Reviewed, UniProtKB/Swiss-Prot Q8N4X5 (AF1L2_HUMAN)

Names and origin

Protein names

Recommended name:
    Actin filament-associated protein 1-like 2
      Short name=AFAP1-like protein 2

Gene names

Name:	AFAP1L2
Synonyms:	KIAA1914, XB130

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	818 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. Ref.8
Subunit structure	Interacts with SRC. Interacts with LCK when tyrosine phosphorylated. Ref.8 Ref.9
Subcellular location	Cytoplasm.
Tissue specificity	Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas. Ref.8
Post-translational modification	Tyrosine phosphorylated (by SRC). Ref.8 Ref.9 Ref.6 Ref.7 Ref.10 Ref.11
Sequence similarities	Contains 2 PH domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	inflammatory response Ref.8 Inferred from direct assay. Source: HGNC positive regulation of epidermal growth factor receptor signaling pathway Ref.8 Inferred from direct assay. Source: HGNC positive regulation of interleukin-8 production Ref.8 Inferred from direct assay. Source: HGNC positive regulation of transcription, DNA-dependent Ref.8 Inferred from direct assay. Source: HGNC regulation of interleukin-6 production Ref.8 Inferred from direct assay. Source: HGNC regulation of mitotic cell cycle Ref.8 Inferred from direct assay. Source: HGNC
Cellular component	cytoplasm Ref.8 Inferred from direct assay. Source: HGNC
Molecular function	SH2 domain binding Ref.8 Inferred from physical interaction. Source: HGNC SH3 domain binding Ref.8 Inferred from physical interaction. Source: HGNC protein tyrosine kinase activator activity Ref.8 Inferred from direct assay. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N4X5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N4X5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     766-769: Missing.

Isoform 3 (identifier: Q8N4X5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-478: Missing.
     811-818: EWEKKGAS → VSSHSQPPLGPAEMSLR

Isoform 4 (identifier: Q8N4X5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: N → NGHSGGFLPTGVPRWVQVPERVIYATITL
     766-769: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 818

818

Actin filament-associated protein 1-like 2

PRO_0000050805

Regions

Domain

175 – 271

97

PH 1

Domain

353 – 447

95

PH 2

Coiled coil

652 – 749

98

Potential

Amino acid modifications

Modified residue

56

1

Phosphotyrosine By similarity

Modified residue

345

1

Phosphothreonine By similarity

Modified residue

383

1

Phosphotyrosine Ref.7

Modified residue

413

1

Phosphotyrosine Ref.6 Ref.7 Ref.11

Modified residue

668

1

Phosphotyrosine Ref.10

Modified residue

669

1

Phosphothreonine Ref.10

Natural variations

Alternative sequence

1 – 478

478

Missing in isoform 3.

VSP_014254

Alternative sequence

135

1

N → NGHSGGFLPTGVPRWVQVPE RVIYATITL in isoform 4.

VSP_036211

Alternative sequence

766 – 769

4

Missing in isoform 2 and isoform 4.

VSP_014255

Alternative sequence

811 – 818

8

EWEKKGAS → VSSHSQPPLGPAEMSLR in isoform 3.

VSP_014256

Natural variant

138

1

G → R: dbSNP rs11196689.

VAR_050505

Natural variant

366

1

S → R: dbSNP rs7075067.

VAR_050506

Natural variant

522

1

T → S: dbSNP rs2781806.

VAR_050507

Natural variant

726

1

E → K: dbSNP rs11599051.

VAR_054214

Experimental info

Mutagenesis

4

1

Y → F: Reduced interaction with SRC. Ref.8

Sequence conflict

13

1

E → K in BAF84401. Ref.4

Sequence conflict

224

1

S → G in BAF84401. Ref.4

Sequence conflict

567

1

N → D in BAB55135. Ref.4

Sequence conflict

596

1

Missing in BAB55135. Ref.4

Sequence conflict

605

1

D → Y in BAB55135. Ref.4

Sequence conflict

608

1

L → Q in AAQ05765. Ref.1

Sequence conflict

630

1

D → G in BAF84401. Ref.4

Sequence conflict

758

1

V → L in AAQ05765. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

818

Helix Strand Turn

Details...

