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Protein

EF-hand calcium-binding domain-containing protein 4A

Gene

CRACR2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in store-operated Ca2+ entry (SOCE).1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular protein localization Source: Ensembl
  • regulation of store-operated calcium entry Source: Ensembl
  • store-operated calcium entry Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 4A
Alternative name(s):
Calcium release-activated calcium channel regulator 2B
Short name:
CRAC channel regulator 2B
Calcium release-activated channel regulator 2B
Gene namesi
Name:CRACR2B
Synonyms:EFCAB4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28703. CRACR2B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi283229.
OpenTargetsiENSG00000177685.
PharmGKBiPA144596437.

Polymorphism and mutation databases

BioMutaiEFCAB4A.
DMDMi300669695.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830441 – 399EF-hand calcium-binding domain-containing protein 4AAdd BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N4Y2.
PaxDbiQ8N4Y2.
PeptideAtlasiQ8N4Y2.
PRIDEiQ8N4Y2.

PTM databases

iPTMnetiQ8N4Y2.
PhosphoSitePlusiQ8N4Y2.

Expressioni

Gene expression databases

BgeeiENSG00000177685.
CleanExiHS_EFCAB4A.
ExpressionAtlasiQ8N4Y2. baseline and differential.
GenevisibleiQ8N4Y2. HS.

Organism-specific databases

HPAiHPA046217.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TCEANCQ8N8B73EBI-10267893,EBI-954696

Protein-protein interaction databases

BioGridi129503. 6 interactors.
IntActiQ8N4Y2. 13 interactors.
STRINGi9606.ENSP00000409256.

Structurei

3D structure databases

ProteinModelPortaliQ8N4Y2.
SMRiQ8N4Y2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 61EF-hand 1PROSITE-ProRule annotationAdd BLAST29
Domaini67 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili181 – 358Sequence analysisAdd BLAST178

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi378 – 383Cys-rich6

Sequence similaritiesi

Belongs to the EFCAB4 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IVA9. Eukaryota.
ENOG410Z5VW. LUCA.
GeneTreeiENSGT00440000033504.
HOGENOMiHOG000112335.
InParanoidiQ8N4Y2.
KOiK17199.
OMAiSREMNKK.
OrthoDBiEOG091G0MRW.
PhylomeDBiQ8N4Y2.
TreeFamiTF329556.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4Y2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPGKPGAD EAQEEEGELE GGSAGPRAAI LEQAEELFLL CDKEAKGFIT
60 70 80 90 100
KHDLQGLQSD LPLTPEQLEA VFESLDRAHT GFLTAREFCL GLGMFVGVAS
110 120 130 140 150
AQGANPCRTP EETFESGGLD VQGTAGSLDE EEEEEERFHT VLEQLGVAPV
160 170 180 190 200
LGKQRAVRTL WARLQRERPE LLGSFEDVLI RASACLEEAA RERDGLEQAL
210 220 230 240 250
RRRESEHERE VRALYEETEQ LREQSRRPPS QNFARGERRS RLELELQSRE
260 270 280 290 300
QDLERAGLRQ RELEQQLHAQ AAEHLEAQAQ NSQLWRAHEA LRTQLEGAQE
310 320 330 340 350
QIRRLESEAR GRQEQTQRDV VAVSRNMQKE KVSLLRQLEL LRELNTRLRD
360 370 380 390
DRDACEARRA GSSCRKALTT ARLPGPTCCC CCCWARPPRR GSGHLPSAR
Length:399
Mass (Da):44,956
Last modified:July 13, 2010 - v3
Checksum:i116E54FD8B3F98CA
GO
Isoform 2 (identifier: Q8N4Y2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.
     90-92: LGL → MPA
     153-153: K → DSRPPSR
     263-399: LEQQLHAQAA...RGSGHLPSAR → VSTRPLPCPH...SPVSILPPSS

Show »
Length:230
Mass (Da):25,685
Checksum:i5D5F3FE5170AF852
GO
Isoform 3 (identifier: Q8N4Y2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-399: LEQQLHAQAA...RGSGHLPSAR → RRGRRLQEHAERESQPATATGAAQGAEYTAAG

