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Q8N4X5

- AF1L2_HUMAN

UniProt

Q8N4X5 - AF1L2_HUMAN

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Protein

Actin filament-associated protein 1-like 2

Gene

AFAP1L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.1 Publication

GO - Molecular functioni

  1. protein tyrosine kinase activator activity Source: HGNC
  2. SH2 domain binding Source: HGNC
  3. SH3 domain binding Source: HGNC

GO - Biological processi

  1. inflammatory response Source: HGNC
  2. positive regulation of epidermal growth factor receptor signaling pathway Source: HGNC
  3. positive regulation of interleukin-8 production Source: HGNC
  4. positive regulation of protein tyrosine kinase activity Source: GOC
  5. positive regulation of transcription, DNA-templated Source: HGNC
  6. regulation of interleukin-6 production Source: HGNC
  7. regulation of mitotic cell cycle Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Actin filament-associated protein 1-like 2
Short name:
AFAP1-like protein 2
Gene namesi
Name:AFAP1L2
Synonyms:KIAA1914, XB130
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:25901. AFAP1L2.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi4 – 41Y → F: Reduced interaction with SRC. 1 Publication

Organism-specific databases

PharmGKBiPA162375773.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 818818Actin filament-associated protein 1-like 2PRO_0000050805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561PhosphotyrosineBy similarity
Modified residuei413 – 4131PhosphotyrosineBy similarity

Post-translational modificationi

Tyrosine phosphorylated (by SRC).2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N4X5.
PaxDbiQ8N4X5.
PRIDEiQ8N4X5.

PTM databases

PhosphoSiteiQ8N4X5.

Expressioni

Tissue specificityi

Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas.1 Publication

Gene expression databases

BgeeiQ8N4X5.
CleanExiHS_AFAP1L2.
ExpressionAtlasiQ8N4X5. baseline and differential.
GenevestigatoriQ8N4X5.

Organism-specific databases

HPAiHPA037843.

Interactioni

Subunit structurei

Interacts with SRC. Interacts with LCK when tyrosine phosphorylated.2 Publications

Protein-protein interaction databases

BioGridi124161. 7 interactions.
MINTiMINT-2877327.
STRINGi9606.ENSP00000303042.

Structurei

Secondary structure

1
818
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi359 – 3646
Beta strandi367 – 3759
Beta strandi380 – 3834
Beta strandi390 – 3967
Turni398 – 4003
Beta strandi402 – 4043
Beta strandi414 – 4196
Beta strandi422 – 4287
Helixi432 – 44514

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2COFNMR-A354-447[»]
ProteinModelPortaliQ8N4X5.
SMRiQ8N4X5. Positions 354-443.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N4X5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 27197PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini353 – 44795PH 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili652 – 74998Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG308979.
GeneTreeiENSGT00390000003998.
HOVERGENiHBG106875.
InParanoidiQ8N4X5.
OrthoDBiEOG7KQ217.
PhylomeDBiQ8N4X5.
TreeFamiTF332622.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00233. PH. 2 hits.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N4X5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERYKALEQL LTELDDFLKI LDQENLSSTA LVKKSCLAEL LRLYTKSSSS
60 70 80 90 100
DEEYIYMNKV TINKQQNAES QGKAPEEQGL LPNGEPSQHS SAPQKSLPDL
110 120 130 140 150
PPPKMIPERK QLAIPKTESP EGYYEEAEPY DTSLNEDGEA VSSSYESYDE
160 170 180 190 200
EDGSKGKSAP YQWPSPEAGI ELMRDARICA FLWRKKWLGQ WAKQLCVIKD
210 220 230 240 250
NRLLCYKSSK DHSPQLDVNL LGSSVIHKEK QVRKKEHKLK ITPMNADVIV
260 270 280 290 300
LGLQSKDQAE QWLRVIQEVS GLPSEGASEG NQYTPDAQRF NCQKPDIAEK
310 320 330 340 350
YLSASEYGSS VDGHPEVPET KDVKKKCSAG LKLSNLMNLG RKKSTSLEPV
360 370 380 390 400
ERSLETSSYL NVLVNSQWKS RWCSVRDNHL HFYQDRNRSK VAQQPLSLVG
410 420 430 440 450
CEVVPDPSPD HLYSFRILHK GEELAKLEAK SSEEMGHWLG LLLSESGSKT
460 470 480 490 500
DPEEFTYDYV DADRVSCIVS AAKNSLLLMQ RKFSEPNTYI DGLPSQDRQE
510 520 530 540 550
ELYDDVDLSE LTAAVEPTEE ATPVADDPNE RESDRVYLDL TPVKSFLHGP
560 570 580 590 600
SSAQAQASSP TLSCLDNATE ALPADSGPGP TPDEPCIKCP ENLGEQQLES
610 620 630 640 650
LEPEDPSLRI TTVKIQTEQQ RISFPPSCPD AVVATPPGAS PPVKDRLRVT
660 670 680 690 700
SAEIKLGKNR TEAEVKRYTE EKERLEKKKE EIRGHLAQLR KEKRELKETL
710 720 730 740 750
LKCTDKEVLA SLEQKLKEID EECRGEESRR VDLELSIMEV KDNLKKAEAG
760 770 780 790 800
PVTLGTTVDT THLENVSPRP KAVTPASAPD CTPVNSATTL KNRPLSVVVT
810
GKGTVLQKAK EWEKKGAS
Length:818
Mass (Da):91,300
Last modified:October 1, 2002 - v1
Checksum:i36040D6D09491DA8
GO
Isoform 2 (identifier: Q8N4X5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     766-769: Missing.

