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Protein

Zinc finger protein 808

Gene

ZNF808

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri231 – 25323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri567 – 58923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri595 – 61723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri623 – 64523C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri651 – 67323C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri679 – 70123C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri707 – 72923C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri735 – 75723C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri763 – 78523C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri791 – 81323C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri819 – 84123C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri847 – 86923C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri875 – 89723C2H2-type 24PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 808
Gene namesi
Name:ZNF808
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33230. ZNF808.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410633.

Polymorphism and mutation databases

BioMutaiZNF808.
DMDMi212288109.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 903903Zinc finger protein 808PRO_0000304991Add
BLAST

Proteomic databases

PaxDbiQ8N4W9.
PRIDEiQ8N4W9.

PTM databases

iPTMnetiQ8N4W9.
PhosphoSiteiQ8N4W9.

Expressioni

Gene expression databases

BgeeiQ8N4W9.
CleanExiHS_ZNF808.
ExpressionAtlasiQ8N4W9. baseline and differential.
GenevisibleiQ8N4W9. HS.

Interactioni

Protein-protein interaction databases

BioGridi132741. 1 interaction.
STRINGi9606.ENSP00000352846.

Structurei

3D structure databases

ProteinModelPortaliQ8N4W9.
SMRiQ8N4W9. Positions 215-900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9875KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 24 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri231 – 25323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri567 – 58923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri595 – 61723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri623 – 64523C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri651 – 67323C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri679 – 70123C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri707 – 72923C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri735 – 75723C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri763 – 78523C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri791 – 81323C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri819 – 84123C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri847 – 86923C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri875 – 89723C2H2-type 24PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N4W9.
OMAiWHRRLHG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N4W9.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 24 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 23 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 23 hits.
PS50157. ZINC_FINGER_C2H2_2. 24 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4W9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLREEAAQKR KGKESGMALP QGRLTFRDVA IEFSLAEWKF LNPAQRALYR
60 70 80 90 100
EVMLENYRNL EAVDISSKHM MKEVLSTGQG NREVIHTGTL QRHQSYHIGD
110 120 130 140 150
FCFQEIEKEI HNIEFQCQED ERNGHEAPTT KIKKLTGSTD QHDHRHAGNK
160 170 180 190 200
PIKDQLGSSF YSHLPELHIF QIKGEIANQL EKSTSDASSV STSQRISCRP
210 220 230 240 250
QIHISNNYGN NPLNSSLLPQ KQEVHMREKS FPCNESGKAF NCSSLLRKHQ
260 270 280 290 300
IPHLGDKQYK CDVCGKLFNH KQYLACHRRC HTGEKPYKCK ECGKSFSYKS
310 320 330 340 350
SLTCHHRLHT GVKPYKCNEC GKVFRQNSAL VIHKAIHTGE KPYKCNECGK
360 370 380 390 400
AFNQQSHLSR HQRLHTGVKP YKCKICEKAF ACHSYLANHT RIHSGEKTYK
410 420 430 440 450
CNECGKAFNH QSSLARHHIL HTGEKPYKCE ECDKVFSQKS TLERHKRIHT
460 470 480 490 500
GEKPYKCKVC DTAFTCNSQL ARHRRIHTGE KTYKCNECRK TFSRRSSLLC
510 520 530 540 550
HRRLHSGEKP YKCNQCGNTF RHRASLVYHR RLHTLEKSYK CTVCNKVFMR
560 570 580 590 600
NSVLAVHTRI HTAKKPYKCN ECGKAFNQQS HLSRHRRLHT GEKPYKCEAC
610 620 630 640 650
DKVFGQKSAL ESHKRIHTGE KPYRCQVCDT AFTWNSQLAR HTRIHTGEKT
660 670 680 690 700
YKCNECGKTF SYKSSLVWHR RLHGGEKSYK CKVCDKAFVC RSYVAKHTRI
710 720 730 740 750
HSGMKPYKCN ECSKTFSNRS SLVCHRRIHS GEKPYKCSEC SKTFSQKATL
760 770 780 790 800
LCHRRLHSGE KPYKCNDCGN TFRHWSSLVY HRRLHTGEKS YKCTVCDKAF
810 820 830 840 850
VRNSYLARHI RIHTAEKPYK CNECGKAFNE QSHLSRHHRI HTGEKPYKCE
860 870 880 890 900
ACDKVFSRKS HLKRHRIIHT GEKPYKCNEC GKAFSDRSTL IHHQAIHGIG

