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Protein

Zinc finger protein 276

Gene

ZNF276

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri434 – 45825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 49026C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 51823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri554 – 57724C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 276
Short name:
Zfp-276
Alternative name(s):
Zinc finger protein 477
Gene namesi
Name:ZNF276
Synonyms:ZFP276, ZNF477
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:23330. ZNF276.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134935042.

Polymorphism and mutation databases

BioMutaiZNF276.
DMDMi296453082.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 614614Zinc finger protein 276PRO_0000047323Add
BLAST

Proteomic databases

EPDiQ8N554.
MaxQBiQ8N554.
PaxDbiQ8N554.
PRIDEiQ8N554.

PTM databases

iPTMnetiQ8N554.
PhosphoSiteiQ8N554.

Expressioni

Gene expression databases

BgeeiQ8N554.
CleanExiHS_ZNF276.
ExpressionAtlasiQ8N554. baseline and differential.
GenevisibleiQ8N554. HS.

Organism-specific databases

HPAiHPA021309.
HPA022255.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GCC1Q96CN93EBI-10265849,EBI-746252
ZBTB8AQ96BR94EBI-750821,EBI-742740

Protein-protein interaction databases

BioGridi124982. 3 interactions.
IntActiQ8N554. 3 interactions.
MINTiMINT-1471309.
STRINGi9606.ENSP00000415836.

Structurei

3D structure databases

ProteinModelPortaliQ8N554.
SMRiQ8N554. Positions 434-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 15375ZADAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri434 – 45825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 49026C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 51823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri554 – 57724C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063153.
HOGENOMiHOG000155790.
HOVERGENiHBG061026.
InParanoidiQ8N554.
OMAiGCDQGHD.
OrthoDBiEOG7SV0TZ.
PhylomeDBiQ8N554.
TreeFamiTF332664.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR012934. Znf_AD.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF07776. zf-AD. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N554-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRDRLGRFL SPGSSRQCGA SDGGGGVSRT RGRPSLSGGP RVDGATARRA
60 70 80 90 100
WGPVGSCGDA GEDGADEAGA GRALAMGHCR LCHGKFSSRS LRSISERAPG
110 120 130 140 150
ASMERPSAEE RVLVRDFQRL LGVAVRQDPT LSPFVCKSCH AQFYQCHSLL
160 170 180 190 200
KSFLQRVNAS PAGRRKPCAK VGAQPPTGAE EGACLVDLIT SSPQCLHGLV
210 220 230 240 250
GWVHGHAASC GALPHLQRTL SSEYCGVIQV VWGCDQGHDY TMDTSSSCKA
260 270 280 290 300
FLLDSALAVK WPWDKETAPR LPQHRGWNPG DAPQTSQGRG TGTPVGAETK
310 320 330 340 350
TLPSTDVAQP PSDSDAVGPR SGFPPQPSLP LCRAPGQLGE KQLPSSTSDD
360 370 380 390 400
RVKDEFSDLS EGDVLSEDEN DKKQNAQSSD ESFEPYPERK VSGKKSESKE
410 420 430 440 450
AKKSEEPRIR KKPGPKPGWK KKLRCEREEL PTIYKCPYQG CTAVYRGADG
460 470 480 490 500
MKKHIKEHHE EVRERPCPHP GCNKVFMIDR YLQRHVKLIH TEVRNYICDE
510 520 530 540 550
CGQTFKQRKH LLVHQMRHSG AKPLQCEVCG FQCRQRASLK YHMTKHKAET
560 570 580 590 600
ELDFACDQCG RRFEKAHNLN VHMSMVHPLT QTQDKALPLE AEPPPGPPSP
610
SVTTEGQAVK PEPT
Length:614
Mass (Da):67,219
Last modified:May 18, 2010 - v4
Checksum:iD63256CFD7DC5040
GO
Isoform 2 (identifier: Q8N554-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Show »
Length:539
Mass (Da):59,850
Checksum:iCA08E6D3F3534F37
GO

Sequence cautioni

The sequence AAH32781.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI10349.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041E → V in AK026482 (PubMed:15616553).Curated
Sequence conflicti180 – 1801E → G in AK026482 (PubMed:15616553).Curated
Sequence conflicti413 – 4131P → Q in AAQ15128 (PubMed:15489334).Curated
Sequence conflicti413 – 4131P → Q in AAQ15129 (PubMed:15489334).Curated
Sequence conflicti434 – 4341Y → H in AAI07604 (PubMed:14605947).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti263 – 2631W → R.2 Publications
Corresponds to variant rs6500437 [ dbSNP | Ensembl ].
VAR_032708
Natural varianti275 – 2751R → W May increase breast cancer risk. 1 Publication
VAR_019125
Natural varianti351 – 3511R → W.1 Publication
Corresponds to variant rs17719249 [ dbSNP | Ensembl ].
VAR_032709
Natural varianti605 – 6051E → D.1 Publication
Corresponds to variant rs17227424 [ dbSNP | Ensembl ].
VAR_019126