Beta strand

359 – 364

6

Beta strand

367 – 375

9

Beta strand

380 – 383

4

Beta strand

390 – 396

7

Turn

398 – 400

3

Beta strand

402 – 404

3

Beta strand

414 – 419

6

Beta strand

422 – 428

7

Helix

432 – 445

14

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 36040D6D09491DA8	FASTA	818	91,300
	10 20 30 40 50 60 MERYKALEQL LTELDDFLKI LDQENLSSTA LVKKSCLAEL LRLYTKSSSS DEEYIYMNKV 70 80 90 100 110 120 TINKQQNAES QGKAPEEQGL LPNGEPSQHS SAPQKSLPDL PPPKMIPERK QLAIPKTESP 130 140 150 160 170 180 EGYYEEAEPY DTSLNEDGEA VSSSYESYDE EDGSKGKSAP YQWPSPEAGI ELMRDARICA 190 200 210 220 230 240 FLWRKKWLGQ WAKQLCVIKD NRLLCYKSSK DHSPQLDVNL LGSSVIHKEK QVRKKEHKLK 250 260 270 280 290 300 ITPMNADVIV LGLQSKDQAE QWLRVIQEVS GLPSEGASEG NQYTPDAQRF NCQKPDIAEK 310 320 330 340 350 360 YLSASEYGSS VDGHPEVPET KDVKKKCSAG LKLSNLMNLG RKKSTSLEPV ERSLETSSYL 370 380 390 400 410 420 NVLVNSQWKS RWCSVRDNHL HFYQDRNRSK VAQQPLSLVG CEVVPDPSPD HLYSFRILHK 430 440 450 460 470 480 GEELAKLEAK SSEEMGHWLG LLLSESGSKT DPEEFTYDYV DADRVSCIVS AAKNSLLLMQ 490 500 510 520 530 540 RKFSEPNTYI DGLPSQDRQE ELYDDVDLSE LTAAVEPTEE ATPVADDPNE RESDRVYLDL 550 560 570 580 590 600 TPVKSFLHGP SSAQAQASSP TLSCLDNATE ALPADSGPGP TPDEPCIKCP ENLGEQQLES 610 620 630 640 650 660 LEPEDPSLRI TTVKIQTEQQ RISFPPSCPD AVVATPPGAS PPVKDRLRVT SAEIKLGKNR 670 680 690 700 710 720 TEAEVKRYTE EKERLEKKKE EIRGHLAQLR KEKRELKETL LKCTDKEVLA SLEQKLKEID 730 740 750 760 770 780 EECRGEESRR VDLELSIMEV KDNLKKAEAG PVTLGTTVDT THLENVSPRP KAVTPASAPD 790 800 810 CTPVNSATTL KNRPLSVVVT GKGTVLQKAK EWEKKGAS
	Isoform 2. Checksum: 9C5F035A6B486D83	FASTA	814	90,860
	10 20 30 40 50 60 MERYKALEQL LTELDDFLKI LDQENLSSTA LVKKSCLAEL LRLYTKSSSS DEEYIYMNKV 70 80 90 100 110 120 TINKQQNAES QGKAPEEQGL LPNGEPSQHS SAPQKSLPDL PPPKMIPERK QLAIPKTESP 130 140 150 160 170 180 EGYYEEAEPY DTSLNEDGEA VSSSYESYDE EDGSKGKSAP YQWPSPEAGI ELMRDARICA 190 200 210 220 230 240 FLWRKKWLGQ WAKQLCVIKD NRLLCYKSSK DHSPQLDVNL LGSSVIHKEK QVRKKEHKLK 250 260 270 280 290 300 ITPMNADVIV LGLQSKDQAE QWLRVIQEVS GLPSEGASEG NQYTPDAQRF NCQKPDIAEK 310 320 330 340 350 360 YLSASEYGSS VDGHPEVPET KDVKKKCSAG LKLSNLMNLG RKKSTSLEPV ERSLETSSYL 370 380 390 400 410 420 NVLVNSQWKS RWCSVRDNHL HFYQDRNRSK VAQQPLSLVG CEVVPDPSPD HLYSFRILHK 430 440 450 460 470 480 GEELAKLEAK SSEEMGHWLG LLLSESGSKT DPEEFTYDYV DADRVSCIVS AAKNSLLLMQ 490 500 510 520 530 540 RKFSEPNTYI DGLPSQDRQE ELYDDVDLSE LTAAVEPTEE ATPVADDPNE RESDRVYLDL 550 560 570 580 590 600 TPVKSFLHGP SSAQAQASSP TLSCLDNATE ALPADSGPGP TPDEPCIKCP ENLGEQQLES 610 620 630 640 650 660 LEPEDPSLRI TTVKIQTEQQ RISFPPSCPD AVVATPPGAS PPVKDRLRVT SAEIKLGKNR 670 680 690 700 710 720 TEAEVKRYTE EKERLEKKKE EIRGHLAQLR KEKRELKETL LKCTDKEVLA SLEQKLKEID 730 740 750 760 770 780 EECRGEESRR VDLELSIMEV KDNLKKAEAG PVTLGTTVDT THLENPKAVT PASAPDCTPV 790 800 810 NSATTLKNRP LSVVVTGKGT VLQKAKEWEK KGAS
	Isoform 3. Checksum: 8E2805F99A1A4DAF	FASTA	349	38,300
	10 20 30 40 50 60 MQRKFSEPNT YIDGLPSQDR QEELYDDVDL SELTAAVEPT EEATPVADDP NERESDRVYL 70 80 90 100 110 120 DLTPVKSFLH GPSSAQAQAS SPTLSCLDNA TEALPADSGP GPTPDEPCIK CPENLGEQQL 130 140 150 160 170 180 ESLEPEDPSL RITTVKIQTE QQRISFPPSC PDAVVATPPG ASPPVKDRLR VTSAEIKLGK 190 200 210 220 230 240 NRTEAEVKRY TEEKERLEKK KEEIRGHLAQ LRKEKRELKE TLLKCTDKEV LASLEQKLKE 250 260 270 280 290 300 IDEECRGEES RRVDLELSIM EVKDNLKKAE AGPVTLGTTV DTTHLENVSP RPKAVTPASA 310 320 330 340 PDCTPVNSAT TLKNRPLSVV VTGKGTVLQK AKVSSHSQPP LGPAEMSLR
	Isoform 4. Checksum: 6E74C70CDB401E24	FASTA	842	93,894
