Q8N584 (TT39C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetratricopeptide repeat protein 39C
Short name=TPR repeat protein 39C

Gene names

Name:	TTC39C
Synonyms:	C18orf17

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the TTC39 family. Contains 3 TPR repeats.
Sequence caution	The sequence AAH32684.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat TPR repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N584-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N584-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Isoform 3 (identifier: Q8N584-3)

The sequence of this isoform differs from the canonical sequence as follows:
     57-76: NHSPLMSFGASFVSFLNAMM → KSFLTSEKTSALPGETQRRL
     77-583: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 583	583	Tetratricopeptide repeat protein 39C		PRO_0000274352
Regions
	Repeat	315 – 348	34	TPR 1
	Repeat	353 – 386	34	TPR 2
	Repeat	485 – 518	34	TPR 3
	Compositional bias	19 – 25	7	Poly-Ala
Natural variations
	Alternative sequence	1 – 61	61	Missing in isoform 2.		VSP_022720
	Alternative sequence	57 – 76	20	NHSPL…LNAMM → KSFLTSEKTSALPGETQRRL in isoform 3.		VSP_046039
	Alternative sequence	77 – 583	507	Missing in isoform 3.		VSP_046040
Experimental info
	Sequence conflict	210	1	E → G in BAC03578. Ref.1
	Sequence conflict	262	1	E → V in BAC03578. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 6, 2007. Version 2. Checksum: 438BF2F476F533AD	FASTA	583	65,870
	10 20 30 40 50 60 MAGSEQQRPR RRDDGDSDAA AAAAAPLQDA ELALAGINML LNNGFRESDQ LFKQYRNHSP 70 80 90 100 110 120 LMSFGASFVS FLNAMMTFEE EKMQLACDDL KTTEKLCESE EAGVIETIKN KIKKNVDVRK 130 140 150 160 170 180 SAPSMVDRLQ RQIIIADCQV YLAVLSFVKQ ELSAYIKGGW ILRKAWKIYN KCYLDINALQ 190 200 210 220 230 240 ELYQKKLTEE SLTSDAANDN HIVAEGVSEE SLNRLKGAVS FGYGLFHLCI SMVPPNLLKI 250 260 270 280 290 300 INLLGFPGDR LQGLSSLMYA SESKDMKAPL ATLALLWYHT VVRPFFALDG SDNKAGLDEA 310 320 330 340 350 360 KEILLKKEAA YPNSSLFMFF KGRIQRLECQ INSALTSFHT ALELAVDQRE IQHVCLYEIG 370 380 390 400 410 420 WCSMIELNFK DAFDSFERLK NESRWSQCYY AYLTAVCQGA TGDVDGAQIV FKEVQKLFKR 430 440 450 460 470 480 KNNQIEQFSV KKAERFRKQT PTKALCVLAS IEVLYLWKAL PNCSFPNLQR MSQACHEVDD 490 500 510 520 530 540 SSVVGLKYLL LGAIHKCLGN SEDAVQYFQR AVKDELCRQN NLYVQPYACY ELGCLLLDKP 550 560 570 580 ETVGRGRALL LQAKEDFSGY DFENRLHVRI HAALASLREL VPQ
	Isoform 2 [UniParc]. Checksum: 24344A674155D963	FASTA	522	59,217
	10 20 30 40 50 60 MSFGASFVSF LNAMMTFEEE KMQLACDDLK TTEKLCESEE AGVIETIKNK IKKNVDVRKS 70 80 90 100 110 120 APSMVDRLQR QIIIADCQVY LAVLSFVKQE LSAYIKGGWI LRKAWKIYNK CYLDINALQE 130 140 150 160 170 180 LYQKKLTEES LTSDAANDNH IVAEGVSEES LNRLKGAVSF GYGLFHLCIS MVPPNLLKII 190 200 210 220 230 240 NLLGFPGDRL QGLSSLMYAS ESKDMKAPLA TLALLWYHTV VRPFFALDGS DNKAGLDEAK 250 260 270 280 290 300 EILLKKEAAY PNSSLFMFFK GRIQRLECQI NSALTSFHTA LELAVDQREI QHVCLYEIGW 310 320 330 340 350 360 CSMIELNFKD AFDSFERLKN ESRWSQCYYA YLTAVCQGAT GDVDGAQIVF KEVQKLFKRK 370 380 390 400 410 420 NNQIEQFSVK KAERFRKQTP TKALCVLASI EVLYLWKALP NCSFPNLQRM SQACHEVDDS 430 440 450 460 470 480 SVVGLKYLLL GAIHKCLGNS EDAVQYFQRA VKDELCRQNN LYVQPYACYE LGCLLLDKPE 490 500 510 520 TVGRGRALLL QAKEDFSGYD FENRLHVRIH AALASLRELV PQ
	Isoform 3 [UniParc]. Checksum: 063CA2A2C5167C08	FASTA	76	8,353
	10 20 30 40 50 60 MAGSEQQRPR RRDDGDSDAA AAAAAPLQDA ELALAGINML LNNGFRESDQ LFKQYRKSFL 70 TSEKTSALPG ETQRRL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Corpus callosum.
[2]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-583 (ISOFORM 1). Tissue: Ovarian adenocarcinoma and Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK091080 mRNA. Translation: BAC03578.1. AC010754 Genomic DNA. No translation available. AC090772 Genomic DNA. No translation available. BC016833 mRNA. No translation available. BC032684 mRNA. Translation: AAH32684.1. Different initiation. BC121034 mRNA. Translation: AAI21035.1. BC121035 mRNA. Translation: AAI21036.1.
IPI	IPI00181911. IPI00827930.
RefSeq	NP_001129465.1. NM_001135993.1. NP_001230354.1. NM_001243425.1. NP_694943.2. NM_153211.3.
UniGene	Hs.128576. Hs.732771.
3D structure databases
ProteinModelPortal	Q8N584.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000323645.
PTM databases
PhosphoSite	Q8N584.
Polymorphism databases
DMDM	125863935.
Proteomic databases
PaxDb	Q8N584.
PRIDE	Q8N584.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304621; ENSP00000306598; ENSG00000168234. ENST00000317571; ENSP00000323645; ENSG00000168234. ENST00000584250; ENSP00000464344; ENSG00000168234.
GeneID	125488.
KEGG	hsa:125488.
UCSC	uc002kuu.3. human.
Organism-specific databases
CTD	125488.
GeneCards	GC18P021572.
H-InvDB	HIX0202665.
HGNC	HGNC:26595. TTC39C.
neXtProt	NX_Q8N584.
PharmGKB	PA162407262.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG240873.
HOGENOM	HOG000007788.
HOVERGEN	HBG081333.
InParanoid	Q8N584.
OMA	NKCYLDI.
OrthoDB	EOG4TQM8P.
Gene expression databases
ArrayExpress	Q8N584.
Bgee	Q8N584.
CleanEx	HS_TTC39C.
Genevestigator	Q8N584.
Family and domain databases
Gene3D	1.25.40.10. 2 hits.
InterPro	IPR019412. OMP_IML2_mit/TPR_39. IPR011990. TPR-like_helical. [Graphical view]
Pfam	PF10300. DUF3808. 1 hit. [Graphical view]
PROSITE	PS50005. TPR. False negative. PS50293. TPR_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TTC39C. human.
GenomeRNAi	125488.
NextBio	35537133.

Entry information

Entry name

TT39C_HUMAN

Accession

Primary (citable) accession number: Q8N584
Secondary accession number(s): B7WP63 , J3QRR1, Q0VAJ2, Q8N284

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.