 35537133.
PROi Q8N584.

Gene expression databases

Bgeei Q8N584.
CleanExi HS_TTC39C.
ExpressionAtlasi Q8N584. baseline and differential.
Genevestigatori Q8N584.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR019412. OMP_IML2_mit/TPR_39.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
Pfami PF10300. DUF3808. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Corpus callosum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-583 (ISOFORM 1).
    Tissue: Ovarian adenocarcinoma and Testis.

Entry informationi

Entry nameiTT39C_HUMAN
AccessioniPrimary (citable) accession number: Q8N584
Secondary accession number(s): B7WP63
, J3QRR1, Q0VAJ2, Q8N284
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3