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Protein

F-box/LRR-repeat protein 6

Gene

FBXL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: ProtInc

GO - Biological processi

  • proteolysis Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 6
Alternative name(s):
F-box and leucine-rich repeat protein 6
F-box protein FBL6
FBL6A
Gene namesi
Name:FBXL6
Synonyms:FBL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:13603. FBXL6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28026.

Polymorphism and mutation databases

DMDMi37537803.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539F-box/LRR-repeat protein 6PRO_0000119847Add
BLAST

Proteomic databases

EPDiQ8N531.
MaxQBiQ8N531.
PaxDbiQ8N531.
PeptideAtlasiQ8N531.
PRIDEiQ8N531.

PTM databases

iPTMnetiQ8N531.
PhosphoSiteiQ8N531.

Expressioni

Gene expression databases

BgeeiENSG00000182325.
CleanExiHS_FBXL6.
GenevisibleiQ8N531. HS.

Organism-specific databases

HPAiHPA008867.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi117624. 20 interactions.
IntActiQ8N531. 18 interactions.
MINTiMINT-4994349.
STRINGi9606.ENSP00000330098.

Structurei

3D structure databases

ProteinModelPortaliQ8N531.
SMRiQ8N531. Positions 196-258, 355-416, 438-504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 162153F-boxAdd
BLAST
Repeati177 – 20327LRR 1Add
BLAST
Repeati204 – 22926LRR 2Add
BLAST
Repeati230 – 25526LRR 3Add
BLAST
Repeati281 – 30727LRR 4Add
BLAST
Repeati312 – 33726LRR 5Add
BLAST
Repeati341 – 36525LRR 6Add
BLAST
Repeati368 – 39326LRR 7Add
BLAST
Repeati394 – 41926LRR 8Add
BLAST
Repeati423 – 44927LRR 9Add
BLAST
Repeati453 – 48129LRR 10Add
BLAST
Repeati482 – 50726LRR 11Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.Curated
Contains 11 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
HOGENOMiHOG000112552.
HOVERGENiHBG051590.
InParanoidiQ8N531.
KOiK10272.
OrthoDBiEOG091G0ABY.
PhylomeDBiQ8N531.
TreeFamiTF324422.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 1 hit.
[Graphical view]
SMARTiSM00367. LRR_CC. 3 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N531-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPASRQVR RRARAAPRPR SAEDWWWDRL APRGSGYHLL QSDSMLLVLS
60 70 80 90 100
EPGPARPRAQ RRASRRTPRQ PPRGPSAAAK PKAGLRSEAA AAPAPAPAPT
110 120 130 140 150
PTPEEGPDAG WGDRIPLEIL VQIFGLLVAA DGPMPFLGRA ARVCRRWQEA
160 170 180 190 200
ASQPALWHTV TLSSPLVGRP AKGGVKAEKK LLASLEWLMP NRFSQLQRLT
210 220 230 240 250
LIHWKSQVHP VLKLVGECCP RLTFLKLSGC HGVTADALVM LAKACCQLHS
260 270 280 290 300
LDLQHSMVES TAVVSFLEEA GSRMRKLWLT YSSQTTAILG ALLGSCCPQL
310 320 330 340 350
QVLEVSTGIN RNSIPLQLPV EALQKGCPQL QVLRLLNLMW LPKPPGRGVA
360 370 380 390 400
PGPGFPSLEE LCLASSTCNF VSNEVLGRLL HGSPNLRLLD LRGCARITPA
410 420 430 440 450
GLQDLPCREL EQLHLGLYGT SDRLTLAKEG SPFLTQKWCH TLRELDLSGQ
460 470 480 490 500
GFSEKDLEQA LAAFLSTPGG SHPALCSLNL RGTRVTPSTV SSVISSCPGL
510 520 530
LYLNLESCRC LPRGLKRAYR GLEEVQWCLE QLLTSPSPS
Length:539
Mass (Da):58,588
Last modified:October 1, 2002 - v1
Checksum:i8153185444653BB2
GO
Isoform 2 (identifier: Q8N531-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-213: Missing.

Show »
Length:533
Mass (Da):57,914
Checksum:i1B9C14DCECFDB41C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei208 – 2136Missing in isoform 2. 2 PublicationsVSP_008498

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026541 mRNA. Translation: BAB15499.1.
AK223088 mRNA. Translation: BAD96808.1.
BC033066 mRNA. Translation: AAH33066.1.
AF174592 mRNA. Translation: AAF04513.1.
CCDSiCCDS47942.1. [Q8N531-2]
CCDS6422.1. [Q8N531-1]
RefSeqiNP_036294.2. NM_012162.3.
NP_078831.4. NM_024555.5.
UniGeneiHs.12271.

Genome annotation databases

EnsembliENST00000331890; ENSP00000330098; ENSG00000182325.
ENST00000455319; ENSP00000403873; ENSG00000182325.
GeneIDi26233.
KEGGihsa:26233.
UCSCiuc003zca.4. human. [Q8N531-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026541 mRNA. Translation: BAB15499.1.
AK223088 mRNA. Translation: BAD96808.1.
BC033066 mRNA. Translation: AAH33066.1.
AF174592 mRNA. Translation: AAF04513.1.
CCDSiCCDS47942.1. [Q8N531-2]
CCDS6422.1. [Q8N531-1]
RefSeqiNP_036294.2. NM_012162.3.
NP_078831.4. NM_024555.5.
UniGeneiHs.12271.

3D structure databases

ProteinModelPortaliQ8N531.
SMRiQ8N531. Positions 196-258, 355-416, 438-504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117624. 20 interactions.
IntActiQ8N531. 18 interactions.
MINTiMINT-4994349.
STRINGi9606.ENSP00000330098.

PTM databases

iPTMnetiQ8N531.
PhosphoSiteiQ8N531.

Polymorphism and mutation databases

DMDMi37537803.

Proteomic databases

EPDiQ8N531.
MaxQBiQ8N531.
PaxDbiQ8N531.
PeptideAtlasiQ8N531.
PRIDEiQ8N531.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331890; ENSP00000330098; ENSG00000182325.
ENST00000455319; ENSP00000403873; ENSG00000182325.
GeneIDi26233.
KEGGihsa:26233.
UCSCiuc003zca.4. human. [Q8N531-1]

Organism-specific databases

CTDi26233.
GeneCardsiFBXL6.
HGNCiHGNC:13603. FBXL6.
HPAiHPA008867.
MIMi609076. gene.
neXtProtiNX_Q8N531.
PharmGKBiPA28026.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
HOGENOMiHOG000112552.
HOVERGENiHBG051590.
InParanoidiQ8N531.
KOiK10272.
OrthoDBiEOG091G0ABY.
PhylomeDBiQ8N531.
TreeFamiTF324422.

Miscellaneous databases

GenomeRNAii26233.
PROiQ8N531.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182325.
CleanExiHS_FBXL6.
GenevisibleiQ8N531. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 1 hit.
[Graphical view]
SMARTiSM00367. LRR_CC. 3 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFBXL6_HUMAN
AccessioniPrimary (citable) accession number: Q8N531
Secondary accession number(s): Q53G43, Q9H5W9, Q9UKC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.