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Protein

Ras-related protein Rab-42

Gene

RAB42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 24GTPBy similarity9
Nucleotide bindingi40 – 46GTPBy similarity7
Nucleotide bindingi70 – 74GTPBy similarity5
Nucleotide bindingi129 – 132GTPBy similarity4
Nucleotide bindingi159 – 161GTPBy similarity3

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719. RAB geranylgeranylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-42Curated
Gene namesi
Name:RAB42Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188060.6.
HGNCiHGNC:28702. RAB42.
neXtProtiNX_Q8N4Z0.

Subcellular locationi

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188060.
PharmGKBiPA134976516.

Polymorphism and mutation databases

BioMutaiRAB42.
DMDMi74751010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002698481 – 218Ras-related protein Rab-42Add BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi216S-geranylgeranyl cysteineBy similarity1
Lipidationi218S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ8N4Z0.
MaxQBiQ8N4Z0.
PaxDbiQ8N4Z0.
PeptideAtlasiQ8N4Z0.
PRIDEiQ8N4Z0.

PTM databases

iPTMnetiQ8N4Z0.
PhosphoSitePlusiQ8N4Z0.

Expressioni

Gene expression databases

BgeeiENSG00000188060.
CleanExiHS_RAB42.
ExpressionAtlasiQ8N4Z0. baseline and differential.
GenevisibleiQ8N4Z0. HS.

Organism-specific databases

HPAiHPA050290.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GLYR1Q49A26-44EBI-12878310,EBI-12143817

Protein-protein interaction databases

IntActiQ8N4Z0. 2 interactors.
STRINGi9606.ENSP00000362932.

Structurei

3D structure databases

ProteinModelPortaliQ8N4Z0.
SMRiQ8N4Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0091. Eukaryota.
ENOG410ZQFG. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000059540.
InParanoidiQ8N4Z0.
KOiK07929.
OMAiTIRCITR.
OrthoDBiEOG091G107V.
PhylomeDBiQ8N4Z0.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4Z0-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAEGCRYQF RVALLGDAAV GKTSLLRSYV AGAPGAPEPE PEPEPTVGAE
60 70 80 90 100
CYRRALQLRA GPRVKLQLWD TAGHERFRCI TRSFYRNVVG VLLVFDVTNR
110 120 130 140 150
KSFEHIQDWH QEVMATQGPD KVIFLLVGHK SDLQSTRCVS AQEAEELAAS
160 170 180 190 200
LGMAFVETSV KNNCNVDLAF DTLADAIQQA LQQGDIKLEE GWGGVRLIHK
210
TQIPRSPSRK QHSGPCQC
Note: No experimental confirmation available. Gene prediction based on EST data.Curated
Length:218
Mass (Da):24,133
Last modified:December 20, 2017 - v2
Checksum:iB06EB7CC11591611
GO
Isoform 2 (identifier: Q8N4Z0-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:105
Mass (Da):11,364
Checksum:i5BF0C346E89E8F07
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0592581 – 113Missing in isoform 2. Add BLAST113

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312176 mRNA. Translation: BAG35109.1.
AL513497 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07684.1.
BC033175 mRNA. Translation: AAH33175.1.
CCDSiCCDS325.1. [Q8N4Z0-2]
RefSeqiNP_001180461.1. NM_001193532.1.
NP_689517.1. NM_152304.1.
UniGeneiHs.652321.
Hs.660005.

Genome annotation databases

EnsembliENST00000373826; ENSP00000362932; ENSG00000188060. [Q8N4Z0-1]
ENST00000465518; ENSP00000491546; ENSG00000188060. [Q8N4Z0-2]
GeneIDi115273.
KEGGihsa:115273.
UCSCiuc001bqu.4. human. [Q8N4Z0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRAB42_HUMAN
AccessioniPrimary (citable) accession number: Q8N4Z0
Secondary accession number(s): A0A1W2PQ57, B2R5G2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 20, 2017
Last modified: January 31, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families