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Protein

Fibrinogen C domain-containing protein 1

Gene

FIBCD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi393CalciumBy similarity1
Metal bindingi395CalciumBy similarity1
Sitei405Implicated in ligand binding1
Sitei415Implicated in ligand binding1
Sitei431Implicated in ligand binding1
Sitei432Implicated in ligand binding1

GO - Molecular functioni

  • chitin binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Calcium, Chitin-binding, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130720-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen C domain-containing protein 1
Gene namesi
Name:FIBCD1
ORF Names:UNQ701/PRO1346
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:25922. FIBCD1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini55 – 461ExtracellularSequence analysisAdd BLAST407

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi393D → N: Complete loss of binding to acetylated bovine serum albumin and reduced binding to chitin; when associated with A-395. 1 Publication1
Mutagenesisi395D → A: Complete loss of binding to acetylated bovine serum albumin and reduced binding to chitin; when associated with N-395. 1 Publication1
Mutagenesisi405Y → S: Significantly reduced binding to acetylated bovine serum albumin and loss of binding to chitin; when associated with S-431. 1 Publication1
Mutagenesisi415H → G: Complete loss of binding to acetylated bovine serum albumin and chitin. 1 Publication1
Mutagenesisi431Y → S: Significantly reduced binding to acetylated bovine serum albumin and loss of binding to chitin; when associated with S-405. 1 Publication1
Mutagenesisi432A → V: Complete loss of binding to acetylated bovine serum albumin and chitin. 1 Publication1
Mutagenesisi443W → S: Slight reduction in binding to acetylated bovine serum albumin and no effect on binding to chitin. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000130720.
PharmGKBiPA134891641.

Polymorphism and mutation databases

BioMutaiFIBCD1.
DMDMi152032456.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943151 – 461Fibrinogen C domain-containing protein 1Add BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi244 ↔ 273PROSITE-ProRule annotation
Glycosylationi340N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi401 ↔ 414PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N539.
PeptideAtlasiQ8N539.
PRIDEiQ8N539.

PTM databases

iPTMnetiQ8N539.
PhosphoSitePlusiQ8N539.

Expressioni

Tissue specificityi

Expressed in the small and large intestinal epithelial cells with a highly polarized localization to the apical surface corresponding to the brush border and in the ducts of the salivary gland.1 Publication

Gene expression databases

BgeeiENSG00000130720.
CleanExiHS_FIBCD1.
ExpressionAtlasiQ8N539. baseline and differential.
GenevisibleiQ8N539. HS.

Organism-specific databases

HPAiHPA053898.
HPA055353.

Interactioni

Subunit structurei

Homotetramer; disulfide-linked.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MALP211455EBI-10200808,EBI-3932027

Protein-protein interaction databases

BioGridi124363. 1 interactor.
IntActiQ8N539. 1 interactor.
STRINGi9606.ENSP00000361413.

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi244 – 249Combined sources6
Beta strandi256 – 260Combined sources5
Beta strandi269 – 274Combined sources6
Helixi277 – 279Combined sources3
Beta strandi282 – 291Combined sources10
Helixi299 – 304Combined sources6
Beta strandi311 – 314Combined sources4
Helixi317 – 324Combined sources8
Beta strandi329 – 336Combined sources8
Beta strandi342 – 353Combined sources12
Turni359 – 363Combined sources5
Beta strandi366 – 375Combined sources10
Helixi380 – 382Combined sources3
Beta strandi395 – 399Combined sources5
Helixi401 – 404Combined sources4
Beta strandi412 – 414Combined sources3
Beta strandi416 – 418Combined sources3
Beta strandi429 – 432Combined sources4
Beta strandi434 – 437Combined sources4
Helixi438 – 441Combined sources4
Beta strandi443 – 446Combined sources4
Beta strandi448 – 456Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4M7FX-ray2.10A/B236-461[»]
4M7HX-ray2.00A/B236-461[»]
ProteinModelPortaliQ8N539.
SMRiQ8N539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 458Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST224