	10 20 30 40 50 60 MERYKALEQL LTELDDFLKI LDQENLSSTA LVKKSCLAEL LRLYTKSSSS DEEYIYMNKV 70 80 90 100 110 120 TINKQQNAES QGKAPEEQGL LPNGEPSQHS SAPQKSLPDL PPPKMIPERK QLAIPKTESP 130 140 150 160 170 180 EGYYEEAEPY DTSLNGHSGG FLPTGVPRWV QVPERVIYAT ITLEDGEAVS SSYESYDEED 190 200 210 220 230 240 GSKGKSAPYQ WPSPEAGIEL MRDARICAFL WRKKWLGQWA KQLCVIKDNR LLCYKSSKDH 250 260 270 280 290 300 SPQLDVNLLG SSVIHKEKQV RKKEHKLKIT PMNADVIVLG LQSKDQAEQW LRVIQEVSGL 310 320 330 340 350 360 PSEGASEGNQ YTPDAQRFNC QKPDIAEKYL SASEYGSSVD GHPEVPETKD VKKKCSAGLK 370 380 390 400 410 420 LSNLMNLGRK KSTSLEPVER SLETSSYLNV LVNSQWKSRW CSVRDNHLHF YQDRNRSKVA 430 440 450 460 470 480 QQPLSLVGCE VVPDPSPDHL YSFRILHKGE ELAKLEAKSS EEMGHWLGLL LSESGSKTDP 490 500 510 520 530 540 EEFTYDYVDA DRVSCIVSAA KNSLLLMQRK FSEPNTYIDG LPSQDRQEEL YDDVDLSELT 550 560 570 580 590 600 AAVEPTEEAT PVADDPNERE SDRVYLDLTP VKSFLHGPSS AQAQASSPTL SCLDNATEAL 610 620 630 640 650 660 PADSGPGPTP DEPCIKCPEN LGEQQLESLE PEDPSLRITT VKIQTEQQRI SFPPSCPDAV 670 680 690 700 710 720 VATPPGASPP VKDRLRVTSA EIKLGKNRTE AEVKRYTEEK ERLEKKKEEI RGHLAQLRKE 730 740 750 760 770 780 KRELKETLLK CTDKEVLASL EQKLKEIDEE CRGEESRRVD LELSIMEVKD NLKKAEAGPV 790 800 810 820 830 840 TLGTTVDTTH LENPKAVTPA SAPDCTPVNS ATTLKNRPLS VVVTGKGTVL QKAKEWEKKG AS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"XB130, a novel adaptor protein for Src binding and activation." Bai X.-H., Keshavjee S., Liu M. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:179-187(2001) [PubMed: 11572484] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Cerebellum and Placenta.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Pancreas.
[6]	"Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules." Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J., Lauffenburger D.A., White F.M. Mol. Cell. Proteomics 4:1240-1250(2005) [PubMed: 15951569] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-413, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-383 AND TYR-413, MASS SPECTROMETRY.
[8]	"XB130, a novel adaptor protein for signal transduction." Xu J., Bai X.-H., Lodyga M., Han B., Xiao H., Keshavjee S., Hu J., Zhang H., Yang B.B., Liu M. J. Biol. Chem. 282:16401-16412(2007) [PubMed: 17412687] [Abstract] Cited for: FUNCTION, INTERACTION WITH SRC, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF TYR-4, PHOSPHORYLATION.
[9]	"Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells." Emaduddin M., Edelmann M.J., Kessler B.M., Feller S.M. Cell Commun. Signal. 6:7-7(2008) [PubMed: 18844995] [Abstract] Cited for: PHOSPHORYLATION, INTERACTION WITH LCK, MASS SPECTROMETRY.
[10]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-668 AND THR-669, MASS SPECTROMETRY. Tissue: Epithelium.
[11]	"An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells." Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A., Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D., Wiley H.S., Qian W.-J. J. Proteome Res. 8:3852-3861(2009) [PubMed: 19534553] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-413, MASS SPECTROMETRY. Tissue: Mammary epithelium.
[12]	"Solution structure of the C-terminal PH domain of hypothetical protein KIAA1914 from human." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 354-448.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF474151 mRNA. Translation: AAQ05765.1.
AB067501 mRNA. Translation: BAB67807.1. Different initiation.
AL355302, AC005383, AL133384 Genomic DNA. Translation: CAI14967.1.
AL355302, AC005383, AL133384 Genomic DNA. Translation: CAI14968.1.
AL133384, AC005383, AL355302 Genomic DNA. Translation: CAI40128.1.
AL133384, AC005383, AL355302 Genomic DNA. Translation: CAI40129.1.
AK027470 mRNA. Translation: BAB55135.1.
AK291712 mRNA. Translation: BAF84401.1.
AK123108 mRNA. Translation: BAG53870.1.
BC024314 mRNA. Translation: AAH24314.1.
BC033212 mRNA. Translation: AAH33212.1.