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7575Missing in isoform 2. 2 PublicationsVSP_026104Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354755 mRNA. Translation: AAQ15128.1.
AF354756 mRNA. Translation: AAQ15129.1.
AC005360 Genomic DNA. No translation available.
AC010538 Genomic DNA. No translation available.
BC032781 mRNA. Translation: AAH32781.2. Different initiation.
BC107603 mRNA. Translation: AAI07604.1.
BC110348 mRNA. Translation: AAI10349.1. Different initiation.
AK026482 mRNA. No translation available.
CCDSiCCDS10986.1. [Q8N554-2]
CCDS45554.1. [Q8N554-1]
RefSeqiNP_001106997.1. NM_001113525.1. [Q8N554-1]
NP_689500.2. NM_152287.3. [Q8N554-2]
XP_006721400.1. XM_006721337.1. [Q8N554-2]
XP_011521762.1. XM_011523460.1. [Q8N554-2]
UniGeneiHs.290154.

Genome annotation databases

EnsembliENST00000289816; ENSP00000289816; ENSG00000158805. [Q8N554-2]
ENST00000443381; ENSP00000415836; ENSG00000158805. [Q8N554-1]
GeneIDi92822.
KEGGihsa:92822.
UCSCiuc002foq.5. human. [Q8N554-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354755 mRNA. Translation: AAQ15128.1.
AF354756 mRNA. Translation: AAQ15129.1.
AC005360 Genomic DNA. No translation available.
AC010538 Genomic DNA. No translation available.
BC032781 mRNA. Translation: AAH32781.2. Different initiation.
BC107603 mRNA. Translation: AAI07604.1.
BC110348 mRNA. Translation: AAI10349.1. Different initiation.
AK026482 mRNA. No translation available.
CCDSiCCDS10986.1. [Q8N554-2]
CCDS45554.1. [Q8N554-1]
RefSeqiNP_001106997.1. NM_001113525.1. [Q8N554-1]
NP_689500.2. NM_152287.3. [Q8N554-2]
XP_006721400.1. XM_006721337.1. [Q8N554-2]
XP_011521762.1. XM_011523460.1. [Q8N554-2]
UniGeneiHs.290154.

3D structure databases

ProteinModelPortaliQ8N554.
SMRiQ8N554. Positions 434-599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124982. 3 interactions.
IntActiQ8N554. 3 interactions.
MINTiMINT-1471309.
STRINGi9606.ENSP00000415836.

PTM databases

iPTMnetiQ8N554.
PhosphoSiteiQ8N554.

Polymorphism and mutation databases

BioMutaiZNF276.
DMDMi296453082.

Proteomic databases

EPDiQ8N554.
MaxQBiQ8N554.
PaxDbiQ8N554.
PRIDEiQ8N554.

Protocols and materials databases

DNASUi92822.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289816; ENSP00000289816; ENSG00000158805. [Q8N554-2]
ENST00000443381; ENSP00000415836; ENSG00000158805. [Q8N554-1]
GeneIDi92822.
KEGGihsa:92822.
UCSCiuc002foq.5. human. [Q8N554-1]

Organism-specific databases

CTDi92822.
GeneCardsiZNF276.
HGNCiHGNC:23330. ZNF276.
HPAiHPA021309.
HPA022255.
MIMi608460. gene.
neXtProtiNX_Q8N554.
PharmGKBiPA134935042.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063153.
HOGENOMiHOG000155790.
HOVERGENiHBG061026.
InParanoidiQ8N554.
OMAiGCDQGHD.
OrthoDBiEOG7SV0TZ.
PhylomeDBiQ8N554.
TreeFamiTF332664.

Miscellaneous databases

ChiTaRSiZNF276. human.
GenomeRNAii92822.
NextBioi77896.
PROiQ8N554.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N554.
CleanExiHS_ZNF276.
ExpressionAtlasiQ8N554. baseline and differential.
GenevisibleiQ8N554. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR012934. Znf_AD.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF07776. zf-AD. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer."
    Wong J.C., Gokgoz N., Alon N., Andrulis I.L., Buchwald M.
    J. Hum. Genet. 48:668-671(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS ARG-263; TRP-275; TRP-351 AND ASP-605.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-614 (ISOFORM 1), VARIANT ARG-263.
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-351 (ISOFORM 1).
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiZN276_HUMAN
AccessioniPrimary (citable) accession number: Q8N554
Secondary accession number(s): Q0VGA1, Q2TBE8, Q3B7H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 111 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.