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Q8N4X5

- AF1L2_HUMAN

UniProt

Q8N4X5 - AF1L2_HUMAN

Protein

Actin filament-associated protein 1-like 2

Gene

AFAP1L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.1 Publication

    GO - Molecular functioni

    1. protein tyrosine kinase activator activity Source: HGNC
    2. SH2 domain binding Source: HGNC
    3. SH3 domain binding Source: HGNC

    GO - Biological processi

    1. inflammatory response Source: HGNC
    2. positive regulation of epidermal growth factor receptor signaling pathway Source: HGNC
    3. positive regulation of interleukin-8 production Source: HGNC
    4. positive regulation of protein tyrosine kinase activity Source: GOC
    5. positive regulation of transcription, DNA-templated Source: HGNC
    6. regulation of interleukin-6 production Source: HGNC
    7. regulation of mitotic cell cycle Source: HGNC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Actin filament-associated protein 1-like 2
    Short name:
    AFAP1-like protein 2
    Gene namesi
    Name:AFAP1L2
    Synonyms:KIAA1914, XB130
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:25901. AFAP1L2.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HGNC

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi4 – 41Y → F: Reduced interaction with SRC. 1 Publication

    Organism-specific databases

    PharmGKBiPA162375773.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 818818Actin filament-associated protein 1-like 2PRO_0000050805Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei56 – 561PhosphotyrosineBy similarity
    Modified residuei413 – 4131PhosphotyrosineBy similarity

    Post-translational modificationi

    Tyrosine phosphorylated (by SRC).2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8N4X5.
    PaxDbiQ8N4X5.
    PRIDEiQ8N4X5.

    PTM databases

    PhosphoSiteiQ8N4X5.

    Expressioni

    Tissue specificityi

    Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ8N4X5.
    BgeeiQ8N4X5.
    CleanExiHS_AFAP1L2.
    GenevestigatoriQ8N4X5.

    Organism-specific databases

    HPAiHPA037843.

    Interactioni

    Subunit structurei

    Interacts with SRC. Interacts with LCK when tyrosine phosphorylated.2 Publications

    Protein-protein interaction databases

    BioGridi124161. 7 interactions.
    MINTiMINT-2877327.
    STRINGi9606.ENSP00000303042.

    Structurei

    Secondary structure

    1
    818
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi359 – 3646
    Beta strandi367 – 3759
    Beta strandi380 – 3834
    Beta strandi390 – 3967
    Turni398 – 4003
    Beta strandi402 – 4043
    Beta strandi414 – 4196
    Beta strandi422 – 4287
    Helixi432 – 44514

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2COFNMR-A354-447[»]
    ProteinModelPortaliQ8N4X5.
    SMRiQ8N4X5. Positions 179-269, 354-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8N4X5.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini175 – 27197PH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini353 – 44795PH 2PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili652 – 74998Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PH domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG308979.
    HOVERGENiHBG106875.
    InParanoidiQ8N4X5.
    OrthoDBiEOG7KQ217.
    PhylomeDBiQ8N4X5.
    TreeFamiTF332622.

    Family and domain databases

    Gene3Di2.30.29.30. 2 hits.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF00169. PH. 2 hits.
    [Graphical view]
    SMARTiSM00233. PH. 2 hits.
    [Graphical view]
    PROSITEiPS50003. PH_DOMAIN. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N4X5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERYKALEQL LTELDDFLKI LDQENLSSTA LVKKSCLAEL LRLYTKSSSS    50
    DEEYIYMNKV TINKQQNAES QGKAPEEQGL LPNGEPSQHS SAPQKSLPDL 100
    PPPKMIPERK QLAIPKTESP EGYYEEAEPY DTSLNEDGEA VSSSYESYDE 150
    EDGSKGKSAP YQWPSPEAGI ELMRDARICA FLWRKKWLGQ WAKQLCVIKD 200
    NRLLCYKSSK DHSPQLDVNL LGSSVIHKEK QVRKKEHKLK ITPMNADVIV 250
    LGLQSKDQAE QWLRVIQEVS GLPSEGASEG NQYTPDAQRF NCQKPDIAEK 300
    YLSASEYGSS VDGHPEVPET KDVKKKCSAG LKLSNLMNLG RKKSTSLEPV 350
    ERSLETSSYL NVLVNSQWKS RWCSVRDNHL HFYQDRNRSK VAQQPLSLVG 400
    CEVVPDPSPD HLYSFRILHK GEELAKLEAK SSEEMGHWLG LLLSESGSKT 450
    DPEEFTYDYV DADRVSCIVS AAKNSLLLMQ RKFSEPNTYI DGLPSQDRQE 500
    ELYDDVDLSE LTAAVEPTEE ATPVADDPNE RESDRVYLDL TPVKSFLHGP 550
    SSAQAQASSP TLSCLDNATE ALPADSGPGP TPDEPCIKCP ENLGEQQLES 600
    LEPEDPSLRI TTVKIQTEQQ RISFPPSCPD AVVATPPGAS PPVKDRLRVT 650
    SAEIKLGKNR TEAEVKRYTE EKERLEKKKE EIRGHLAQLR KEKRELKETL 700
    LKCTDKEVLA SLEQKLKEID EECRGEESRR VDLELSIMEV KDNLKKAEAG 750
    PVTLGTTVDT THLENVSPRP KAVTPASAPD CTPVNSATTL KNRPLSVVVT 800
    GKGTVLQKAK EWEKKGAS 818
    Length:818
    Mass (Da):91,300
    Last modified:October 1, 2002 - v1
    Checksum:i36040D6D09491DA8
    GO
    Isoform 2 (identifier: Q8N4X5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         766-769: Missing.