IPI

IPI00181905.
IPI00382615.
IPI00455138.
IPI00902986.

RefSeq

NP_001001936.1.
NP_115939.1.

UniGene

Hs.501106

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2COF	NMR	-	A	354-447	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

Q8N4X5.

PTM databases

PhosphoSite

Q8N4X5.

Proteomic databases

PRIDE

Q8N4X5.

Genome annotation databases

Ensembl

ENST00000304129; ENSP00000303042; ENSG00000169129; Homo sapiens. [Genome view]

GeneID

84632.

KEGG

hsa:84632.

UCSC

uc001lbn.1. human.
uc001lbo.1. human.
uc001lbq.1. human.

Organism-specific databases

CTD

84632.

GeneCards

GC10M116045.

HGNC

HGNC:25901. AFAP1L2.

MIM

612420. gene.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q8N4X5.

Gene expression databases

ArrayExpress

Q8N4X5.

Bgee

Q8N4X5.

CleanEx

HS_AFAP1L2.

Genevestigator

Q8N4X5.

GermOnline

ENSG00000169129. Homo sapiens.

Family and domain databases

InterPro

IPR011993. PH_type.
IPR001849. Pleckstrin_homology.
[Graphical view]

Gene3D

G3DSA:2.30.29.30. PH_type. 2 hits.

Pfam

PF00169. PH. 2 hits.
[Graphical view]

SMART

SM00233. PH. 2 hits.
[Graphical view]

PROSITE

PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

74555.

SOURCE

Search...

Entry information

Entry name

AF1L2_HUMAN

Accession

Primary (citable) accession number: Q8N4X5
Secondary accession number(s): A8K6P7 , B3KVQ8, Q2UZW3, Q8TB54, Q96PX4, Q96SY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	October 1, 2002
Last modified:	November 24, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.