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Q8N531 (FBXL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box/LRR-repeat protein 6
Alternative name(s):
F-box and leucine-rich repeat protein 6
F-box protein FBL6
FBL6A
Gene names
Name:FBXL6
Synonyms:FBL6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length539 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex By similarity.

Subunit structure

Directly interacts with SKP1 and CUL1 By similarity.

Sequence similarities

Contains 1 F-box domain.

Contains 11 LRR (leucine-rich) repeats.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Coding sequence diversityAlternative splicing
   DomainLeucine-rich repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein ubiquitination

Traceable author statement Ref.4. Source: GOC

proteolysis

Traceable author statement Ref.4. Source: ProtInc

   Molecular_functionubiquitin-protein ligase activity

Traceable author statement Ref.4. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N531-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N531-2)

The sequence of this isoform differs from the canonical sequence as follows:
     208-213: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 539539F-box/LRR-repeat protein 6
PRO_0000119847

Regions

Domain10 – 162153F-box
Repeat177 – 20327LRR 1
Repeat204 – 22926LRR 2
Repeat230 – 25526LRR 3
Repeat281 – 30727LRR 4
Repeat312 – 33726LRR 5
Repeat341 – 36525LRR 6
Repeat368 – 39326LRR 7
Repeat394 – 41926LRR 8
Repeat423 – 44927LRR 9
Repeat453 – 48129LRR 10
Repeat482 – 50726LRR 11

Natural variations

Alternative sequence208 – 2136Missing in isoform 2.
VSP_008498

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 8153185444653BB2

FASTA53958,588
        10         20         30         40         50         60 
MAAPASRQVR RRARAAPRPR SAEDWWWDRL APRGSGYHLL QSDSMLLVLS EPGPARPRAQ 

        70         80         90        100        110        120 
RRASRRTPRQ PPRGPSAAAK PKAGLRSEAA AAPAPAPAPT PTPEEGPDAG WGDRIPLEIL 

       130        140        150        160        170        180 
VQIFGLLVAA DGPMPFLGRA ARVCRRWQEA ASQPALWHTV TLSSPLVGRP AKGGVKAEKK 

       190        200        210        220        230        240 
LLASLEWLMP NRFSQLQRLT LIHWKSQVHP VLKLVGECCP RLTFLKLSGC HGVTADALVM 

       250        260        270        280        290        300 
LAKACCQLHS LDLQHSMVES TAVVSFLEEA GSRMRKLWLT YSSQTTAILG ALLGSCCPQL 

       310        320        330        340        350        360 
QVLEVSTGIN RNSIPLQLPV EALQKGCPQL QVLRLLNLMW LPKPPGRGVA PGPGFPSLEE 

       370        380        390        400        410        420 
LCLASSTCNF VSNEVLGRLL HGSPNLRLLD LRGCARITPA GLQDLPCREL EQLHLGLYGT 

       430        440        450        460        470        480 
SDRLTLAKEG SPFLTQKWCH TLRELDLSGQ GFSEKDLEQA LAAFLSTPGG SHPALCSLNL 

       490        500        510        520        530 
RGTRVTPSTV SSVISSCPGL LYLNLESCRC LPRGLKRAYR GLEEVQWCLE QLLTSPSPS 

« Hide

Isoform 2 [UniParc].

Checksum: 1B9C14DCECFDB41C
Show »

FASTA53357,914

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skin.
[4]"Identification of a family of human F-box proteins."
Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M., Pagano M.
Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 90-372 (ISOFORMS 1/2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK026541 mRNA. Translation: BAB15499.1.
AK223088 mRNA. Translation: BAD96808.1.
BC033066 mRNA. Translation: AAH33066.1.
AF174592 mRNA. Translation: AAF04513.1.
RefSeqNP_036294.2. NM_012162.3.
NP_078831.4. NM_024555.5.
UniGeneHs.12271.

3D structure databases

ProteinModelPortalQ8N531.
SMRQ8N531. Positions 191-534.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117624. 3 interactions.
IntActQ8N531. 1 interaction.
MINTMINT-4994349.
STRING9606.ENSP00000330098.

PTM databases

PhosphoSiteQ8N531.

Polymorphism databases

DMDM37537803.

Proteomic databases

PaxDbQ8N531.
PRIDEQ8N531.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331890; ENSP00000330098; ENSG00000182325. [Q8N531-1]
ENST00000455319; ENSP00000403873; ENSG00000182325. [Q8N531-2]
GeneID26233.
KEGGhsa:26233.
UCSCuc003zca.3. human. [Q8N531-2]
uc003zcb.3. human. [Q8N531-1]

Organism-specific databases

CTD26233.
GeneCardsGC08M145579.
HGNCHGNC:13603. FBXL6.
HPAHPA008867.
MIM609076. gene.
neXtProtNX_Q8N531.
PharmGKBPA28026.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG258260.
HOGENOMHOG000112552.
HOVERGENHBG051590.
InParanoidQ8N531.
KOK10272.
OMARWHEAAS.
OrthoDBEOG70S74T.
PhylomeDBQ8N531.
TreeFamTF324422.

Gene expression databases

ArrayExpressQ8N531.
BgeeQ8N531.
CleanExHS_FBXL6.
GenevestigatorQ8N531.

Family and domain databases

InterProIPR001810. F-box_dom.
[Graphical view]
SUPFAMSSF81383. SSF81383. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi26233.
NextBio48411.
PROQ8N531.
SOURCESearch...

Entry information

Entry nameFBXL6_HUMAN
AccessionPrimary (citable) accession number: Q8N531
Secondary accession number(s): Q53G43, Q9H5W9, Q9UKC7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM