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Protein

F-box/LRR-repeat protein 6

Gene

FBXL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: ProtInc

GO - Biological processi

  • proteolysis Source: ProtInc

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 6
Alternative name(s):
F-box and leucine-rich repeat protein 6
F-box protein FBL6
FBL6A
Gene namesi
Name:FBXL6
Synonyms:FBL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000182325.10
HGNCiHGNC:13603 FBXL6
MIMi609076 gene
neXtProtiNX_Q8N531

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28026

Polymorphism and mutation databases

DMDMi37537803

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198471 – 539F-box/LRR-repeat protein 6Add BLAST539

Proteomic databases

EPDiQ8N531
MaxQBiQ8N531
PaxDbiQ8N531
PeptideAtlasiQ8N531
PRIDEiQ8N531

PTM databases

iPTMnetiQ8N531
PhosphoSitePlusiQ8N531

Expressioni

Gene expression databases

BgeeiENSG00000182325
CleanExiHS_FBXL6
GenevisibleiQ8N531 HS

Organism-specific databases

HPAiHPA008867

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi117624, 21 interactors
IntActiQ8N531, 18 interactors
STRINGi9606.ENSP00000330098

Structurei

3D structure databases

ProteinModelPortaliQ8N531
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 162F-boxAdd BLAST153
Repeati177 – 203LRR 1Add BLAST27
Repeati204 – 229LRR 2Add BLAST26
Repeati230 – 255LRR 3Add BLAST26
Repeati281 – 307LRR 4Add BLAST27
Repeati312 – 337LRR 5Add BLAST26
Repeati341 – 365LRR 6Add BLAST25
Repeati368 – 393LRR 7Add BLAST26
Repeati394 – 419LRR 8Add BLAST26
Repeati423 – 449LRR 9Add BLAST27
Repeati453 – 481LRR 10Add BLAST29
Repeati482 – 507LRR 11Add BLAST26

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1947 Eukaryota
ENOG410XQ54 LUCA
HOGENOMiHOG000112552
HOVERGENiHBG051590
InParanoidiQ8N531
KOiK10272
OrthoDBiEOG091G0ABY
PhylomeDBiQ8N531
TreeFamiTF324422

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF13516 LRR_6, 1 hit
SMARTiView protein in SMART
SM00367 LRR_CC, 3 hits
SUPFAMiSSF81383 SSF81383, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N531-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPASRQVR RRARAAPRPR SAEDWWWDRL APRGSGYHLL QSDSMLLVLS
60 70 80 90 100
EPGPARPRAQ RRASRRTPRQ PPRGPSAAAK PKAGLRSEAA AAPAPAPAPT
110 120 130 140 150
PTPEEGPDAG WGDRIPLEIL VQIFGLLVAA DGPMPFLGRA ARVCRRWQEA
160 170 180 190 200
ASQPALWHTV TLSSPLVGRP AKGGVKAEKK LLASLEWLMP NRFSQLQRLT
210 220 230 240 250
LIHWKSQVHP VLKLVGECCP RLTFLKLSGC HGVTADALVM LAKACCQLHS
260 270 280 290 300
LDLQHSMVES TAVVSFLEEA GSRMRKLWLT YSSQTTAILG ALLGSCCPQL
310 320 330 340 350
QVLEVSTGIN RNSIPLQLPV EALQKGCPQL QVLRLLNLMW LPKPPGRGVA
360 370 380 390 400
PGPGFPSLEE LCLASSTCNF VSNEVLGRLL HGSPNLRLLD LRGCARITPA
410 420 430 440 450
GLQDLPCREL EQLHLGLYGT SDRLTLAKEG SPFLTQKWCH TLRELDLSGQ
460 470 480 490 500
GFSEKDLEQA LAAFLSTPGG SHPALCSLNL RGTRVTPSTV SSVISSCPGL
510 520 530
LYLNLESCRC LPRGLKRAYR GLEEVQWCLE QLLTSPSPS
Length:539
Mass (Da):58,588
Last modified:October 1, 2002 - v1
Checksum:i8153185444653BB2
GO
Isoform 2 (identifier: Q8N531-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-213: Missing.

Show »
Length:533
Mass (Da):57,914
Checksum:i1B9C14DCECFDB41C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008498208 – 213Missing in isoform 2. 2 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026541 mRNA Translation: BAB15499.1
AK223088 mRNA Translation: BAD96808.1
BC033066 mRNA Translation: AAH33066.1
AF174592 mRNA Translation: AAF04513.1
CCDSiCCDS47942.1 [Q8N531-2]
CCDS6422.1 [Q8N531-1]
RefSeqiNP_036294.2, NM_012162.3
NP_078831.4, NM_024555.5
UniGeneiHs.12271

Genome annotation databases

EnsembliENST00000331890; ENSP00000330098; ENSG00000182325
ENST00000455319; ENSP00000403873; ENSG00000182325
GeneIDi26233
KEGGihsa:26233
UCSCiuc003zca.4 human [Q8N531-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFBXL6_HUMAN
AccessioniPrimary (citable) accession number: Q8N531
Secondary accession number(s): Q53G43, Q9H5W9, Q9UKC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health