Q8N531 (FBXL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
F-box/LRR-repeat protein 6

Alternative name(s):
F-box and leucine-rich repeat protein 6
F-box protein FBL6
FBL6A

Gene names

Name:	FBXL6
Synonyms:	FBL6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	539 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex By similarity.
Subunit structure	Directly interacts with SKP1 and CUL1 By similarity.
Sequence similarities	Contains 1 F-box domain. Contains 11 LRR (leucine-rich) repeats.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Alternative splicing
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Traceable author statement Ref.4. Source: ProtInc
Molecular_function	ubiquitin-protein ligase activity Traceable author statement Ref.4. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N531-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N531-2)

The sequence of this isoform differs from the canonical sequence as follows:
     208-213: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 539	539	F-box/LRR-repeat protein 6		PRO_0000119847
Regions
	Domain	10 – 162	153	F-box
	Repeat	177 – 203	27	LRR 1
	Repeat	204 – 229	26	LRR 2
	Repeat	230 – 255	26	LRR 3
	Repeat	281 – 307	27	LRR 4
	Repeat	312 – 337	26	LRR 5
	Repeat	341 – 365	25	LRR 6
	Repeat	368 – 393	26	LRR 7
	Repeat	394 – 419	26	LRR 8
	Repeat	423 – 449	27	LRR 9
	Repeat	453 – 481	29	LRR 10
	Repeat	482 – 507	26	LRR 11
Natural variations
	Alternative sequence	208 – 213	6	Missing in isoform 2.		VSP_008498

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 8153185444653BB2	FASTA	539	58,588
	10 20 30 40 50 60 MAAPASRQVR RRARAAPRPR SAEDWWWDRL APRGSGYHLL QSDSMLLVLS EPGPARPRAQ 70 80 90 100 110 120 RRASRRTPRQ PPRGPSAAAK PKAGLRSEAA AAPAPAPAPT PTPEEGPDAG WGDRIPLEIL 130 140 150 160 170 180 VQIFGLLVAA DGPMPFLGRA ARVCRRWQEA ASQPALWHTV TLSSPLVGRP AKGGVKAEKK 190 200 210 220 230 240 LLASLEWLMP NRFSQLQRLT LIHWKSQVHP VLKLVGECCP RLTFLKLSGC HGVTADALVM 250 260 270 280 290 300 LAKACCQLHS LDLQHSMVES TAVVSFLEEA GSRMRKLWLT YSSQTTAILG ALLGSCCPQL 310 320 330 340 350 360 QVLEVSTGIN RNSIPLQLPV EALQKGCPQL QVLRLLNLMW LPKPPGRGVA PGPGFPSLEE 370 380 390 400 410 420 LCLASSTCNF VSNEVLGRLL HGSPNLRLLD LRGCARITPA GLQDLPCREL EQLHLGLYGT 430 440 450 460 470 480 SDRLTLAKEG SPFLTQKWCH TLRELDLSGQ GFSEKDLEQA LAAFLSTPGG SHPALCSLNL 490 500 510 520 530 RGTRVTPSTV SSVISSCPGL LYLNLESCRC LPRGLKRAYR GLEEVQWCLE QLLTSPSPS
	Isoform 2 [UniParc]. Checksum: 1B9C14DCECFDB41C	FASTA	533	57,914
	10 20 30 40 50 60 MAAPASRQVR RRARAAPRPR SAEDWWWDRL APRGSGYHLL QSDSMLLVLS EPGPARPRAQ 70 80 90 100 110 120 RRASRRTPRQ PPRGPSAAAK PKAGLRSEAA AAPAPAPAPT PTPEEGPDAG WGDRIPLEIL 130 140 150 160 170 180 VQIFGLLVAA DGPMPFLGRA ARVCRRWQEA ASQPALWHTV TLSSPLVGRP AKGGVKAEKK 190 200 210 220 230 240 LLASLEWLMP NRFSQLQRLT LIHWKSQLVG ECCPRLTFLK LSGCHGVTAD ALVMLAKACC 250 260 270 280 290 300 QLHSLDLQHS MVESTAVVSF LEEAGSRMRK LWLTYSSQTT AILGALLGSC CPQLQVLEVS 310 320 330 340 350 360 TGINRNSIPL QLPVEALQKG CPQLQVLRLL NLMWLPKPPG RGVAPGPGFP SLEELCLASS 370 380 390 400 410 420 TCNFVSNEVL GRLLHGSPNL RLLDLRGCAR ITPAGLQDLP CRELEQLHLG LYGTSDRLTL 430 440 450 460 470 480 AKEGSPFLTQ KWCHTLRELD LSGQGFSEKD LEQALAAFLS TPGGSHPALC SLNLRGTRVT 490 500 510 520 530 PSTVSSVISS CPGLLYLNLE SCRCLPRGLK RAYRGLEEVQ WCLEQLLTSP SPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
[4]	"Identification of a family of human F-box proteins." Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M., Pagano M. Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 90-372 (ISOFORMS 1/2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK026541 mRNA. Translation: BAB15499.1. AK223088 mRNA. Translation: BAD96808.1. BC033066 mRNA. Translation: AAH33066.1. AF174592 mRNA. Translation: AAF04513.1.
IPI	IPI00166767. IPI00377163.
RefSeq	NP_036294.1. NM_012162.2. NP_078831.3. NM_024555.4.
UniGene	Hs.12271.
3D structure databases
ProteinModelPortal	Q8N531.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N531. 1 interaction.
MINT	MINT-4994349.
STRING	9606.ENSP00000330098.
PTM databases
PhosphoSite	Q8N531.
Polymorphism databases
DMDM	37537803.
Proteomic databases
PaxDb	Q8N531.
PRIDE	Q8N531.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331890; ENSP00000330098; ENSG00000182325. ENST00000455319; ENSP00000403873; ENSG00000182325.
GeneID	26233.
KEGG	hsa:26233.
UCSC	uc003zca.3. human. uc003zcb.3. human.
Organism-specific databases
CTD	26233.
GeneCards	GC08M145579.
HGNC	HGNC:13603. FBXL6.
MIM	609076. gene.
neXtProt	NX_Q8N531.
PharmGKB	PA28026.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG258260.
HOGENOM	HOG000112552.
HOVERGEN	HBG051590.
InParanoid	Q8N531.
KO	K10272.
OMA	LQHSMVE.
PhylomeDB	Q8N531.
Gene expression databases
ArrayExpress	Q8N531.
Bgee	Q8N531.
CleanEx	HS_FBXL6.
Genevestigator	Q8N531.
GermOnline	ENSG00000182325. Homo sapiens.
Family and domain databases
InterPro	IPR001810. F-box_dom_cyclin-like. [Graphical view]
SUPFAM	SSF81383. F-box_dom_Skp2-like. 1 hit.
PROSITE	PS50181. FBOX. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26233.
NextBio	48411.
SOURCE	Search...

Entry information

Entry name

FBXL6_HUMAN

Accession

Primary (citable) accession number: Q8N531
Secondary accession number(s): Q53G43, Q9H5W9, Q9UKC7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	October 1, 2002
Last modified:	May 29, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.