Show »
Length:814
Mass (Da):90,860
Checksum:i9C5F035A6B486D83
GO
Isoform 3 (identifier: Q8N4X5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-478: Missing.
     811-818: EWEKKGAS → VSSHSQPPLGPAEMSLR

Show »
Length:349
Mass (Da):38,300
Checksum:i8E2805F99A1A4DAF
GO
Isoform 4 (identifier: Q8N4X5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: N → NGHSGGFLPTGVPRWVQVPERVIYATITL
     766-769: Missing.

Show »
Length:842
Mass (Da):93,894
Checksum:i6E74C70CDB401E24
GO

Sequence cautioni

The sequence BAB67807.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131E → K in BAF84401. (PubMed:14702039)Curated
Sequence conflicti224 – 2241S → G in BAF84401. (PubMed:14702039)Curated
Sequence conflicti567 – 5671N → D in BAB55135. (PubMed:14702039)Curated
Sequence conflicti596 – 5961Missing in BAB55135. (PubMed:14702039)Curated
Sequence conflicti605 – 6051D → Y in BAB55135. (PubMed:14702039)Curated
Sequence conflicti608 – 6081L → Q in AAQ05765. 1 PublicationCurated
Sequence conflicti630 – 6301D → G in BAF84401. (PubMed:14702039)Curated
Sequence conflicti758 – 7581V → L in AAQ05765. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti138 – 1381G → R.
Corresponds to variant rs11196689 [ dbSNP | Ensembl ].
VAR_050505
Natural varianti366 – 3661S → R.
Corresponds to variant rs7075067 [ dbSNP | Ensembl ].
VAR_050506
Natural varianti522 – 5221T → S.
Corresponds to variant rs2781806 [ dbSNP | Ensembl ].
VAR_050507
Natural varianti726 – 7261E → K.
Corresponds to variant rs11599051 [ dbSNP | Ensembl ].
VAR_054214

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 478478Missing in isoform 3. 1 PublicationVSP_014254Add
BLAST
Alternative sequencei135 – 1351N → NGHSGGFLPTGVPRWVQVPE RVIYATITL in isoform 4. 1 PublicationVSP_036211
Alternative sequencei766 – 7694Missing in isoform 2 and isoform 4. 2 PublicationsVSP_014255
Alternative sequencei811 – 8188EWEKKGAS → VSSHSQPPLGPAEMSLR in isoform 3. 1 PublicationVSP_014256

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF474151 mRNA. Translation: AAQ05765.1.
AB067501 mRNA. Translation: BAB67807.1. Different initiation.
AL355302, AC005383, AL133384 Genomic DNA. Translation: CAI14967.1.
AL355302, AC005383, AL133384 Genomic DNA. Translation: CAI14968.1.
AL133384, AC005383, AL355302 Genomic DNA. Translation: CAI40128.1.
AL133384, AC005383, AL355302 Genomic DNA. Translation: CAI40129.1.
AK027470 mRNA. Translation: BAB55135.1.
AK291712 mRNA. Translation: BAF84401.1.
AK123108 mRNA. Translation: BAG53870.1.
BC024314 mRNA. Translation: AAH24314.1.
BC033212 mRNA. Translation: AAH33212.1.
CCDSiCCDS31286.1. [Q8N4X5-1]
CCDS31287.1. [Q8N4X5-2]
RefSeqiNP_001001936.1. NM_001001936.2. [Q8N4X5-1]
NP_001274753.1. NM_001287824.1.
NP_115939.1. NM_032550.3. [Q8N4X5-2]
UniGeneiHs.501106.