    Show »
    Length:814
    Mass (Da):90,860
    Checksum:i9C5F035A6B486D83
    GO
    Isoform 3 (identifier: Q8N4X5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-478: Missing.
         811-818: EWEKKGAS → VSSHSQPPLGPAEMSLR

    Show »
    Length:349
    Mass (Da):38,300
    Checksum:i8E2805F99A1A4DAF
    GO
    Isoform 4 (identifier: Q8N4X5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         135-135: N → NGHSGGFLPTGVPRWVQVPERVIYATITL
         766-769: Missing.

    Show »
    Length:842
    Mass (Da):93,894
    Checksum:i6E74C70CDB401E24
    GO

    Sequence cautioni

    The sequence BAB67807.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131E → K in BAF84401. (PubMed:14702039)Curated
    Sequence conflicti224 – 2241S → G in BAF84401. (PubMed:14702039)Curated
    Sequence conflicti567 – 5671N → D in BAB55135. (PubMed:14702039)Curated
    Sequence conflicti596 – 5961Missing in BAB55135. (PubMed:14702039)Curated
    Sequence conflicti605 – 6051D → Y in BAB55135. (PubMed:14702039)Curated
    Sequence conflicti608 – 6081L → Q in AAQ05765. 1 PublicationCurated
    Sequence conflicti630 – 6301D → G in BAF84401. (PubMed:14702039)Curated
    Sequence conflicti758 – 7581V → L in AAQ05765. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti138 – 1381G → R.
    Corresponds to variant rs11196689 [ dbSNP | Ensembl ].
    VAR_050505
    Natural varianti366 – 3661S → R.
    Corresponds to variant rs7075067 [ dbSNP | Ensembl ].
    VAR_050506
    Natural varianti522 – 5221T → S.
    Corresponds to variant rs2781806 [ dbSNP | Ensembl ].
    VAR_050507
    Natural varianti726 – 7261E → K.
    Corresponds to variant rs11599051 [ dbSNP | Ensembl ].
    VAR_054214

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 478478Missing in isoform 3. 1 PublicationVSP_014254Add
    BLAST
    Alternative sequencei135 – 1351N → NGHSGGFLPTGVPRWVQVPE RVIYATITL in isoform 4. 1 PublicationVSP_036211
    Alternative sequencei766 – 7694Missing in isoform 2 and isoform 4. 2 PublicationsVSP_014255
    Alternative sequencei811 – 8188EWEKKGAS → VSSHSQPPLGPAEMSLR in isoform 3. 1 PublicationVSP_014256

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF474151 mRNA. Translation: AAQ05765.1.
    AB067501 mRNA. Translation: BAB67807.1. Different initiation.
    AL355302, AC005383, AL133384 Genomic DNA. Translation: CAI14967.1.
    AL355302, AC005383, AL133384 Genomic DNA. Translation: CAI14968.1.
    AL133384, AC005383, AL355302 Genomic DNA. Translation: CAI40128.1.
    AL133384, AC005383, AL355302 Genomic DNA. Translation: CAI40129.1.
    AK027470 mRNA. Translation: BAB55135.1.
    AK291712 mRNA. Translation: BAF84401.1.
    AK123108 mRNA. Translation: BAG53870.1.
    BC024314 mRNA. Translation: AAH24314.1.
    BC033212 mRNA. Translation: AAH33212.1.
    CCDSiCCDS31286.1. [Q8N4X5-1]
    CCDS31287.1. [Q8N4X5-2]
    RefSeqiNP_001001936.1. NM_001001936.2. [Q8N4X5-1]
    NP_001274753.1. NM_001287824.1.
    NP_115939.1. NM_032550.3. [Q8N4X5-2]
    UniGeneiHs.501106.