KFD
Length:903
Mass (Da):104,825
Last modified:July 22, 2008 - v2
Checksum:iBA38357A1D5A5CBA
GO
Isoform 2 (identifier: Q8N4W9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Show »
Length:834
Mass (Da):96,803
Checksum:i5CD2918D6ED0A673
GO

Sequence cautioni

The sequence AAH33230.1 differs from that shown.In 3'-UTR.Curated
The sequence AAI30352.1 differs from that shown.In 3'-UTR.Curated
The sequence AAI30354.1 differs from that shown.In 3'-UTR.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti134 – 1341K → N.
Corresponds to variant rs329964 [ dbSNP | Ensembl ].
VAR_045823
Natural varianti262 – 2621D → N.
Corresponds to variant rs329965 [ dbSNP | Ensembl ].
VAR_045824

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6969Missing in isoform 2. 1 PublicationVSP_034946Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749856 mRNA. Translation: CAH18701.1.
AC022150 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72084.1.
BC033230 mRNA. Translation: AAH33230.1. Sequence problems.
BC130351 mRNA. Translation: AAI30352.1. Sequence problems.
BC130353 mRNA. Translation: AAI30354.1. Sequence problems.
CCDSiCCDS46167.1. [Q8N4W9-1]
RefSeqiNP_001034975.2. NM_001039886.3. [Q8N4W9-1]
XP_005258963.1. XM_005258906.2. [Q8N4W9-1]
XP_005258964.1. XM_005258907.2. [Q8N4W9-1]
XP_005258966.1. XM_005258909.2. [Q8N4W9-2]
XP_011525256.1. XM_011526954.1. [Q8N4W9-1]
UniGeneiHs.729294.

Genome annotation databases

EnsembliENST00000359798; ENSP00000352846; ENSG00000198482. [Q8N4W9-1]
ENST00000487863; ENSP00000420522; ENSG00000198482. [Q8N4W9-2]
GeneIDi388558.
KEGGihsa:388558.
UCSCiuc002pzq.3. human. [Q8N4W9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749856 mRNA. Translation: CAH18701.1.
AC022150 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72084.1.
BC033230 mRNA. Translation: AAH33230.1. Sequence problems.
BC130351 mRNA. Translation: AAI30352.1. Sequence problems.
BC130353 mRNA. Translation: AAI30354.1. Sequence problems.
CCDSiCCDS46167.1. [Q8N4W9-1]
RefSeqiNP_001034975.2. NM_001039886.3. [Q8N4W9-1]
XP_005258963.1. XM_005258906.2. [Q8N4W9-1]
XP_005258964.1. XM_005258907.2. [Q8N4W9-1]
XP_005258966.1. XM_005258909.2. [Q8N4W9-2]
XP_011525256.1. XM_011526954.1. [Q8N4W9-1]
UniGeneiHs.729294.

3D structure databases

ProteinModelPortaliQ8N4W9.
SMRiQ8N4W9. Positions 215-900.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132741. 1 interaction.
STRINGi9606.ENSP00000352846.

PTM databases

iPTMnetiQ8N4W9.
PhosphoSiteiQ8N4W9.

Polymorphism and mutation databases

BioMutaiZNF808.
DMDMi212288109.

Proteomic databases

PaxDbiQ8N4W9.
PRIDEiQ8N4W9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359798; ENSP00000352846; ENSG00000198482. [Q8N4W9-1]
ENST00000487863; ENSP00000420522; ENSG00000198482. [Q8N4W9-2]
GeneIDi388558.
KEGGihsa:388558.
UCSCiuc002pzq.3. human. [Q8N4W9-1]

Organism-specific databases

CTDi388558.
GeneCardsiZNF808.
HGNCiHGNC:33230. ZNF808.
neXtProtiNX_Q8N4W9.
PharmGKBiPA162410633.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N4W9.
OMAiWHRRLHG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N4W9.
TreeFamiTF343410.

Miscellaneous databases

GenomeRNAii388558.
NextBioi102151.
PROiQ8N4W9.

Gene expression databases

BgeeiQ8N4W9.
CleanExiHS_ZNF808.
ExpressionAtlasiQ8N4W9. baseline and differential.
GenevisibleiQ8N4W9. HS.

Family and domain databases

Gene3Di3.30.160.60. 24 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 23 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 23 hits.
PS50157. ZINC_FINGER_C2H2_2. 24 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Retina.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.

Entry informationi

Entry nameiZN808_HUMAN
AccessioniPrimary (citable) accession number: Q8N4W9
Secondary accession number(s): Q68CN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 22, 2008
Last modified: May 11, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.