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Protein

Zinc finger protein 808

Gene

ZNF808

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri231 – 253C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 589C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri595 – 617C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri623 – 645C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri651 – 673C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri735 – 757C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri763 – 785C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri791 – 813C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri819 – 841C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri847 – 869C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri875 – 897C2H2-type 24PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 808
Gene namesi
Name:ZNF808
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000198482.10
HGNCiHGNC:33230 ZNF808
neXtProtiNX_Q8N4W9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410633

Polymorphism and mutation databases

BioMutaiZNF808
DMDMi212288109

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049911 – 903Zinc finger protein 808Add BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8N4W9
MaxQBiQ8N4W9
PaxDbiQ8N4W9
PeptideAtlasiQ8N4W9
PRIDEiQ8N4W9

PTM databases

iPTMnetiQ8N4W9
PhosphoSitePlusiQ8N4W9

Expressioni

Gene expression databases

BgeeiENSG00000198482
CleanExiHS_ZNF808
ExpressionAtlasiQ8N4W9 baseline and differential
GenevisibleiQ8N4W9 HS

Interactioni

Protein-protein interaction databases

BioGridi132741, 2 interactors
STRINGi9606.ENSP00000352846

Structurei

3D structure databases

ProteinModelPortaliQ8N4W9
SMRiQ8N4W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 98KRABPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri231 – 253C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 589C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri595 – 617C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri623 – 645C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri651 – 673C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri735 – 757C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri763 – 785C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri791 – 813C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri819 – 841C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri847 – 869C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri875 – 897C2H2-type 24PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00690000102079
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8N4W9
OMAiACDKVFS
OrthoDBiEOG091G02KC
PhylomeDBiQ8N4W9
TreeFamiTF343410

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 23 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 14 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 23 hits
PS50157 ZINC_FINGER_C2H2_2, 24 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4W9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLREEAAQKR KGKESGMALP QGRLTFRDVA IEFSLAEWKF LNPAQRALYR
60 70 80 90 100
EVMLENYRNL EAVDISSKHM MKEVLSTGQG NREVIHTGTL QRHQSYHIGD
110 120 130 140 150
FCFQEIEKEI HNIEFQCQED ERNGHEAPTT KIKKLTGSTD QHDHRHAGNK
160 170 180 190 200
PIKDQLGSSF YSHLPELHIF QIKGEIANQL EKSTSDASSV STSQRISCRP
210 220 230 240 250
QIHISNNYGN NPLNSSLLPQ KQEVHMREKS FPCNESGKAF NCSSLLRKHQ
260 270 280 290 300
IPHLGDKQYK CDVCGKLFNH KQYLACHRRC HTGEKPYKCK ECGKSFSYKS
310 320 330 340 350
SLTCHHRLHT GVKPYKCNEC GKVFRQNSAL VIHKAIHTGE KPYKCNECGK
360 370 380 390 400
AFNQQSHLSR HQRLHTGVKP YKCKICEKAF ACHSYLANHT RIHSGEKTYK
410 420 430 440 450
CNECGKAFNH QSSLARHHIL HTGEKPYKCE ECDKVFSQKS TLERHKRIHT
460 470 480 490 500
GEKPYKCKVC DTAFTCNSQL ARHRRIHTGE KTYKCNECRK TFSRRSSLLC
510 520 530 540 550
HRRLHSGEKP YKCNQCGNTF RHRASLVYHR RLHTLEKSYK CTVCNKVFMR
560 570 580 590 600
NSVLAVHTRI HTAKKPYKCN ECGKAFNQQS HLSRHRRLHT GEKPYKCEAC
610 620 630 640 650
DKVFGQKSAL ESHKRIHTGE KPYRCQVCDT AFTWNSQLAR HTRIHTGEKT
660 670 680 690 700
YKCNECGKTF SYKSSLVWHR RLHGGEKSYK CKVCDKAFVC RSYVAKHTRI
710 720 730 740 750
HSGMKPYKCN ECSKTFSNRS SLVCHRRIHS GEKPYKCSEC SKTFSQKATL
760 770 780 790 800
LCHRRLHSGE KPYKCNDCGN TFRHWSSLVY HRRLHTGEKS YKCTVCDKAF
810 820 830 840 850
VRNSYLARHI RIHTAEKPYK CNECGKAFNE QSHLSRHHRI HTGEKPYKCE
860 870 880 890 900
ACDKVFSRKS HLKRHRIIHT GEKPYKCNEC GKAFSDRSTL IHHQAIHGIG

KFD
Length:903
Mass (Da):104,825
Last modified:July 22, 2008 - v2
Checksum:iBA38357A1D5A5CBA
GO
Isoform 2 (identifier: Q8N4W9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Show »
Length:834
Mass (Da):96,803
Checksum:i5CD2918D6ED0A673
GO

Sequence cautioni

The sequence AAH33230 differs from that shown. In 3'-UTR.Curated
The sequence AAI30352 differs from that shown. In 3'-UTR.Curated
The sequence AAI30354 differs from that shown. In 3'-UTR.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045823134K → N. Corresponds to variant dbSNP:rs329964Ensembl.1
Natural variantiVAR_045824262D → N. Corresponds to variant dbSNP:rs329965Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0349461 – 69Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749856 mRNA Translation: CAH18701.1
AC022150 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72084.1
BC033230 mRNA Translation: AAH33230.1 Sequence problems.
BC130351 mRNA Translation: AAI30352.1 Sequence problems.
BC130353 mRNA Translation: AAI30354.1 Sequence problems.
CCDSiCCDS46167.1 [Q8N4W9-1]
RefSeqiNP_001034975.2, NM_001039886.3 [Q8N4W9-1]
NP_001308353.1, NM_001321424.1 [Q8N4W9-1]
NP_001308354.1, NM_001321425.1 [Q8N4W9-1]
XP_005258966.1, XM_005258909.3 [Q8N4W9-2]
UniGeneiHs.729294

Genome annotation databases

EnsembliENST00000359798; ENSP00000352846; ENSG00000198482 [Q8N4W9-1]
ENST00000487863; ENSP00000420522; ENSG00000198482 [Q8N4W9-2]
GeneIDi388558
KEGGihsa:388558
UCSCiuc002pzq.3 human [Q8N4W9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN808_HUMAN
AccessioniPrimary (citable) accession number: Q8N4W9
Secondary accession number(s): Q68CN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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