ID   DJC22_HUMAN             Reviewed;         341 AA.
AC   Q8N4W6; B3KP54;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 143.
DE   RecName: Full=DnaJ homolog subfamily C member 22;
GN   Name=DNAJC22;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May function as a co-chaperone.
CC   -!- INTERACTION:
CC       Q8N4W6; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12162311, EBI-16439278;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AK055747; BAG51566.1; -; mRNA.
DR   EMBL; CH471111; EAW58066.1; -; Genomic_DNA.
DR   EMBL; BC033236; AAH33236.1; -; mRNA.
DR   CCDS; CCDS8785.1; -.
DR   RefSeq; NP_001291873.1; NM_001304944.1.
DR   RefSeq; NP_079178.2; NM_024902.3.
DR   AlphaFoldDB; Q8N4W6; -.
DR   SMR; Q8N4W6; -.
DR   BioGRID; 123031; 41.
DR   IntAct; Q8N4W6; 1.
DR   STRING; 9606.ENSP00000446830; -.
DR   iPTMnet; Q8N4W6; -.
DR   PhosphoSitePlus; Q8N4W6; -.
DR   BioMuta; DNAJC22; -.
DR   DMDM; 74728914; -.
DR   MassIVE; Q8N4W6; -.
DR   PaxDb; 9606-ENSP00000446830; -.
DR   PeptideAtlas; Q8N4W6; -.
DR   ProteomicsDB; 71983; -.
DR   Antibodypedia; 25951; 100 antibodies from 15 providers.
DR   DNASU; 79962; -.
DR   Ensembl; ENST00000395069.3; ENSP00000378508.2; ENSG00000178401.16.
DR   Ensembl; ENST00000549441.7; ENSP00000446830.1; ENSG00000178401.16.
DR   Ensembl; ENST00000647553.1; ENSP00000498036.1; ENSG00000178401.16.
DR   GeneID; 79962; -.
DR   KEGG; hsa:79962; -.
DR   MANE-Select; ENST00000549441.7; ENSP00000446830.1; NM_001304944.2; NP_001291873.1.
DR   UCSC; uc001rua.4; human.
DR   AGR; HGNC:25802; -.
DR   CTD; 79962; -.
DR   GeneCards; DNAJC22; -.
DR   HGNC; HGNC:25802; DNAJC22.
DR   HPA; ENSG00000178401; Tissue enriched (liver).
DR   neXtProt; NX_Q8N4W6; -.
DR   OpenTargets; ENSG00000178401; -.
DR   PharmGKB; PA162383905; -.
DR   VEuPathDB; HostDB:ENSG00000178401; -.
DR   eggNOG; KOG0714; Eukaryota.
DR   GeneTree; ENSGT00390000012136; -.
DR   HOGENOM; CLU_057927_1_0_1; -.
DR   InParanoid; Q8N4W6; -.
DR   OMA; VWWHCLL; -.
DR   OrthoDB; 10644at2759; -.
DR   PhylomeDB; Q8N4W6; -.
DR   TreeFam; TF324581; -.
DR   PathwayCommons; Q8N4W6; -.
DR   SignaLink; Q8N4W6; -.
DR   BioGRID-ORCS; 79962; 28 hits in 1147 CRISPR screens.
DR   ChiTaRS; DNAJC22; human.
DR   GenomeRNAi; 79962; -.
DR   Pharos; Q8N4W6; Tbio.
DR   PRO; PR:Q8N4W6; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q8N4W6; Protein.
DR   Bgee; ENSG00000178401; Expressed in right lobe of liver and 174 other cell types or tissues.
DR   ExpressionAtlas; Q8N4W6; baseline and differential.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; DnaJ domain; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR007829; TM2.
DR   PANTHER; PTHR44733; DNAJ HOMOLOG SUBFAMILY C MEMBER 22; 1.
DR   PANTHER; PTHR44733:SF1; DNAJ HOMOLOG SUBFAMILY C MEMBER 22; 1.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF05154; TM2; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; Chaperone J-domain; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
DR   Genevisible; Q8N4W6; HS.
PE   1: Evidence at protein level;
KW   Chaperone; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..341
FT                   /note="DnaJ homolog subfamily C member 22"
FT                   /id="PRO_0000325862"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          277..341
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
SQ   SEQUENCE   341 AA;  38086 MW;  0246AFCB12D09917 CRC64;
     MAKGLLVTYA LWAVGGPAGL HHLYLGRDSH ALLWMLTLGG GGLGWLWEFW KLPSFVAQAN
     RAQGQRQSPR GVTPPLSPIR FAAQVIVGIY FGLVALISLS SMVNFYIVAL PLAVGLGVLL
     VAAVGNQTSD FKNTLGSAFL TSPIFYGRPI AILPISVAAS ITAQRHRRYK ALVASEPLSV
     RLYRLGLAYL AFTGPLAYSA LCNTAATLSY VAETFGSFLN WFSFFPLLGR LMEFVLLLPY
     RIWRLLMGET GFNSSCFQEW AKLYEFVHSF QDEKRQLAYQ VLGLSEGATN EEIHRSYQEL
     VKVWHPDHNL DQTEEAQRHF LEIQAAYEVL SQPRKPWGSR R
//