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Protein

Putative Ras-related protein Rab-42

Gene

RAB42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 19GTPBy similarity4

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719. RAB geranylgeranylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Ras-related protein Rab-42
Gene namesi
Name:RAB42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188060.6.
HGNCiHGNC:28702. RAB42.

Subcellular locationi

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188060.
PharmGKBiPA134976516.

Polymorphism and mutation databases

BioMutaiRAB42.
DMDMi74751010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002698481 – 105Putative Ras-related protein Rab-42Add BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi103S-geranylgeranyl cysteineBy similarity1
Modified residuei105Cysteine methyl esterBy similarity1
Lipidationi105S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ8N4Z0.
PaxDbiQ8N4Z0.
PeptideAtlasiQ8N4Z0.
PRIDEiQ8N4Z0.

PTM databases

iPTMnetiQ8N4Z0.
PhosphoSitePlusiQ8N4Z0.

Expressioni

Gene expression databases

BgeeiENSG00000188060.
CleanExiHS_RAB42.
GenevisibleiQ8N4Z0. HS.

Organism-specific databases

HPAiHPA050290.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GLYR1Q49A26-44EBI-12878310,EBI-12143817

Protein-protein interaction databases

IntActiQ8N4Z0. 2 interactors.
STRINGi9606.ENSP00000362932.

Structurei

3D structure databases

ProteinModelPortaliQ8N4Z0.
SMRiQ8N4Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0091. Eukaryota.
ENOG410ZQFG. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000059540.
InParanoidiQ8N4Z0.
KOiK07929.
OMAiTIRCITR.
OrthoDBiEOG091G107V.
PhylomeDBiQ8N4Z0.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N4Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQGPDKVI FLLVGHKSDL QSTRCVSAQE AEELAASLGM AFVETSVKNN
60 70 80 90 100
CNVDLAFDTL ADAIQQALQQ GDIKLEEGWG GVRLIHKTQI PRSPSRKQHS

GPCQC
Length:105
Mass (Da):11,364
Last modified:October 1, 2002 - v1
Checksum:i5BF0C346E89E8F07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312176 mRNA. Translation: BAG35109.1.
AL513497 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07684.1.
BC033175 mRNA. Translation: AAH33175.1.
CCDSiCCDS325.1.
RefSeqiNP_001180461.1. NM_001193532.1.
NP_689517.1. NM_152304.1.
UniGeneiHs.652321.

Genome annotation databases

EnsembliENST00000373826; ENSP00000362932; ENSG00000188060.
GeneIDi115273.
KEGGihsa:115273.
UCSCiuc001bqu.4. human.

Similar proteinsi

Entry informationi

Entry nameiRAB42_HUMAN
AccessioniPrimary (citable) accession number: Q8N4Z0
Secondary accession number(s): B2R5G2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. N-terminally truncated compared to paralogs.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families