Show »
Length:294
Mass (Da):32,746
Checksum:i83B10BF18E8717B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03147977R → Q.1 PublicationCorresponds to variant rs7126805dbSNPEnsembl.1
Natural variantiVAR_031480153K → E.1 PublicationCorresponds to variant rs28558789dbSNPEnsembl.1
Natural variantiVAR_031481173G → S.Corresponds to variant rs35567200dbSNPEnsembl.1
Natural variantiVAR_031482248S → I.2 PublicationsCorresponds to variant rs4075289dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242901 – 89Missing in isoform 2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_02429190 – 92LGL → MPA in isoform 2. 1 Publication3
Alternative sequenceiVSP_024292153K → DSRPPSR in isoform 2. 1 Publication1
Alternative sequenceiVSP_024293263 – 399LEQQL…LPSAR → VSTRPLPCPHGRPCTLPLCL SVPGLSGAWGTRSTPGKRGR SSPVSILPPSS in isoform 2. 1 PublicationAdd BLAST137
Alternative sequenceiVSP_039545263 – 399LEQQL…LPSAR → RRGRRLQEHAERESQPATAT GAAQGAEYTAAG in isoform 3. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU952799 mRNA. Translation: ADD96763.1.
AK075180 mRNA. Translation: BAC11455.1.
AP006621 Genomic DNA. No translation available.
BC033196 mRNA. Translation: AAH33196.1.
BC073821 mRNA. Translation: AAH73821.1.
CCDSiCCDS41588.1. [Q8N4Y2-3]
CCDS65995.1. [Q8N4Y2-1]
RefSeqiNP_001273535.1. NM_001286606.1. [Q8N4Y2-1]
NP_775855.3. NM_173584.4. [Q8N4Y2-3]
XP_016873088.1. XM_017017599.1. [Q8N4Y2-3]
UniGeneiHs.660936.

Genome annotation databases

EnsembliENST00000450448; ENSP00000409256; ENSG00000177685. [Q8N4Y2-3]
ENST00000525077; ENSP00000435299; ENSG00000177685. [Q8N4Y2-1]
ENST00000528542; ENSP00000432334; ENSG00000177685. [Q8N4Y2-3]
GeneIDi283229.
KEGGihsa:283229.
UCSCiuc001lrv.3. human. [Q8N4Y2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU952799 mRNA. Translation: ADD96763.1.
AK075180 mRNA. Translation: BAC11455.1.
AP006621 Genomic DNA. No translation available.
BC033196 mRNA. Translation: AAH33196.1.
BC073821 mRNA. Translation: AAH73821.1.
CCDSiCCDS41588.1. [Q8N4Y2-3]
CCDS65995.1. [Q8N4Y2-1]
RefSeqiNP_001273535.1. NM_001286606.1. [Q8N4Y2-1]
NP_775855.3. NM_173584.4. [Q8N4Y2-3]
XP_016873088.1. XM_017017599.1. [Q8N4Y2-3]
UniGeneiHs.660936.

3D structure databases

ProteinModelPortaliQ8N4Y2.
SMRiQ8N4Y2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129503. 6 interactors.
IntActiQ8N4Y2. 13 interactors.
STRINGi9606.ENSP00000409256.

PTM databases

iPTMnetiQ8N4Y2.
PhosphoSitePlusiQ8N4Y2.

Polymorphism and mutation databases

BioMutaiEFCAB4A.
DMDMi300669695.

Proteomic databases

MaxQBiQ8N4Y2.
PaxDbiQ8N4Y2.
PeptideAtlasiQ8N4Y2.
PRIDEiQ8N4Y2.

Protocols and materials databases

DNASUi283229.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000450448; ENSP00000409256; ENSG00000177685. [Q8N4Y2-3]
ENST00000525077; ENSP00000435299; ENSG00000177685. [Q8N4Y2-1]
ENST00000528542; ENSP00000432334; ENSG00000177685. [Q8N4Y2-3]
GeneIDi283229.
KEGGihsa:283229.
UCSCiuc001lrv.3. human. [Q8N4Y2-1]

Organism-specific databases

CTDi283229.
DisGeNETi283229.
GeneCardsiCRACR2B.
HGNCiHGNC:28703. CRACR2B.
HPAiHPA046217.
MIMi614177. gene.
neXtProtiNX_Q8N4Y2.
OpenTargetsiENSG00000177685.
PharmGKBiPA144596437.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVA9. Eukaryota.
ENOG410Z5VW. LUCA.
GeneTreeiENSGT00440000033504.
HOGENOMiHOG000112335.
InParanoidiQ8N4Y2.
KOiK17199.
OMAiSREMNKK.
OrthoDBiEOG091G0MRW.
PhylomeDBiQ8N4Y2.
TreeFamiTF329556.

Miscellaneous databases

GenomeRNAii283229.
PROiQ8N4Y2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177685.
CleanExiHS_EFCAB4A.
ExpressionAtlasiQ8N4Y2. baseline and differential.
GenevisibleiQ8N4Y2. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFC4A_HUMAN
AccessioniPrimary (citable) accession number: Q8N4Y2
Secondary accession number(s): D5LPR2, Q8NBW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 13, 2010
Last modified: November 30, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.