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Protein

EF-hand calcium-binding domain-containing protein 4A

Gene

CRACR2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in store-operated Ca2+ entry (SOCE).1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular protein localization Source: Ensembl
  • regulation of store-operated calcium entry Source: Ensembl
  • store-operated calcium entry Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 4A
Alternative name(s):
Calcium release-activated calcium channel regulator 2B
Short name:
CRAC channel regulator 2B
Calcium release-activated channel regulator 2B
Gene namesi
Name:CRACR2B
Synonyms:EFCAB4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000177685.16
HGNCiHGNC:28703 CRACR2B
MIMi614177 gene
neXtProtiNX_Q8N4Y2

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi283229
OpenTargetsiENSG00000177685
PharmGKBiPA144596437

Polymorphism and mutation databases

BioMutaiEFCAB4A
DMDMi300669695

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830441 – 399EF-hand calcium-binding domain-containing protein 4AAdd BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N4Y2
PaxDbiQ8N4Y2
PeptideAtlasiQ8N4Y2
PRIDEiQ8N4Y2

PTM databases

iPTMnetiQ8N4Y2
PhosphoSitePlusiQ8N4Y2

Expressioni

Gene expression databases

BgeeiENSG00000177685
CleanExiHS_EFCAB4A
ExpressionAtlasiQ8N4Y2 baseline and differential
GenevisibleiQ8N4Y2 HS

Organism-specific databases

HPAiHPA046217

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi129503, 7 interactors
IntActiQ8N4Y2, 14 interactors
STRINGi9606.ENSP00000409256

Structurei

3D structure databases

ProteinModelPortaliQ8N4Y2
SMRiQ8N4Y2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 61EF-hand 1PROSITE-ProRule annotationAdd BLAST29
Domaini67 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili181 – 358Sequence analysisAdd BLAST178

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi378 – 383Cys-rich6

Sequence similaritiesi

Belongs to the EFCAB4 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IVA9 Eukaryota
ENOG410Z5VW LUCA
GeneTreeiENSGT00440000033504
HOGENOMiHOG000112335
InParanoidiQ8N4Y2
KOiK17199
OMAiLWTRLQR
OrthoDBiEOG091G0MRW
PhylomeDBiQ8N4Y2
TreeFamiTF329556

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4Y2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPGKPGAD EAQEEEGELE GGSAGPRAAI LEQAEELFLL CDKEAKGFIT
60 70 80 90 100
KHDLQGLQSD LPLTPEQLEA VFESLDRAHT GFLTAREFCL GLGMFVGVAS
110 120 130 140 150
AQGANPCRTP EETFESGGLD VQGTAGSLDE EEEEEERFHT VLEQLGVAPV
160 170 180 190 200
LGKQRAVRTL WARLQRERPE LLGSFEDVLI RASACLEEAA RERDGLEQAL
210 220 230 240 250
RRRESEHERE VRALYEETEQ LREQSRRPPS QNFARGERRS RLELELQSRE
260 270 280 290 300
QDLERAGLRQ RELEQQLHAQ AAEHLEAQAQ NSQLWRAHEA LRTQLEGAQE
310 320 330 340 350
QIRRLESEAR GRQEQTQRDV VAVSRNMQKE KVSLLRQLEL LRELNTRLRD
360 370 380 390
DRDACEARRA GSSCRKALTT ARLPGPTCCC CCCWARPPRR GSGHLPSAR
Length:399
Mass (Da):44,956
Last modified:July 13, 2010 - v3
Checksum:i116E54FD8B3F98CA
GO
Isoform 2 (identifier: Q8N4Y2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.
     90-92: LGL → MPA
     153-153: K → DSRPPSR
     263-399: LEQQLHAQAA...RGSGHLPSAR → VSTRPLPCPH...SPVSILPPSS

Show »
Length:230
Mass (Da):25,685
Checksum:i5D5F3FE5170AF852
GO
Isoform 3 (identifier: Q8N4Y2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-399: LEQQLHAQAA...RGSGHLPSAR → RRGRRLQEHAERESQPATATGAAQGAEYTAAG

Show »
Length:294
Mass (Da):32,746
Checksum:i83B10BF18E8717B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03147977R → Q1 PublicationCorresponds to variant dbSNP:rs7126805Ensembl.1
Natural variantiVAR_031480153K → E1 PublicationCorresponds to variant dbSNP:rs28558789Ensembl.1
Natural variantiVAR_031481173G → S. Corresponds to variant dbSNP:rs35567200Ensembl.1
Natural variantiVAR_031482248S → I2 PublicationsCorresponds to variant dbSNP:rs4075289Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242901 – 89Missing in isoform 2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_02429190 – 92LGL → MPA in isoform 2. 1 Publication3
Alternative sequenceiVSP_024292153K → DSRPPSR in isoform 2. 1 Publication1
Alternative sequenceiVSP_024293263 – 399LEQQL…LPSAR → VSTRPLPCPHGRPCTLPLCL SVPGLSGAWGTRSTPGKRGR SSPVSILPPSS in isoform 2. 1 PublicationAdd BLAST137
Alternative sequenceiVSP_039545263 – 399LEQQL…LPSAR → RRGRRLQEHAERESQPATAT GAAQGAEYTAAG in isoform 3. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU952799 mRNA Translation: ADD96763.1
AK075180 mRNA Translation: BAC11455.1
AP006621 Genomic DNA No translation available.
BC033196 mRNA Translation: AAH33196.1
BC073821 mRNA Translation: AAH73821.1
CCDSiCCDS41588.1 [Q8N4Y2-3]
CCDS65995.1 [Q8N4Y2-1]
RefSeqiNP_001273535.1, NM_001286606.1 [Q8N4Y2-1]
NP_775855.3, NM_173584.4 [Q8N4Y2-3]
XP_016873088.1, XM_017017599.1 [Q8N4Y2-3]
UniGeneiHs.660936

Genome annotation databases

EnsembliENST00000450448; ENSP00000409256; ENSG00000177685 [Q8N4Y2-3]
ENST00000525077; ENSP00000435299; ENSG00000177685 [Q8N4Y2-1]
ENST00000528542; ENSP00000432334; ENSG00000177685 [Q8N4Y2-3]
GeneIDi283229
KEGGihsa:283229
UCSCiuc001lrv.3 human [Q8N4Y2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiEFC4A_HUMAN
AccessioniPrimary (citable) accession number: Q8N4Y2
Secondary accession number(s): D5LPR2, Q8NBW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 13, 2010
Last modified: April 25, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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