    Genome annotation databases

    EnsembliENST00000304129; ENSP00000303042; ENSG00000169129. [Q8N4X5-1]
    ENST00000369271; ENSP00000358276; ENSG00000169129. [Q8N4X5-2]
    GeneIDi84632.
    KEGGihsa:84632.
    UCSCiuc001lbm.3. human. [Q8N4X5-3]
    uc001lbn.3. human. [Q8N4X5-1]
    uc001lbo.3. human. [Q8N4X5-2]
    uc001lbp.3. human. [Q8N4X5-4]

    Polymorphism databases

    DMDMi68052360.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF474151 mRNA. Translation: AAQ05765.1 .
    AB067501 mRNA. Translation: BAB67807.1 . Different initiation.
    AL355302 , AC005383 , AL133384 Genomic DNA. Translation: CAI14967.1 .
    AL355302 , AC005383 , AL133384 Genomic DNA. Translation: CAI14968.1 .
    AL133384 , AC005383 , AL355302 Genomic DNA. Translation: CAI40128.1 .
    AL133384 , AC005383 , AL355302 Genomic DNA. Translation: CAI40129.1 .
    AK027470 mRNA. Translation: BAB55135.1 .
    AK291712 mRNA. Translation: BAF84401.1 .
    AK123108 mRNA. Translation: BAG53870.1 .
    BC024314 mRNA. Translation: AAH24314.1 .
    BC033212 mRNA. Translation: AAH33212.1 .
    CCDSi CCDS31286.1. [Q8N4X5-1 ]
    CCDS31287.1. [Q8N4X5-2 ]
    RefSeqi NP_001001936.1. NM_001001936.2. [Q8N4X5-1 ]
    NP_001274753.1. NM_001287824.1.
    NP_115939.1. NM_032550.3. [Q8N4X5-2 ]
    UniGenei Hs.501106.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2COF NMR - A 354-447 [» ]
    ProteinModelPortali Q8N4X5.
    SMRi Q8N4X5. Positions 179-269, 354-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124161. 7 interactions.
    MINTi MINT-2877327.
    STRINGi 9606.ENSP00000303042.

    PTM databases

    PhosphoSitei Q8N4X5.

    Polymorphism databases

    DMDMi 68052360.

    Proteomic databases

    MaxQBi Q8N4X5.
    PaxDbi Q8N4X5.
    PRIDEi Q8N4X5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304129 ; ENSP00000303042 ; ENSG00000169129 . [Q8N4X5-1 ]
    ENST00000369271 ; ENSP00000358276 ; ENSG00000169129 . [Q8N4X5-2 ]
    GeneIDi 84632.
    KEGGi hsa:84632.
    UCSCi uc001lbm.3. human. [Q8N4X5-3 ]
    uc001lbn.3. human. [Q8N4X5-1 ]
    uc001lbo.3. human. [Q8N4X5-2 ]
    uc001lbp.3. human. [Q8N4X5-4 ]

    Organism-specific databases

    CTDi 84632.
    GeneCardsi GC10M116045.
    HGNCi HGNC:25901. AFAP1L2.
    HPAi HPA037843.
    MIMi 612420. gene.
    neXtProti NX_Q8N4X5.
    PharmGKBi PA162375773.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308979.
    HOVERGENi HBG106875.
    InParanoidi Q8N4X5.
    OrthoDBi EOG7KQ217.
    PhylomeDBi Q8N4X5.
    TreeFami TF332622.

    Miscellaneous databases

    EvolutionaryTracei Q8N4X5.
    GenomeRNAii 84632.
    NextBioi 74555.
    PROi Q8N4X5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N4X5.
    Bgeei Q8N4X5.
    CleanExi HS_AFAP1L2.
    Genevestigatori Q8N4X5.

    Family and domain databases

    Gene3Di 2.30.29.30. 2 hits.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF00169. PH. 2 hits.
    [Graphical view ]
    SMARTi SM00233. PH. 2 hits.
    [Graphical view ]
    PROSITEi PS50003. PH_DOMAIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "XB130, a novel adaptor protein for Src binding and activation."
      Bai X.-H., Keshavjee S., Liu M.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Cerebellum and Placenta.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Pancreas.
    6. Cited for: FUNCTION, INTERACTION WITH SRC, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF TYR-4, PHOSPHORYLATION.
    7. "Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells."
      Emaduddin M., Edelmann M.J., Kessler B.M., Feller S.M.
      Cell Commun. Signal. 6:7-7(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, INTERACTION WITH LCK, IDENTIFICATION BY MASS SPECTROMETRY.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Solution structure of the C-terminal PH domain of hypothetical protein KIAA1914 from human."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 354-448.

    Entry informationi

    Entry nameiAF1L2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N4X5
    Secondary accession number(s): A8K6P7
    , B3KVQ8, Q2UZW3, Q8TB54, Q96PX4, Q96SY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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