Genome annotation databases

EnsembliENST00000304129; ENSP00000303042; ENSG00000169129. [Q8N4X5-1]
ENST00000369271; ENSP00000358276; ENSG00000169129. [Q8N4X5-2]
GeneIDi84632.
KEGGihsa:84632.
UCSCiuc001lbm.3. human. [Q8N4X5-3]
uc001lbn.3. human. [Q8N4X5-1]
uc001lbo.3. human. [Q8N4X5-2]
uc001lbp.3. human. [Q8N4X5-4]

Polymorphism databases

DMDMi68052360.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF474151 mRNA. Translation: AAQ05765.1 .
AB067501 mRNA. Translation: BAB67807.1 . Different initiation.
AL355302 , AC005383 , AL133384 Genomic DNA. Translation: CAI14967.1 .
AL355302 , AC005383 , AL133384 Genomic DNA. Translation: CAI14968.1 .
AL133384 , AC005383 , AL355302 Genomic DNA. Translation: CAI40128.1 .
AL133384 , AC005383 , AL355302 Genomic DNA. Translation: CAI40129.1 .
AK027470 mRNA. Translation: BAB55135.1 .
AK291712 mRNA. Translation: BAF84401.1 .
AK123108 mRNA. Translation: BAG53870.1 .
BC024314 mRNA. Translation: AAH24314.1 .
BC033212 mRNA. Translation: AAH33212.1 .
CCDSi CCDS31286.1. [Q8N4X5-1 ]
CCDS31287.1. [Q8N4X5-2 ]
RefSeqi NP_001001936.1. NM_001001936.2. [Q8N4X5-1 ]
NP_001274753.1. NM_001287824.1.
NP_115939.1. NM_032550.3. [Q8N4X5-2 ]
UniGenei Hs.501106.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2COF NMR - A 354-447 [» ]
ProteinModelPortali Q8N4X5.
SMRi Q8N4X5. Positions 354-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124161. 7 interactions.
MINTi MINT-2877327.
STRINGi 9606.ENSP00000303042.

PTM databases

PhosphoSitei Q8N4X5.

Polymorphism databases

DMDMi 68052360.

Proteomic databases

MaxQBi Q8N4X5.
PaxDbi Q8N4X5.
PRIDEi Q8N4X5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304129 ; ENSP00000303042 ; ENSG00000169129 . [Q8N4X5-1 ]
ENST00000369271 ; ENSP00000358276 ; ENSG00000169129 . [Q8N4X5-2 ]
GeneIDi 84632.
KEGGi hsa:84632.
UCSCi uc001lbm.3. human. [Q8N4X5-3 ]
uc001lbn.3. human. [Q8N4X5-1 ]
uc001lbo.3. human. [Q8N4X5-2 ]
uc001lbp.3. human. [Q8N4X5-4 ]

Organism-specific databases

CTDi 84632.
GeneCardsi GC10M116045.
HGNCi HGNC:25901. AFAP1L2.
HPAi HPA037843.
MIMi 612420. gene.
neXtProti NX_Q8N4X5.
PharmGKBi PA162375773.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308979.
GeneTreei ENSGT00390000003998.
HOVERGENi HBG106875.
InParanoidi Q8N4X5.
OrthoDBi EOG7KQ217.
PhylomeDBi Q8N4X5.
TreeFami TF332622.

Miscellaneous databases

EvolutionaryTracei Q8N4X5.
GenomeRNAii 84632.
NextBioi 74555.
PROi Q8N4X5.
SOURCEi Search...

Gene expression databases

Bgeei Q8N4X5.
CleanExi HS_AFAP1L2.
ExpressionAtlasi Q8N4X5. baseline and differential.
Genevestigatori Q8N4X5.

Family and domain databases

Gene3Di 2.30.29.30. 2 hits.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF00169. PH. 2 hits.
[Graphical view ]
SMARTi SM00233. PH. 2 hits.
[Graphical view ]
PROSITEi PS50003. PH_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "XB130, a novel adaptor protein for Src binding and activation."
    Bai X.-H., Keshavjee S., Liu M.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Cerebellum and Placenta.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pancreas.
  6. Cited for: FUNCTION, INTERACTION WITH SRC, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF TYR-4, PHOSPHORYLATION.
  7. "Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells."
    Emaduddin M., Edelmann M.J., Kessler B.M., Feller S.M.
    Cell Commun. Signal. 6:7-7(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, INTERACTION WITH LCK, IDENTIFICATION BY MASS SPECTROMETRY.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Solution structure of the C-terminal PH domain of hypothetical protein KIAA1914 from human."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 354-448.

Entry informationi

Entry nameiAF1L2_HUMAN
AccessioniPrimary (citable) accession number: Q8N4X5
Secondary accession number(s): A8K6P7
, B3KVQ8, Q2UZW3, Q8TB54, Q96PX4, Q96SY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3