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiQ8N539.
OMAiRDNDHSE.
OrthoDBiEOG091G03M1.
PhylomeDBiQ8N539.
TreeFamiTF351983.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N539-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVNDRWKTMG GAAQLEDRPR DKPQRPSCGY VLCTVLLALA VLLAVAVTGA
60 70 80 90 100
VLFLNHAHAP GTAPPPVVST GAASANSALV TVERADSSHL SILIDPRCPD
110 120 130 140 150
LTDSFARLES AQASVLQALT EHQAQPRLVG DQEQELLDTL ADQLPRLLAR
160 170 180 190 200
ASELQTECMG LRKGHGTLGQ GLSALQSEQG RLIQLLSESQ GHMAHLVNSV
210 220 230 240 250
SDILDALQRD RGLGRPRNKA DLQRAPARGT RPRGCATGSR PRDCLDVLLS
260 270 280 290 300
GQQDDGVYSV FPTHYPAGFQ VYCDMRTDGG GWTVFQRRED GSVNFFRGWD
310 320 330 340 350
AYRDGFGRLT GEHWLGLKRI HALTTQAAYE LHVDLEDFEN GTAYARYGSF
360 370 380 390 400
GVGLFSVDPE EDGYPLTVAD YSGTAGDSLL KHSGMRFTTK DRDSDHSENN
410 420 430 440 450
CAAFYRGAWW YRNCHTSNLN GQYLRGAHAS YADGVEWSSW TGWQYSLKFS
460
EMKIRPVRED R
Length:461
Mass (Da):50,744
Last modified:July 10, 2007 - v2
Checksum:iB217DBFD370A3443
GO
Isoform 2 (identifier: Q8N539-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: Missing.
     317-357: LKRIHALTTQ...GSFGVGLFSV → PLDRCTLSLA...PPVPGGPTLQ
     358-461: Missing.

Show »
Length:198
Mass (Da):21,564
Checksum:i62988F2B05D27622
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79L → V in AAH32953 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0266181 – 158Missing in isoform 2. 1 PublicationAdd BLAST158
Alternative sequenceiVSP_026619317 – 357LKRIH…GLFSV → PLDRCTLSLALLVPVAPSPT PPHSFVNVLHPPVPGGPTLQ in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_026620358 – 461Missing in isoform 2. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358311 mRNA. Translation: AAQ88678.1.
AK027716 mRNA. Translation: BAB55319.1.
AL161733 Genomic DNA. Translation: CAM45760.1.
AL161733 Genomic DNA. Translation: CAM45761.1.
BC032953 mRNA. Translation: AAH32953.1.
CCDSiCCDS6937.1. [Q8N539-1]
RefSeqiNP_001138578.1. NM_001145106.1. [Q8N539-1]
NP_116232.3. NM_032843.4. [Q8N539-1]
UniGeneiHs.133205.

Genome annotation databases

EnsembliENST00000372338; ENSP00000361413; ENSG00000130720. [Q8N539-1]
ENST00000448616; ENSP00000414501; ENSG00000130720. [Q8N539-1]
GeneIDi84929.
KEGGihsa:84929.
UCSCiuc004bzz.4. human. [Q8N539-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358311 mRNA. Translation: AAQ88678.1.
AK027716 mRNA. Translation: BAB55319.1.
AL161733 Genomic DNA. Translation: CAM45760.1.
AL161733 Genomic DNA. Translation: CAM45761.1.
BC032953 mRNA. Translation: AAH32953.1.
CCDSiCCDS6937.1. [Q8N539-1]
RefSeqiNP_001138578.1. NM_001145106.1. [Q8N539-1]
NP_116232.3. NM_032843.4. [Q8N539-1]
UniGeneiHs.133205.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4M7FX-ray2.10A/B236-461[»]
4M7HX-ray2.00A/B236-461[»]
ProteinModelPortaliQ8N539.
SMRiQ8N539.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124363. 1 interactor.
IntActiQ8N539. 1 interactor.
STRINGi9606.ENSP00000361413.

PTM databases

iPTMnetiQ8N539.
PhosphoSitePlusiQ8N539.

Polymorphism and mutation databases

BioMutaiFIBCD1.
DMDMi152032456.

Proteomic databases

PaxDbiQ8N539.
PeptideAtlasiQ8N539.
PRIDEiQ8N539.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372338; ENSP00000361413; ENSG00000130720. [Q8N539-1]
ENST00000448616; ENSP00000414501; ENSG00000130720. [Q8N539-1]
GeneIDi84929.
KEGGihsa:84929.
UCSCiuc004bzz.4. human. [Q8N539-1]

Organism-specific databases

CTDi84929.
GeneCardsiFIBCD1.
H-InvDBHIX0008476.
HGNCiHGNC:25922. FIBCD1.
HPAiHPA053898.
HPA055353.
MIMi613357. gene.
neXtProtiNX_Q8N539.
OpenTargetsiENSG00000130720.
PharmGKBiPA134891641.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiQ8N539.
OMAiRDNDHSE.
OrthoDBiEOG091G03M1.
PhylomeDBiQ8N539.
TreeFamiTF351983.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130720-MONOMER.

Miscellaneous databases

GenomeRNAii84929.
PROiQ8N539.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130720.
CleanExiHS_FIBCD1.
ExpressionAtlasiQ8N539. baseline and differential.
GenevisibleiQ8N539. HS.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBCD1_HUMAN
AccessioniPrimary (citable) accession number: Q8N539
Secondary accession number(s): A3KFK0, Q6UXK6, Q96SJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.